International Journal of Obesity最新文献

{"title":"Association of BCHE gene SNP rs1803274 (K-variant) and rs3495 with obesity in Pakistani population group.","authors":"Amna Amir, Sabir Hussain, Syed Tahir Abbas Shah, Rabia Habib, Zahid Muneer, Eugenie Nepovimova, Kamil Kuca, Syed Muhammad Nurulain","doi":"10.1038/s41366-025-01715-7","DOIUrl":"10.1038/s41366-025-01715-7","url":null,"abstract":"<p><strong>Background: </strong>Obesity plays a crucial role in the development of metabolic disorders including diabetes, coronary and renal diseases. There are several factors involved in the pathology of obesity, including chronic inflammation and exposure to environmental contaminants. Recently, the cholinergic co-hydrolyzing enzyme BChE has been associated with clinical conditions such as diabetes and obesity. This study aims to investigate the levels of BChE and inflammatory markers in the serum, as well as the association between two specific BCHE gene variants (rs1803274 and rs3495) and the risk of obesity in the Pakistani population.</p><p><strong>Methods: </strong>The study recruited 350 people with obesity and 200 volunteers with no obesity. Proinflammatory cytokines (TNF-α, IL-6, and IL-1β) levels were quantified using ELISA kits, while the analysis of BCHE gene SNPs rs1803274 (K-variant) and rs3495 was conducted using the tetra-primer amplification refractory mutation-PCR (tetra-ARM-PCR) and PCR-restriction fragment length polymorphism (RFLP) methods, respectively. Additionally, clinico-pathological parameters HDL, LDL, BMI, Homa-IR, insulin, glucose, blood pressure was also assessed in subjects of current study.</p><p><strong>Results: </strong>Results showed significantly higher levels of BChE, TNF-α, IL-1β, and IL-6 in the obesity group compared to the group without obesity. Furthermore, the obesity group exhibited higher blood pressure and LDL levels, as well as lower HDL levels when compared to group without obesity. Logistic regression analysis revealed a relationship between obesity and higher BChE activity, blood pressure, LDL, and lower HDL levels. The study also found a statistically significant association between the BCHE gene SNPs rs1803274 (K-variant) and rs3495 and the risk of obesity (OR = 2.01; CI = 1.21-3.33; p = 0.0063; OR = 1.80; CI = 1.09-2.96, respectively).</p><p><strong>Conclusions: </strong>In conclusion, the study suggests that BChE and inflammatory cytokines play a significant role in the development and pathogenesis of obesity and can also act as good diagnostic biomarkers for obesity and its related metabolic disorders.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"881-887"},"PeriodicalIF":4.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating preschool-aged chronotype and social jetlag as predictors of early adolescent diet and BMI z-score: an eight-year follow-up from the DAGIS study.","authors":"Anna M Abdollahi, Ilona Merikanto, Henna Vepsäläinen, Xinyue Li, Emmi Tilli, Henna Peltonen, Ilse Tillman, Carola Ray, Josefine Björkqvist, Eva Roos, Reetta Lehto, Maijaliisa Erkkola","doi":"10.1038/s41366-024-01702-4","DOIUrl":"10.1038/s41366-024-01702-4","url":null,"abstract":"<p><strong>Background/objectives: </strong>Circadian health plays an important role in overall well-being. The objective of this study was to examine whether potential indicators of circadian disruption, such as exhibiting a later chronotype or greater social jetlag, in preschool-age could predict dietary habits or BMI z-scores in an eight-year follow-up.</p><p><strong>Subjects/methods: </strong>Our data included 210 children who participated in the DAGIS Survey in 2015-2016 (baseline, mean [SD] age: 4.69 [0.89] years) and DAGIS Next in 2023 (follow-up, age: 12.03 [0.90] years). Chronotype and social jetlag were calculated from baseline sleep measures assessed from 7-day actigraphy. Diet was assessed at follow-up with a Food Frequency Questionnaire, which evaluated the weekly consumption frequency of (1) fruits and vegetables and (2) sugary foods and drinks. BMI z-score based on Finnish growth references was calculated from height and weight measures from baseline and follow-up. Associations were analyzed with linear regression models.</p><p><strong>Results: </strong>Follow-up BMI z-score was predicted by both preschool-aged chronotype (β-est: 0.22 [95% CI: 0.01, 0.42] p = 0.03) and social jetlag (β-est: 0.33 [95% CI: 0.02, 0.65], p = 0.04) after covariate adjustment. No associations were observed between preschool-aged chronotype or social jetlag and preadolescent fruit and vegetable or sugary food and drink consumption.</p><p><strong>Conclusions: </strong>Having a later chronotype and greater social jetlag during preschool age predicted a higher preadolescent weight outcome. Obesity prevention initiatives should include efforts to reduce the risk of circadian disruption among young children, by accounting for chronotype and aiming to reduce social jetlag in interventions.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"793-800"},"PeriodicalIF":4.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intramyocellular lipid use is altered with exercise in males with childhood-onset obesity despite no differences in substrate oxidation.","authors":"S Feola, L Al-Nabelsi, B T Tam, J Near, J A Morais, S Santosa","doi":"10.1038/s41366-025-01720-w","DOIUrl":"10.1038/s41366-025-01720-w","url":null,"abstract":"<p><strong>Objective: </strong>Compared to adulthood-onset obesity (AO), those with childhood-onset obesity (CO) are at greater risk of metabolic disease. However, the differences between these two obesity phenotypes are not clear. The aim of this study is to investigate how the age of obesity onset (CO vs. AO) affects the use of intramyocellular (IMCL) and extramyocellular (EMCL) lipids in response to exercise.</p><p><strong>Methods: </strong>Males with CO (n = 5) and AO (n = 5) were recruited. At the first study visit, body composition was measured via dual-energy x-ray absorptiometry (DEXA). Energy expenditure and substrate oxidation were measured via indirect calorimetry. Participants were provided with standardized meals for 3 days prior to the exercise study visit. At the exercise study visit, IMCL and EMCL were measured via magnetic resonance spectroscopy (MRS) before and after 90-minutes of moderate intensity cycling with indirect calorimetry.</p><p><strong>Results: </strong>Substrate oxidation at rest and during exercise was not different between groups. Post-exercise, a decrease in IMCL was observed in the AO group that was not demonstrated in the CO group. There were no changes in EMCL post-exercise in either group.</p><p><strong>Conclusions: </strong>This was the first study to compare the effects of exercise on IMCL and EMCL use in males with CO and AO. The decreases in IMCL of the AO group is similar with those observed in the literature in lean individuals. We made the novel observation that with moderate intensity cycling, males with CO do not appear to use IMCL as effectively as those with AO, suggesting perturbations in IMCL metabolism.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"915-920"},"PeriodicalIF":4.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical activity and metabolic health: Is it all in the timing?","authors":"Joseph Henson, Melanie J Davies, Andrew P Hall, Thomas Yates","doi":"10.1038/s41366-025-01736-2","DOIUrl":"10.1038/s41366-025-01736-2","url":null,"abstract":"","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"749-750"},"PeriodicalIF":4.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"V̇O₂peak estimation in people with overweight and obesity before and after a 14-week lifestyle intervention.","authors":"Mikkel Thunestvedt Hansen, Karina Husted, Johanne Louise Modvig, Kristine Kjær Lange, Cecilie Moe Weinreich, Cathrine Tranberg, Tue Rømer, Arthur Ingersen, Flemming Dela, Jørn Wulff Helge","doi":"10.1038/s41366-025-01713-9","DOIUrl":"10.1038/s41366-025-01713-9","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the validity and applicability of a non-exercise estimation of cardiorespiratory fitness using resting seismocardiography (SCG eV̇O₂peak) in people with overweight and obesity before and after a 14-week lifestyle intervention.</p><p><strong>Methods: </strong>The study was carried out at a Folk high school that offers 14-week courses on lifestyle changes where participants live at the school and voluntarily participate in daily lectures and activities. Sixty-seven men and women with age and body mass index between 18 and 70 years and 25-50 kg·m^-2 were tested at baseline, and 52 had a follow-up test after 14 weeks. Testing included the determination of anthropometric variables, an SCG eV̇O₂peak at supine rest, and a gold standard V̇O₂peak test on a cycle ergometer until voluntary exhaustion.</p><p><strong>Results: </strong>Agreement analysis for V̇O₂peak at baseline (n = 67, SCG eV̇O₂peak: 26.9 ± 1.9 ml·min^-1·kg^-1, V̇O₂peak: 26.6 ± 1.6 ml·min^-1·kg^-1, mean ± 95% confidence interval) showed a bias of 0.3 ± 1.0 ml·min^-1·kg^-1 with 95% limits of agreement (LoA) ranging ± 9.8 ml·min^-1·kg^-1. A Pearson's correlation of r = 0.78 (p < 0.0001) and a standard error of estimate (SEE) of 5.0 ml·min^-1·kg^-1 were found between methods. At follow-up (n = 52), body mass was reduced by 6.6 ± 1.4 kg (p < 0.0001). V̇O₂peak increased by 3.3 ± 0.9 ml·min^-1·kg^-1 and 175 ± 78 ml·min^-1 and SCG eV̇O₂peak by 2.6 ± 0.8 ml·min^-1·kg^-1 and 93 ± 76 ml·min^-1 (two-way ANOVA repeated measure: intervention p < 0.0001, method p = 0.939 and interaction p = 0.125, relative V̇O₂peak). A Pearson's correlation of r = 0.37 (p < 0.05) was found between changes in relative V̇O₂peak but not for absolute V̇O₂peak r = 0.10 (p = 0.402).</p><p><strong>Conclusions: </strong>The SCG method is accurate for estimating V̇O₂peak and appropriate for detecting group changes in both relative and absolute V̇O₂peak following a lifestyle intervention in people with overweight and obesity. Furthermore, the method can detect individual changes in V̇O₂peak but not independently of body mass changes. Yet, the applicability is still limited by the relatively large variation in LoA and SEE.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"864-871"},"PeriodicalIF":4.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between early age body mass index and the risk of adulthood cardiovascular diseases: a systematic review and meta-analysis.","authors":"Zifeng Qiu, Zhihao Liu, Nan Zhang, Fangfang Fan, Haoyu Weng, Long Zhang, Yan Zhang, Jianping Li","doi":"10.1038/s41366-024-01710-4","DOIUrl":"10.1038/s41366-024-01710-4","url":null,"abstract":"<p><strong>Background: </strong>Several studies have attempted to demonstrate the associations between body mass index (BMI) in early age and cardiovascular diseases (CVDs). However, their findings were inconsistent and inconclusive, indicating the need for further investigation.</p><p><strong>Methods: </strong>We conducted a systematic review and meta-analysis of studies focusing on BMI in early age (age from 2 to 22) in relation to CVDs in adulthood, including coronary artery disease (CHD), ischemic and hemorrhagic stroke, myocardial infarction and heart failure. Fixed-effects and Random-effects models were used to pool the data. Sex, age, adjustment of socioeconomic status and fatal events specific analysis were conducted to examine their effects on the results.</p><p><strong>Results: </strong>Thirty-eight studies were eligible for inclusion. BMI in early age was positively related to CVD (HR = 1.18, 95% CI: 1.07-1.30), CHD (HR = 1.13, 95% CI: 1.07-1.19), heart failure (HR = 1.16, 95% CI: 1.11-1.20) but not stroke (HR = 0.99, 95% CI: 0.93-1.05). The results remained consistent after stratified by sex, fatal or non-fatal events and adjustment for socioeconomic status. Further age-specific analysis showed that both childhood and early adulthood group showed positive associations on CHD and HF. While estimates in early adulthood for all CVDs were numerically higher than that for childhood. Category analyses showed a positive association between being overweight or obesity and adulthood CVDs, including stroke.</p><p><strong>Conclusion: </strong>We found a positive association between early-age BMI and adulthood cardiovascular diseases except for stroke.</p><p><strong>Trial registration: </strong>Systemic review registration https://www.crd.york.ac.uk/Prospero/ , identifier CRD42023403602.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"766-775"},"PeriodicalIF":4.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing online chat-based artificial intelligence models for weight loss recommendation appropriateness and bias in the presence of guideline incongruence.","authors":"Eugene Annor, Joseph Atarere, Nneoma Ubah, Oladoyin Jolaoye, Bryce Kunkle, Olachi Egbo, Daniel K Martin","doi":"10.1038/s41366-025-01717-5","DOIUrl":"10.1038/s41366-025-01717-5","url":null,"abstract":"<p><strong>Background and aim: </strong>Managing obesity requires a comprehensive approach that involves therapeutic lifestyle changes, medications, or metabolic surgery. Many patients seek health information from online sources and artificial intelligence models like ChatGPT, Google Gemini, and Microsoft Copilot before consulting health professionals. This study aims to evaluate the appropriateness of the responses of Google Gemini and Microsoft Copilot to questions on pharmacologic and surgical management of obesity and assess for bias in their responses to either the ADA or AACE guidelines.</p><p><strong>Methods: </strong>Ten questions were compiled into a set and posed separately to the free editions of Google Gemini and Microsoft Copilot. Recommendations for the questions were extracted from the ADA and the AACE websites, and the responses were graded by reviewers for appropriateness, completeness, and bias to any of the guidelines.</p><p><strong>Results: </strong>All responses from Microsoft Copilot and 8/10 (80%) responses from Google Gemini were appropriate. There were no inappropriate responses. Google Gemini refused to respond to two questions and insisted on consulting a physician. Microsoft Copilot (10/10; 100%) provided a higher proportion of complete responses than Google Gemini (5/10; 50%). Of the eight responses from Google Gemini, none were biased towards any of the guidelines, while two of the responses from Microsoft Copilot were biased.</p><p><strong>Conclusion: </strong>The study highlights the role of Microsoft Copilot and Google Gemini in weight loss management. The differences in their responses may be attributed to the variation in the quality and scope of their training data and design.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"896-901"},"PeriodicalIF":4.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of prenatal maternal sex steroid hormones in weight and adiposity at birth and growth trajectories during infancy.","authors":"Ying Meng, Loralei L Thornburg, Caitlin Dreisbach, Charlotte Orzolek, Amber Kautz, Hannah R Murphy, Zorimar Rivera-Núñez, Christina Wang, Richard K Miller, Thomas G O'Connor, Emily S Barrett","doi":"10.1038/s41366-025-01743-3","DOIUrl":"10.1038/s41366-025-01743-3","url":null,"abstract":"<p><strong>Objective: </strong>Intrauterine factors can impact fetal and child growth and may underlie the developmental origins of childhood obesity. Sex steroid hormone exposure during pregnancy is a plausible target because of the impact on placental vascularization, nutrient transportation, adipogenesis, and epigenetic modifications. In this study we assessed maternal sex steroid hormones in each trimester in relation to birthweight, neonatal adiposity, and infant growth trajectories, and evaluated sensitive windows of development.</p><p><strong>Methods: </strong>Participants from a prospective pregnancy cohort who delivered at term were included in the analysis (n = 252). Estrone, estradiol, and estriol, as well as total and free testosterone throughout gestation were assessed using high-performance liquid chromatography and tandem mass spectrometry. Path analyses were used to assess the direct associations of sex steroid hormones in each trimester with birth outcomes and infant growth trajectories (birth to 12 months) adjusting for covariates and considering moderation by sex.</p><p><strong>Results: </strong>The associations between prenatal sex steroid hormones and fetal/infant growth varied by sex and timing of hormone exposure. First-trimester estrone was associated with higher birthweight z-scores (β = 0.37, 95% CI: 0.02, 0.73) and truncal skinfold thickness (TST) at birth (β = 0.94, 95% CI: 0.34, 1.54) in female infants. Third-trimester total testosterone was associated with higher TST at birth (β = 0.47, 95% CI: 0.03, 0.86) in both sexes. First-trimester estrone and estradiol and first- and third-trimester testosterone were associated with lower probabilities of high stable weight trajectory compared to low stable weight trajectory (Estrone: β = -3.87, 95% CI: -6.59, -1.16; Estradiol: β = -4.36, 95% CI: -7.62, -1.11; First-trimester testosterone: β = -3.53, 95% CI: -6.63, -0.43; Third-trimester testosterone: β = -3.67, 95% CI: -6.66, -0.69) during infancy in male infants.</p><p><strong>Conclusions: </strong>We observed associations between prenatal sex steroid hormone exposure and birthweight, neonatal adiposity and infant growth that were sex and gestational timing dependent. Our findings suggest further investigation on additional mechanisms linking prenatal sex steroid exposure and fetal/postnatal growth is needed.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"954-964"},"PeriodicalIF":4.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare variants in the melanocortin 4 receptor gene (MC4R) are associated with abdominal fat and insulin resistance in youth with obesity.","authors":"Brittany Galuppo, Prabhath Mannam, Jacopo Bonet, Bridget Pierpont, Domenico Trico', Carrie Haskell-Luevano, Mark D Ericson, Katie T Freeman, William M Philbrick, Allen E Bale, Sonia Caprio, Nicola Santoro","doi":"10.1038/s41366-024-01706-0","DOIUrl":"10.1038/s41366-024-01706-0","url":null,"abstract":"<p><strong>Background: </strong>Rare variants in melanocortin 4 receptor gene (MC4R) result in a severe form of early-onset obesity; however, it is unclear how these variants may affect abdominal fat distribution, intrahepatic fat accumulation, and related metabolic sequelae.</p><p><strong>Methods: </strong>Eight hundred seventy-seven youth (6-21 years) with overweight/obesity, recruited from the Yale Pediatric Obesity Clinic in New Haven, CT, underwent genetic analysis to screen for functionally damaging, rare variants (MAF < 0.01) in MC4R. Participants were assigned to a Pathogenic Variant or No Pathogenic Variant group and completed a 10-timepoint 180-min oral glucose tolerance test (OGTT) and abdominal MRI.</p><p><strong>Results: </strong>Compared to the No Pathogenic Variant group, the Pathogenic Variant group demonstrated significantly greater glucose concentrations (AUC_tot: 24.7 ± 1.22 g/dL × 180 min vs. 21.9 ± 1.41 g/dL × 180 min; p = 0.001), insulin levels (AUC_tot: 57.4 ± 11.5 mU/mL × 180 min vs. 35.5 ± 8.90 mU/mL × 180 min; p = 0.002), and lower insulin sensitivity (WBISI: 1.01 ± 0.137 vs. 1.85 ± 0.036; p = 0.0008) during the OGTT. The Pathogenic Variant group also presented with greater visceral adipose tissue (VAT) (85.1 cm² ± 10.3 vs. 56.1 cm² ± 1.64; p = 0.003) and intrahepatic fat content (HFF%) (19.4% ± 4.94 vs. 8.21% ± 0.495; p = 0.012) than the No Pathogenic Variant group despite the two groups having similar BMI z-scores (p = 0.255), subcutaneous adipose tissue (SAT) (p = 0.643), and total body fat (p = 0.225).</p><p><strong>Conclusions: </strong>Pathogenic variants in MC4R are associated with increased VAT, HFF%, and insulin resistance, independent from the degree of obesity in youth.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"819-826"},"PeriodicalIF":4.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing based clustering of childhood BMI trajectories reveals differential maturational patterns; Study in the Northern Finland Birth Cohorts 1966 and 1986.","authors":"Anni Heiskala, J Derek Tucker, Priyanka Choudhary, Rozenn Nedelec, Justiina Ronkainen, Olli Sarala, Marjo-Riitta Järvelin, Mikko J Sillanpää, Sylvain Sebert","doi":"10.1038/s41366-025-01714-8","DOIUrl":"10.1038/s41366-025-01714-8","url":null,"abstract":"<p><strong>Background/objectives: </strong>Children's biological age does not always correspond to their chronological age. In the case of BMI trajectories, this can appear as phase variation, which can be seen as shift, stretch, or shrinking between trajectories. With maturation thought of as a process moving towards the final state - adult BMI, we assessed whether children can be divided into latent groups reflecting similar maturational age of BMI. The groups were characterised by early factors and time-related features of the trajectories.</p><p><strong>Subjects/methods: </strong>We used data from two general population birth cohort studies, Northern Finland Birth Cohorts 1966 and 1986 (NFBC1966 and NFBC1986). Height (n = 6329) and weight (n = 6568) measurements were interpolated in 34 shared time points using B-splines, and BMI values were calculated between 3 months to 16 years. Pairwise phase distances of 2999 females and 3163 males were used as a similarity measure in k-medoids clustering.</p><p><strong>Results: </strong>We identified three clusters of trajectories in females and males (Type 1: females, n = 1566, males, n = 1669; Type 2: females, n = 1028, males, n = 973; Type 3: females, n = 405, males, n = 521). Similar distinct timing patterns were identified in males and females. The clusters did not differ by sex, or early growth determinants studied.</p><p><strong>Conclusions: </strong>Trajectory cluster Type 1 reflected to the shape of what is typically illustrated as the childhood BMI trajectory in literature. However, the other two have not been identified previously. Type 2 pattern was more common in the NFBC1966 suggesting a generational shift in BMI maturational patterns.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"872-880"},"PeriodicalIF":4.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}