个体化雾化噬菌体治疗婴儿碳青霉烯耐药鲍曼不动杆菌和肺炎克雷伯菌所致肺部感染。

IF 4.3 2区医学 Q1 INFECTIOUS DISEASES

International Journal of Infectious Diseases Pub Date : 2025-09-18 DOI:10.1016/j.ijid.2025.108075

Huiyuan Yan, Nannan Wu, Jinlan Zhou, Anjie Jin, Mengjun Cheng, Jianfang Liu, Qian Yang, Chuanqing Wang, Leiyan He, Weiming Chen, Yixue Wang, Zhenyu Zhang, Caiyan Zhang, Weili Yang, Guoping Lu, Gangfeng Yan

{"title":"个体化雾化噬菌体治疗婴儿碳青霉烯耐药鲍曼不动杆菌和肺炎克雷伯菌所致肺部感染。","authors":"Huiyuan Yan, Nannan Wu, Jinlan Zhou, Anjie Jin, Mengjun Cheng, Jianfang Liu, Qian Yang, Chuanqing Wang, Leiyan He, Weiming Chen, Yixue Wang, Zhenyu Zhang, Caiyan Zhang, Weili Yang, Guoping Lu, Gangfeng Yan","doi":"10.1016/j.ijid.2025.108075","DOIUrl":null,"url":null,"abstract":"A 9-month-old ICU patient with persistent carbapenem-resistant Acinetobacter baumannii pneumonia developed a secondary infection of carbapenem-resistant Klebsiella pneumoniae. A customized, preoptimized phage cocktail was administered twice daily for 3 consecutive days, resulting in eradication of the pathogens and reduction in their abundance in the lung and gut microbiota.","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108075"},"PeriodicalIF":4.3000,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Personalized aerosolized bacteriophage treatment of a pulmonary infection due to carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae in an infant.\",\"authors\":\"Huiyuan Yan, Nannan Wu, Jinlan Zhou, Anjie Jin, Mengjun Cheng, Jianfang Liu, Qian Yang, Chuanqing Wang, Leiyan He, Weiming Chen, Yixue Wang, Zhenyu Zhang, Caiyan Zhang, Weili Yang, Guoping Lu, Gangfeng Yan\",\"doi\":\"10.1016/j.ijid.2025.108075\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A 9-month-old ICU patient with persistent carbapenem-resistant Acinetobacter baumannii pneumonia developed a secondary infection of carbapenem-resistant Klebsiella pneumoniae. A customized, preoptimized phage cocktail was administered twice daily for 3 consecutive days, resulting in eradication of the pathogens and reduction in their abundance in the lung and gut microbiota.\",\"PeriodicalId\":14006,\"journal\":{\"name\":\"International Journal of Infectious Diseases\",\"volume\":\" \",\"pages\":\"108075\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2025-09-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Infectious Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.ijid.2025.108075\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Infectious Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ijid.2025.108075","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

摘要

1例9个月大的持续性耐碳青霉烯鲍曼不动杆菌肺炎患者继发感染耐碳青霉烯肺炎克雷伯菌。一种定制的、预先优化的噬菌体鸡尾酒连续3天每天两次，导致病原体的根除，并减少其在肺部和肠道微生物群中的丰度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Personalized aerosolized bacteriophage treatment of a pulmonary infection due to carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae in an infant.

A 9-month-old ICU patient with persistent carbapenem-resistant Acinetobacter baumannii pneumonia developed a secondary infection of carbapenem-resistant Klebsiella pneumoniae. A customized, preoptimized phage cocktail was administered twice daily for 3 consecutive days, resulting in eradication of the pathogens and reduction in their abundance in the lung and gut microbiota.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

International Journal of Infectious Diseases 医学-传染病学

CiteScore

18.90

自引率

2.40%

发文量

1020

审稿时长

30 days

期刊介绍： International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.