Quality of life improvements associated with weight loss using a novel shape-shifting hydrogel capsule: RESET study results.

IF 3.8 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

International Journal of Obesity Pub Date : 2025-09-16 DOI:10.1038/s41366-025-01910-6

Robert F Kushner, Jamy D Ard, Thomas A Wadden, Patrick M O'Neil, Harold E Bays, Frank L Greenway, John M Jakicic, Holly R Wyatt, Yael Kenan, Liora Cohen Asaraf, Ryan H Ryan

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引用次数: 0

Abstract

Objective: To evaluate the impact of the Epitomee capsule on quality of life (QOL) and its association with weight loss in adults with overweight and obesity.

Methods: This study analyzed the RESET double-blind, placebo-controlled results, focusing on predefined QOL endpoints and post hoc analyses. A total of 279 participants with a BMI of 27-40 kg/m² were treated for 24 weeks with Epitomee or placebo, along with lifestyle intervention. Statistical analyses examined changes in IWQOL-Lite-CT scores, their relationship with weight loss, and subgroup differences.

Results: Compared to the placebo group, the Epitomee group consistently showed improved outcomes in total IWQOL-Lite-CT score and Physical Function sub-score (p < 0.05), as well as numerically higher improvements in the Physical and Psychosocial sub-scores, although these did not reach statistical significance. Both treatment groups showed a significant improvement (p < 0.05) from baseline in the IWQOL-Lite-CT total score, as well as in Physical, Physical Function, and Psychosocial sub-scores over the 24-week period. A stronger correlation between weight loss and QOL improvements was observed with Epitomee vs. placebo.

Conclusions: The Epitomee capsule, with lifestyle intervention, is associated with IWQOL-Lite-CT improvement, highlighting its potential as an effective non-pharmaceutical adjunct to lifestyle intervention for enhancing health outcomes in individuals with overweight and obesity.

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使用一种新型可变形水凝胶胶囊与减肥相关的生活质量改善：RESET研究结果。

目的：评价Epitomee胶囊对超重肥胖成人生活质量（QOL）的影响及其与体重减轻的关系。方法：本研究对RESET双盲、安慰剂对照结果进行分析，重点关注预先设定的生活质量终点和事后分析。共有279名BMI为27-40 kg/m²的参与者接受了24周的Epitomee或安慰剂治疗，同时进行了生活方式干预。统计分析检查了IWQOL-Lite-CT评分的变化、它们与体重减轻的关系以及亚组差异。结果：与安慰剂组相比，Epitomee组在IWQOL-Lite-CT总分和身体功能亚评分方面均表现出改善的结果(p)。结论：结合生活方式干预的Epitomee胶囊与IWQOL-Lite-CT改善有关，突出了其作为生活方式干预的有效非药物辅助手段的潜力，可改善超重和肥胖个体的健康结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Obesity 医学-内分泌学与代谢

CiteScore

10.00

自引率

2.00%

发文量

221

审稿时长

3 months

期刊介绍： The International Journal of Obesity is a multi-disciplinary forum for research describing basic, clinical and applied studies in biochemistry, physiology, genetics and nutrition, molecular, metabolic, psychological and epidemiological aspects of obesity and related disorders. We publish a range of content types including original research articles, technical reports, reviews, correspondence and brief communications that elaborate on significant advances in the field and cover topical issues.