International Journal of Obesity最新文献

{"title":"Glucose circadian rhythm assessment in pregnant women for gestational diabetes screening","authors":"Rafael Bravo, Kyung Hyun Lee, Sarah A. Nazeer, Jocelyn A. Cornthwaite, Michal Fishel Bartal, Claudia Pedroza","doi":"10.1038/s41366-024-01636-x","DOIUrl":"https://doi.org/10.1038/s41366-024-01636-x","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Gestational diabetes mellitus (GDM) is the most common complication during pregnancy, and it is associated with short- and long-term health impairments. Even with increasing incidence rates worldwide, to date, GDM lacks an international standard diagnosis criterion.</p><h3 data-test=\"abstract-sub-heading\">Objective</h3><p>To elucidate whether a chronobiological perspective may improve the identification of patients at risk for neonatal complications.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>We analyzed a dataset with 92 recruited pregnant patients with Continuous Glucose Monitoring (CGM) data obtained in a blinded study. The primary outcome consisted in evaluating whether the composite of adverse neonatal outcomes could be predicted by chronobiological variables derived from fitting glucose oscillation to a circadian rhythm. The secondary neonatal outcomes included preterm birth, neonatal intensive care unit admission, hypoglycemia, mechanical ventilation or continuous positive airway pressure, hyperbilirubinemia, and hospital length of stay. The secondary maternal outcomes included weight gain during pregnancy, hypertensive disorders of pregnancy, induction of labor, cesarean delivery, and postpartum complications. 87 subjects had enough data to study for glucose circadian rhythmicity.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>We developed a 3-covariate model including two chronobiological metrics, the midline estimating statistic of rhythm (MESOR) and glucose M10 start-time, and age that was predictive of the primary outcome, and associated with maternal secondary outcomes (preeclampsia with severe features and weight gain during pregnancy), and newborn secondary outcomes (preterm delivery &lt; 37 weeks, indicated preterm delivery, NICU admission, need for CPAP, and differences in length of hospital stay).</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>Chronobiological parameters might contribute to a better identification of the adverse outcomes associated with GDM in both the mother and newborn.</p><figure></figure>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142254767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Influence of hypobaric hypoxia on leptin levels in men.","authors":"M Tschöp,C J Strasburger,M Töpfer,H Hautmann,R Riepl,R Fischer,G Hartmann,K Morrison,M Appenzeller,W Hildebrandt,J Biollaz,P Bärtsch","doi":"10.1038/s41366-024-01635-y","DOIUrl":"https://doi.org/10.1038/s41366-024-01635-y","url":null,"abstract":"","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142254769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the association between individual, family, and program characteristics and change in health outcomes 12 months after enrollment into the CANadian Pediatric Weight management Registry (CANPWR)","authors":"Patrick G. McPhee, Geoff D. C. Ball, Annick Buchholz, Jill K. Hamilton, Josephine Ho, Ian Zenlea, Lehana Thabane, Katherine M. Morrison","doi":"10.1038/s41366-024-01631-2","DOIUrl":"https://doi.org/10.1038/s41366-024-01631-2","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Objectives</h3><p>To examine individual, family, and program characteristics associated with changes in anthropometric and cardiometabolic health indicators in children with overweight or obesity after participating in multidisciplinary obesity management for 12 months.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Participants included children 2–17 years old with overweight or obesity enrolled in the CANadian Pediatric Weight Management Registry (CANPWR). Multiple linear regression analyses were conducted to investigate the associations between individual, family, and program characteristics and changes in anthropometry (WHO BMI <i>z</i>-score) and cardiometabolic health indicators (systolic and diastolic blood pressure; fasting and 2-h glucose post-oral glucose tolerance test (OGTT); high density lipoprotein- (HDL) and non-HDL cholesterol and fasting triglycerides).</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>BMI <i>z</i>-score data were available from 1065/1286 (82.8%) at 6-months post-baseline and 893/1286 (69.4%) at 12-months post-baseline. At 6-months, BMI <i>z</i>-score decreased relative to baseline (mean difference (MD) [95% confidence interval (CI)] = −0.08 [−0.10 to −0.06]; <i>p</i> &lt; 0.001). BMI <i>z</i>-score (MD [95% CI] = −0.08 [−0.13 to −0.04); <i>p</i> = 0.001) and fasting triglycerides (MD [95% CI] = −0.07 [−0.13 to −0.02); <i>p</i> = 0.011) decreased at 12 months from baseline. Older age at baseline (estimated <i>β</i> = 0.025; 95% CI [0.006, 0.042], <i>p</i> = 0.007) and female sex (estimated <i>β</i> = 0.241; 95% CI [0.108, 0.329], <i>p</i> &lt; 0.001) were associated with a worsened Δ BMI <i>z</i>-score at 12 months, while total hours with mental health provider (estimated <i>β</i> = −0.015; 95% CI [−0.030, −0.001], <i>p</i> = 0.049) was associated with an improved Δ BMI <i>z</i>-score at 12 months. Hours with an exercise counselor (estimated <i>β</i> = 0.023; 95% CI [0.008, 0.039], <i>p</i> = 0.003) were associated with improved HDL, while hours with a registered dietitian (estimated <i>β</i> = −0.026; 95% CI [−0.051, −0.001], <i>p</i> = 0.044) were associated with improved non-HDL cholesterol.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>Male sex and hours spent with a mental health provider, exercise counselor, and registered dietitian were related to significant improvements in several anthropometric and cardiometabolic health indicators at 12 months post-baseline.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142254770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The decorin and myostatin response to acute whole body vibration: impact of adiposity, sex, and race","authors":"Morgan N. Broniec, Kimberly Norland, Jeffrey Thomas, Xiaoling Wang, Ryan A. Harris","doi":"10.1038/s41366-024-01630-3","DOIUrl":"https://doi.org/10.1038/s41366-024-01630-3","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Traditional forms of exercise affect immune, metabolic, and myokine responses and contribute to a multitude of health benefits. Whole body vibration (WBV) has recently emerged as an exercise mimetic that may be more tolerable for those individuals that cannot perform traditional exercise. However, the myokines response to acute WBV in humans has yet to be fully elucidated.</p><h3 data-test=\"abstract-sub-heading\">Objective</h3><p>To characterize the decorin and myostatin response to acute whole body vibration (WBV) and determine the impact of adiposity, sex, and race.</p><h3 data-test=\"abstract-sub-heading\">Subjects</h3><p>One hundred twenty-nine adults (32.8 ± 0.4 years, 66.7% female, 53.5% non-Hispanic Black) were recruited as part of an ongoing, longitudinal twin cohort parent study. Participants were classified into three groups: those with obesity (OB: ≥30 kg/m²), those who are overweight (OW: ≥25 and &lt;30 kg/m²), or those with normal weight (NW: &lt;25 kg/m²) based on BMI.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Blood was collected at baseline (PRE), immediately post (POST), and 1 h (1H), 3 h (3H), and 24 h (24H) post WBV. The acute WBV protocol consisted of 10 cycles of 1 min of vibration exercise followed by 30 s of standing rest.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The response was similar between NW and OW, so these groups were combined for analysis (NW/OW: BMI &lt; 30 kg/m²). Overall, circulating concentrations of decorin were higher (<i>p</i> &lt; 0.001) POST (8.80 ± 0.19 pg/mL) and significantly lower (<i>p</i>’s ≤ 0.005) at 1H (8.66 ± 0.19 pg/mL) and 3H (8.68 ± 0.19 pg/mL), compared to PRE (8.71 ± 0.19 pg/mL). Decorin POST was greater (<i>p</i> = 0.016) in the OB group (8.82 ± 0.18 pg/mL) compared to the NW/OW group (8.77 ± 0.20 pg/mL). Overall, myostatin was higher (<i>p</i> = 0.002) POST (54.93 ± 1.04 pg/mL) and lower (<i>p</i> &lt; 0.001) at 24H (49.13 ± 1.04 pg/mL) compared to PRE (53.49 ± 1.04 pg/mL). The myostatin response was lower (<i>p</i>’s ≤ 0.001) in female and non-Hispanic White individuals compared to male and non-Hispanic Black individuals, respectively.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>A single bout of WBV can facilitate the release of decorin and myostatin into circulation, a similar response to traditional exercise. Additionally, adiposity, sex and race should be considered when evaluating the myokines response to WBV.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142254768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body mass index changes and their association with SARS-CoV-2 infection: a real-world analysis","authors":"Jithin Sam Varghese, Yi Guo, Mohammed K. Ali, W. Troy Donahoo, Rosette J. Chakkalakal","doi":"10.1038/s41366-024-01628-x","DOIUrl":"https://doi.org/10.1038/s41366-024-01628-x","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Objective</h3><p>To study body mass index (BMI) changes among individuals aged 18–99 years with and without SARS-CoV-2 infection.</p><h3 data-test=\"abstract-sub-heading\">Subjects/Methods</h3><p>Using real-world data from the OneFlorida+ Clinical Research Network of the National Patient-Centered Clinical Research Network, we compared changes over time in BMI in an Exposed cohort (positive SARS-CoV-2 test between March 2020–January 2022), to a contemporary Unexposed cohort (negative SARS-CoV-2 tests), and an age/sex-matched Historical control cohort (March 2018–January 2020). BMI (kg/m²) was retrieved from objective measures of height and weight in electronic health records. We used target trial approaches to estimate BMI at start of follow-up and change per 100 days of follow-up for Unexposed and Historical cohorts relative to the Exposed cohort by categories of sex, race &amp; ethnicity, age, and hospitalization status.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The study sample consisted of 249,743 participants (19.2% Exposed, 61.5% Unexposed, 19.3% Historical cohort) of whom 62% were women, 21.5% Non-Hispanic Black, 21.4% Hispanic and 5.6% Non-Hispanic other and had an average age of 51.9 years (SD: 18.9). At start of follow-up, relative to the Unexposed cohort (mean BMI: 29.3 kg/m² [95% CI: 29.1, 29.4]), the Exposed (0.07 kg/m² [95% CI; 0.01, 0.12]) had higher mean BMI and Historical controls (−0.20 kg/m² [95% CI; −0.25, −0.15]) had lower mean BMI. Over 100 days, BMI did not change (0 kg/m² [95% CI: −0.03, 0.03]) for the Exposed cohort, decreased (−0.04 kg/m² [95% CI; −0.05, −0.02]) for the Unexposed cohort and increased (0.03 kg/m² [95% CI; 0.01, 0.04]) for the Historical cohort. Observed differences in BMI at start of follow-up and over 100 days were consistent between Unexposed and Exposed cohorts for most subgroups, except at start of follow-up period among Males and those 65 years or older who had lower BMI among Exposed.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>In a diverse real-world cohort of adults, mean BMI of those with and without SARS-CoV2 infection varied in their trajectories. The mechanisms and implications of weight retention following SARS-CoV-2 infection remain unclear.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142254762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steatotic liver disease associated with 2,4-dienoyl-CoA reductase 1 deficiency","authors":"Benno Kohlmaier, Kristijan Skok, Carolin Lackner, Greta Haselrieder, Thomas Müller, Sabrina Sailer, Johannes Zschocke, Markus A. Keller, A. S. Knisely, Andreas R. Janecke","doi":"10.1038/s41366-024-01634-z","DOIUrl":"https://doi.org/10.1038/s41366-024-01634-z","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Metabolic dysfunction-associated steatotic liver disease (MASLD) is considered multifactorial with a number of predisposing gene polymorphisms known.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>The occurrence of MASLD in 7 and 10 year old siblings, one without classical risk factors and one with type 2 diabetes suggested a monogenic etiology and prompted next-generation sequencing. Exome sequencing was performed in the proband, both parents and both siblings. The impact of a likely disease-causing DNA variant was assessed on the transcript and protein level.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Two siblings have hepatomegaly, elevated serum transaminase activity, and steatosis and harbor a homozygous <i>DECR1</i> splice-site variant, c.330+3A&gt;T. The variant caused <i>DECR1</i> transcript decay. Immunostaining demonstrated lack of DECR1 in patient liver.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>These patients may represent the first individuals with DECR1 deficiency, then defining within MASLD an autosomal-recessive entity, well corresponding to the reported steatotic liver disease in <i>Decr1</i> knockout mice. <i>DECR1</i> may need to be considered in the genetic work-up of MASLD.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142254834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-enhancing physical activity in obesity management: the need to (seriously) go beyond weight loss","authors":"Jean-Michel Oppert, Cécile Ciangura, Alice Bellicha","doi":"10.1038/s41366-024-01632-1","DOIUrl":"https://doi.org/10.1038/s41366-024-01632-1","url":null,"abstract":"<p>There are many false hopes around the impact of physical activity and exercise in obesity management, especially regarding weight loss. Narrowly focusing on weight loss only leads to disappointment for patients and practitioners. Indeed, in persons with overweight or obesity, exercise training, specifically aerobic (i.e. endurance) training, is associated with significant additional weight and fat loss compared to the absence of training. However the magnitude of this effect remains modest, amounting to only 2–3 kg additional weight or fat loss on average. We therefore argue that this conversation needs to be re-oriented towards the many potential health benefits of physical activity that can be seen beyond weight loss. Exercise training has been shown to improve the cardiometabolic risk profile by effects including decreasing abdominal visceral fat and improving insulin sensitivity. Aerobic, as well as combined aerobic and resistance (i.e. strength) training, increase cardiorespiratory fitness, a major risk factor for ill health. Resistance training improves muscle strength, another major component of physical fitness, even in the absence of a significant change in muscle mass. Beyond body mass loss, recognizing the broad value of physical activity/exercise in improving health and quality of life of people with obesity is a crucial perspective shift.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142254835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: The cardiovascular exercise response in children with overweight or obesity measured by cardiovascular magnetic resonance imaging","authors":"Meddy N. Bongers-Karmaoui,&nbsp;Alexander Hirsch,&nbsp;Ricardo P. J. Budde,&nbsp;Arno A. W. Roest,&nbsp;Vincent W. V. Jaddoe,&nbsp;Romy Gaillard","doi":"10.1038/s41366-024-01627-y","DOIUrl":"10.1038/s41366-024-01627-y","url":null,"abstract":"","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41366-024-01627-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142287178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1,25‑Dihydroxyvitamin D3 mitigates the adipogenesis induced by bisphenol A in 3T3-L1 and hAMSC through miR-27-3p regulation","authors":"Donatella Paola Provvisiero, Mariarosaria Negri, Feliciana Amatrudo, Roberta Patalano, Tatiana Montò, Cristina de Angelis, Chiara Graziadio, Gabriella Pugliese, Giulia de Alteriis, Annamaria Colao, Rosario Pivonello, Silvia Savastano, Claudia Pivonello","doi":"10.1038/s41366-024-01629-w","DOIUrl":"https://doi.org/10.1038/s41366-024-01629-w","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Endocrine-disrupting compounds, including bisphenol A (BPA), may promote obesity influencing basal metabolic rate and shifting metabolism towards energy storage. The role of 1,25‑Dihydroxyvitamin D3 (VitD) in counteracting adipogenesis is still a matter of debate. Thus, the current study aims to investigate whether and how VitD exposure during adipogenesis could prevent the pro-adipogenic effect of BPA in two adipocyte models, mouse 3T3-L1 cell line and human adipose-derived mesenchymal stem cells (hAMSC).</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>3T3-L1, mouse pre-adipocytes and human adipose-derived mesenchymal stem cells (hAMSC) were treated with VitD (10⁻⁷ M) and BPA (10⁻⁸ M and 10⁻⁹ M), alone or in combination, throughout the differentiation in mature adipocytes. Cellular lipid droplet accumulation was assessed by Oil Red O staining, mRNA and protein expression of key adipogenic markers, transcription factors, and cytokines were investigated by RT-qPCR and WB, respectively. miRNAs involved in the regulation of adipogenic transcription factors were evaluated by RT-qPCR, and highly potent steric-blocking oligonucleotides (miRNA inhibitors) were used to modulate miRNAs expression.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Pre-adipocytes express VitD receptor (VDR) in basal condition, but during the differentiation process VDR expression reduces if not stimulated by the ligand. VitD significantly decreases lipid accumulation, with a consequent reduction in adipogenic marker expression, and counteracts the pro-adipogenic effect of BPA in 3T3-L1 and hAMSC during differentiation. This effect is associated to the increased expression of miR-27a-3p and miR-27b-3p. The blocking of miR-27a-3p and miR-27b-3p through miRNA inhibitors prevents the anti-adipogenic effect of VitD in both cell models.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>These results suggest that in cultured 3T3-L1 and hAMSC VitD induces an anti-adipogenic effect and prevents BPA pro-adipogenic effect by triggering at least in part epigenetic mechanisms involving miR-27-3p.</p><figure></figure>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142206143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alcohol use disorders after bariatric surgery: a study using linked health claims and survey data","authors":"Oliver Riedel,&nbsp;Malte Braitmaier,&nbsp;Mark Dankhoff,&nbsp;Ulrike Haug,&nbsp;Melanie Klein,&nbsp;Wiebke Zachariassen,&nbsp;Jana Hoyer","doi":"10.1038/s41366-024-01606-3","DOIUrl":"10.1038/s41366-024-01606-3","url":null,"abstract":"Previous studies have repeatedly reported alcohol use disorders (AUDs) in patients after bariatric surgery (BS). This research field can benefit from studies combining health claims data with survey data. Based on a combined retrospective cohort and cross-sectional study, 2151 patients with BS identified in a large health claims database received a questionnaire, by which we assessed the presence of AUDs based on a validated instrument (AUDIT) as well as by ICD-10 codes from the health claims data. We described patients with vs. without AUDs regarding sex, time since surgery, satisfaction with weight loss and health care resource utilization (HCRU). The majority of patients were female (80.7%) with a median time since surgery of 6 years (Interquartile range: 4–9 years). For the majority of patients, the bariatric intervention was either a RYGB-Bypass (50%) or sleeve gastrectomy (43%). Overall, 3% had at least one AUD diagnosis code in the claims data (men: 5.5%, women: 2.5%). Among men, 43.6% of diagnoses were coded after but not before the surgery (women: 52%). According to AUDIT (completed by 1496 patients), 9.4% of all patients showed at least hazardous/harmful alcohol consumption. Higher scores were associated with sex of the person, longer time since surgery, dissatisfaction with the weight loss and higher HCRU, with contradicting results regarding psychotherapeutic care. The proportion with AUDs in the study population gives rise to concern as alcohol consumption should be restricted after BS. The results suggest the necessity for close monitoring and post-surgical care.","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11502494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}