A study of sarcopenia in patients with type 2 diabetes mellitus of more than 10 years duration and its association with bone mineral density.

IF 1.6 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Irish Journal of Medical Science Pub Date : 2025-08-06 DOI:10.1007/s11845-025-04050-y

B Parthasarathy, Kirubhakaran K, S Pravin Selvam

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引用次数: 0

Abstract

Introduction: Diabetes mellitus is a growing global health concern, with an estimated 643 million individuals projected to be affected by 2030. Sarcopenia, once considered a normal part of aging, is now known to be associated with chronic diseases, including type 2 diabetes mellitus (T2DM). Muscle mass typically declines by approximately 8% per decade after age 40, accelerating to 15-25% per decade after age 70.

Aim: To determine the prevalence of sarcopenia in patients with T2DM of more than 10 years' duration and evaluate its association with bone mineral density (BMD).

Methods: An observational study was conducted at a tertiary care hospital in Salem from January to October 2024. A total of 120 patients with T2DM for over 10 years were included. Data collected included demographics, medical history (fractures, comorbidities, use of insulin, bisphosphonates, or vitamin D supplements), and physical examination findings (weight, height, BMI, and blood pressure). Sarcopenia and BMD were assessed using dual-energy X-ray absorptiometry (DEXA).

Results: The mean age of participants was 63.4 ± 8.7 years. Most had diabetes for 10-15 years (56.7%), and 32.5% had 16-20 years. The mean BMI was 25.7 ± 3.4 kg/m². Sarcopenia was present in 30.0% of participants. Additionally, 48.3% had osteopenia and 28.3% had osteoporosis.

Conclusion: Routine screening for sarcopenia and BMD in older adults with long-standing T2DM is essential for early intervention. Good glycemic control may help mitigate the risk of sarcopenia and related complications.

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10年以上2型糖尿病患者肌肉减少症与骨密度关系的研究

导读：糖尿病是一个日益严重的全球健康问题，预计到2030年将有6.43亿人受到影响。肌肉减少症，曾经被认为是衰老的正常部分，现在被认为与慢性疾病有关，包括2型糖尿病（T2DM）。40岁以后，肌肉质量通常每十年下降约8%，70岁以后每十年加速下降15-25%。目的：了解骨骼肌减少症在病程超过10年的2型糖尿病患者中的患病率，并评估其与骨密度（BMD）的关系。方法：于2024年1 - 10月在塞勒姆市一家三级医院进行观察性研究。共纳入120例10年以上T2DM患者。收集的数据包括人口统计学、病史（骨折、合并症、胰岛素、双膦酸盐或维生素D补充剂的使用）和体格检查结果（体重、身高、BMI和血压）。采用双能x线骨密度仪（DEXA）评估骨骼肌减少症和骨密度。结果：参与者平均年龄63.4±8.7岁。大多数糖尿病患者病程为10-15年（56.7%），32.5%为16-20年。平均BMI为25.7±3.4 kg/m2。30.0%的参与者出现肌肉减少症。此外，48.3%患有骨质减少症，28.3%患有骨质疏松症。结论：对老年长期T2DM患者进行骨骼肌减少症和骨密度的常规筛查对早期干预至关重要。良好的血糖控制可能有助于降低肌肉减少症和相关并发症的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Irish Journal of Medical Science 医学-医学：内科

CiteScore

3.70

自引率

4.80%

发文量

357

审稿时长

4-8 weeks

期刊介绍： The Irish Journal of Medical Science is the official organ of the Royal Academy of Medicine in Ireland. Established in 1832, this quarterly journal is a contribution to medical science and an ideal forum for the younger medical/scientific professional to enter world literature and an ideal launching platform now, as in the past, for many a young research worker. The primary role of both the Academy and IJMS is that of providing a forum for the exchange of scientific information and to promote academic discussion, so essential to scientific progress.