International Journal of Obesity最新文献

{"title":"Diurnal timing of physical activity in relation to obesity and diabetes in the German National Cohort (NAKO).","authors":"Michael J Stein, Andrea Weber, Fabian Bamberg, Hansjörg Baurecht, Klaus Berger, Patricia Bohmann, Hermann Brenner, Julian Brummer, Marcus Dörr, Beate Fischer, Sylvia Gastell, Karin Halina Greiser, Volker Harth, Antje Hebestreit, Jana-Kristin Heise, Florian Herbolsheimer, Till Ittermann, André Karch, Thomas Keil, Alexander Kluttig, Lilian Krist, Karin B Michels, Rafael Mikolajczyk, Matthias Nauck, Katharina Nimptsch, Nadia Obi, Tobias Pischon, Olga Pivovarova-Ramich, Tamara Schikowski, Börge Schmidt, Matthias B Schulze, Karen Steindorf, Stephanie Zylla, Michael F Leitzmann","doi":"10.1038/s41366-025-01721-9","DOIUrl":"10.1038/s41366-025-01721-9","url":null,"abstract":"<p><strong>Background: </strong>Physical activity supports weight regulation and metabolic health, but its timing in relation to obesity and diabetes remains unclear. We aimed to assess the diurnal timing of physical activity and its association with obesity and diabetes.</p><p><strong>Methods: </strong>We cross-sectionally analyzed hip-worn accelerometry data from 61,116 participants aged 20-75 in the German National Cohort between 2015 and 2019. We divided physical activity into sex- and age-standardized quartiles of total morning (06:00-11:59), afternoon (12:00-17:59), evening (18:00-23:59), and nighttime (00:00-06:00) physical activity. Using multivariable logistic regression, we estimated associations of physical activity timing with obesity (BMI ≥ 30.0 kg/m²) and diabetes (self-reported or HbA1c ≥ 6.5%). We accounted for sex, age, study region, education, employment, risky alcohol use, smoking, night shift work, and sleep duration.</p><p><strong>Results: </strong>High afternoon (top vs. bottom quartile, OR: 0.36, 95% CI: 0.33-0.38) and evening physical activity (OR: 0.45, 95% CI: 0.42-0.48) showed lower obesity odds than high morning activity (OR: 0.71, 95% CI: 0.66-0.76), whereas nighttime activity increased obesity odds (OR: 1.58, 95% CI: 1.48-1.68). Associations were similar for diabetes, with the lowest odds for afternoon (OR: 0.47, 95% CI: 0.42-0.53), followed by evening (OR: 0.56, 95% CI: 0.50-0.62) and morning activity (OR: 0.80, 95% CI: 0.71-0.89), and higher odds for nighttime activity (OR: 1.43, 95% CI: 1.29-1.58). Findings were not modified by employment status, night shift work, and sleep duration.</p><p><strong>Conclusions: </strong>Our cross-sectional findings require longitudinal corroboration but suggest afternoon and evening activity provide greater metabolic health benefits than morning activity, while nighttime activity is discouraged.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"921-930"},"PeriodicalIF":4.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fasting appetite-related gut hormone responses after weight loss induced by calorie restriction, exercise, or both in people with overweight or obesity: a meta-analysis.","authors":"Zhuoxiu Jin, Jiajin Li, Alice E Thackray, Tonghui Shen, Kevin Deighton, James A King, David J Stensel","doi":"10.1038/s41366-025-01726-4","DOIUrl":"10.1038/s41366-025-01726-4","url":null,"abstract":"<p><strong>Objectives: </strong>Altered appetite-related gut hormone concentrations may reflect a physiological adaptation facilitating weight regain after weight loss. This review investigates hormonal changes after weight loss achieved through calorie restriction (CR), exercise (EX), or both combined (CREX).</p><p><strong>Methods: </strong>A systematic search of PubMed (MEDLINE), EMBASE, SPORTDiscus, Cochrane Library, Web of Science, and ClinicalTrials.gov was conducted to identify randomised controlled trials (RCTs) and non-RCTs reporting in a fasting state either pre- and post-intervention appetite-related hormone concentrations or the changes therein after weight loss. The hormones examined were ghrelin, peptide tyrosine tyrosine (PYY), glucagon-like peptide -1 (GLP-1), and cholecystokinin (CCK), in their total and/or active form. Standardised mean differences (SMD) were extracted as the effect size.</p><p><strong>Results: </strong>127 studies were identified: 19 RCTs, 108 non-RCTs, 1305 and 4725 participants, respectively. In response to weight loss induced by CR, EX or CREX, the meta-analysis revealed an increase in total ghrelin from both RCTs (SMD: 0.55, 95% CI: 0.07-1.04) and non-RCTs (SMD: 0.24, 95% CI: 0.14-0.35). A decrease in acylated ghrelin was identified for RCTs (SMD: -0.58, 95% CI: -1.09 to -0.06) but an increase was observed for non-RCTs (SMD: 0.15, 95% CI: 0.03 to 0.27). Findings also revealed a decrease in PYY (total PYY: SMD: -0.17, 95%CI: -0.28 to -0.06; PYY_3-36: SMD: -0.17, 95%CI: -0.32 to -0.02) and active GLP-1 (SMD: -0.16, 95% CI: -0.28 to -0.05) from non-RCTs. Changes in hormones did not differ among the three interventions when controlling for weight loss. Meta-regression indicated that greater weight loss was associated with a greater increase in total ghrelin.</p><p><strong>Conclusions: </strong>Weight loss induced by CR, EX, or CREX elicits an increase in total ghrelin, but varied responses in other appetite-related hormones. The extent of weight loss influences changes in appetite-related gut hormone concentrations.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"776-792"},"PeriodicalIF":4.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What defines a cell type? Perspectives from adipocyte biology.","authors":"Enzo Nisoli, Saverio Cinti","doi":"10.1038/s41366-024-01696-z","DOIUrl":"10.1038/s41366-024-01696-z","url":null,"abstract":"","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"751-754"},"PeriodicalIF":4.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five-year follow-up of a randomized weight loss trial on a digital health behaviour change support system.","authors":"Eero Turkkila, Taru Pekkala, Heta Merikallio, Marko Merikukka, Laura Heikkilä, Janne Hukkanen, Harri Oinas-Kukkonen, Tuire Salonurmi, Anna-Maria Teeriniemi, Terhi Jokelainen, Markku J Savolainen","doi":"10.1038/s41366-025-01742-4","DOIUrl":"10.1038/s41366-025-01742-4","url":null,"abstract":"<p><strong>Background: </strong>The weight regain after successful weight loss is a common challenge. This study aimed to assess the long-term effectiveness of a web-based health behaviour change support system (HBCSS) utilizing persuasive systems design (PSD) and methods of cognitive behavioural therapy (CBT). We have previously demonstrated the two-year effectiveness of the HBCSS.</p><p><strong>Methods: </strong>In total, 532 participants with overweight or obesity (BMI 27-35 kg m^-2) were split into three groups with different intensities of intervention: CBT-based group counselling, self-help guidance (SHG), and usual care. These groups were further divided into HBCSS and non-HBCSS groups. The HBCSS was a 52-week programme. The follow-up took five years in total.</p><p><strong>Results: </strong>Mean weight change (%) (95% CI) from baseline among HBCSS and non-HBCSS users was 1.5 (-0.02 to 2.9), p = 0.056 and 1.9 (0.3-3.3), p = 0.005, respectively, at five years. Of the six groups, the SHG group without HBCSS had a statistically significant increase in weight (%) from baseline at five years (3.1, 95% CI 0.6 to 5.6, p = 0.010). The other groups did not have a significant increase in weight. There was no significant difference between groups at five years in weight. Fewer blood pressure medications were started over the five-year period in HBCSS group (p = 0.046).</p><p><strong>Conclusion: </strong>The 12-month HBCSS intervention was not able to maintain reduced weight better than non-HBCSS at 5 years. However, there were significant weight difference favouring HBCSS over the whole 5-year period. The decrease in the need for antihypertensives suggests that the significant weight loss by HBCSS at early years has a health-promoting legacy effect.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"949-953"},"PeriodicalIF":4.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lack of fibro-inflammatory response in human mammary adipose tissue in obesity.","authors":"Frédérique Fallone, Marie Rebeaud, Caroline Bouche, Jessica Fontaine, Carlo Arellano, Manuelle Ducoux-Petit, Lucyle Orgerit, Rémi Deudon, Rémy Nicolle, Camille Franchet, David Estève, Emmanuelle Mouton-Barbosa, Stéphanie Dauvillier, Mohamed Moutahir, Odile Burlet-Schiltz, Anne Bouloumié, Charlotte Vaysse, Catherine Muller","doi":"10.1038/s41366-024-01705-1","DOIUrl":"10.1038/s41366-024-01705-1","url":null,"abstract":"<p><strong>Background: </strong>Understanding how obesity impacts human mammary adipose tissue (MAT) biology is crucial for deciphering its role in mammary epithelium during both physiological and pathophysiological processes, including breast cancer. Hypertrophic mammary adipocytes and Crown-Like Structures are present in MAT of patients with obesity but whether these changes initiate a fibro-inflammatory response at the tissue level remains insufficiently explored.</p><p><strong>Objective: </strong>We investigated the markers of adipose tissue dysfunction (immune cell infiltration, secretion pattern and fibrosis) in tumor-free MAT of patients with obesity versus patients who are lean.</p><p><strong>Methods: </strong>Tumor-free MAT were obtained from 96 women with (n = 43) or without (n = 53) obesity who underwent mastectomy for breast cancer risk reduction or treatment. Immune and non-immune cell infiltration were determined using flow cytometry. Bulk transcriptomic was used to characterize the phenotype of CD206+ macrophages whose infiltration is increased in patients with obesity. Conditioned-medium were prepared from MAT to characterize their secretome and dose adipokines and cytokines by ELISA assay. The extra-cellular matrix (ECM) deposition was evaluated by Masson trichrome staining on cross-stained sections, 3D imaging of red picrosirius-stained tissues and measure of hydroxyproline content.</p><p><strong>Results: </strong>We observed an increase of CD206+/HLA-DR+ macrophages in the stromal vascular fraction of MAT from patients with obesity compared to patients who are lean. Other immune cell infiltration and endothelial or adipose progenitor cell numbers were similar between groups. Bulk transcriptomics on CD206+ macrophages revealed a significant decrease in ECM component expression and processing in obesity. In addition, no heightened secretion of pro-inflammatory cytokines, TGF-β1 or MCP-1 was observed in the samples from patients with obesity. ECM characterization revealed an absence of fibrosis, with MAT of patients with obesity showing even a slightly reduced collagen secretion and deposition compared with their lean counterparts.</p><p><strong>Conclusions: </strong>Obesity is not associated with inflammation nor fibrosis in MAT, highlighting its unique behavior.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"809-818"},"PeriodicalIF":4.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cachectic biomarkers as confounders behind the obesity paradox in patients with acute decompensated heart failure.","authors":"Yusuke Miura, Satoshi Higuchi, Takashi Kohno, Yasuyuki Shiraishi, Mitsunobu Kitamura, Yuji Nagatomo, Yumiko Kawakubo Ichihara, Atsushi Mizuno, Shintaro Nakano, Kyoko Soejima, Ayumi Goda, Shun Kohsaka, Tsutomu Yoshikawa","doi":"10.1038/s41366-025-01716-6","DOIUrl":"10.1038/s41366-025-01716-6","url":null,"abstract":"<p><strong>Background: </strong>Obesity is a risk factor for heart failure (HF) development but is associated with a lower incidence of mortality in HF patients. This obesity paradox may be confounded by unrecognized comorbidities, including cachexia.</p><p><strong>Methods: </strong>A retrospective assessment was conducted using data from a prospectively recruiting multicenter registry, which included consecutive acute heart failure patients. A low, normal, and high body mass index (BMI) was defined as <20 kg/m², 20-25 kg/m², and ≥25 kg/m², respectively. Cachexia was defined as a combination of BMI < 20 kg/m² and any biochemical abnormalities including albumin, hemoglobin, or C-reactive protein. Patients with either of the three biochemical abnormalities were categorized as those with cachectic biomarkers. Two-year all-cause, cardiac, and noncardiac mortality were evaluated.</p><p><strong>Results: </strong>This study evaluated 3314 patients (mean BMI, 22 ± 4 kg/m² [low BMI with cachexia, 828 (25%); low BMI without cachexia, 273 (8%); normal BMI, 1584 (48%); high BMI, 629 (19%)]). Overall, an increase of 1 point in BMI was associated with a decreased incidence of all-cause mortality (adjusted hazard ratio [HR], 0.92; 95% confidence interval [CI], 0.90-0.94; p < 0.001). Regardless of the mode of death, the low BMI with cachexia indicated the worst prognosis, while the low BMI without cachexia showed a similar prognosis to the normal BMI. Cachectic biomarkers, which were observed more frequently in the low BMI, predicted a higher incidence of 2-year all-cause mortality across the BMI categories (adjusted HR for the low BMI, 1.90; 95% CI, 1.30-2.77; p = 0.001; adjusted HR for the normal BMI, 1.94; 95% CI, 1.34-2.79; p < 0.001; adjusted HR for the high BMI, 3.60; 95% CI, 1.61-8.08; p = 0.002).</p><p><strong>Conclusions: </strong>BMI could be only a surrogate marker. The cachectic biomarkers may reflect the underlying conditions and contribute to elucidating the obesity paradox.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"888-895"},"PeriodicalIF":4.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between maternal pre-pregnancy BMI and mean diffusivity of the hippocampus and amygdala in infants.","authors":"Aylin Rosberg, Harri Merisaari, John D Lewis, Niloofar Hashempour, Minna Lukkarinen, Jerod M Rasmussen, Noora M Scheinin, Linnea Karlsson, Hasse Karlsson, Jetro J Tuulari","doi":"10.1038/s41366-025-01730-8","DOIUrl":"10.1038/s41366-025-01730-8","url":null,"abstract":"<p><strong>Background: </strong>Maternal pre-pregnancy obesity may negatively affect offspring outcomes, including neurodevelopment. This study examined the relationship between maternal pre-pregnancy body mass index (MBMI) and the microstructure of the hippocampus and amygdala in neonates.</p><p><strong>Methods: </strong>Diffusion tensor imaging was used to assess mean diffusivity (MD) in these brain regions in 122 infants (mean gestational age: 39.9 weeks, mean age at scan: 24.8 days) from the FinnBrain Birth Cohort Study ( www.finnbrain.fi ). Linear regression was applied to explore associations between MBMI and MD at the regional level, while non-parametric permutation analysis was used for voxelwise investigations.</p><p><strong>Results: </strong>A positive association was found between MBMI and hippocampal MD, particularly in the right hippocampus. Voxelwise analyses showed stronger associations in distinct areas: posterior for the right hippocampus and anterior for the left. No significant association was found between MBMI and amygdala MD.</p><p><strong>Conclusion: </strong>These findings suggest that in utero exposure to high MBMI may influence hippocampal microstructure in infants, underscoring the need for further research on the intergenerational effects of maternal obesity on early brain development.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"938-941"},"PeriodicalIF":4.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12095046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultraviolet exposure of mice fed a high fat diet reduces weight gain and markers of liver disease progression.","authors":"Gareth Hazell, Marina Khazova, Hannah Mancey, Raymond Shek, Paul O'Mahoney","doi":"10.1038/s41366-025-01779-5","DOIUrl":"https://doi.org/10.1038/s41366-025-01779-5","url":null,"abstract":"<p><strong>Background: </strong>Research suggests that ultraviolet (UV) exposure of mice placed on a high fat diet can reduce incidence of metabolic disease. However, current research had primarily focused on male mice with UV outside level of terrestrial sunlight.</p><p><strong>Objectives: </strong>Here we attempt to address this imbalance, with a pilot study presented wherein female mice C57Bl6 mice are included, with UV exposure at level comparable to low dose (non-burning) sunlight exposure.</p><p><strong>Methods: </strong>2% UV-B and 98% UV-At a dose of 1.83 J/cm² with UV-A and 0.04 J/ cm² UV-B were delivered over a 10-min timeframe twice weekly. Mice were placed on a low-fat diet or high fat diet, with the high fat diet cohort either exposed twice weekly to UV light or sham exposed.</p><p><strong>Results: </strong>Non-significant trends are observed for weight amelioration in UV exposed mice across both sexes at study endpoint, whereas in the liver, a reduction of lipid droplet size due to UV exposure is observed. Assessment of vitamin D status at study endpoint shows that the high fat diet increases 25(OH)D level in both sexes, more so in female mice, with further non-significant rises due to UV exposure.</p><p><strong>Conclusions: </strong>This study supports previous evidence that non-vitamin D mediated pathways may be responsible for the outcomes reported in this study. The UV exposures used in this study also resulted in minimal damage to ex vivo skin or in vitro cells, as assessed by cyclobutene-pyrimidine dimers (CPD's) (characteristic signature mutations induced by UV), and double stranded breaks, further demonstrating the potential benefit of such exposures. This study supports and builds on current evidence that non-vitamin D pathways mediated through UV exposure may be beneficial in slowing weight gain and liver disease progression.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human adaptation response to obesity.","authors":"Alireza Jahanbani, Davood Rezazadeh, Elham Sajadi, Mahdiyeh Haj Hosseini, Deniz Ketabchi, Narges EskandariRoozbahani","doi":"10.1038/s41366-025-01791-9","DOIUrl":"https://doi.org/10.1038/s41366-025-01791-9","url":null,"abstract":"<p><p>This article examines the human body's adaptive responses to obesity from biological, behavioral, and evolutionary perspectives. It explores how ancient survival mechanisms, such as fat storage during scarcity, have persisted but become maladaptive in modern contexts of food abundance and sedentary lifestyles. Using the Thrifty Gene Hypothesis and General Adaptation Syndrome (GAS), the study investigates how chronic stress and genetic predispositions contribute to obesity. Chronic stress, as described in GAS, is linked to obesity through mechanisms like prolonged cortisol elevation, which promotes fat storage, particularly in the abdominal region, and disrupts hunger and satiety regulation. The article also explores the possibility that contemporary chronic stress may cause the body to buffer stressful conditions through fat accumulation. While the Thrifty Gene Hypothesis suggests that genetic traits evolved to optimize energy storage during scarcity, contributing to obesity in modern environments, it remains controversial. Critics argue that it oversimplifies obesity's causes, such as lifestyle and environmental factors. Although genetic variations influencing obesity susceptibility continue to evolve, the physiological mechanisms of fat storage and stress adaptation have remained largely unchanged since ancient times.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing patients to choose one obesity treatment over another: a qualitative study.","authors":"H C Craig, D Alsaeed, E Al Ozairi, S Norris, J Holian, C Kennedy, H Heneghan, D McGillicuddy, E Farrell, E Hollmann, W Al-Najim, C W le Roux","doi":"10.1038/s41366-025-01789-3","DOIUrl":"https://doi.org/10.1038/s41366-025-01789-3","url":null,"abstract":"<p><strong>Background: </strong>When deciding a treatment option for the disease of obesity, knowing what the patient's preferences are and what factors have influenced them can support healthcare professionals (HCPs) in tailoring their management plan. Little is known about patient preferences for obesity treatment. The present study was designed to identify factors that may influence these preferences.</p><p><strong>Objective: </strong>We aimed to identify factors affecting patient preferences and subsequent obesity treatment preferences among those seeking treatment for obesity-related disorders.</p><p><strong>Methods: </strong>Using a participatory action research design, we conducted World Café focus groups as part of a triangulation process with previously collected individual interviews and photovoice. Using purposive sampling, 12 patients with obesity complications of chronic kidney disease, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease took part. Thematic analysis was conducted to review themes, determine their significance, and report the findings.</p><p><strong>Results: </strong>Five themes emerged from the World Café on what influences patient treatment choice, which were 1) lack of resources, 2) healthcare professionals' knowledge gaps, 3) lack of understanding, 4) emotional impact, and 5) support from family, friends, and HCPs. This data was then reviewed with the findings from the previous methodologies of one-to-one interviews and photovoice. Overall, four main themes were identified, which were 1) structural factors, 2) physical and emotional impact, 3) knowledge (of healthcare professionals and patients), and 4) support.</p><p><strong>Conclusion: </strong>This study demonstrates the importance of ensuring access to all treatment options by developing effective treatment plans with clear information for patients.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}