Abdominal skeletal muscle quality and quantity are independently and jointly associated with cardiometabolic health in children.

IF 3.8 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

International Journal of Obesity Pub Date : 2025-09-16 DOI:10.1038/s41366-025-01903-5

Emiliano Miranda-Ferrua, Cristina Cadenas-Sanchez, María Medrano, Jonatan R Ruiz, Fernando Idoate, Maddi Osés, Mara Concepción, Rafael Cabeza, Idoia Labayen

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Abstract

Objective: To investigate the independent and joint associations between intermuscular abdominal adipose tissue and abdominal skeletal muscle tissue with cardiometabolic health indicators in children.

Methods: This cross-sectional study included 114 children (10.6 ± 1.1 y, 54% girls) and 56 children (11.3 ± 1.5 y, 39% girls) from two cohorts. Total abdominal area (TAA), intermuscular abdominal adipose tissue (IMAAT) and abdominal skeletal muscular tissue (AMT) were measured by magnetic resonance imaging. Cardiometabolic health was evaluated by triglycerides-to-HDL ratio (TG/HDL), mean arterial pressure (MAP), HOMA-IR and metabolic syndrome z-score (MetSynd).

Results: IMAAT was associated with higher MetSynd regardless of total adiposity in both cohorts (P < 0.05). In the EFIGRO project, the associations of IMAAT with HOMA-IR and TG/HDL ratio were independent of total adiposity (P < 0.05). The relationship of IMAAT with MAP was attenuated after controlling for total adiposity in both cohorts (P < 0.09). The AMT/TAA ratio was inversely associated with the TG/HDL ratio, MAP, HOMA-IR, and MetSynd in both cohorts (P < 0.01). Joint associations showed that children with high IMAAT and low AMT/TAA ratio had significantly higher HOMA-IR (P < 0.01) and MetSynd (P < 0.05) than those with low IMAAT and high AMT/TAA ratio in both cohorts.

Conclusions: Both high IMAAT and low AMT are associated to poor cardiometabolic health already in childhood.

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腹部骨骼肌质量和数量与儿童心脏代谢健康独立或共同相关。

目的：探讨儿童腹肌间脂肪组织和腹肌骨骼肌组织与心脏代谢健康指标之间的独立或联合关系。方法：本横断面研究包括来自两个队列的114名儿童（10.6±1.1岁，女孩54%）和56名儿童（11.3±1.5岁，女孩39%）。采用磁共振成像技术测量大鼠腹部总面积（TAA）、肌间脂肪组织（IMAAT）和腹部骨骼肌组织（AMT）。通过甘油三酯/高密度脂蛋白比值（TG/HDL）、平均动脉压（MAP）、HOMA-IR和代谢综合征z-score （MetSynd）评估心脏代谢健康。结论：高IMAAT和低AMT都与儿童期不良的心脏代谢健康有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Obesity 医学-内分泌学与代谢

CiteScore

10.00

自引率

2.00%

发文量

221

审稿时长

3 months

期刊介绍： The International Journal of Obesity is a multi-disciplinary forum for research describing basic, clinical and applied studies in biochemistry, physiology, genetics and nutrition, molecular, metabolic, psychological and epidemiological aspects of obesity and related disorders. We publish a range of content types including original research articles, technical reports, reviews, correspondence and brief communications that elaborate on significant advances in the field and cover topical issues.