International Journal of Obesity最新文献

{"title":"Prediabetes: a new indication for GLP-1s?","authors":"Caroline M Apovian","doi":"10.1038/s41366-025-01930-2","DOIUrl":"https://doi.org/10.1038/s41366-025-01930-2","url":null,"abstract":"","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of laparoscopic vertical sleeve gastrectomy (LVSG) on lower esophageal sphincter pressure (LESP), lower esophageal sphincter length (LESL) and gastroesophageal reflux disease (GERD) using esophageal function tests (EFTs): a systematic review and meta-analysis.","authors":"Muhammed Ashraf Memon, Rossita Mohamad Yunus, Khorshed Alam, Zahirul Hoque, Shahjahan Khan","doi":"10.1038/s41366-025-01926-y","DOIUrl":"https://doi.org/10.1038/s41366-025-01926-y","url":null,"abstract":"<p><strong>Background: </strong>LVSG seems to increase the risk of GERD despite significant weight loss. We compared pre- and postoperative esophageal function test data (in conjunction with the BMI loss) to evaluate the impact of post-LVSG on lower esophageal sphincter pressure (LESP), lower esophageal sphincter length (LESL), and DeMeester Score (DMS).</p><p><strong>Methods: </strong>Articles analyzing esophageal manometry ±24 h pH-study pre- and post-LVSG were identified using electronic databases from 1999 to 2023. The Critical Appraisal Skills Programme Checklist for Cohort Studies was used for quality assessment. The DerSimonian and Laird random effects model was used for continuous data analysis. Heterogeneity was assessed using the Cochrane Q statistic and I² index. Leave one out sensitivity analysis was undertaken to assess the robustness and validity of our analysis. Egger's test was used to evaluate potential publication bias in our meta-analysis.</p><p><strong>Results: </strong>Nineteen studies totaling 668 patients were evaluated (F = 445, M = 131). A significant reduction of 3.82 mm Hg in LESP was observed after LVSG based on 16 studies (WMD 3.82, 95% CI 1.74, 5.90; p < 0.001, I² = 88.6%). LESL did not reveal any significant difference between pre- and post-LVSG based on nine studies (WMD 0.05, 95% CI -0.15, 0.26; p = 0.625, I² = 83.1%). DMS showed a significant increase of 11.72 post LVSG based on 12 studies (WMD -11.72, 95% CI -17.15 to -6.30; p < 0.001, I² = 91.5%). Significant BMI loss of 13.26 kg/m² was observed post LVSG based on 12 studies (WMD 13.26, 95% CI 11.65 to 14.88, Z = 16.07, p < 0.001).</p><p><strong>Conclusions: </strong>LVSG is associated with a significant decrease in LESP and a significant increase in the DMS post-LVSG, leading to the worsening or development of new GERD symptoms despite significant BMI reduction. The limitations of our meta-analysis include small sample sizes, short follow-up, heterogeneity, lack of data on some confounders and inadequate quality of some studies.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The weight of weight: the salience of body weight in the impression formation process.","authors":"Margaux de Chanaleilles, Boris Cheval, Hervé Dubouchaud, Aïna Chalabaev","doi":"10.1038/s41366-025-01921-3","DOIUrl":"https://doi.org/10.1038/s41366-025-01921-3","url":null,"abstract":"<p><strong>Background/objectives: </strong>Western societies preach slimness. However, overweight and obesity are increasing. Individuals living with overweight often face weight discrimination. No studies have investigated the salience of body weight in the impression formation. This study aims to examine the salience of the overweight attribute in shaping first impressions.</p><p><strong>Subjects/methods: </strong>Sixty participants were recruited, among them eleven were excluded because they did not fully complete the study, and we included forty-nine participants (M_age = 25.82 years, SD = 13.44; 19 women). Participants were asked to describe fictitious characters who differed in age, gender, skin color, and weight. Targets with overweight (i.e., five characters with overweight) constituted the experimental condition and non-overweight targets formed the control condition (i.e., five characters without overweight). Targets were presented to participants in a pseudo-random order (participants could not see the same target more than once).</p><p><strong>Results: </strong>Multilevel analyses showed that weight-related words were used more frequently to describe the overweight target than the non-overweight target (25.41% vs 11.83%; OR = 1.56, 95% CI 1.24-1.96, p < 0.01). Moreover, the probability of using a weight-related word to describe overweighted targets was significantly higher for the earlier words, than for the later words - (OR = 3.82, 95% CI 2.36-6.20, p < 0.001 for the first, OR = 2.44, 95% CI 1.78-3.33 for the second, OR = 1.62, 95% CI 1.24-2.12, p < 0.001 for the third, and fourth OR = 1.08, 95% CI 0.73-1.60, p = 0.695 words used to describe the character).</p><p><strong>Conclusion: </strong>These findings support that the overweight characteristics of individuals is salient are the impression formation process.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The associations of objective, behaviorally measured hunger and weight-related variables with Food Craving Inventory subscales in adults with obesity.","authors":"William R Quarles, Alexis Brown, Martin Binks","doi":"10.1038/s41366-025-01925-z","DOIUrl":"https://doi.org/10.1038/s41366-025-01925-z","url":null,"abstract":"<p><strong>Background/objectives: </strong>The Food Craving Inventory (FCI) measures the frequency of food cravings along five dimensions: overall food cravings, cravings for sweets, cravings for high-fat food, cravings for starchy food, and cravings for fast food. Evidence of the influence of current hunger on FCI scores is equivocal and challenged by methodological limitations, including the use of self-reported hunger and the lack of control for phase of the menstrual cycle. We aimed to examine (1) the potential association of objective, behaviorally measured hunger (hours since last caloric intake; FAST) with responses on the FCI, controlling for the influence of the menstrual cycle and (2) the relationships of the FCI with weight-related measures (i.e., body mass index, BMI; body weight, BW; body fat percentage, BF) in individuals with obesity.</p><p><strong>Subjects/methods: </strong>Thirty-two adults with obesity (BMI 30-39.9 kg/m²) were included. Subjects' BW and BF were measured via bioelectrical impedance, and BMI was calculated. On a separate day, subjects were administered the FCI after an intended 8-h fast. For premenopausal women, this was during the second half of the follicular phase of their menstrual cycle. Linear correlations between FCI subscales and each of BW, BMI, BF and FAST were performed.</p><p><strong>Results: </strong>FAST correlated with cravings for sweets (r = 0.381, p = 0.034) and showed a trend for overall cravings (r = 0.331, p = 0.069). BW, BMI, and BF did not correlate with any of the FCI subscales.</p><p><strong>Conclusions: </strong>Our results show that current, objective, behaviorally defined hunger (FAST) may influence FCI scores after controlling for menstrual cycle phase. However, FCI scores showed no relationship to BMI, BW, or BF, indicating that FCI scores may not reflect enduring patterns related to long-term weight gain. Future research should use objective hunger measures as covariates when interpreting FCI data and should exercise caution in treating FCI scores as indicators of long-term obesity risk.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of weight loss through dietary interventions on cardiometabolic health in older adults.","authors":"Klodian Dhana, Neelum T Aggarwal, Robin M Voigt, Jennifer Ventrelle, Kumar B Rajan, Rima Kaddurah-Daouk, Santica M Marcovina, Xiaoran Liu, Puja Agarwal, Christy Tangney, Konstantinos Arfanakis, Frank M Sacks, Lisa L Barnes","doi":"10.1038/s41366-025-01902-6","DOIUrl":"https://doi.org/10.1038/s41366-025-01902-6","url":null,"abstract":"<p><strong>Background: </strong>With the increasing prevalence of obesity and its negative consequences on health, weight management emerges as a priority for public health, especially in older adults, in whom obesity is linked to increased risks of chronic diseases such as cardiovascular disease. We performed a study investigating the association of intentional weight loss through dietary intervention on cardiometabolic health among older adults participating in the MIND trial.</p><p><strong>Methods: </strong>The MIND trial enrolled overweight individuals aged 65-84 who self-reported a suboptimal diet. Participants were randomized to the MIND or a control diet for 3 years; both diets promoted weight loss through mild caloric restriction (250 kcal). Of 604 individuals enrolled in the trial, 518 were included in the analysis. We calculated the percentage of weight loss based on measured weight at the baseline and year 3 and categorized individuals into four groups: no weight loss (e.g., weight gain), <5%, 5-10%, and >10% weight loss. Cardiometabolic health included traditional lipid biomarkers, biomarkers of inflammation, and glycosylated hemoglobin. Linear mixed-effect models were used to evaluate the associations of weight loss with cardiometabolic health.</p><p><strong>Results: </strong>At the baseline, mean age was 70 (SD = 4.1) years, 332 (65%) were women, and BMI was 33.8 (SD = 5.9) kg/m2. Compared to people who did not lose weight, those with >10% weight loss significantly improved their biomarkers of cardiometabolic health at the year 3 visit as follows: LDL cholesterol levels decreased by 8.3%, triglycerides by 28.2%, and HDL increased by 12.4%. As for biomarkers of inflammation, GlycA decreased by 7.5%, hs-IL6 by 33.0%, hs-CRP by 59.4%, and adiponectin increased by 53.7%. These improvements in biomarkers of cardiometabolic health did not differ by dietary intervention.</p><p><strong>Conclusion: </strong>Weight loss through dietary interventions with mild calorie restriction resulted in favorable changes in cardiometabolic risk factors among older adults with overweight and obesity.</p><p><strong>Clinical trial registration number: </strong>NCT02817074.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical and economic burden of obesity in low- and middle-income countries: a systematic review.","authors":"Francis Fatoye, Chidozie Mbada, Faatihah Niyi-Odumosu, Clara Fatoye, Ushotanefe Useh, Zalmai Hakimi, Tadesse Gebrye","doi":"10.1038/s41366-025-01913-3","DOIUrl":"https://doi.org/10.1038/s41366-025-01913-3","url":null,"abstract":"<p><p>Obesity has emerged as a critical public health challenge globally, with substantial health and economic repercussions. This study aimed to evaluate the literature on the clinical and economic burdens associated with obesity, specifically in low- and middle-income countries (LMICs). A systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was performed. The CINAHL, MEDLINE, PubMed, Web of Science and Scopus databases were systematically searched for studies published from inception to March 28, 2025. The costs of illness for all included studies were converted to 2024 United States (US) dollars, using country-specific gross domestic product inflators. Conversion to US dollars was based on purchasing power parity (PPP). The quality of all included studies was assessed via the Newcastle‒Ottawa Scale (NOS). Of the total of 676 reports identified by the search strategy, six studies were prevalence-based, four studies were survey-based, and three model-based studies (n = 13) were eligible for inclusion on the basis of predefined inclusion criteria. These studies published data from Brazil, Ghana, China, Iran, South Africa, Mexico, and Thailand. Three of the 13 studies reported indirect costs. Two studies reported the clinical impact of obesity. Methodological quality was deemed moderate. The annual direct and indirect costs associated with obesity for a population in LMICs ranged from USD 0.2 billion to USD 12.56 billion and USD 223 million to USD 227.5 million, respectively. Hospitalisation was the main cost driver in five of the included studies. One study reported the total number of hospitalisations/number of person-years for men and women as 803/9207 and 2354/25,173, respectively. This is the first systematic review to summarise the clinical and economic burdens associated with obesity in LMICs. The clinical and economic burden of obesity on individuals and healthcare systems is significant, necessitating effective prevention and management strategies. To increase the accuracy and comparability of findings, future research should adopt a standardised cost-of-illness methodology. This approach will provide clearer insights into the economic impact of obesity and facilitate more effective public health interventions.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of tirzepatide on weight management in patients with and without diabetes: a systematic review and meta-analysis.","authors":"Eduardo Cerchi, Paula Arruda do Espírito Santo, Mariana Carvalho de Oliveira, Carolina Castro Porto Silva Janovsky, Bruno Halpern","doi":"10.1038/s41366-025-01920-4","DOIUrl":"https://doi.org/10.1038/s41366-025-01920-4","url":null,"abstract":"<p><strong>Aims: </strong>To conduct a systematic review and meta-analysis comparing tirzepatide versus placebo for weight management, with analyses stratified by diabetes status to precisely assess its efficacy and safety in individuals with and without diabetes.</p><p><strong>Methods: </strong>We systematically searched MEDLINE, Embase, and Cochrane Library for randomized controlled trials comparing once-weekly tirzepatide (5-15 mg) versus placebo in adults with or without diabetes for at least 26 weeks. For each subpopulation analysis, the random-effects model was used to calculate pooled risk ratios (RRs) and mean differences (MDs), with their 95% confidence intervals, for dichotomous and continuous endpoints, respectively. Statistical significance was considered at p < 0.05.</p><p><strong>Results: </strong>We included five trials (n = 2,174) in patients with diabetes (BMI ≥ 23 kg/m²) and five (n = 4,467) in patients without diabetes (BMI ≥ 27 [≥24 in Asia] kg/m²). Compared with placebo, tirzepatide led to significantly greater relative and absolute weight reductions in patients with (RR -9.54%, p < 0.01; MD -9.06 kg, p < 0.01) and without diabetes (RR -17.15%, p < 0.01; MD -18.11 kg, p < 0.01). In both subpopulations, tirzepatide also significantly increased the probability of achieving weight reductions of ≥5%, ≥10%, and ≥15%, as well as improved BMI, waist circumference, blood pressure, hemoglobin A1c, and lipid levels. Notably, weight-related benefits with tirzepatide were significantly greater in patients without diabetes, whereas its safety was similar across subpopulations and predominantly consisted of mild to moderate, well-tolerated adverse events.</p><p><strong>Conclusions: </strong>Compared with placebo, tirzepatide resulted in statistically significant and clinically meaningful weight reduction, especially in patients without diabetes (with overweight/obesity), with an acceptable safety profile.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Placental expression of the serotonin transporter (SERT) gene: associations with maternal overweight/obesity and neonatal anthropometry.","authors":"Maja Perić, Marina Horvatiček, Maja Kesić, Maja Žutić, Lipa Čičin-Šain, Jasminka Štefulj","doi":"10.1038/s41366-025-01918-y","DOIUrl":"https://doi.org/10.1038/s41366-025-01918-y","url":null,"abstract":"<p><strong>Objectives: </strong>We investigated the relationship between maternal pre-pregnancy body mass index (BMI) and expression of key serotonin-regulating genes (namely, metabolic enzymes, transmembrane transporters and receptors) in term placentas, including a possible moderating effect of glucose tolerance status (normal glucose tolerance (NGT) vs. gestational diabetes mellitus (GDM)). Associations between placental expression of serotonin-regulating genes and neonatal anthropometry were also explored.</p><p><strong>Methods: </strong>The study included 105 women with overweight/obesity (OWO) and 111 women with normal-weight (NW), all giving birth at term by planned cesarean section. Placental tissue was collected from the fetal side using a standardized protocol. Expression of serotonin-regulating genes was quantified by RT-qPCR and/or ELISA.</p><p><strong>Results: </strong>Pre-pregnancy OWO, GDM or their interaction were not associated with mRNA levels of tryptophan hydroxylase 1 (TPH1), monoamine-oxidase A (MAOA), organic cation transporter 3 (OCT3), and serotonin receptor 2A (HTR2A) in term placentas. However, mRNA levels of plasma membrane monoamine transporter (PMAT) were significantly upregulated in association with pre-pregnancy OWO, regardless of GDM status (p = 0.014). Furthermore, in women with NGT, but not in women with GDM, pre-pregnancy OWO was associated with decreased placental serotonin transporter (SERT) mRNA levels (p = 0.001), while placental SERT protein levels were increased in women with pre-pregnancy OWO and further elevated in women with concurrent GDM (p = 0.005). In addition, higher placental SERT mRNA levels negatively predicted birth weight and newborn length and, in women with NGT, partially mediated the association between pre-pregnancy BMI and birth weight.</p><p><strong>Conclusion: </strong>The results show associations between maternal pre-pregnancy OWO and altered expression of high- and low-affinity serotonin transport genes (SERT and PMAT, respectively). Among the genes analyzed, SERT may play a role in linking maternal OWO to fetal growth. The results underscore the importance of further functional studies into the placental serotonin system in the context of maternal OWO.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic impact of central adiposity on systolic blood pressure in females: interaction and mediation by TG/HDL-C, HbA1c, and uric acid across BMI categories.","authors":"Rizki Amalia Gumilang, Chyi-Huey Bai","doi":"10.1038/s41366-025-01917-z","DOIUrl":"https://doi.org/10.1038/s41366-025-01917-z","url":null,"abstract":"<p><strong>Background: </strong>Genetic predisposition to central adiposity is associated with metabolic dysfunction and obesity-related hypertension. This study investigated the association between genetic predisposition of general and central adiposity and systolic blood pressure (SBP) across body mass index (BMI) categories. Additionally, we explored whether, among females, the metabolic factors, triglyceride-to-HDL cholesterol (TG/HDL-C) ratio, glycated hemoglobin (HbA1c), and serum uric acid (SUA), modulate these relationships.</p><p><strong>Methods: </strong>This cross-sectional study included 10,734 females from the Taiwan Biobank. Associations between polygenic score of body mass index (PGS-BMI), waist-circumference (PGS-WC), waist to hip ratio (PGS-WHR), waist to height ratio (PGS-WHtR) and SBP were assessed using multivariable generalized additive models (GAM). The strongest PGS was further examined for interaction and mediation effects with metabolic factors across BMI categories. Polygenic pathway analyses were also conducted to identify underlying biological mechanisms.</p><p><strong>Results: </strong>Among the four PGSs, PGS-WC showed the strongest association with SBP, particularly in females with normal weight (β = 0.026, 95% CI: 0.002-0.050; p_linear = 0.033; effective degree of freedom (edf) = 1.063; F = 3.201; p_smooth = 0.060) and overweight (β = -0.058, 95% CI: -0.095 to -0.021; p_linear = 0.002; edf = 2.272; F = 4.073; p_smooth = 0.006). The TG/HDL-C ratio significantly modulated this association across normal weight, overweight, and obesity categories in both interaction and mediation analyses. Polygenic pathway implicated biological processes including signal transduction, metabolism, immune regulation, and DNA repair.</p><p><strong>Conclusion: </strong>These findings underscore the genetic influence of central adiposity on SBP regulation, particularly among females with normal weight and overweight. The TG/HDL-C ratio plays a key role in modulating this relationship, suggesting that metabolic risk-targeted interventions may enhance hypertension prevention and management in genetically susceptible populations.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145175523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular risk factors associated with BMI and metabolic health phenotypes based on measures of coagulation factors.","authors":"María M Valle, Ariadna Robledo, Sean O'Leary, Lourdes Basurto, Elba Reyes-Maldonado, Jennyfer Gaspar, Erika Rosales, Sara Vega-Garcia, Carlos Martínez-Murillo","doi":"10.1038/s41366-025-01915-1","DOIUrl":"https://doi.org/10.1038/s41366-025-01915-1","url":null,"abstract":"<p><strong>Introduction: </strong>While the classification of metabolically healthy individuals with obesity remains uncertain, recent research links central obesity to thromboembolism and cardiovascular disease, potentially indicating a hypercoagulable state in some individuals with obesity. This study investigates coagulation and inflammation differences between obesity and normal-weight phenotypes.</p><p><strong>Methods: </strong>225 adult women, participants were subjected to clinical examinations, and biochemical assessments. These assessments classified participants into four distinct phenotypes, namely MHNW (individuals with Metabolically Healthy Normal Weight), MUNW (individuals with Metabolically Unhealthy Normal Weight), MHO (individuals with Metabolically Healthy Obesity), and MUO (individuals with Metabolically Unhealthy Obesity), based on a combination of body mass index (BMI) and metabolic criteria. Subsequently, hemostatic proteins and interleukin levels were compared.</p><p><strong>Results: </strong>Among 225 female patients, the MHO group was younger, with higher measurements like visceral fat and BMI, while MUO had the highest values in homeostatic model assessment for insulin resistance (HOMA-IR), triglycerides and low-density lipoprotein cholesterol (LDL-c). Coagulation proteins showed normal levels. However, MHNW had significantly lower FV, and groups without obesity (MHNW and MUNW) had lower FVIII and FIX. FXII in MHNW did not significantly differ. Inflammatory markers revealed IL-6 negatively correlated with PC and AT but positively with FVIII and FIX. IL-10 negatively correlated with FII, FV, FVII, FXI, and FXII, while TNF-α and IL-1 positively correlated with FVIII and FIX.</p><p><strong>Conclusion: </strong>This study challenges the MUNW metric, revealing metabolic marker elevations in women without obesity. Additionally, MHO individuals exhibited pro-coagulant protein increases compared to MUO, suggesting limited clinical utility in categorizing the broader population with obesity. Our exploratory findings highlight how the interplay between metabolic health and body size phenotypes could challenge conventional frameworks for assessing health risk.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145175513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}