International Journal of Infectious Diseases最新文献

{"title":"A case of giant amebic liver abscess persisting for years after treatment.","authors":"Rei Yasukochi, Hitoshi Kawasuji, Masayoshi Ezaki, Yusuke Takegoshi, Makito Kaneda, Yushi Murai, Kentaro Nagaoka, Yoshihiro Yamamoto","doi":"10.1016/j.ijid.2025.108077","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.108077","url":null,"abstract":"<p><p>A 64-year-old male was admitted with a giant liver abscess five days after the onset of fever. Upon admission, he received intravenous antibiotics, including metronidazole (MNZ), and underwent percutaneous liver abscess drainage. Despite early intervention, he developed severe respiratory failure requiring mechanical ventilation, and the abscess rapidly enlarged to 15.1 cm in diameter by clinical day 9. His general condition and systemic inflammation improved after four weeks of antibiotic therapy with MNZ, meropenem, and daptomycin. Entamoeba histolytica was later identified by PCR in the drained fluid, confirming the diagnosis of amebic liver abscess (ALA). However, liver lesion has remained large over several years. Follow-up CT showed the abscess measured 13.0 cm at 1 year and 9.2 cm at 3 years post-treatment. This case highlights a remarkably rare presentation of ALA in which a giant liver lesion had not disappeared for years despite appropriate treatment, underscoring the need for caution in cases of severe ALA with fulminant progression.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108077"},"PeriodicalIF":4.3,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breaking the Barrier: Transforming the Diagnosis and Management of Penicillin and Cephalosporin Allergy in China: Prevalence, Diagnostic Challenges, and Implications for Public Health and Clinical Practice.","authors":"Lanting Wang, Shengan Chen, Lin Lin, Ranran Dai, Xiaoqing Zhao, Shunming Xu, Shaoqing Yu, Wei Dong, Xiaojian Zhou, Xiaoyan Dong, Qiufang Qian, Weichun Ni, Yurong Gu, Haibo Ye, Chao Yuan, Xiaobo Zhang, Ling Yang, Lei Li, Meiling Jin, Dylan Lee, Li Ma, Xiaoqun Luo","doi":"10.1016/j.ijid.2025.108076","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.108076","url":null,"abstract":"<p><strong>Background: </strong>β-lactam allergy labels are common in routine care but are variably verified. This manuscript assessed prevalence, clinical features, verification practices, and penicillin-cephalosporin cross- occurrence across multiple hospitals in China.</p><p><strong>Methods: </strong>Multicenter cross-sectional questionnaire in outpatient clinics at 22 institutions (n=6,070). Adjudication relied on routine records and prior testing performed in care. \"Clinically confirmed\" allergy required a chart-documented reaction and/or a previously positive skin test; indeterminate entries were coded \"uncertain.\" Cross- occurrence required confirmation for both classes. No de novo skin testing or drug provocation was performed by the study team; severe cutaneous adverse reactions were described without re-exposure. Descriptive statistics and χ² tests were used; logistic regression adjusted for prespecified covariates (age, sex, parental allergy history).</p><p><strong>Results: </strong>Self-reported penicillin allergy was 21.9% (1,331/6,070); self-reported cephalosporin allergy was 4.5% (273/6,070). Among respondents reporting cephalosporin allergy, 28.9% (79/273) had skin-test positivity documented in routine care. Confirmed penicillin-cephalosporin cross- occurrence was 2.3% (140/6,070). Testing practices varied across sites, and drug provocation was generally not implemented.</p><p><strong>Conclusions: </strong>In this multicenter survey adjudicated from routine care, clinically confirmed β-lactam allergy was substantially lower than self-report, and confirmed penicillin-cephalosporin cross- occurrence was uncommon (2.3%). Clear confirmation criteria and phenotype-based triage using existing documentation can support safe delabelling and more appropriate first-line β-lactam use; the accompanying SOP provides procedural detail for replication.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108076"},"PeriodicalIF":4.3,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct Clinical and Laboratory Markers Associated with Disease Duration and Viral Clearance in Foshan's 2025 Chikungunya Outbreak.","authors":"Zenghai Wang, Qun Lin, Caijie Liao, Yiqian Wang","doi":"10.1016/j.ijid.2025.108080","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.108080","url":null,"abstract":"<p><strong>Background: </strong>Chikungunya fever (CHIKV) is a re-emerging arboviral disease with significant public health impact. Data on clinical and laboratory predictors of disease course in China are limited. This study aimed to assess the associations between clinical and laboratory parameters with both time from symptom onset and viral clearance in patients with confirmed CHIKV infection.</p><p><strong>Methods: </strong>We conducted a retrospective observational study of 372 patients with RT-PCR-confirmed CHIKV infection admitted to Lecong Hospital, Foshan, China, between July and August 2025. Demographic, clinical, and laboratory data were extracted from medical records. Pearson correlation was used to evaluate associations between clinical variables and (i) days from symptom onset, and (ii) time to viral clearance.</p><p><strong>Results: </strong>Days from symptom onset were positively correlated with AST (r = 0.2088, P < 0.0001), ALT (r = 0.1533, P = 0.0043), and fever duration (r = 0.3401, P < 0.0001), while NEU showed a weak negative correlation (r = -0.1182, P = 0.0342). CK was negatively correlated with days from symptom onset (r = -0.1528, P = 0.0121). Time to viral clearance was positively correlated with age (r = 0.1896, P = 0.0069), joint pain duration (r = 0.2248, P = 0.0013), rash duration (r = 0.06763, P = 0.0339), and initial symptom duration (r = 0.1410, P = 0.0443).</p><p><strong>Conclusion: </strong>Elevated liver enzymes and reduced neutrophil counts were associated with longer symptom duration, while older age and prolonged joint pain, rash, and initial symptoms predicted delayed viral clearance. These findings may assist clinicians in identifying patients at risk of prolonged illness and inform targeted management strategies during CHIKV outbreaks in China and similar settings. Our study represents one of the first systematic analyses of clinical and laboratory markers associated with disease course and viral clearance in CHIKV-infected patients in China.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108080"},"PeriodicalIF":4.3,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145174950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in clinical and laboratory parameters according to prior rotavirus vaccination status in children hospitalized for viral gastroenteritis.","authors":"Muna Omar, Dani Cohen, Roula Abu-Jabal, Emilia Anis, Basheer Mawassi, Khitam Muhsen, Eias Kassem","doi":"10.1016/j.ijid.2025.108078","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.108078","url":null,"abstract":"<p><strong>Background: </strong>Rotavirus vaccination is effective in preventing acute gastroenteritis (AGE), but evidence regarding its potential non-specific effects remains elusive. We examined the associations of prior rotavirus vaccination with clinical and laboratory parameters in children with viral AGE, exploring potential non-specific effects of rotavirus vaccine.</p><p><strong>Methods: </strong>A single-center study was conducted in Israel, including 494 children aged 2-23 months hospitalized during 2011-2015. Demographics and clinical and laboratory data were obtained via parental interviews, and from medical records, and rotavirus vaccination status (pentavalent vaccine) was determined via the national immunization registry.</p><p><strong>Results: </strong>Overall, 8.7% of the participants were unvaccinated for rotavirus, 29.8% partially vaccinated, and 61.5% were fully vaccinated. Fully vaccinated participants had significantly higher hemoglobin levels: beta-coefficient 0.58 (95% CI 0.18-0.98), hematocrit 1.89 (0.77-3.03), and lymphocytes: 1.51 (0.63-2.39) levels, but a lower lymphocyte-neutrophil ratio than unvaccinated participants. The likelihood of having a urine culture performed was lower in fully vaccinated participants (OR=0.21, 0.07-0.61). Complete-series vaccination was inversely related to rotavirus detection (OR=0.17, 0.05-0.57).</p><p><strong>Conclusion: </strong>Rotavirus vaccination correlates with better nutritional status and lower inflammation in AGE patients, suggesting additional beneficial effects of the vaccine and highlighting the need to increase vaccination coverage.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108078"},"PeriodicalIF":4.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prophylaxis Followed by Preemptive Approach Versus Prophylaxis to Prevent CMV infection in CMV-Seropositive Kidney Transplant Recipients Receiving Anti-Thymocyte Globulin Induction Therapy.","authors":"Theerapong Rattanaruangsup, Rungthiwa Kitpermkiat, Jackrapong Bruminhent","doi":"10.1016/j.ijid.2025.108073","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.108073","url":null,"abstract":"<p><strong>Background: </strong>CMV infection is a major complication in CMV-seropositive kidney transplant recipients receiving ATG induction. This study compared CMV infection rates between hybrid (prophylaxis plus preemptive) and universal prophylaxis strategies in this high-risk group.</p><p><strong>Methods: </strong>We retrospectively studied CMV-seropositive KT recipients receiving ATG (2018-2024), comparing a hybrid strategy (IV ganciclovir plus CMV DNA monitoring) with universal prophylaxis (3-month oral valganciclovir). Outcomes included CMV infection, clinically significant CMV infection (CsCMVi), and adverse events. Risk factors for CsCMVi were analyzed using multivariate Cox regression.</p><p><strong>Results: </strong>A total of 111 CMV-seropositive KT recipients were included (75 hybrid, 36 prophylaxis). CMV infection was significantly more frequent in the hybrid group (70.7% vs. 16.7%, p<0.001), as was CsCMVi (33.3% vs. 5.6%, p=0.001) and allograft dysfunction (45.3% vs. 16.7%, p=0.01). Hematologic toxicities (neutropenia, leukopenia, lymphopenia) were comparable (all p=NS). In multivariate analysis, independent risk factors for CsCMVi included the hybrid strategy (HR 6.06; 95% CI,1.04-35.36; p=0.045), higher panel-reactive antibody (HR 1.02; 95% CI,1.00-1.04; p=0.019), and >40% decline in eGFR at discharge (HR 48.09; 95% CI,4.39-527.20; p=0.002). Hypertension was protective (HR 0.12; 95% CI,0.04-0.80; p=0.024).</p><p><strong>Conclusion: </strong>In CMV-seropositive recipients receiving lymphocyte-depleting induction, a hybrid strategy of initial prophylaxis followed by preemptive therapy was associated with inferior outcomes compared to universal prophylaxis.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108073"},"PeriodicalIF":4.3,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized aerosolized bacteriophage treatment of a pulmonary infection due to carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae in an infant.","authors":"Huiyuan Yan, Nannan Wu, Jinlan Zhou, Anjie Jin, Mengjun Cheng, Jianfang Liu, Qian Yang, Chuanqing Wang, Leiyan He, Weiming Chen, Yixue Wang, Zhenyu Zhang, Caiyan Zhang, Weili Yang, Guoping Lu, Gangfeng Yan","doi":"10.1016/j.ijid.2025.108075","DOIUrl":"10.1016/j.ijid.2025.108075","url":null,"abstract":"<p><p>A 9-month-old ICU patient with persistent carbapenem-resistant Acinetobacter baumannii pneumonia developed a secondary infection of carbapenem-resistant Klebsiella pneumoniae. A customized, preoptimized phage cocktail was administered twice daily for 3 consecutive days, resulting in eradication of the pathogens and reduction in their abundance in the lung and gut microbiota.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108075"},"PeriodicalIF":4.3,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disseminated Mycobacterium kansasii infection revealing GATA2 haploinsufficiency after presumed tuberculosis and early lung cancer.","authors":"Chun-Hao Wang, Liang-En Hwang, Wang-Da Liu, Yu-Ting Yen, Jin-Shing Chen, Yih-Leong Chang, Ching-Kai Lin, Hung-Ming Chang, Aristine Cheng, Un-In Wu","doi":"10.1016/j.ijid.2025.108074","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.108074","url":null,"abstract":"<p><p>A 46-year-old previously healthy and asymptomatic woman was incidentally found to have right lung opacities after a traffic accident. Histology revealed chronic granulomatous inflammation, leading to an initial diagnosis of tuberculosis with partial response to treatment. A persistent right upper lobe nodule was later confirmed as minimally invasive lung adenocarcinoma. Post-wedge resection, she developed recurrent fever, dyspnea, weight loss, leukopenia, and monocytopenia. Subsequent PET revealed marked mediastinal lymphadenopathy, and mycobacterial cultures of biopsied lymph nodes and bone marrow yielded Mycobacterium kansasii. Further immunologic evaluation identified B-cell and NK-cell deficiency without detectable anti-interferon-gamma autoantibodies. Genetic testing uncovered a novel heterozygous GATA2 mutation, establishing a diagnosis of MonoMAC syndrome. Notably, one asymptomatic sister carried the same pathogenic variant. This case highlights the importance of considering GATA2 haploinsufficiency in adults with atypical mycobacterial infections and cytopenias. Early recognition enables targeted infection surveillance, multi-system assessment, family genetic counseling, and definitive hematopoietic stem cell transplantation planning when indicated.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108074"},"PeriodicalIF":4.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Impact of Influenza A Coinfection on Staphylococcus aureus Pneumonia during the 2024-2025 Influenza Season in New York City.","authors":"Kimberly Mae Soultan, Anjali Kewalramani, Alison Bradbury, Yongsheng Wang, Marie Abdallah, Briana Episcopia Rn, John Quale","doi":"10.1016/j.ijid.2025.108072","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.108072","url":null,"abstract":"<p><strong>Background: </strong>Prior studies have emphasized adverse outcomes of bacterial pneumonia, especially due to methicillin-resistant Staphylococcus aureus (MRSA), in patients co-infected with influenza.</p><p><strong>Methods: </strong>Listings of patients, admitted from an 11-hospital system in New York City, with community-onset pneumonia due to SA were obtained during the winter 2024 and 2025 influenza seasons.</p><p><strong>Results: </strong>Compared to winter 2024, in 2025 the number of patients admitted with SA pneumonia increased from 55 cases (2.2 patients per 1000 admissions) to 84 cases (3.2 patients per 1000 admissions, P=.03). This increase was driven by influenza-related cases: from 0.28 cases/1000 admissions in 2024 to 1.1 cases/1000 admissions (P=.0005) in 2025. Of the 28 influenza-related cases in 2025, 1) 27 had co-infection with influenza A, 2) 13 were bacteremic, and 3) 15 had methicillin-susceptible SA (MSSA). Patients with MSSA coinfection were more likely to require ICU admission. Only two of the 28 patients had received the seasonal influenza vaccination prior to admission.</p><p><strong>Conclusion: </strong>During the 2025 influenza season in New York City, there was a significant rise, compared to the 2024 season, of admitted patients with SA pneumonia co-infected with influenza. Nearly half had concomitant bacteremia and patients with MSSA had a more virulent onset of illness.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108072"},"PeriodicalIF":4.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Tick-borne Neoehrlichia mikurensis in Individuals Undergoing B-cell Depleting Therapy in Denmark: A Prospective Cohort Study 2023-2024.","authors":"Helene Mens, Rosa Gynthersen, Jeppe Romme Christensen, Morten Blinkenberg, Finn Sellebjerg, Daniel El Fassi, Bente Glintborg, Dorte Vendelbo Jensen, Jørgen Skov Jensen, Anne-Mette Lebech","doi":"10.1016/j.ijid.2025.108069","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.108069","url":null,"abstract":"<p><strong>Background: </strong>Neoehrlichia mikurensis is an emerging tick-borne pathogen posing a particular risk to individuals undergoing B-cell depleting therapy (BCDT).</p><p><strong>Objective: </strong>To establish a rational testing strategy for N. mikurensis among individuals on BCDT METHODS: We conducted a prospective cohort study between January 2023 and December 2024 on Adults receiving BCDT, in the Capital Region of Denmark. A digital questionnaire covered tick exposure and symptoms. Blood was tested for N. mikurensis DNA by real-time PCR.</p><p><strong>Results: </strong>Of 1,211 eligible individuals, 443 (37%) were enrolled. The median age was 54 years, and 62% were female. PCR testing was performed on 389 participants, detecting N. mikurensis DNA in 1.0% (4/389; 95% CI: 0.4-2.6). All infected individuals reported prolonged symptoms (e.g., fatigue, fever, unintended weight loss) and responded rapidly to doxycycline therapy. Notably, only one of the four cases exhibited elevated CRP. Symptom-based screening yielded a high likelihood ratio of 25 for identifying positive cases.</p><p><strong>Conclusions: </strong>Our results indicate that employing a symptom-based testing strategy for N. mikurensis is a rational approach for individuals undergoing BCDT.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108069"},"PeriodicalIF":4.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Success and limitations of the French public health strategy after 2 years of large implementation of respiratory syncytial virus prophylaxis: experience of a tertiary hospital (2018-2025).","authors":"Nicolas Veyrenche, Julie Toubiana, Hélène Chappuy, Christophe Delacourt, Matthieu Bendavid, Perrine Parize, Camille Roger, Marianne Leruez-Ville, Jacques Fourgeaud, Pierre Frange","doi":"10.1016/j.ijid.2025.108071","DOIUrl":"10.1016/j.ijid.2025.108071","url":null,"abstract":"<p><strong>Objectives: </strong>France has gradually implemented prophylaxis against RSV infections in infants since 2023 and, more recently, in the elderly. This study described the recent evolution of the RSV-hospital burden in a French tertiary hospital.</p><p><strong>Methods: </strong>Characteristics of patients admitted during the 2023/2024 and 2024/2025 RSV seasons with a RSV-lower respiratory tract infection (LRTI) were compared to those of patients admitted during three preprophylaxis RSV seasons.</p><p><strong>Results: </strong>Overall, 1114 pediatric inpatients and 41 adults with RSV-LRTI were enrolled, of whom 36% had ≥1 chronic complex condition (CCC). Compared to the preprophylaxis period, the RSV-hospital burden decreased in pediatric units in 2024/2025 (1.4 versus 1.7/1000 inpatients, P = 0.004), as did the proportion of infants aged <6 months among inpatients with RSV-LRTI (27.8% versus 57.7%, P < 0.0001) and that of all subjects requiring admission to intensive care units (17.4% versus 37.7%, P < 0.0001). However, the proportion of inpatients with RSV-LRTI from other age groups did not decrease in recent years. In adult units, the RSV-hospital burden increased in 2024/2025 compared to the preprophylaxis period (0.8 versus 0.4/1000 inpatients, P < 0.0001).</p><p><strong>Conclusions: </strong>The reduction of the RSV-hospital burden mostly impacted infants <6 months of age. Efforts are needed to reduce the RSV-hospital burden in other age groups, especially in children aged 6-11 months and older individuals with CCC.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108071"},"PeriodicalIF":4.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}