International Journal of Obesity最新文献

{"title":"Correction: Microbiome and pregnancy: focus on microbial dysbiosis coupled with maternal obesity.","authors":"Kalie F Beckers, Juliet P Flanagan, Jenny L Sones","doi":"10.1038/s41366-025-01817-2","DOIUrl":"10.1038/s41366-025-01817-2","url":null,"abstract":"","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"1421"},"PeriodicalIF":4.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized controlled trial of time-restricted eating: secondary analyses of breath acetone.","authors":"Candida J Rebello, Dachuan Zhang, Joseph C Anderson, Rebecca F Bowman, Pamela M Peeke, Frank L Greenway","doi":"10.1038/s41366-025-01818-1","DOIUrl":"10.1038/s41366-025-01818-1","url":null,"abstract":"<p><p>Studies of prolonged fasting produced spectacular weight loss and demonstrated that ketone bodies rise for approximately three weeks before stabilizing as production and utilization rates equilibrate. Although starvation is no longer an accepted obesity treatment, an extended period of fasting is the basis of time-restricted eating which produces metabolic benefits. Nevertheless, the pattern of change in ketone bodies with time-restricted eating has never been investigated. We collected weekly fasting measures of breath acetone from subjects (N = 60) who were on an eight-week, calorie-restricted diet and were randomized to different time-restricted eating windows. Subjects participating in a 14-hour fast, 10-hour eating window (14:10) lost more weight than subjects participating in a 12-hour fast, 12-hour eating window (12:12) as previously reported (Nutr Diabetes 2021; 11(1): 6). Ketone bodies assessed via breath acetone showed an increase for the first three weeks without a significant difference between groups. From weeks four to eight, breath acetone levels were lower in the 14:10 compared to the 12:12 group (between group difference: 5.45 ± 2.1 parts per million, mean ± SE, p = 0.012). We show for the first time that ketone bodies decrease after a period of adaptation to time-restricted eating of a calorie-restricted diet likely from enhanced fat oxidation and ketone utilization.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"1416-1418"},"PeriodicalIF":3.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of intermittent fasting on blood pressure in adults with overweight or obesity: a systematic review.","authors":"Yaxin Guo, Lijie Lu, Luying Chen, Yaojian Wang, Fangfang Zhao, Yuerong Jiang","doi":"10.1038/s41366-025-01823-4","DOIUrl":"10.1038/s41366-025-01823-4","url":null,"abstract":"<p><strong>Background: </strong>Previous intermittent fasting (IF) studies have reported inconsistent findings regarding its antihypertensive effects and safety.</p><p><strong>Objective: </strong>This study aimed to assess the effects and safety of IF on blood pressure (BP), anthropometrics, and cardiometabolic risk markers in individuals with overweight or obesity compared to a no-intervention control group.</p><p><strong>Methods: </strong>Relevant studies were retrieved from multiple databases, including CNKI, Wanfang, VIP, SinoMed, PubMed, Embase, the Cochrane Library, and Web of Science, up to April 30, 2024. A meta-analysis was performed using Stata version 18.0 and RevMan 5.4, calculating mean differences (MD) or risk ratios (RR) with 95% confidence intervals (CI) via the Knapp-Hartung modified random-effects model. Publication bias was evaluated using a contour-enhanced funnel plot and Egger's test.</p><p><strong>Results: </strong>Fifteen studies (n = 929) were included. IF significantly reduced systolic blood pressure (SBP) (MD = -4.43 mmHg, 95% CI: -5.83 to -3.03, p < 0.001) and diastolic blood pressure (DBP) (MD = -2.00 mmHg, 95% CI: -3.23 to -0.78, p < 0.001) compared to control. IF also improved anthropometric measures, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), and Triglycerides (TG). Seven studies reported minor adverse effects. Although the IF group showed a higher risk of vomiting (RR = 1.11, 95% CI: 1.04-1.19, p = 0.01) and irritability (RR = 1.22, 95% CI: 1.13-1.31, p < 0.001) compared to the control group, these reactions were predominantly observed during the initial phase of the intervention and were self-resolving.</p><p><strong>Conclusions: </strong>IF significantly lowered SBP and DBP in individuals with overweight or obesity, particularly in high-risk subgroups (obesity, age ≥45 years, and prehypertension/hypertension), with a favorable safety profile. Due to heterogeneity, future trials should standardize IF regimens and target these subgroups to confirm generalizability.</p><p><strong>Clinical trial registration: </strong>The review protocol has been registered on PROSPERO (CRD42024540777).</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"1240-1251"},"PeriodicalIF":3.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BMI, waist circumference, and waist-to-hip trajectories and all-cause, CVD, and cancer mortality by sex in people without diabetes.","authors":"Zailing Xing, Douglas D Schocken, Janice C Zgibor, Amy C Alman","doi":"10.1038/s41366-025-01778-6","DOIUrl":"10.1038/s41366-025-01778-6","url":null,"abstract":"<p><strong>Objectives: </strong>We examined the associations of BMI, waist circumference, and waist-to-hip ratio trajectories with mortality in people without diabetes.</p><p><strong>Methods: </strong>We analyzed 7601 people without diabetes from the Atherosclerosis Risk in Communities Study. We used latent class analysis to identify trajectory patterns for BMI, waist circumference, and waist-to-hip. We employed propensity score matching to enhance the balance of covariates and used Cox proportional hazards regression models to examine the associations.</p><p><strong>Results: </strong>In females, the high trajectory of BMI was associated with higher cancer mortality risks than the low group, with the hazard ratio and 95% confidence interval of 1.76 (1.14-2.73). The high waist circumference trajectory was related to increased all-cause, CVD, and cancer mortality risks in males. The moderate and high waist-to-hip ratio trajectories were associated with elevated all-cause and CVD mortality risks in females, and the high trajectory was associated with high all-cause mortality risks in males. The mean lifespan of deceased females did not significantly differ across the trajectories. However, the mean lifespan of males in the waist circumference high group (73.0 years) was shorter than the low group (75.3 years).</p><p><strong>Conclusions: </strong>Sex differences were observed in the long-term impact of high BMI, waist circumference, and waist-to-hip ratio on mortality risks and lifespan in people without diabetes.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"1363-1372"},"PeriodicalIF":4.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which adiposity marker is most strongly associated with all‑cause and cause‑specific mortality? a prospective study of 158,699 Mexican adults.","authors":"Weder Alves da Silva, Leandro F M Rezende, Adilson Marques, Marcelo de Maio Nascimento, Eduardo Nilson, Diego G D Christofaro, Roberto Fernandes da Costa, Gerson Ferrari","doi":"10.1038/s41366-025-01827-0","DOIUrl":"https://doi.org/10.1038/s41366-025-01827-0","url":null,"abstract":"<p><strong>Background: </strong>Various methods have been used to assess adiposity and its associations with morbidity and mortality. In this study, we aimed to examine the association of four adiposity markers with all‑cause and cause‑specific mortality, while evaluating the potential influence of reverse causation bias.</p><p><strong>Methods: </strong>This prospective cohort study included 158,699 participants from the Mexico City Prospective Study. Cox regression models were performed to estimate the associations of body mass index, waist circumference, waist-to-height ratio, and waist-to-hip ratio with mortality risk. To minimize the influence of reverse causation, we excluded participants with prevalent diseases at baseline and conducted additional analyses excluding deaths occurring within the first 2, 5, and 10 years of follow-up.</p><p><strong>Results: </strong>Over a median of 15.5 years, 28,296 death were recorded. Waist circumference values above the recommended cutoff considered high were associated with higher all-cause mortality after the exclusion of the first 2, 5, and 10 years of follow-up (HR: 1.83; 95% CI: 1.26-2.55, HR: 1.83; 95% CI: 1.23-2.62, and HR: 1.85; 95% CI: 1.14-2.70, respectively). Elevated waist-to-hip ratio was associated with increased all-cause mortality across the same exclusion periods (HR: 1.71; 95% CI: 1.07-2.30, HR: 1.70; 95% CI: 1.05-2.49, and HR: 1.71; 95% CI: 1.01-2.52). High waist circumference was strongly associated with CVD mortality after exclusion of the first 2, 5, and 10 years (HR: 4.76; 95% CI: 1.70-11.82, HR: 4.75; 95% CI: 1.56-11.88, and HR: 4.73; 95% CI: 1.42-12.90, respectively). Elevated waist-to-hip ratio similarly showed associations with CVD mortality (HR: 2.69; 95% CI: 1.10-5.60, HR: 2.66; 95% CI: 1.12-5.75, and HR: 2.64; 95% CI: 1.03-7.32). Body mass index, waist circumference, waist-to-height ratio, and waist-hip ratio were not associated with respiratory and cancer mortality.</p><p><strong>Conclusions: </strong>Waist circumference was the adiposity marker most strongly associated with all-cause and CVD mortality, even after excluding the first 10 years of follow-up.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of aldafermin expressing-Escherichia coli Nissle 1917 along with dietary change on visceral adipose tissue in MASLD mouse model.","authors":"Valeria Iannone, Maija Vaittinen, Carlos Gómez-Gallego, Santtu Mikkonen, Johnson Lok, Giuseppe D'Auria, Ruben Vazquez-Uribe, Ida Tikkanen, Morten Otto Alexander Sommer, Hani El-Nezami, Marjukka Kolehmainen","doi":"10.1038/s41366-025-01774-w","DOIUrl":"10.1038/s41366-025-01774-w","url":null,"abstract":"<p><strong>Background: </strong>Visceral adipose tissue (VAT) accumulation in obesity has been implicated as a key factor in the development of metabolic dysfunction-associated steatotic liver disease (MASLD). Apart from lifestyle change interventions, there is no effective therapy against MASLD. In this study, the effect of a novel microbial therapy along with dietary change on VAT and VAT-liver crosstalk was evaluated in a MASLD mouse model.</p><p><strong>Methods: </strong>MASLD was induced by feeding eighteen C57BL/6J male mice with the American Lifestyle-Induced Obesity diet for fourteen weeks. Subsequently, during the following seven weeks, all mice were switched to standard diet and the intervention group received single gelatine cubes containing 10⁹ CFU each of aldafermin-expressing Escherichia coli Nissle (EcNA, n = 6); while the control groups received either 10⁹ CFU/gelatine cube of non-modified Escherichia coli Nissle (EcN, n = 6) or gelatin cube with no treatment (CTRL, n = 6). The effect of EcNA on epididymal visceral adipose tissue (eVAT) morphology was evaluated by histology and the gene expression profile in eVAT and liver by RNA-sequencing analysis.</p><p><strong>Results: </strong>After seven weeks of intervention, EcNA, when compared to CTRL group, induced smaller adipocytes (p-value = 0.0217 for diameter, p-value = 0.0386 for area). Gene Set Enrichment Analysis in eVAT showed significant upregulation of fatty acid metabolism (FDR-adjusted p-value = 0.001), oxidative phosphorylation (FDR-adjusted p-value < 2.2e-16), peroxisome (FDR-adjusted p-value = 0.0185), and thermogenesis (FDR-adjusted p-value = 0.0199) pathways when EcNA was compared to EcN group. In addition, the impact of EcNA in eVAT-liver gene expression crosstalk was underlined by the upregulation of Bcl6 and Cnst expression in both tissues when EcNA was compared to CTRL and EcN groups.</p><p><strong>Conclusions: </strong>These results support the beneficial effects of EcNA, along with dietary change intervention, in obesity-associated MASLD. This microbial therapy could potentially boost the improvements induced by dietary change in eVAT metabolism and its crosstalk with the liver.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"1334-1344"},"PeriodicalIF":4.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathways linking BMI trajectories and mental health in an adult population-based cohort: role of emotional eating and body dissatisfaction.","authors":"Stephanie Schrempft, Cecilia Jiménez-Sánchez, Hélène Baysson, María-Eugenia Zaballa, Julien Lamour, Silvia Stringhini, Idris Guessous, Mayssam Nehme","doi":"10.1038/s41366-025-01772-y","DOIUrl":"10.1038/s41366-025-01772-y","url":null,"abstract":"<p><strong>Background: </strong>Overweight and obesity are associated with poor mental health, and the association is bidirectional. Few studies have examined the association between weight change and mental health over time. We aimed to provide further insight into the association between weight gain and mental health, with a focus on emotional eating and body dissatisfaction as mediating factors.</p><p><strong>Methods: </strong>Height and weight were self-reported upon registration, and in Spring 2022, 2023, and 2024 in the Specchio cohort (Geneva, Switzerland). BMI trajectories were estimated by (1) mixed-effects models to calculate participants' personal slopes (increase in BMI score per year), and (2) testing the odds of an upward BMI category transition from baseline to last follow-up. The associations of behavioural and psychosocial factors with BMI trajectories (slopes and transitions), and BMI trajectories with mental health outcomes were estimated using regressions adjusted for age, sex, education, and physical health condition. Structural equation modelling was used to test mediating pathways.</p><p><strong>Results: </strong>Among 7388 participants (59% women, mean age 51 years), factors associated with increasing BMI over 4 years included financial hardship, short sleep duration, less physical activity, more leisure screen time, depressive and anxiety symptoms, and emotional eating (β range [95% CI] = 0.03 [0, 0.05]-0.12 [0.09, 0.15]). Increasing BMI was associated with body dissatisfaction (β = 0.36 [0.33, 0.38]) and poorer quality of life (β = -0.06 [-0.09, -0.03]) at 4-year follow-up after adjustment for anxiety and depressive symptoms at baseline. Emotional eating partly mediated the association between anxiety and depressive symptoms at baseline and increasing BMI, and between financial hardship and increasing BMI. Body dissatisfaction and poorer self-rated health partly mediated the association between increasing BMI and quality of life at follow-up.</p><p><strong>Conclusions: </strong>Emotional eating and body dissatisfaction contribute to the association between BMI trajectories and mental health and should be considered in weight management and mental health promotion strategies.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"1317-1326"},"PeriodicalIF":4.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The intensity of exercise and inflammation markers in women with overweight & obesity: a systematic review and network meta-analysis.","authors":"Liang Tan, Duo Huang, Bo Liu, Zbigniew Ossowski, Ning Wang, Weihua Yan","doi":"10.1038/s41366-025-01777-7","DOIUrl":"10.1038/s41366-025-01777-7","url":null,"abstract":"<p><strong>Objectives: </strong>The purpose of this network meta-analysis (NMA) of randomized controlled trials (RCT) was to examine the effects of different exercise intensities on inflammatory markers in women with overweight/obesity.</p><p><strong>Methods: </strong>A systematic search for RCTs that met the inclusion criteria for the period up to October 2024. random effects NMA was performed within a frequency-based framework.</p><p><strong>Results: </strong>A total of 75 RCTs were included (3989 participants). High-intensity exercise significantly modulated leptin and adiponectin levels, but had a nonsignificant effect on TNF-α, CRP, and IL-6 levels. Moderate-intensity exercise significantly modulated TNF-α, CRP, IL-6, leptin, and adiponectin levels. Surface under the cumulative ranking curve (SUCRA) probability ranking showed that moderate-intensity exercise was the most recommended exercise intensity for reducing TNF-α, CRP, IL-6, and leptin levels, and for modulating adiponectin levels, moderate-intensity exercise also had a SUCRA value of 65.4%, so we believe that moderate-intensity exercise may be the most robust type of exercise intensity in terms of the breadth of effects. Subgroup analysis showed that moderate-intensity aerobic exercise (MAE) significantly reduced TNF-α levels. Moderate-intensity resistance training (MRT) is the most recommended type for decreasing IL-6 and leptin levels. Moderate-intensity combined exercise (MCE) is the best type of exercise for managing CRP and adiponectin levels.</p><p><strong>Conclusions: </strong>There were significant differences in the effects of different exercise intensities on specific inflammatory markers in women living with overweight and obesity. Moderate-intensity exercise may be the most robust type of exercise intensity. Future studies should consider the importance of exercise duration and volume (e.g., in MET* minutes/week) to better understand the relationship between exercise intensity and inflammatory markers. The effects of combining exercise and diet on inflammatory markers in women with overweight and obesity should also be explored in greater depth.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"1229-1239"},"PeriodicalIF":4.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding applications of GLP-1 therapies: a careful view.","authors":"Domenico Azzolino, Tiziano Lucchi","doi":"10.1038/s41366-025-01788-4","DOIUrl":"10.1038/s41366-025-01788-4","url":null,"abstract":"","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"1207-1208"},"PeriodicalIF":4.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detecting monogenic obesity: a systematic exome-wide workup of over 500 individuals.","authors":"Robert Künzel, Helene Faust, Linnaeus Bundalian, Matthias Blüher, Mariami Jasaszwili, Anna Kirstein, Albrecht Kobelt, Antje Körner, Denny Popp, Eric Wenzel, Rami Abou Jamra, Johannes R Lemke, Torsten Schöneberg, Robert Stein, Antje Garten, Diana Le Duc","doi":"10.1038/s41366-025-01819-0","DOIUrl":"10.1038/s41366-025-01819-0","url":null,"abstract":"<p><strong>Background/objectives: </strong>Obesity poses a major public health concern. Although BMI heritability is estimated at 40-80%, genetic diagnostics remain challenging. This study aims to (i) assess the diagnostic yield of monogenic obesity in a large patient sample using exome-wide data, (ii) identify predictors to improve genetic testing criteria, and (iii) evaluate whether the identified genes are included in public obesity gene panels.</p><p><strong>Subjects/methods: </strong>We reviewed the genetic test results of 521 patients with obesity. 84.7% underwent whole-exome analysis, 15.3% were analyzed using a multi-thousand-gene panel.</p><p><strong>Results: </strong>Monogenic obesity was diagnosed in 5.8% of patients, while 7.1% carried a potentially obesogenic variant. Diagnostic yield was higher in children (6.3%) and patients with syndromic obesity (7.0%). Surprisingly, diagnostic yield was lower in severe obesity cases. 40% of patients with monogenic obesity carried variants in genes not included in current obesity panels.</p><p><strong>Conclusion: </strong>Overall, 12.9% of patients had monogenic obesity or a potentially obesogenic variant. These findings suggest that genetic testing should not be limited to patients with extreme obesity. Current obesity panels miss crucial syndromic genes, demonstrating a need for more comprehensive panels and the superiority of whole-exome sequencing in obesity.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":"1400-1411"},"PeriodicalIF":4.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}