International Journal of Obesity最新文献

{"title":"Is a higher body mass index associated with longer duration of survival with disability in frail than in non-frail older adults?","authors":"Daiki Watanabe, Tsukasa Yoshida, Yuya Watanabe, Yosuke Yamada, Misaka Kimura","doi":"10.1038/s41366-024-01681-6","DOIUrl":"10.1038/s41366-024-01681-6","url":null,"abstract":"This study investigated the hitherto unclear association of body mass index (BMI) with age at overall, disability, and disability-free survival in older adults with and without frailty. This prospective cohort study enroled 10232 Japanese adults aged ≥65 years, who underwent follow-up for adverse events, from the Kyoto-Kameoka Study conducted from 2011–2016. BMI, calculated based on self-reported height and body weight, was classified into five categories: <18.5, 18.5–21.4, 21.5–24.9, 25.0–27.4, and ≥27.5 kg/m2. Frailty was assessed using the validated Kihon Checklist. The relationships between BMI and disability and mortality were analysed using multivariate Cox proportional hazards models and Laplace regression. During the 5.3-year median follow-up period (45472 person-years), 2348 (22.9%) incidences of disabilities occurred. After adjusting for confounders, including medical history and lifestyle, individuals in the lowest and highest BMI categories had a higher hazard ratio (HR) of disability [<18.5 kg/m2: HR: 1.31, confidence interval (CI): 1.16–1.49; ≥27.5 kg/m2: HR: 1.27, 95% CI: 1.08–1.49, p for non-linearity <0.001] compared with that of those with BMI = 21.5–24.9 kg/m2. In the 50th percentile differences in age at overall and disability-free survival, participants with BMI < 18.5 kg/m2 were more likely to die before disability incidence [survival with disability (overall survival – disability-free survival): −10.2 months]; those with BMI ≥ 27.5 kg/m2 had longer survival with disability (12.5 months). These relationships were more marked in the frailty-stratified model, where in the BMI ≥ 27.5 kg/m2 group, individuals with frailty survived longer with disability (27.2 months) than did individuals without frailty (6.2 months). Higher BMI is associated with a longer duration of survival with disability among older adults, especially in those with frailty. Therefore, reversing frailty should be prioritised because individuals with frailty have a shorter probability of disability-free survival than do individuals without frailty, regardless of BMI.","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":"49 2","pages":"348-356"},"PeriodicalIF":4.2,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41366-024-01681-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proposed shorter duration protocols for measuring resting energy expenditure utilizing whole-room indirect calorimetry.","authors":"Russell Rising, Hannah D Kittrell, Jeanine B Albu","doi":"10.1038/s41366-024-01667-4","DOIUrl":"https://doi.org/10.1038/s41366-024-01667-4","url":null,"abstract":"<p><strong>Background: </strong>Sixty minutes is currently the shortest testing duration for 24-h resting energy expenditure (24-h REE) utilizing whole-room indirect calorimetry.</p><p><strong>Objective: </strong>Show that recalculated 30-min extrapolated 24-h REE from previously published 60-min metabolic data are valid.</p><p><strong>Methods: </strong>Propane consumption linearity was determined through an 8-h combustion test. Thereafter, metabolic data for 24-h extrapolated ventilation rates of oxygen (VO₂; l/d), carbon dioxide (VCO₂; l/d), respiratory quotient (RQ; VCO₂/VO₂), and REE (MJ/d) from ten 60-min propane combustion tests were recalculated to reflect a 30-min testing duration. A similar analysis was performed utilizing data from 60-min subject metabolic measurements within a whole-room indirect calorimeter (4597 liters) specific for measuring resting energy expenditure (REE). Statistical (p < 0.05) comparisons between recalculated and original 60-min metabolic data were determined by SPSS (version 29).</p><p><strong>Results: </strong>Propane consumption during a combustion test was found to be linear for up to 8-h. Furthermore, no differences existed between propane stoichiometry and combustion for any of the extrapolated 24-h metabolic parameters when recalculated from 60-min propane combustion data to reflect a 30-min duration. Finally, similar results were obtained for all recalculated subject metabolic data.</p><p><strong>Conclusions: </strong>Recalculated extrapolated 24-h metabolic data derived from a 30-min testing duration appear to be valid. This suggests that whole-room indirect calorimetry could be an adjunct for various weight loss or other programs where accurate metabolic measurements are required.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dosing of antidepressants in relation to body weight in children and adolescents with overweight.","authors":"Julia Izsak, Elin E Kimland, Jari Martikainen, Elin Dahlén, Jenny M Kindblom","doi":"10.1038/s41366-024-01677-2","DOIUrl":"https://doi.org/10.1038/s41366-024-01677-2","url":null,"abstract":"<p><p>Overweight and obesity in children and adolescents may impact pharmacokinetics and drug exposure. The aim of the present study was to evaluate doses of antidepressants in relation to body weight in children. We used data from the BMI Epidemiology Study (BEST) Gothenburg cohort and the National Prescribed Drug Register and included children and adolescents with a prescription of fluoxetine (n = 347) or sertraline (n = 733) and a weight measurement. For fluoxetine, individuals with overweight or obesity received slightly lower doses at first prescriptions, but not in iterated prescriptions. The weight-normalized dose was lower in individuals with overweight or obesity in first and iterated prescriptions, compared with normal weight (p < 0.01). For sertraline, there were no significant dose differences between individuals with overweight or obesity, compared with normal weight. However, pronounced differences were seen in dose per kilogram body weight in both first and iterated prescriptions (p < 0.01). We conclude that the doses of fluoxetine and sertraline were essentially similar in individuals with overweight or obesity, but the weight-normalized doses were clearly lower. Given the ongoing obesity epidemic, larger studies addressing optimal dosing in individuals with elevated weight are warranted.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effects of different beverages on weight loss in adults: a systematic review and network meta-analysis of randomized trials.","authors":"Hossein Shahinfar, Nastaran Payandeh, Sheida Zeraattalab-Motlagh, Kimia Torabynasab, Ahmad Jayedi, Haniehsadat Ejtahed, Shirin Hasani-Ranjbar, Sakineh Shab-Bidar","doi":"10.1038/s41366-024-01673-6","DOIUrl":"10.1038/s41366-024-01673-6","url":null,"abstract":"<p><strong>Background: </strong>There is a lack of clarity on the comparative effects of different beverages on weight loss in adults.</p><p><strong>Objective: </strong>This study aimed at quantifying and ranking the effects of different beverages on weight loss.</p><p><strong>Methods: </strong>We searched PubMed, Scopus, and Web of Science up to January 2023. We included randomized trials evaluating the comparative effects of two or more beverages, or compared a beverage against a control group (water, no intervention), for weight loss in adults. We conducted a random-effects network meta-analysis (NMA) with a Bayesian framework to estimate mean difference [MD] and 95% credible interval [CrI].</p><p><strong>Results: </strong>In total, 78 randomized trials with 4168 participants were eligible. Low/no-calorie sweetened beverages (LNCSB) was effective for weight loss compared with water (MD: -0.79 kg, 95% CrI: -1.35, -0.18), milk (MD: -0.80 kg, 95% CrI: -1.59, -0.01), fruit juice (MD: -0.83 kg, 95% CrI: -1.47, -0.13), sugar-sweetened beverages (SSB) (MD: -1.08 kg, 95% CrI: -1.65, -0.50), and no intervention (MD: -1.19 kg, 95% CrI: -1.93, -0.41). However, in sensitivity analyses, no significant effect was seen in trials with a low risk of bias and those that implemented calorie restriction. LNCSB drinking was effective for waist circumference reduction compared with water (MD: -1.85 cm, 95% CrI: -3.47, -0.22). The certainty of evidence from most comparisons was rated low.</p><p><strong>Conclusions: </strong>This study suggested evidence of low certainty that intake of LNCSBs can result in a small weight loss when used as a substitute for other beverages. Considering the low certainty of evidence, more research is needed to compare the effects of different beverages on body weight.</p><p><strong>Trial registration: </strong>Not applicable, but the protocol of this systematic review was registered at PROSPERO (registration number: CRD42023407937).</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Effects of Mediterranean diet during pregnancy on the onset of overweight or obesity in the offspring: a randomized trial","authors":"Serena Coppola,&nbsp;Lorella Paparo,&nbsp;Giorgio Bedogni,&nbsp;Rita Nocerino,&nbsp;Davide Costabile,&nbsp;Mariella Cuomo,&nbsp;Lorenzo Chiariotti,&nbsp;Laura Carucci,&nbsp;Annalisa Agangi,&nbsp;Marcello Napolitano,&nbsp;Francesco Messina,&nbsp;Annalisa Passariello,&nbsp;Roberto Berni Canani","doi":"10.1038/s41366-024-01670-9","DOIUrl":"10.1038/s41366-024-01670-9","url":null,"abstract":"","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":"49 1","pages":"154-155"},"PeriodicalIF":4.2,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41366-024-01670-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight loss and metabolic effects of an ALDH1A1-specific inhibitor, FSI-TN42, in a diet induced mouse model of obesity.","authors":"Jisun Paik, Andy Kim, Kevin Fogassy, Jessica M Snyder, Thea Brabb, Kimberly A Dill-McFarland, Qianchuan He, John K Amory","doi":"10.1038/s41366-024-01676-3","DOIUrl":"https://doi.org/10.1038/s41366-024-01676-3","url":null,"abstract":"<p><strong>Background: </strong>Retinoic acid (RA) participates in weight regulation and energy metabolism. Mice lacking ALDH1A1, one of the major enzymes responsible for RA biosynthesis, are resistant to diet-induced obesity. Previously, we identified FSI-TN42 (N42) as an ALDH1A1-specific inhibitor and reported its pharmacokinetics and pharmacodynamics as well as its efficacy in weight suppression.</p><p><strong>Methods: </strong>In the first study, C57BL/6 J male mice were fed a high fat diet for 8 weeks to induce obesity. Mice were then divided into three groups and fed (1) moderate fat diet (MFD), (2) MFD + WIN 18,446 (1 g/kg diet), or (3) MFD + N42 (1 g/kg diet) for 8 weeks. A control group of mice were fed a low-fat diet for the entire period. Mice were weighed weekly and fasting glucose was determined every 4 weeks. Tissues were examined for potential toxicity using histopathology and complete blood counts. In the second study, we examined influences of N42 on energy balance and/or appetite by determining food intake, activity and energy expenditure in mice with obesity treated with MFD or MFD + N42. Lastly, we tested fertility with a mating study.</p><p><strong>Results: </strong>N42 significantly accelerated weight loss compared to MFD alone in mice with obesity by reducing fat mass without decreasing lean mass. N42 did not alter food intake or activity levels. While mice treated with N42 lost significantly more weight, they maintained a similar level of energy expenditure compared to mice fed MFD only. Mice fed N42 preferentially used fat postprandially, especially under thermoneutral or mild cold challenge. N42 did not affect male fertility.</p><p><strong>Conclusions: </strong>N42 promotes weight loss when used with MFD in mice with diet-induced obesity without causing significant organ toxicity or male infertility. Future studies will determine if N42 can be used to promote further weight loss if combined with current weight loss drugs.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic bariatric surgery for adults with overweight and obesity: a systematic review and network meta-analysis","authors":"Jing Zhu,&nbsp;Yongqi Yan,&nbsp;Xinyi Qiu,&nbsp;Shaowei Lin,&nbsp;Junping Wen","doi":"10.1038/s41366-024-01678-1","DOIUrl":"10.1038/s41366-024-01678-1","url":null,"abstract":"Endoscopic bariatric surgery (EBS) is a new treatment for obesity. We compared the efficacy, safety, and probability of metabolic complications of different EBSs with laparoscopic sleeve gastrectomy (LSG). This systematic review and network meta-analysis (NMA) included searches of PubMed, Web of Science, and the Cochrane Library from January 1, 2017, to December 27, 2022, to find comparative trials of EBS procedures and EBS with LSG. We performed a frequentist model NMA to summarize the evidence and ranked the interventions according to SUCRA scores. The search for this NMA yielded 14,160 articles, of which 18 eligible trials recruited 766,135 participants for procedures including LSG, endoscopic sleeve gastroplasty (ESG), nonadjustable intragastric balloon (NIB), BioEnterics Intragastric Balloon (BIB), and adjustable intragastric balloon (AIB). Definitive evidence suggests that LSG is most effective for weight reduction. Compared with LSG, NIB, SMD = −0.49 [95% CI −0.79, −0.18]; AIB, SMD = −0.41 [95% CI −0.76, −0.06] and ESG, SMD = −0.31 [95% CI −0.33, −0.29] in the index of percentage total weight loss under six months. In terms of safety outcomes, ESG had the lowest incidence of adverse events; the order of the observed incidence of adverse events from small to large was ESG, NIB, AIB, LSG, and BIB. ESG is an effective and safe minimally invasive surgical method for people with overweight and obesity. Its 12-month effect is better than that of NIB, and its influence on lipid metabolism makes it more protective of the cardiovascular system and liver. PROSPERO: CRD42022375343.","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":"49 2","pages":"237-245"},"PeriodicalIF":4.2,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anemia in patients ten years after bariatric surgery.","authors":"Mimmi Karlsson, Johan Ottosson, Spencer Clarkson, Klas Sjöberg","doi":"10.1038/s41366-024-01675-4","DOIUrl":"https://doi.org/10.1038/s41366-024-01675-4","url":null,"abstract":"<p><strong>Background: </strong>More than 10% of the global population has a BMI above 35. Bariatric surgery is an efficient way to treat this condition. Unfortunately, there is a risk of nutritional deficiencies. The number of studies after a longer time span is scarce. The aim of this study was to determine the occurrence of anaemia five and ten years after bariatric surgery and how it was related to substitution therapy.</p><p><strong>Patients and methods: </strong>Registry data from individuals having primary bariatric surgery in the Scandinavian Obesity Surgery Registry (SOReg) from 2007 to 2022 and with a follow-up at five or ten years was retrieved. Demographic data including weight, as well as method of surgery, Hb levels, supplementation, PPI use and stomal ulcerations were recorded.</p><p><strong>Results: </strong>In total, 39,992 individuals (mean age 41 years, range 18-74, 77% women) could be included. The majority, 78%, had undergone laparoscopic Roux-en-Y gastric bypass. After five years, 2838/13,944 women (20.3%) and 456/4049 men (11.2%) had anaemia. After ten years, 644/3400 women (18.9%) and 178/947 men (18.8%) had anaemia. The use of oral iron increased from 40 to 45%, and the need for parenteral iron intake increased from 5 to 11%.</p><p><strong>Conclusions: </strong>Anaemia is a significant but manageable condition five and ten years after bariatric surgery. Despite the prescription of oral iron supplements to 45% ten years after surgery, the Hb levels could still not be fully restored. Consequently, the importance of follow-up visits and continuous supplementation is emphasised.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of a health promotion program on overweight in vulnerable children from primary schools (BeE-school): A cluster-randomized controlled trial","authors":"Juliana Martins,&nbsp;Cláudia Augusto,&nbsp;Maria José Silva,&nbsp;Ana Duarte,&nbsp;Silvana Peixoto Martins,&nbsp;Henedina Antunes,&nbsp;Paulo Novais,&nbsp;Beatriz Pereira,&nbsp;Paula Veiga,&nbsp;Rafaela Rosário","doi":"10.1038/s41366-024-01672-7","DOIUrl":"10.1038/s41366-024-01672-7","url":null,"abstract":"Obesity is a complex, multifactorial disease with rising global prevalence. Considering its significant association with lower socioeconomic status, implementing obesity prevention programs in vulnerable school-age children is particularly pertinent. This cluster-randomized controlled trial aims to evaluate the effectiveness of a health promotion program on overweight in vulnerable children from primary schools. The BeE-school study involved 735 children (51.7% boys, average age 7.7 (1.2) years old) from 10 primary schools in the Northern region of Portugal, identified as Educational Territories for Priority Intervention. After the initial assessment, the schools were randomized into two groups: one receiving the intervention (4 schools, n = 353) and the other not (6 schools, n = 382). The intervention included education and training teachers for 16 weeks, their implementation in the classroom, and giving families challenges every two weeks during this length of time. The program’s effectiveness was assessed short-term, immediately post-intervention (for 95.5% of participants) and long-term, one year after (for 50.8%). We considered the difference in BMI z-scores (BMIz), waist-to-height ratio and waist-to-weight ratio, from baseline to post-intervention and follow-up assessment. In post-intervention, intervened children presented a significant reduction in all the three measures of adiposity: BMIz (B = −0.098, 95% CI: −0.156 to −0.040, p = 0.001), waist-to-height ratio (B = −0.007, 95% CI: −0.010 to −0.003, p &lt; 0.001) and waist-to-weight ratio (B = −0.121, 95% CI: −0.193 to −0.048, p = 0.001). One year after the intervention ended the decrease in BMIz remained significant (B = −0.114, 95% CI: −0.213 to −0.015, p = 0.023). Conclusion: The school-based intervention, focusing on teacher training in health promotion and involving families, proved to be effective in improving body composition in socially vulnerable children.","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":"49 2","pages":"332-339"},"PeriodicalIF":4.2,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of metabolic dysfunction-associated steatotic liver disease and of its genetics on kidney function in childhood obesity.","authors":"Anna Di Sessa, Sarah Zarrilli, Gianmario Forcina, Vittoria Frattolillo, Ornella Camponesco, Claudia Migliaccio, Serena Ferrara, Giuseppina Rosaria Umano, Grazia Cirillo, Emanuele Miraglia Del Giudice, Pierluigi Marzuillo","doi":"10.1038/s41366-024-01674-5","DOIUrl":"https://doi.org/10.1038/s41366-024-01674-5","url":null,"abstract":"<p><strong>Objectives: </strong>Evidence linked metabolic associated steatotic liver disease (MASLD) to kidney damage with the potential contribution of the I148M variant of the Patatin-like phospholipase containing domain 3 (PNPLA3) gene. We aimed at investigating the relationship of MASLD and of its genetics with kidney function in children with obesity.</p><p><strong>Methods: </strong>A comprehensive evaluation including genotyping for the I148M PNPLA3 polymorphism was performed in 1037 children with obesity. Fatty liver (FL) was assessed by liver ultrasound. According to MASLD criteria, subjects with obesity but without FL were included in group 1, while patients with obesity and FL (encompassing one MASLD criterion) were clustered into group 2. Group 3 included patients with obesity, FL, and metabolic dysregulation (encompassing >1 MASLD criterion).</p><p><strong>Results: </strong>Alanine transaminase levels significantly increased while estimated glomerular filtration rate (eGFR) significantly reduced from group 1 to 3. Group 3 showed a higher percentage of carriers of the I148M allele of the PNPLA3 gene compared to other groups (p < 0.0001). Carriers of group 2 and of group 3 showed reduced eGFR levels than noncarriers of group 2 (p = 0.04) and of group 3 (p = 0.02), respectively. A general linear model for eGFR variance in the study population showed an inverse association of eGFR with both MASLD and PNPLA3 genotypes (p = 0.011 and p = 0.02, respectively). An inverse association of eGFR with MASLD was also confirmed only in carriers (p = 0.006).</p><p><strong>Conclusions: </strong>The coexistence of more than 1 MASLD criterion in children with obesity seems to adversely affect kidney function. The PNPLA3 I148M allele further impacts on this association.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}