The role of transforming growth factor beta-1 (TGF-β1) in the development of fibrosis in keratoconus.

IF 1.6 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Irish Journal of Medical Science Pub Date : 2025-08-06 DOI:10.1007/s11845-025-04029-9

Mustafa Yildirim

{"title":"The role of transforming growth factor beta-1 (TGF-β1) in the development of fibrosis in keratoconus.","authors":"Mustafa Yildirim","doi":"10.1007/s11845-025-04029-9","DOIUrl":null,"url":null,"abstract":"Background: The etiology of keratoconus, a disease characterized by deterioration in the extracellular matrix and thinning of the corneal stroma, has not yet been fully elucidated. Recent studies have drawn attention to the relationship between TGF-β1 (Transforming Growth Factor Beta-1) and keratoconus because of its essential role in extracellular matrix secretion.Aims: This study aimed to assess serum TGF-β1 levels in keratoconus patients and demonstrate its potential for estimating the severity of the disease.Materials and methods: The study prospectively included 63 patients diagnosed with keratoconus, followed-up between October 2023 and May 2024, and 65 healthy individuals. Patients were divided into four groups according to the Amsler-Krumeich classification. Serum TGF-β1 levels were measured from venous blood samples taken from the patient and control groups using ELISA.Results: In the patient group, TGF-β1 levels were 357.13 pg/ml (165.43-793.91) and 233.71 pg/ml (117.95-583.72) in the control group. TGF-β1 levels in the patient group were significantly higher than in the control group (p = 0.001). When keratoconus was examined according to stage, it was determined that TGF-β1 levels increased as the severity of the disease increased (p < 0.05 for all groups). No statistical difference was found between the groups in terms of age and gender.Conclusion: Considering that TGF-β1 is effective in the formation of fibrosis, high TGF-β1 levels may play a role in the scar formation observed in the advanced stages of keratoconus patients.","PeriodicalId":14507,"journal":{"name":"Irish Journal of Medical Science","volume":" ","pages":""},"PeriodicalIF":1.6000,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Irish Journal of Medical Science","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11845-025-04029-9","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The etiology of keratoconus, a disease characterized by deterioration in the extracellular matrix and thinning of the corneal stroma, has not yet been fully elucidated. Recent studies have drawn attention to the relationship between TGF-β1 (Transforming Growth Factor Beta-1) and keratoconus because of its essential role in extracellular matrix secretion.

Aims: This study aimed to assess serum TGF-β1 levels in keratoconus patients and demonstrate its potential for estimating the severity of the disease.

Materials and methods: The study prospectively included 63 patients diagnosed with keratoconus, followed-up between October 2023 and May 2024, and 65 healthy individuals. Patients were divided into four groups according to the Amsler-Krumeich classification. Serum TGF-β1 levels were measured from venous blood samples taken from the patient and control groups using ELISA.

Results: In the patient group, TGF-β1 levels were 357.13 pg/ml (165.43-793.91) and 233.71 pg/ml (117.95-583.72) in the control group. TGF-β1 levels in the patient group were significantly higher than in the control group (p = 0.001). When keratoconus was examined according to stage, it was determined that TGF-β1 levels increased as the severity of the disease increased (p < 0.05 for all groups). No statistical difference was found between the groups in terms of age and gender.

Conclusion: Considering that TGF-β1 is effective in the formation of fibrosis, high TGF-β1 levels may play a role in the scar formation observed in the advanced stages of keratoconus patients.

查看原文本刊更多论文

转化生长因子β -1 （TGF-β1）在圆锥角膜纤维化发生中的作用

背景：圆锥角膜是一种以细胞外基质恶化和角膜基质变薄为特征的疾病，其病因尚未完全阐明。由于TGF-β1（转化生长因子β -1）在细胞外基质分泌中起重要作用，近年来的研究开始关注其与圆锥角膜的关系。目的：本研究旨在评估圆锥角膜患者血清TGF-β1水平，并证明其在估计疾病严重程度方面的潜力。材料与方法：本研究前瞻性纳入63例诊断为圆锥角膜的患者，随访时间为2023年10月至2024年5月，健康个体65例。根据Amsler-Krumeich分类将患者分为四组。采用ELISA法检测患者和对照组静脉血血清TGF-β1水平。结果：患者组TGF-β1水平为357.13 pg/ml(165.43 ~ 793.91)，对照组为233.71 pg/ml（117.95 ~ 583.72）。患者组TGF-β1水平显著高于对照组（p = 0.001）。对圆锥角膜进行分期检查时，发现TGF-β1水平随着病情的加重而升高(p)。结论：考虑到TGF-β1在纤维化的形成中是有效的，高TGF-β1水平可能在晚期圆锥角膜患者观察到的瘢痕形成中起作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Irish Journal of Medical Science 医学-医学：内科

CiteScore

3.70

自引率

4.80%

发文量

357

审稿时长

4-8 weeks

期刊介绍： The Irish Journal of Medical Science is the official organ of the Royal Academy of Medicine in Ireland. Established in 1832, this quarterly journal is a contribution to medical science and an ideal forum for the younger medical/scientific professional to enter world literature and an ideal launching platform now, as in the past, for many a young research worker. The primary role of both the Academy and IJMS is that of providing a forum for the exchange of scientific information and to promote academic discussion, so essential to scientific progress.