International Journal of Obesity最新文献

{"title":"Socioeconomic position, genetic susceptibility, and epigenetic profiles in obesity across the life course: a systematic review.","authors":"J van Uhm, R E H Meeusen, P R Jansen, M M van Haelst, E F C van Rossum, E L T van den Akker","doi":"10.1038/s41366-026-02181-5","DOIUrl":"https://doi.org/10.1038/s41366-026-02181-5","url":null,"abstract":"<p><strong>Background: </strong>While genetic studies have identified hundreds of loci associated with adiposity, the phenotypic expression of this individual genetic risk is not fixed but dependent on environmental circumstances. Socioeconomic Position (SEP), which includes education, income, and area-level deprivation, serves as an important environmental modulator of genetic liability. However, the literature on Gene-Environment (G×E) interactions remains fragmented, particularly regarding how these evolve across the life course.</p><p><strong>Aim: </strong>Provide a comprehensive overview of available literature on how SEP factors relate to the effects of polygenic risk scores (PRS), genetic susceptibility, and epigenetic mechanisms in obesity.</p><p><strong>Methods: </strong>Following PRISMA guidelines, we searched five databases for human studies examining SEP, genetic or epigenetic markers, life course, and adiposity-related outcomes. In total, we synthesized 98 studies (79 genetic, 21 epigenetic, including two papers contributing to both domains) and assessed risk of bias using QUIPS.</p><p><strong>Results: </strong>Lower SEP, particularly lower educational attainment and greater area-level deprivation, was often associated with stronger genetic susceptibility to obesity, although findings differed by SEP component, life stage, PRS construction, outcome definition, ancestry, and analytical framework. Among the 29 studies formally testing genetic susceptibility-by-SEP interactions, PRS-size patterns were descriptive rather than indicating a clear hierarchy: large PRS produced the greatest number of formal interaction findings, while medium PRS showed a high proportion of significant findings in fewer and less comparable studies. Epigenetic analyses identified DNA methylation at stress-related and metabolic loci as a potential pathway linking socioeconomic disadvantage to obesity, though tissue specificity and causal direction remain limiting factors.</p><p><strong>Conclusion: </strong>Lower educational attainment and socioeconomic deprivation appear to amplify genetic susceptibility to obesity, although evidence remains heterogeneous in PRS construction, SEP operationalization, outcome definition, ancestry, and analytical framework. Emerging evidence suggests educational attainment and early-life socioeconomic conditions may represent modifiable contexts influencing genetic obesity risk across the life course.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in eating behavior in people with obesity after the use of a mobile health behavior change support system: an 18-month randomized controlled trial.","authors":"Silja Rantaiso, Laura Heikkilä, Marjukka Nurkkala, Heta Merikallio, Noora Oikarinen, Harri Oinas-Kukkonen, Markku J Savolainen, Janne Hukkanen","doi":"10.1038/s41366-026-02176-2","DOIUrl":"https://doi.org/10.1038/s41366-026-02176-2","url":null,"abstract":"<p><strong>Background/objectives: </strong>Due to the increasing prevalence of obesity, more effective methods are needed to support an individual's eating behavior. We investigated the effects of a mobile health behavior change support system (mHBCSS) on eating behavior and the associations between changes in eating behavior and weight loss.</p><p><strong>Methods: </strong>Altogether 200 volunteers (age 18-65 years, BMI 30-40 kg/m²) were enrolled in this study. Participants were randomized into two groups: group 1 with an immediate access to mHBCSS, or group 2 with a 6-month waiting period before mHBCSS. Three-Factor Eating Questionnaire-R18 and Binge Eating Scale were completed, and body weight was measured (0, 6, 12, and 18 months). The primary outcome was changes in cognitive restraint, uncontrolled eating, emotional eating, and binge eating.</p><p><strong>Results: </strong>After 6 months, in group 1 with immediate access to mHBCSS cognitive restraint increased (8.4 scores, 95% CI: 4.1-12.8), while uncontrolled eating [-8.2 (-11.9 to -4.4)], emotional eating [-9.4 (-14.4 to -4.5)], and binge eating [-3.4 (-4.9 to -1.9)] decreased (all p < 0.001). Also, weight loss in group 1 was associated with an increase in cognitive restraint (p = 0.015), and decreases in uncontrolled eating, emotional eating, and binge eating (all p < 0.001) at the 6-month visit. No significant changes during the first 6 months were observed in group 2. Group 2 demonstrated the same changes in eating behavior after using the mHBCSS for 6 months. Significant eating behavior changes were maintained to the end of the follow-up in both groups. The retention rate was 98.5%, 89.0%, and 79.0% at the 6-, 12-, and 18-month visits.</p><p><strong>Conclusion: </strong>The 6-month use of mHBCSS improved eating behavior, and changes in eating behavior were associated with weight loss. The stand-alone mobile application appears to be an effective method for changing eating behavior among people with obesity.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148648532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The increase in fat-free mass during weight loss does not prevent greater than predicted reductions in resting energy expenditure in recreational athletes.","authors":"Mikael F Kanaan, Samir Nait-Yahia, Éric Doucet","doi":"10.1038/s41366-026-02179-z","DOIUrl":"https://doi.org/10.1038/s41366-026-02179-z","url":null,"abstract":"<p><p>Energy restriction and resistance training (RT) are commonly used by athletes to induce body weight and fat losses and improve power to mass ratio. Weight loss-induced greater than predicted decrease in resting energy expenditure (GPDR) has repeatedly been reported in individuals with obesity. However, less is known about GPDR in trained athletes who consume adequate protein and who perform RT to maintain fat-free mass (FFM) during weight loss. Thirty-six recreational athletes (14 F; 22 M) from two separate weight loss studies were included for secondary analysis. We examined the effects of short-term weight loss with RT and adequate protein intakes on GPDR in recreational athletes. We found significant reductions in resting energy expenditure (REE) (~ -140 kcal/d; p < 0.001) and GPDR based on our prediction equation (p < 0.001). What is more, we report that the decrease in REE and the presence of GPDR were observed even in individuals who had gained FFM by the end of the interventions. Our findings suggest that even increases in FFM, by means of RT and adequate protein intake does not prevent the decline in REE, nor the onset of GPDR in recreational athletes subjected to caloric deficits and fat loss.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148620031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The short ACE2 isoform is upregulated in adipose tissue from women with obesity.","authors":"Maria Salazar, Diogo Teixeira, Sandra Marisa Oliveira, Francisca Saraiva, Carlos Pinho, Mariana Jarnalo, Inês Correia-Sá, Inês Falcão-Pires, Daniela Freitas, Adelino Leite-Moreira, Delminda Neves, Henrique Almeida, Adriana Rodrigues, Alexandra Gouveia","doi":"10.1038/s41366-026-02177-1","DOIUrl":"https://doi.org/10.1038/s41366-026-02177-1","url":null,"abstract":"<p><strong>Background/objectives: </strong>A novel short ACE2 isoform, lacking the SARS-CoV-2 binding domain and upregulated by interferons, was recently identified in human respiratory epithelia, spermatozoa, liver, and gastrointestinal and urogenital tracts. This study is the first to describe its presence in human adipose tissue (AT).</p><p><strong>Subjects/methods: </strong>AT samples were collected from middle-aged women without obesity in subcutaneous regions-abdominal superficial, abdominal deep, and thigh-as well as from the visceral epiploon. Subcutaneous abdominal AT was also obtained from middle-aged women with previous obesity and from older women with and without obesity. Short ACE2 expression was determined by immunohistochemistry and Western blotting in AT, mature adipocytes, and stromal vascular fraction (SVF).</p><p><strong>Results: </strong>Short ACE2 showed comparable expression in both subcutaneous and visceral AT, with enrichment in adipocytes. In contrast, full-length ACE2 displayed a different pattern, as its levels did not significantly differ between the SVF and adipocytes. Moreover, short ACE2 levels were higher in AT from women with obesity compared with those without obesity. Interestingly, short ACE2 expression was also elevated in AT from women with previous obesity.</p><p><strong>Conclusions: </strong>Given that short ACE2 expression is induced by interferons, its upregulation in AT under obesity may reflect the interferon-enriched inflammatory environment characteristic of this condition. These findings identify AT, particularly adipocytes, as a relevant site for short ACE2 expression and regulation, expanding current knowledge on short ACE2 isoform biology.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148619994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between changes in body weight and cognitive function in the elderly.","authors":"Yulu Zhong, Bin Guo, Yaoyao Wang, Yinan Li, Qinghai Li, Xinjuan Yu, Jimei Guo, Tao Wang","doi":"10.1038/s41366-026-02182-4","DOIUrl":"https://doi.org/10.1038/s41366-026-02182-4","url":null,"abstract":"<p><strong>Background: </strong>Cognitive function is a major concern in aging society. Current studies on the impact of body weight changes on cognitive abilities present conflicting results. This study explored the relationship between weight changes during adulthood and cognitive function in later life.</p><p><strong>Methods: </strong>Data were obtained from the National Health and Nutrition Examination Survey (NHANES) and a total of 5097 participants aged 60 years or older with recalled weight at young and middle adulthood were included. Absolute weight change was categorized into five groups: weight loss of at least 2.5 kg, weight change within 2.5 kg (reference group), weight gain of at least 2.5 kg but less than 10.0 kg, weight gain of at least 10 kg but less than 20.0 kg, and weight gain of at least 20.0 kg. Cognitive function was assessed using the Digit Symbol Substitution Test (DSST). Logistic regression models adjusted for covariates were used to compute the odds ratios (ORs) and 95% confidence intervals (CIs) for the association between weight changes and cognitive function.</p><p><strong>Results: </strong>From age 25 to 10 years before survey, participants with small to moderate weight gain (increase of ≥2.5 kg and <10 kg) exhibited a decreased risk of cognitive impairment compared to those with stable weight (weight change within 2.5 kg), with an OR of 0.64 (95% CI = 0.48 to 0.85, P = 0.003). For moderate to substantial weight gain (increase of ≥10 kg and <20 kg), the OR was 0.61 (95% CI = 0.46-0.79, P < 0.001). From age 25 years to survey, the OR for moderate to substantial weight gain was 0.66 (95% CI = 0.50-0.89, P = 0.007). Restricted cubic spline indicated a U-shaped relationship between the absolute weight change and cognitive function.</p><p><strong>Conclusions: </strong>Moderate weight gain from early adulthood to late life was associated with a reduced risk of cognitive impairment, while weight loss showed a non-significant trend toward increased risk.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148602924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to concerns with the statistical analysis in “Effect of combined GLP-1 analogue and bupropion/naltrexone on weight loss: a retrospective cohort study”","authors":"James Naude,&nbsp;Ali Zentner,&nbsp;Priya Suresh,&nbsp;Jesse Bittman,&nbsp;Nadia Khan","doi":"10.1038/s41366-026-02135-x","DOIUrl":"10.1038/s41366-026-02135-x","url":null,"abstract":"","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":"50 8","pages":"1852-1853"},"PeriodicalIF":5.4,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148602950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"What Patients Want\": a qualitative study of expectations and ideal clinical encounters in obesity consultations.","authors":"Tak Ying Louise Ko, Francisca Contreras, Werd Al-Najim, Carel W le Roux","doi":"10.1038/s41366-026-02170-8","DOIUrl":"https://doi.org/10.1038/s41366-026-02170-8","url":null,"abstract":"<p><strong>Background: </strong>Although obesity is increasingly recognized as a chronic, relapsing disease, clinical consultations remain inconsistently delivered, often perceived by patients as generic, stigmatizing, and insufficiently person-centered. While dissatisfaction with weight-related care is well documented, limited research has systematically examined how patients themselves define the core features of an effective obesity consultation.</p><p><strong>Objective: </strong>This study aimed to develop a patient-informed framework for clinical obesity consultations by exploring the expectations and experiences of individuals with lived experience of obesity.</p><p><strong>Methods: </strong>A qualitative descriptive design was employed. Twenty adults (BMI ≥ 27 kg/m² with at least one obesity-related complication) who had received treatment for obesity were recruited via purposive sampling. Semi-structured interviews were conducted via Zoom, transcribed, anonymized, and analyzed using reflexive thematic analysis. Coding was inductive and organized using MAXQDA.</p><p><strong>Results: </strong>Participants articulated a coherent and detailed model of the ideal clinical encounter, extending beyond previously reported dissatisfaction. Five key themes were identified: (1) the need for consent-based and context-sensitive initiation of weight discussions; (2) the rejection of moralizing or reductive language in favor of medically grounded and neutral communication; (3) recognition of obesity as heterogeneous, multifactorial disease requiring individualized assessment; (4) expectations for clear, evidence-based information on treatment options and likely outcomes; and (5) a strong preference for ongoing, relationship-based support rather than episodic advice. Patients revealed that unmet informational and relational needs, especially regarding clinical competence, emotional sensitivity, and collaborative treatment planning, were primary barriers to trust and engagement.</p><p><strong>Conclusion: </strong>This study advances current understanding by proposing a patient-defined model for obesity consultations, with implications for improving clinical communication, shared decision-making, and continuity of care.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ten-year comparative outcomes of one-anastomosis gastric bypass versus single-anastomosis duodeno-ileal bypass as revisional procedures after sleeve gastrectomy.","authors":"Abdelwahed Yahmadi, Asaad F Salama, Hamzah El Baba, Jawher Baazaoui, Mohamed Bougmiza, Mohammed Al Kuwari","doi":"10.1038/s41366-026-02171-7","DOIUrl":"https://doi.org/10.1038/s41366-026-02171-7","url":null,"abstract":"<p><strong>Background: </strong>A substantial proportion of patients have insufficient weight loss or clinically significant weight regain after sleeve gastrectomy (SG) and require revisional surgery. One-anastomosis gastric bypass (OAGB) and single-anastomosis duodeno-ileal bypass (SADI-S) are commonly used conversion procedures, but long-term comparative data are limited.</p><p><strong>Objectives: </strong>To compare 10-year weight, metabolic, nutritional and safety outcomes of OAGB versus SADI-S performed as conversion procedures for weight recurrence after SG.</p><p><strong>Setting: </strong>Tertiary referral bariatric center.</p><p><strong>Methods: </strong>In this retrospective comparative cohort study, adults undergoing conversion of SG to OAGB or SADI-S for weight recurrence between January 2014 and January 2016 were identified. Demographic, anthropometric, metabolic and micronutrient data, comorbidity status and complications were collected at baseline (time of conversion) and at 1, 5 and 10 years. Analyses were primarily descriptive. Between-group comparisons used appropriate parametric/non-parametric tests for continuous variables and Fisher's exact/chi-square tests for categorical variables; no multivariable longitudinal adjustment was performed, and findings should therefore be interpreted cautiously in view of the retrospective, non-randomized design.</p><p><strong>Results: </strong>Ninety patients underwent revisional surgery (OAGB n = 47; SADI-S n = 43). At 1 year, weight outcomes were similar between groups. SADI-S achieved higher %EWL and %TWL at 5 years; however, 10-year weight and BMI outcomes were comparable. Lipid profiles were more favorable after SADI-S (lower total cholesterol at 1, 5 and 10 years; lower triglycerides at 5 and 10 years), whereas several micronutrient levels were higher after OAGB (including calcium, zinc, vitamin D and folate at multiple time points), with higher vitamin B12 after SADI-S. Comorbidity outcomes and overall complication rates were similar, and no mortality was observed during follow-up.</p><p><strong>Conclusions: </strong>In this retrospective cohort with 10-year follow-up, OAGB and SADI-S were associated with comparable long-term weight outcomes when used as conversion procedures after SG. SADI-S was associated with more favorable lipid parameters, whereas OAGB showed higher levels of several micronutrients over follow-up. These findings should be interpreted as observational associations and may help inform, rather than determine, individualized procedure selection alongside structured long-term surveillance.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148561925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Declines in plasma erythritol levels and improvements in insulin sensitivity and glucose metabolism: POUNDS lost trial.","authors":"Yoriko Heianza, Jennifer C Rood, Catherine M Champagne, Frank B Hu, George A Bray, Frank M Sacks, Lu Qi","doi":"10.1038/s41366-026-02152-w","DOIUrl":"https://doi.org/10.1038/s41366-026-02152-w","url":null,"abstract":"<p><strong>Background: </strong>Erythritol is a non-nutritive sweetener that is also endogenously produced from glucose. We investigated whether declines in plasma erythritol and other sugar alcohols (polyols) in response to weight-loss dietary interventions were significantly associated with long-term improvements in glucose metabolism and insulin sensitivity.</p><p><strong>Methods: </strong>Plasma erythritol, mannitol/sorbitol, and arabitol/xylitol were repeatedly measured among adults with overweight or obesity who participated in the POUNDS Lost trial (n = 802 at baseline and n = 664 at 6 months). We analyzed associations of changes in erythritol, mannitol/sorbitol, and arabitol/xylitol from baseline to 6 months with changes in homeostasis model assessment of insulin resistance (HOMA-IR), fasting insulin, fasting glucose, and HbA1c at 6 months and 2 years of intervention.</p><p><strong>Results: </strong>Plasma erythritol levels were positively related to HOMA-IR, fasting insulin, and glycemic markers at baseline. Greater declines in plasma erythritol in response to the interventions were associated with greater reductions in HOMA-IR (p < 0.001) and fasting insulin (p < 0.001) at 6 months. Similar associations were found for changes in arabitol/xylitol, but not for mannitol/sorbitol. Every 1 SD reduction in plasma erythritol during the initial 6-month period was related to long-term (2-year) decreases in log-transformed HOMA-IR (β [SE] -0.07 [0.02], p = 0.008) and glycemic markers (β -1.0 [0.44] mg/dL, p = 0.025 for fasting glucose; β -0.05% [0.02%], p = 0.019 for HbA1c).</p><p><strong>Conclusion: </strong>Declines in plasma erythritol may be related to long-term improvements in insulin sensitivity and glycemic status during weight-loss dietary interventions in adults with overweight or obesity.</p>","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148535682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are we measuring the same disease? Clinical obesity as a definition-dependent construct.","authors":"Jin Eui Kim, Hannah Oh","doi":"10.1038/s41366-026-02174-4","DOIUrl":"https://doi.org/10.1038/s41366-026-02174-4","url":null,"abstract":"","PeriodicalId":14183,"journal":{"name":"International Journal of Obesity","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148549155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}