Impact of royal jelly consumption on oxidative stress, anti-oxidant markers and physical activities of patients with multiple sclerosis: a randomized double-blind placebo-controlled study.

IF 1.6 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Irish Journal of Medical Science Pub Date : 2025-08-18 DOI:10.1007/s11845-025-04009-z

Zahra Eslamifar, Farzaneh Manucheri, Saeed Ghanbari, Mohammadreza Zandi, Susan Sabbagh

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引用次数: 0

Abstract

Background: The study investigates the effects of royal jelly (RJ) on patients with relapsing-remitting multiple sclerosis (RRMS), focusing on its potential to reduce oxidative stress, improve antioxidant levels, and enhance quality of life.

Methods: A total of 61 RRMS patients were randomly assigned to either a RJ group or a placebo group, receiving a daily dose of 500 mg for 45 days. Key outcomes measured included expanded disability status scale (EDSS) scores, levels of malondialdehyde (MDA), and activities of antioxidants such as catalase (CAT) and superoxide dismutase (SOD), along with assessments of fatigue and quality of life.

Results: Results indicated that the RJ group experienced a significant reduction in EDSS scores (P < 0.001) and MDA levels (P < 0.0001). The activity of SOD and CAT after consumption of RJ had increased significantly (P < 0.0001, P < 0.001), respectively. Additionally, improvements were noted in some parameters of fatigue and quality of life measures.

Conclusion: The findings suggest that RJ may help decrease oxidative stress and improve motor function and anti-oxidant capacity in MS patients, potentially slowing disease progression.

Trial registration: This study was registered on the Iranian Registry of Clinical Trials (Registration No. IRCT20220116053732N1) on 2022.05.08.

查看原文本刊更多论文

食用蜂王浆对多发性硬化症患者氧化应激、抗氧化标志物和身体活动的影响：一项随机双盲安慰剂对照研究

背景：本研究探讨蜂王浆（RJ）对复发-缓解型多发性硬化症（RRMS）患者的影响，重点关注其降低氧化应激、提高抗氧化水平和提高生活质量的潜力。方法：共有61例RRMS患者被随机分配到RJ组或安慰剂组，每天接受500 mg的剂量，持续45天。测量的主要结果包括扩展残疾状态量表（EDSS）评分、丙二醛（MDA）水平、过氧化氢酶（CAT）和超氧化物歧化酶（SOD）等抗氧化剂的活性，以及疲劳和生活质量的评估。结果表明，RJ组EDSS评分显著降低(P)。结论：RJ可能有助于降低MS患者的氧化应激，改善运动功能和抗氧化能力，可能减缓疾病进展。试验注册：本研究已在伊朗临床试验注册中心注册(注册号：。IRCT20220116053732N1)于2022.05.08发布。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Irish Journal of Medical Science 医学-医学：内科

CiteScore

3.70

自引率

4.80%

发文量

357

审稿时长

4-8 weeks

期刊介绍： The Irish Journal of Medical Science is the official organ of the Royal Academy of Medicine in Ireland. Established in 1832, this quarterly journal is a contribution to medical science and an ideal forum for the younger medical/scientific professional to enter world literature and an ideal launching platform now, as in the past, for many a young research worker. The primary role of both the Academy and IJMS is that of providing a forum for the exchange of scientific information and to promote academic discussion, so essential to scientific progress.