International Journal of Obesity最新文献

{"title":"Novel model of childhood appetitive traits in children with obesity.","authors":"Sunaina Nigam, Mengqi Zhu, Ashley H Shoemaker, Amy C Gross, Claudia K Fox, Vidhu V Thaker","doi":"10.1038/s41366-025-01747-z","DOIUrl":"10.1038/s41366-025-01747-z","url":null,"abstract":"<p><strong>Background/objectives: </strong>Appetitive traits have a central role in energy intake and development of obesity. Child Eating Behavior Questionnaire (CEBQ) is a validated psychometric tool to measure appetitive traits in children. This study sought to assess the CEBQ factor structure in children with obesity. We hypothesized that hedonic traits are more prominent with obesity and in older children.</p><p><strong>Subjects/methods: </strong>This cross-sectional observational study used CEBQ data from three geographically diverse centers in children with obesity. Eight known CEBQ subscales and the established factor model were compared by severity of obesity, age and sex. Exploratory factor analysis (EFA) to define the appetitive trait factor structure was undertaken in a training dataset and validated in a test set.</p><p><strong>Results: </strong>Children with obesity (n = 814) showed higher food response, enjoyment of food, emotional overeating and desire to drink compared to population-based controls (p < 0.001) that correlated with obesity severity. The EFA identified a novel six-factor model with a new \"Food avidity\" factor that explained 15.8% of the variance. Satiety responsiveness (p < 0.001) and emotional undereating (p = 0.03) were lower in youth over 6 years compared to younger, while food fussiness and food avidity were the same, without any sex differences.</p><p><strong>Conclusions: </strong>CEBQ is useful to assess appetitive traits in children with obesity. The novel factor structure in youth with obesity suggests that temporal or phenotypic differences necessitate a revision of the established factor model. The new factor structure may be used to develop a hyperphagia questionnaire.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling COVID-19 lockdowns shaped the growth of Chinese preschool children.","authors":"Peiling Cai, Mengping Wang, Zhen Yang, Yueyao Luo, Fanli Zhou, Peng Ye, Yuxuan Liu, Yurong Li, Chao Huang, Brett D Hambly, Jingchun Fan, Xiaoping Yu, Shisan Bao","doi":"10.1038/s41366-025-01756-y","DOIUrl":"https://doi.org/10.1038/s41366-025-01756-y","url":null,"abstract":"<p><strong>Background: </strong>Although COVID-19 is no longer classified as a pandemic, its serious impact on human health, particularly among children in China, remains profound due to the country's lengthy and highly restrictive zero-tolerance policy. This study aims to explore the potential influence of COVID-19 on the growth of preschool children.</p><p><strong>Methods: </strong>The participants of the study were preschool children identified in 2018, forming the baseline cohort. We systematically monitored their routine physical examination data over the following three years-2019, 2020, and 2021. Data on dependent variables such as median differences, growth levels, and nutritional status assessments were collected. Specifically, we selected 3-year-old children from the 2018 cohort and followed them for four years, analyzing paired data from 2018 to 2021 to assess the impact of COVID-19 lockdown measures on their growth. Tracking the same cohort over time with paired data reduces intergroup biases caused by variations in participants.</p><p><strong>Results: </strong>The results of the study indicate that the major lockdown during the COVID-19 pandemic did not hinder height growth; in fact, it slightly promoted it among preschool children. However, the lockdown also accelerated weight gain, and the changes in both height and weight led to variations in BMI.</p><p><strong>Conclusion: </strong>We conclude that the prevalence of children with overweight and obesity during the lockdown period was significantly higher compared to pre-pandemic levels, suggesting that lockdown measures exacerbated these conditions. Moreover, these negative effects are likely to persist in the long term.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Greater durability of weight loss at ten years with gastric bypass compared to sleeve gastrectomy.","authors":"Sarah Ying Tse Tan, Yong Qin Lee, Gwyneth Syn, Fan Shuen Tseng, Jasmine Kai Ling Chua, Hong Chang Tan, Emily Tse Lin Ho, Jean Paul Kovalik, Chin Hong Lim, Alvin Kim Hock Eng, Weng Hoong Chan, Eugene Kee Wee Lim, Jeremy Tian Hui Tan, Angelina Xiangying Foo, Orlanda Qi Mei Goh, Phong Ching Lee","doi":"10.1038/s41366-025-01760-2","DOIUrl":"https://doi.org/10.1038/s41366-025-01760-2","url":null,"abstract":"<p><strong>Introduction: </strong>Sleeve gastrectomy (SG) and gastric bypass (GB) are the most commonly performed bariatric surgeries. However, there is insufficient data on which leads to greater long-term (10 year) weight loss.</p><p><strong>Methods: </strong>Subjects who underwent SG and GB from 2008-2013 were followed up at 2, 5, and 10 years post-operatively for weight and diabetes (DM) outcomes. Percentage total weight loss (%TWL), weight regain ( ≥ 20% from nadir) and DM remission rates were compared.</p><p><strong>Results: </strong>Subjects (n = 253) who underwent SG (60.9%) and GB (39.1%) were included. The mean age was 41.4 ± 10.6 y, 39.1% were male, and the mean body mass index was 42.1 ± 9.3 kg/m² with no significant difference between groups. The GB group had a greater proportion of subjects with DM (83.8% vs 19.5%, p < 0.001). At 2 y, %TWL was comparable (GB: 22.3 ± 9.6%, SG: 22.6 ± 10.5%, p = 0.824). However, those who underwent GB had significantly higher %TWL at 5 y (GB: 21.5 ± 8.9%, SG 18.0 ± 11.3%, p = 0.029) and 10 y (GB: 21.0 ± 9.0%, SG: 15.4 ± 12.1%, p = 0.001). The rate of significant weight regain was higher amongst the SG group at both 5 y (SG: 14.7%, GB: 3.8%, p = 0.018) and 10 y (SG: 27.9%, GB: 13.7%, p = 0.037) post-operatively. On multiple linear regression, GB remained significantly associated with greater %TWL at 10 y compared to SG (b = 5.51; adjusted p-value = 0.013), after adjusting for age, sex, pre-operative BMI, pre-operative glycemic status, and surgery year. There was no difference in DM remission rates at 10 y (SG: 26.7%, GB: 19.1%, p = 0.385).</p><p><strong>Conclusion: </strong>GB was able to produce greater %TWL and less weight regain than SG at 5 and 10 years post-operatively. There was no difference in long-term DM remission rates between the two surgeries.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the bidirectional associations of ADHD symptomatology, nutritional status, and body composition in childhood: evidence from a Brazilian Birth Cohort Study.","authors":"Bárbara Peter Gonçalves, Thais Martins-Silva, Isabel Bierhals, Joseph Murray, Marlos R Domingues, Pedro C Hallal, Luciana Tovo-Rodrigues, Andréa Dâmaso Bertoldi","doi":"10.1038/s41366-025-01745-1","DOIUrl":"10.1038/s41366-025-01745-1","url":null,"abstract":"<p><strong>Background: </strong>Attention deficit hyperactivity disorder (ADHD) has been linked to excessive weight; however, the underlying mechanisms of this association are not well understood. To date, the bidirectional associations between ADHD and nutritional status in childhood have been explored in a limited number of studies, with particularly few of those incorporating body composition data. This study aims to evaluate the associations of ADHD symptoms, nutritional status, and body composition in childhood.</p><p><strong>Methods: </strong>We analyzed data from 3940 children from the 2015 Pelotas (Brazil) Birth Cohort at 4 and 6-7 years of age. Linear regression was performed to evaluate the association between ADHD symptoms and nutritional status (weight, height, and body mass index [BMI]) at ages 4 and 6-7, as well as body composition, specifically fat mass (FF) and fat-free mass (FFM) at ages 6-7. Moreover, a cross-lagged panel model (CLPM) analysis between ADHD symptoms and BMI was performed to explore the bidirectional associations.</p><p><strong>Results: </strong>ADHD symptoms were associated with increased height (β 0.01, 95%CI 0.001, 0.026) and FFM (β 0.02, 95%CI 0.008-0.035) at age 4, and increased BMI (β0.02, 95%IC 0.002, 0.038), weight (β 0. 02, 95%CI 0.005, 0.039), height (β 0.01, 95%CI 0.000, 0.024), and FFM (β 0.02, 95%CI 0.012, 0.040) at ages 6-7. Although the CLPM indicated a small effect suggesting a bidirectional relationship between ADHD symptoms and BMI, the observed associations were not statistically significant: ADHD scores at age 4 predicting BMI z-scores at ages 6-7 (β 0.003; 95% CI: -0.026, 0.020), and BMI z-scores at age 4 predicting ADHD scores at ages 6-7 (β 0.013; 95% CI: -0.018, 0.044).</p><p><strong>Conclusion: </strong>Children with higher ADHD symptoms showed increased growth in weight, height, and BMI. The observed increase in weight and BMI was attributed to greater FFM in these children.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexually dimorphic effects of angiopoietin-like 2 on energy metabolism and hypothalamic neuropeptide regulation.","authors":"Romane Manceau, Pinçon Anthony, Cécile Hryhorczuk, Pauline Labbé, Nathalie Thorin-Trescases, Stephanie Fulton, Éric Thorin","doi":"10.1038/s41366-025-01754-0","DOIUrl":"10.1038/s41366-025-01754-0","url":null,"abstract":"<p><strong>Background: </strong>Adipokines regulate body weight and metabolism by targeting the hypothalamus, influencing feeding, energy expenditure (EE) and insulin sensitivity. Angiopoietin-like 2 (Angptl2) is a pro-inflammatory adipokine linking obesity to insulin resistance. Both Angptl2 and its receptor are expressed in the central nervous system. Yet, the contribution of Angptl2 to the regulation of energy metabolism and relevant hypothalamic neuropeptides in male and female mice is unknown. We aim at determining the impact of Angptl2 knockdown (KD) on energy balance, nutrient partitioning and hypothalamic responses to a standard (STD) or high-fat diet (HFD) in mice.</p><p><strong>Methods: </strong>Three-month-old male and female Angptl2-KD mice and wildtype (WT) littermates were fed 16 weeks either a STD or a HFD. Body weight, food consumption and insulin sensitivity were assessed along with measurements of EE, respiratory exchange ratio (RER) and locomotor activity. We quantified the expression of Angptl2 and its receptors itga5, mag and pirb in the medio-basal hypothalamus (MBH) of WT mice, and MBH neuropeptide Y (NPY), agouti-related neuropeptide (AgRP) and proopiomelanocortin (POMC) gene expression in both KD and control fasting mice.</p><p><strong>Results: </strong>Lack of Angptl2 reduced food intake in males on both diets, and in females on HFD. In KD males, this anorexigenic effect was associated with lower body weight, increased EE, improved insulin sensitivity and lower hypothalamic orexigenic NPY expression compared to controls. Female Angptl2-KD mice however, exhibited unaltered body weight, EE and insulin sensitivity, and elevated NPY, AgRP and MC4R expression compared to controls. Fasting caused an increase in the MBH of mag expression in males and females but Angptl2 expression only in female mice.</p><p><strong>Conclusions: </strong>Angptl2 KD improved diet-induced obesity and associated metabolic dysfunction in male mice. The lack of similar changes in female mice and divergent MBH neuropeptide profile suggest that sex-dependent mechanisms underly the anabolic effects of this proinflammatory adipokine.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation testing of a weight management nutrition knowledge questionnaire for Chinese adults (C-WMNKQ).","authors":"Jia Song, Jing Fang, Ke-Ren Huang, Mi-Zhi Wu, Fang-Fang Chen, Ming-Xia Zhu, Wei-Ying Xu, Su-Fen Zheng, Jian-Fen Qin","doi":"10.1038/s41366-025-01750-4","DOIUrl":"https://doi.org/10.1038/s41366-025-01750-4","url":null,"abstract":"<p><strong>Objective: </strong>To develop a weight management nutrition knowledge questionnaire for Chinese adults (C-WMNKQ) and to test its reliability and validity.</p><p><strong>Methods: </strong>We evaluated the content validity of the questionnaire using the expert consultation method, evaluated the face validity of the questionnaire through a pre-survey, eliminated the questions that did not meet the criteria through item difficulty, item differentiation, and inter-item correlation. We verified the construct validity using the known-groups comparison method. Correlation analysis by comparing it with the general nutrition knowledge questionnaire for Chinese adults (C-GNKQ) was conducted for criterion validity evaluation. The internal consistency reliability, split-half reliability, and test-retest reliability validation were also evaluated, and relevant evidence of expected convergent validity was obtained.</p><p><strong>Results: </strong>The final C-WMNKQ contains 39 items in 5 dimensions. The overall internal consistency of the C-WMNKQ was 0.808 for Cronbach's alpha coefficient, 0.81 for ω coefficient, 0.788 for Guttman's coefficient, 0.843 for Spearman's correlation coefficient, and 0.908 for overall ICC (95% CI = 0.870-0.935). Meeting the criterion of structural validity, nutrition professionals scored 26.3% higher than those in the financial field, p < 0.001. The correlation coefficient between the total C-WMNKQ score and the total C-GNKQ score was 0.641, p < 0.001, which is good for criterion validity. In terms of convergent validity, the level of nutrition knowledge of women was higher than that of men, the partial nutrition knowledge score of participants aged 35-54 years old was significantly higher than that of participants aged 18-34 years old, the level of nutrition knowledge of those with higher education was higher. Participants with per capita monthly household income >8000RMB had significantly higher partial nutrition knowledge scores than those with <3000RMB and 3000-5000RMB.</p><p><strong>Conclusions: </strong>C-WMNKQ has good reliability and validity and can be used as a valid tool to assess the nutrition knowledge of Chinese adults related to weight management.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of methods used in the management of maternal obesity on pregnancy and birth outcomes: a systematic review with meta-analysis.","authors":"Döndü Kurnaz, Zekiye Karaçam","doi":"10.1038/s41366-025-01748-y","DOIUrl":"https://doi.org/10.1038/s41366-025-01748-y","url":null,"abstract":"<p><strong>Aim: </strong>This study was conducted to determine the effects of the methods used in the management of maternal obesity on pregnancy and birth outcomes.</p><p><strong>Materials and methods: </strong>This study was conducted following the PRISMA Statement. The articles to be used in the meta-analysis were searched in PubMed, National Thesis Center, DergiPark, MEDLINE, Cochrane Library and EBSCO search engines in October 2021 and updated in September 2023. The methodological qualities of the studies were evaluated using ROB2. The data were synthesized using meta-analysis, and the GRADE approach was used to rate the certainty of the evidence and the strength of the recommendations. Twenty-one studies published between 2013 and 2021 were included in the study. The total sample size of the studies was 7695.</p><p><strong>Results: </strong>Weight management interventions significantly reduced weight gain during pregnancy (p < 0.001) and birth weight (p < 0.01). Did not affect other adverse pregnancy outcomes included in the synthesis (p > 0.05). The subgroup analyses showed that the method of handing out brochures resulted in lower levels of birth weight (p < 0.01) and weight gained during pregnancy (p < 0.001); the use of metformin was associated with a significant drop in admissions to the neonatal intensive care unit (p < 0.01); the method of exercise was associated with lower in gestational diabetes (p < 0.001), weight gained during pregnancy (p < 0.001), birth weight (p = 0.01) and large-for-gestational-age baby birth (p < 0.05), while and the combination of diet and exercise significantly reduced weight gained during pregnancy (p = 0.001). The certainty of evidence assessed using GRADE for all 15 critical outcomes was high 15 outcomes.</p><p><strong>Conclusion: </strong>The study revealed that methods used in the treatment of maternal obesity may reduce some negative maternal and newborn outcomes, but it is more important to start pregnancy with an ideal weight.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal obesity promotes impaired renal autophagic process and kidney injury in male offspring.","authors":"Nichakorn Phengpol, Sasivimon Promsan, Nattavadee Pengrattanachot, Onanong Jaruan, Prempree Sutthasupha, Anusorn Lungkaphin","doi":"10.1038/s41366-025-01751-3","DOIUrl":"10.1038/s41366-025-01751-3","url":null,"abstract":"<p><strong>Background: </strong>Obesity during pregnancy increases the risk of obesity, insulin resistance, diabetes, and the development and progression of chronic kidney disease (CKD) in later life in offspring. Impaired renal autophagic process is linked to kidney dysfunction in the setting of increased renal lipid accumulation. The aim of this study was to elucidate the effect of maternal obesity on kidney injury related to impaired renal autophagic process in the offspring.</p><p><strong>Methods: </strong>Maternal obesity model was conducted using female C57BL/6 mice fed with high-fat diet (HFD) for 8 weeks before mating. HFD was consecutively maintained throughout gestation and lactation. Male offspring were selected for investigation after weaning. Metabolic parameters and kidney morphology were performed. Renal insulin signaling, lipid metabolism, lipid accumulation, fibrosis and autophagy were determined.</p><p><strong>Results: </strong>Male offspring of HFD fed mothers developed obesity with insulin resistance, hyperglycemia, hyperlipidemia and consequently promoted kidney injury. Maternal obesity increased CD36, FAS, SREBP1c and Perilipin-2 while suppressed PPARα and CPT1A. The reduction of AMPK, SIRT1, Beclin-1, LC3B, and LAMP2 and the elevation of mTOR and SQSTM1/P62 were observed. These findings indicated the impairment of autophagy and renal lipid metabolism exaggerating renal lipid accumulation in the offspring of maternal obesity.</p><p><strong>Conclusions: </strong>This study demonstrated that long-term HFD consumption in mothers promoted obesity with insulin resistance related kidney injury through the impairment of autophagic process and renal lipid metabolism in the offspring. These circumstances accelerated kidney injury and contributed to an increased susceptibility to CKD in male offspring of maternal obesity.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of subclinical hypothyroidism on kidney damage in children with obesity.","authors":"Anna Di Sessa, Josè Alberto D'Anna, Rosa Melone, Gianmario Forcina, Giusy Capasso, Giuseppina Rosaria Umano, Emanuele Miraglia Del Giudice, Pierluigi Marzuillo","doi":"10.1038/s41366-025-01752-2","DOIUrl":"https://doi.org/10.1038/s41366-025-01752-2","url":null,"abstract":"<p><strong>Background/objectives: </strong>The interplay of subclinical hypothyroidism (SH) with obesity has been well-documented, while an intriguing but still controversial association with kidney damage (KD) has recently emerged. Given the heightened cardiometabolic risk inherent to pediatric obesity, this might further impact on the overall health of children with obesity. Therefore, we aimed at evaluating the impact of SH on KD in children with obesity.</p><p><strong>Subjects/methods: </strong>We retrospectively examined 355 children with obesity stratified according to presence or absence of SH. KD was defined as reduced estimated glomerular filtration rate (eGFR<90 mL/min/1.73 m²) and/or hypertension, and/or albuminuria (≥30 mg/g urinary creatinine), while SH was defined by thyroid stimulating hormone (TSH) > 4.5μ UI/ml with normal free triiodothyronine and free thyroxine levels.</p><p><strong>Results: </strong>Children with SH showed a higher KD prevalence than those without SH (p = 0.004). They also had lower eGFR levels than their counterparts without SH (p = 0.001) and showed an adjusted OR to have KD of 2.04 (95% CI: 1.15-3.61; p = 0.015). A general linear model for eGFR variance showed an inverse association of eGFR with TSH levels (p < 0.0001).</p><p><strong>Conclusions: </strong>Although preliminary, our data suggested an increased risk of KD in children with obesity and SH.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GLP-1 receptor agonists causing euglycemic ketoacidosis in patients without diabetes: a brief review.","authors":"Nikhil Sood, Venkata Buddhavarapu, Rohini Garg","doi":"10.1038/s41366-025-01749-x","DOIUrl":"https://doi.org/10.1038/s41366-025-01749-x","url":null,"abstract":"","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}