Association of relative fat mass with the incidence of type 2 diabetes: over a decade follow-up from the TLGS.

IF 3.8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Soroush Masrouri, Navid Ebrahimi, Soroush Soraneh, Fereidoun Azizi, Farzad Hadaegh
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Abstract

Aims and background: Relative fat mass (RFM) is strongly associated with type 2 diabetes (T2DM) and has been shown to be a better predictor than body mass index (BMI) and waist circumference (WC). This study aims to investigate the association between RFM and incident T2DM among adults in the Tehran Lipid and Glucose Study cohort.

Methods: Data from 8419 participants (4716 women; mean age, 40.52 years) were analyzed. Logistic regression was used to assess the association of RFM with insulin resistance, metabolic syndrome, and its components at baseline. Cox proportional hazards models were applied to evaluate the association between RFM and incident T2DM. Wald tests were used to compare RFM hazard ratios (HRs) with those of BMI, WC, and waist-to-hip ratio (WHR) in the Cox model.

Results: Over a median follow-up of 14 years, 1382 individuals (16.42%) developed T2DM. RFM was significantly associated with insulin resistance, metabolic syndrome, and its components at baseline in both men and women. In the multivariable-adjusted model, each standard deviation increase in RFM was associated with a 1.26-fold (1.02-1.57, P = 0.037) higher risk of T2DM in men and a 1.52-fold (1.27-1.81, P < 0.001) higher risk in women. These associations were stronger in younger individuals and remained significant only in women after adjusting for insulin resistance and restricting the analysis to normoglycemic individuals. The increased T2DM risk associated with RFM was comparable to that associated with WC in both men and women (Pdifference > 0.05).

Conclusions: While RFM is strongly associated with the risk of T2DM, particularly in women and younger individuals, it does not outperform WC.

相对脂肪量与2型糖尿病发病率的关系:TLGS超过十年的随访。
目的和背景:相对脂肪量(RFM)与2型糖尿病(T2DM)密切相关,并且已被证明是比体重指数(BMI)和腰围(WC)更好的预测指标。本研究旨在调查德黑兰脂质和葡萄糖研究队列中成人RFM与2型糖尿病发病率之间的关系。方法:对8419名参与者(4716名女性,平均年龄40.52岁)的数据进行分析。采用Logistic回归评估RFM与胰岛素抵抗、代谢综合征及其组成部分在基线时的相关性。采用Cox比例风险模型评估RFM与T2DM发病之间的关系。采用Wald检验比较Cox模型中RFM风险比(HRs)与BMI、WC和腰臀比(WHR)的风险比。结果:在中位随访14年期间,1382人(16.42%)发展为T2DM。在男性和女性中,RFM与胰岛素抵抗、代谢综合征及其基线成分显著相关。在多变量调整模型中,RFM每增加一个标准差与男性T2DM风险增加1.26倍(1.02-1.57,P = 0.037)和1.52倍(1.27-1.81,P值差异0.05)相关。结论:虽然RFM与2型糖尿病的风险密切相关,特别是在女性和年轻人中,但它并不优于WC。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International Journal of Obesity
International Journal of Obesity 医学-内分泌学与代谢
CiteScore
10.00
自引率
2.00%
发文量
221
审稿时长
3 months
期刊介绍: The International Journal of Obesity is a multi-disciplinary forum for research describing basic, clinical and applied studies in biochemistry, physiology, genetics and nutrition, molecular, metabolic, psychological and epidemiological aspects of obesity and related disorders. We publish a range of content types including original research articles, technical reports, reviews, correspondence and brief communications that elaborate on significant advances in the field and cover topical issues.
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