International Journal of Infectious Diseases最新文献_第4页

Emergence of cefiderocol resistance during therapy in NDM-5-producing Klebsiella pneumoniae isolates harboring siderophore receptors mutations.

IF 4.8 2区医学

International Journal of Infectious Diseases Pub Date : 2024-11-30 DOI: 10.1016/j.ijid.2024.107321

Luc Deroche, Albane Rozenholc, François Arrivé, Jean-Philippe Martellosio, Gwenaël Le Moal, Arnaud W Thille, Olivier Barraud, Sandrine Marchand, Julien M Buyck

引用次数: 0

A case of Ustilago spp. infection identified by whole genome sequencing in a pediatric patient undergoing open-chest extracorporeal membrane oxygenation.

IF 4.8 2区医学

International Journal of Infectious Diseases Pub Date : 2024-11-29 DOI: 10.1016/j.ijid.2024.107320

Valeria Fox, Gianluca Vrenna, Gianluca Foglietta, Luna Colagrossi, Barbara Lucignano, Manuela Onori, Venere Cortazzo, Marilena Agosta, Martina Rossitto, Maria Del Carmen Pereyra Boza, Vanessa Fini, Annarita Granaglia, Maria Giovanna Paglietti, Elisabetta Verrillo, Renato Cutrera, Paola Bernaschi, Carlo Federico Perno

{"title":"A case of Ustilago spp. infection identified by whole genome sequencing in a pediatric patient undergoing open-chest extracorporeal membrane oxygenation.","authors":"Valeria Fox, Gianluca Vrenna, Gianluca Foglietta, Luna Colagrossi, Barbara Lucignano, Manuela Onori, Venere Cortazzo, Marilena Agosta, Martina Rossitto, Maria Del Carmen Pereyra Boza, Vanessa Fini, Annarita Granaglia, Maria Giovanna Paglietti, Elisabetta Verrillo, Renato Cutrera, Paola Bernaschi, Carlo Federico Perno","doi":"10.1016/j.ijid.2024.107320","DOIUrl":"10.1016/j.ijid.2024.107320","url":null,"abstract":"Objectives: Patients undergoing extracorporeal membrane oxygenation (ECMO) are susceptible to fungal infections, also from rare or emerging pathogens. We present a case of a 3-year-old male patient hospitalized for respiratory failure and subjected to open-chest ECMO support, with a fungal infection from a pathogen not identifiable by standard methods.Methods: Although T2Candida panel (T2 Biosystems) resulted negative, blood cultures resulted positive for fungi after 4 days, confirmed by Gram staining. The fungus underwent typing using Bruker matrix-assisted laser desorption ionization-time of flight mass spectrometry system and Autobio Autof ms1000, which could not precisely identify the microorganism. Ultimately, whole genome sequencing (WGS) was performed directly on blood culture.Results: WGS analysis revealed in 5 days the presence of a fungus belonging to the Ustilago genus, a group of fungi commonly found in the environment but rarely causing human diseases.Conclusions: To the best of our knowledge, we presented the first case of an Ustilago spp infection in a pediatric patient undergoing ECMO, not identified by standard techniques but only by WGS performed directly on a blood sample in 5 days. Despite the paucity of literature on Ustilago spp infections treatment, therapy adjustments led to the eradication of the pathogen, underscoring the importance of advanced molecular techniques for the correct and timely identification of these microorganisms.","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107320"},"PeriodicalIF":4.8,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and risk factors for bacteremia in community-acquired pneumonia: A systematic review and meta-analysis.

IF 4.8 2区医学

International Journal of Infectious Diseases Pub Date : 2024-11-29 DOI: 10.1016/j.ijid.2024.107312

Shanshan Wu, Lin Chen, Xiaoyan Zhang, Jiali Fan, Fajuan Tang, Dongqiong Xiao

{"title":"Prevalence and risk factors for bacteremia in community-acquired pneumonia: A systematic review and meta-analysis.","authors":"Shanshan Wu, Lin Chen, Xiaoyan Zhang, Jiali Fan, Fajuan Tang, Dongqiong Xiao","doi":"10.1016/j.ijid.2024.107312","DOIUrl":"10.1016/j.ijid.2024.107312","url":null,"abstract":"Background: Bacteremia represents a significant complication in patients with community-acquired pneumonia (CAP). Nonetheless, there is currently a dearth of systematic research that determines the precise prevalence and risk factors of bacteremia in CAP patients.Methods: PubMed, Cochrane Library, Embase, and Web of Science databases were searched for published studies on the prevalence or risk factors for CAP with bacteremia up to April 21, 2024. The NOS scale was utilized to appraise the study quality, and the META process was carried out in R language.Results: 58,342 CAP patients were enrolled in 22 studies. Of these patients, 29,610 underwent blood culture tests, and 2332 patients had positive blood culture results. Meta-analysis pooled results showed that the incidence of bacteremia was 5.1% (95% CI: 3.6-6.8%) in CAP patients. The prevalence of co-bacteremia was 3.1% (95% CI: 1.5-5.1%) in minors and 6.9% (95% CI: 5.2%-8.8%) in adults. The most common pathogens of CAP were Streptococcus pneumoniae, Staphylococcus aureus. In addition, a summary of the original studies found that the risk factors for bacteremia in CAP patients were diverse and varied.Conclusions: The incidence of bacteremia in CAP patients warrants significant attention. There is a pressing need to establish more specific bacterial screening protocols.","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107312"},"PeriodicalIF":4.8,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ATP-binding cassette transporters and drug resistance in cutaneous leishmaniasis.

IF 4.8 2区医学

International Journal of Infectious Diseases Pub Date : 2024-11-27 DOI: 10.1016/j.ijid.2024.107315

Marina B R de Santana, Giulia O Miranda, Lucas P Carvalho

引用次数: 0

Expression of Concern: Risk factors for symptoms of infection and microbial carriage among French medical students abroad

IF 4.8 2区医学

International Journal of Infectious Diseases Pub Date : 2024-11-27 DOI: 10.1016/j.ijid.2024.107319

引用次数: 0

Predictors of hospitalisation, death and incomplete/non-recovery from SARS-CoV-2 in an ambulatory global population.

IF 4.8 2区医学

International Journal of Infectious Diseases Pub Date : 2024-11-26 DOI: 10.1016/j.ijid.2024.107285

Sarah L Pett

{"title":"Predictors of hospitalisation, death and incomplete/non-recovery from SARS-CoV-2 in an ambulatory global population.","authors":"Sarah L Pett","doi":"10.1016/j.ijid.2024.107285","DOIUrl":"https://doi.org/10.1016/j.ijid.2024.107285","url":null,"abstract":"Objectives: To provide globally representative data on hospitalisation and death in recently SARS-CoV-2-positive ambulatory populations.Methods: We enrolled SARS-CoV-2-positive ambulatory adults in the cohort studies, ICOS (47 sites, 5 continents), and PCOS (Liberia) and followed for 28-days. Kaplan-Meier estimates of percentage of those hospitalised or died were derived. Risk factors for hospitalisation, death, and failure to recover were identified using Cox and logistic models respectively.Results: 9817(ICOS) and 125(PCOS) participants, 46·7% male; median age 43 years; 24·5% with comorbidity(s); 0·8% pregnant; 9·3% SARS-CoV-2 vaccinated, were enrolled June-2020 and January-2022. By 28 days, 424(4·3%) participants were hospitalised or had died; most within 7 days of enrolment(3·4%). Hospitalisation or death declined over calendar time i.e. 7·5%(2020); 4·1(first-half 2021) and 2·1%(second-half 2021), P<0·0001. Older age, male sex, comorbidities, pregnancy, symptomatic disease were each independently associated with hospitalisation or death; SARS-CoV-2 vaccination reduced this risk. At 28 days, 26·1% and 29.9% reported ongoing symptoms and failure to return to pre-morbid health respectively.Conclusions: These global SARS-CoV-2 ambulatory cohort studies identified demographic/clinical risks for hospitalisation or death. Vaccination does not fully explain hospitalisation and death declines over time. Symptomatic recovery and return to pre-morbid health were incomplete at 28 days in ≈one third.","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107285"},"PeriodicalIF":4.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes of adjunctive eravacycline for severe and fulminant Clostridioides difficile infection. 艰难梭状芽孢杆菌重症和暴发性感染辅助用药依拉维辛的疗效。

IF 4.8 2区医学

International Journal of Infectious Diseases Pub Date : 2024-11-26 DOI: 10.1016/j.ijid.2024.107314

Christen J Arena, Rachel M Kenney, Mayur Ramesh, Susan L Davis, Michael P Veve

{"title":"Outcomes of adjunctive eravacycline for severe and fulminant Clostridioides difficile infection.","authors":"Christen J Arena, Rachel M Kenney, Mayur Ramesh, Susan L Davis, Michael P Veve","doi":"10.1016/j.ijid.2024.107314","DOIUrl":"10.1016/j.ijid.2024.107314","url":null,"abstract":"Objectives: To characterize eravacycline (ERV) treatment for severe or fulminant Clostridioides difficile infection (CDI) and describe patient outcomes.Methods: This was an institutional review board-approved, cross-sectional study of hospitalized adult patients with CDI who received adjunctive ERV with standard-of-care antibiotics for CDI from January 2019 to December 2023 at a five-hospital health system. Patients were included if they received ERV with standard-of-care antibiotics for ≥24 hours for severe or fulminant CDI. Patients with a history colectomy or with non-CDI ERV indications were excluded. The primary outcome was the proportion of patients that required colectomy due to C. difficile; secondary outcome was all-cause mortality at 30 days.Results: Seventy-five patients were included: 25 (33%) had severe and 50 (67%) fulminant CDI and 23 (31%) had refractory severe/fulminant CDI. Patients receiving ERV were frequently immunocompromised (30, 40%) and required treatment in an intensive care unit (46, 61%). Eleven (14.7%) patients required colectomy within 30 days of adjunctive ERV; 28 (37%) patients died at 30-days.Conclusions: ERV may be useful as a potential adjunctive therapy for severe or fulminant CDI. Patients receiving ERV often were immunocompromised and had fulminant disease with critical illness. Future comparative studies are needed to evaluate the impact of adjunctive ERV for CDI.","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107314"},"PeriodicalIF":4.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142739134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SARS-CoV-2 serologic surveillance among people living with HIV in Nigeria, April 2022 to January 2023. 2022 年 4 月至 2023 年 1 月对尼日利亚艾滋病病毒感染者进行 SARS-CoV-2 血清学监测。

IF 4.8 2区医学

International Journal of Infectious Diseases Pub Date : 2024-11-21 DOI: 10.1016/j.ijid.2024.107309

Helen M Chun, Sophia Osawe, Samuel Adams-Dabban, Jennifer Favaloro, Nnaemeka C Iriemenam, Emilio Dirlikov, Diana Martin, Kyle Milligan, Andrew Abutu, Olumide Okunoye, Mary Okoli, Olusola Akanbi, Oluwaseun Akinmulero, Rita Okonkwo, Oyewole Oyedele, Stacie Greby, Alash'le Abimiku, McPaul I J Okoye, Ray W Shiraishi

{"title":"SARS-CoV-2 serologic surveillance among people living with HIV in Nigeria, April 2022 to January 2023.","authors":"Helen M Chun, Sophia Osawe, Samuel Adams-Dabban, Jennifer Favaloro, Nnaemeka C Iriemenam, Emilio Dirlikov, Diana Martin, Kyle Milligan, Andrew Abutu, Olumide Okunoye, Mary Okoli, Olusola Akanbi, Oluwaseun Akinmulero, Rita Okonkwo, Oyewole Oyedele, Stacie Greby, Alash'le Abimiku, McPaul I J Okoye, Ray W Shiraishi","doi":"10.1016/j.ijid.2024.107309","DOIUrl":"10.1016/j.ijid.2024.107309","url":null,"abstract":"Objectives: Evidence indicates that people living with HIV (PLHIV) are more impacted by COVID-19. The burden of SARS-CoV-2 infection among PLHIV is unknown in Nigeria.Methods: We conducted repeated cross-sectional SARS-CoV-2 serosurveys in 14 states and the Federal Capital Territory in Nigeria among PLHIV who had an HIV viral load (VL) test during April 2022 to January 2023. Evidence of SARS-CoV-2 immunoglobulin G (IgG) antibodies was assessed using a multiplex bead assay to measure IgG to spike (S), receptor binding domain (RBD), and nucleocapsid (N) proteins to identify potential infection and/or vaccination status.Results: Between April 2022 and January 2023, 47,614 remnant VL samples were included and tested for SARS-CoV-2 antibodies. Seroprevalence of SARS-CoV-2 infection, defined as IgG antibodies to spike and RBD591 [S+] and nucleocapsid [N+], (S+N+), ranged between 21.1% (95% confidence intervals [CI]: 11.4-31.8) in Ekiti State in January 2023 to 71.4% (95% CI 71.9-81.9) in Gombe State in November 2022, with overall steady trends within and between states over time, across age and sex.Conclusion: High rates of SARS-CoV-2 antibody seroprevalence among PLHIV in Nigeria were observed. This underscores the need to understand the association between HIV and SARS-CoV-2 to inform strategies to reduce the threat posed by COVID-19.","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107309"},"PeriodicalIF":4.8,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Occult COVID-19 in an immunosuppressed patient with migratory pulmonary infiltrates. 一名患有移行性肺部浸润的免疫抑制患者体内隐匿的 COVID-19。

IF 4.8 2区医学

International Journal of Infectious Diseases Pub Date : 2024-11-19 DOI: 10.1016/j.ijid.2024.107296

Cristina Veintimilla, Ana Álvarez-Uría Miyares, Sergio Buenestado-Serrano, Rosalía Palomino-Cabrera, Ignacio Gomez Centurion, Pilar Catalán, Patricia Muñoz, Laura Pérez-Lago, Darío García de Viedma

{"title":"Occult COVID-19 in an immunosuppressed patient with migratory pulmonary infiltrates.","authors":"Cristina Veintimilla, Ana Álvarez-Uría Miyares, Sergio Buenestado-Serrano, Rosalía Palomino-Cabrera, Ignacio Gomez Centurion, Pilar Catalán, Patricia Muñoz, Laura Pérez-Lago, Darío García de Viedma","doi":"10.1016/j.ijid.2024.107296","DOIUrl":"10.1016/j.ijid.2024.107296","url":null,"abstract":"The clinical presentation of SARS-CoV-2 infection is often more severe and persistent in immunosuppressed hosts. We present the case of a patient with mantle cell lymphoma under treatment with rituximab and ibrutinib who had multiple hospitalizations with pulmonary infiltrates following mild SARS-CoV-2 infection and repeated negative nasopharyngeal (NP) RT-PCR tests. SARS-CoV-2 was eventually detected in bronchoalveolar lavage fluid and the symptoms resolved after treatment with remdesivir. Whole genome sequencing was performed on the initial and final viral strains. Sequence comparison of the two showed that the final strain was derived from the former. Both were identical except for 15 differential single nucleotide polymorphisms, indicating that the virus had persisted undetected over time in this patient. Occult COVID-19 should be considered in immunocompromised patients with persistent respiratory symptoms despite negative NP RT-PCR tests. Systematic bronchoalveolar lavage fluid testing is recommended for accurate diagnosis and management.","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107296"},"PeriodicalIF":4.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preventing catheter-associated urinary tract infections: A position paper of the International Society for Infectious Diseases, 2024 update. 预防导尿管相关尿路感染：国际传染病学会立场文件，2024 年更新。

IF 4.8 2区医学

International Journal of Infectious Diseases Pub Date : 2024-11-17 DOI: 10.1016/j.ijid.2024.107304

Victor Daniel Rosenthal, Ziad A Memish, Emanuele Nicastri, Sebastiano Leone, Gonzalo Bearman

{"title":"Preventing catheter-associated urinary tract infections: A position paper of the International Society for Infectious Diseases, 2024 update.","authors":"Victor Daniel Rosenthal, Ziad A Memish, Emanuele Nicastri, Sebastiano Leone, Gonzalo Bearman","doi":"10.1016/j.ijid.2024.107304","DOIUrl":"10.1016/j.ijid.2024.107304","url":null,"abstract":"Objectives: This review, conducted by a panel of experts assembled by the International Society for Infectious Diseases, seeks to consolidate the latest recommendations for preventing catheter-associated urinary tract infections (CAUTIs). It offers insights into CAUTI rates and the associated extended hospital stays, costs, mortality, and risk factors across high- and low- to middle-income countries.Methods: An in-depth review of current recommendations and evidence-based strategies for CAUTI prevention was undertaken. To develop practical preventive measures, the expert panel examined data on CAUTI incidence, related health care impacts, and risk factors across various economic contexts.Results: The review highlights notable differences in CAUTI rates, health care costs, extended hospital stays, and mortality between high- and low- to middle-income countries. It emphasizes evidence-based strategies for CAUTI prevention, demonstrating their effectiveness across diverse health care environments.Conclusions: This position paper offers recommendations and insights intended to assist health care professionals in effectively preventing CAUTIs. Implementing evidence-based preventive strategies has the potential to lower CAUTI rates, reduce related costs, and enhance patient outcomes in high- and low- to middle-income countries.","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107304"},"PeriodicalIF":4.8,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0