International Journal of Infectious Diseases最新文献

{"title":"mRNA COVID-19 vaccines induce superior IgA titers in cancer patients compared to viral vector vaccines: Implications for immunization strategies.","authors":"Yana Debie, Lise Verbruggen, Marc Peeters, Peter A van Dam, Timon Vandamme","doi":"10.1016/j.ijid.2025.107939","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.107939","url":null,"abstract":"<p><strong>Objectives: </strong>IgA antibodies are involved in mucosal immunity and eliminate pathogens immediately at the point of entry. Vaccine-induced IgA antibodies could contribute to an additional layer of protection against SARS-CoV-2 for infection prone cancer patients. This might be particularly relevant for cancer patients as they mount reduced IgG antibody titers after dual-dose BNT162b2 COVID-19 vaccination and even lower responses after double-dose ChAdOx1 vaccination, compared to healthy individuals. However, data on vaccine-induced IgA antibodies are scarce, especially in cancer patients.</p><p><strong>Methods: </strong>This study compares SARS-CoV-2 anti-S1 IgA antibodies after dual-dose BNT162b2 vs ChAdOx1 vaccination in cancer patients. SARS-CoV-2 anti-S1 IgA antibodies were quantified in serum samples collected 7 days after second vaccination dose (N=213) (IEQ-CoVS1RBD-IgA-1-RB ELISA kit, RayBiotech) and analyzed with colorimetric detection. Additionally correlations with different aspects of humoral immunity were assessed (neutralizing and IgG antibodies).</p><p><strong>Results: </strong>Significant lower anti-S1 IgA antibody titers were reported in cancer patients after dual-dose ChAdOx1 compared to BNT162b2 vaccination. Moreover, cancer patients that received dual-dose BNT162b2 vaccination had a significant 16.44 fold increased chance to mount detectable IgA antibodies compared to patients receiving ChAdOx1 vaccination.</p><p><strong>Conclusion: </strong>These findings highlight the potential role of boosters or alternative strategies to sustain mucosal immunity.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107939"},"PeriodicalIF":4.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concerns about statistical analyses in the study on polymyxin B treatment of carbapenem-resistant Gram-negative bacilli infections.","authors":"Jing Zhao, Yue Bi","doi":"10.1016/j.ijid.2025.107936","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.107936","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107936"},"PeriodicalIF":4.8,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of malaria in pregnancy on infant neurodevelopment and malaria susceptibility during the first year of life in Kinshasa, the Democratic Republic of the Congo.","authors":"Japhet Kabalu Tshiongo, Lise Kuseke, Thierry Kalonji, Patrick Mitashi, Aimée Mupuala, Kassoum Kayentao, Trésor Zola Matuvanga, Vivi Maketa Tevuzula, Yann Kafala, Henk D F H Schallig, Hypolite Muhindo Mavoko, Petra F Mens","doi":"10.1016/j.ijid.2025.107927","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.107927","url":null,"abstract":"<p><strong>Background: </strong>Maternal malaria can influence children's neurodevelopment and increase their early childhood malaria susceptibility. This study compares the neurodevelopment and malaria susceptibility of infants born to mothers infected or uninfected at time of delivery.</p><p><strong>Methods: </strong>A cohort of 388 mother-child pairs was recruited at delivery. Maternal malaria was assessed by microscopy at birth and infant malaria was based on a history of fever. Infant neurodevelopment was evaluated at 4-6 weeks, 6 months, and 12 months using the Mullen Scales of Early Learning (MSEL), which include scores for gross motor (GM) and early learning composite (ELC). Infant malaria incidence and neurological functioning were compared based on malaria exposure at delivery.</p><p><strong>Results: </strong>In total 62/385 (16.1%) infants were exposed to malaria at delivery confirmed by microscopy for both peripheral and placental malaria.. These exposed infants had a significantly lower birth weight (LBW) (2824.68 ± 493.85 g) than those born of uninfected mothers (3032.69 ± 487.8 g; p = 0.0023). GM at 12 months showed no significant differences between groups (mean GM score for exposed: 47.2 ± 9.8 vs. unexposed: 47.6 ± 9.7; p = 0.757). However, infants exposed to malaria infection had significantly lower ECL (-7.70 [95% CI: -15.0, -0.36]; p = 0.04). Infant malaria, malnutrition and LBW were significantly associated with reduced GM scores (-1.2 [95% CI: -2.25, -0.18], p = 0.021; -0.96 [95% CI: -1.92, -0.02], and -1.59 [95% CI: -3.06, -0.11], respectively). Malaria incidence peaked at 12 months, affecting 54.7% of the exposed group versus 70.6% of non-exposed infant (RR = 1.04 [95% CI: 0.87-1.25], p = 0.631).</p><p><strong>Conclusions: </strong>Malaria at delivery was associated with impaired ELC but not with GM. Malaria susceptibility during the first 12 months was not influenced by maternal malaria exposure. However, LBW, malnutrition and infant malaria impacted infant development.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107927"},"PeriodicalIF":4.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The morbidity spectrum of influenza, respiratory syncytial virus, human metapneumovirus and human parainfluenza virus in young children by age and country income level: a systematic review and meta-analysis.","authors":"Lian He, Jitian Weng, Fuyu Zhu, Yuhe Zhang, Junru Chen, Shuting Chen, Miaojia Lu, Harish Nair, You Li, Xin Wang","doi":"10.1016/j.ijid.2025.107938","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.107938","url":null,"abstract":"<p><strong>Background: </strong>Influenza virus (IFV), respiratory syncytial virus (RSV), human metapneumovirus (hMPV) and parainfluenza virus (hPIV) cause substantial disease burden in children under 5 years, but the infection spectrum remains unclear.</p><p><strong>Methods: </strong>We systematically reviewed studies published between 1995 and 2023 to estimate probabilities between viral test positivity, symptomatic infections, acute lower respiratory infections (ALRI), ALRI with chest-wall indrawing (CWI), ALRI hospitalisation, and very severe ALRI - p(symptomatic | test positive), p(ALRI | symptomatic), p(CWI | ALRI), p(hosp | ALRI) and p(very severe | hosp). (PROSPERO CRD42024584039; CRD42023439269).</p><p><strong>Results: </strong>Based on 129 studies, we estimated that 67.7% of IFV test-positives were symptomatic and 16.2% of symptomatic IFV infections developed ALRI. In children under 2 years, 71.8% of RSV test-positives were symptomatic. Across the viruses, the estimated p(CWI | ALRI) and p(hosp | ALRI) were higher in infants than older children; between 2.6% and 41.2% of hospitalised children with ALRI were very severe, with higher estimates in low and lower-middle income countries.</p><p><strong>Conclusions: </strong>Infants and children under 5 years in low and lower-middle income countries are important risk groups for immunisation due to their high vulnerability to severe outcomes. These findings provide critical data to support immunisation assessment and development of immunisation strategies.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107938"},"PeriodicalIF":4.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute generalized exanthematous pustulosis associated with human parvovirus B19 infection.","authors":"Juliette Coursier, Aymeric Hennemann, Léa Malinowski, Quentin Lepiller, Joséphine Moreau, François Aubin","doi":"10.1016/j.ijid.2025.107935","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.107935","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107935"},"PeriodicalIF":4.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and genetic diversity of common human coronaviruses in Beijing, 2015-2023: A prospective multicenter study.","authors":"Qi Huang, Lu Kang, Xiaofeng Wei, Cheng Gong, Hui Xie, Maozhong Li, Yiting Wang, Mei Dong, Fang Huang","doi":"10.1016/j.ijid.2025.107926","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.107926","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the epidemiological and genetic features of common human coronaviruses (HCoVs) in Beijing in the context of the COVID-19 pandemic.</p><p><strong>Methods: </strong>We collected clinical samples from patients with acute respiratory tract infections (ARTIs) in 35 sentinel hospitals from 2015 to 2023. HCoVs were detected via multiple real-time PCRs, and S gene sequencing and phylogenetic analysis were subsequently performed.</p><p><strong>Results: </strong>From 2015 to 2023, the combined detection rate of HCoVs was 1.55% (909/58,550). During the COVID-19 pandemic, a significant increase in HCoVs detection was observed (P < 0.001). Overall, the epidemic season of four HCoVs was from July to October, and each HCoV showed different epidemic seasons. Notably, HCoV-NL63 and HCoV-229E exhibited pronounced annual alternations in prevalence. The highest combined detection rates of HCoVs were in the ≥60 years age group (1.85%), followed by the 0-5 years age group (1.48%). HCoV-229E was more prevalent in patients with severe community-acquired pneumonia (sCAP) (P=0.001). Phylogenetic analyses revealed that the four HCoVs were subjected to negative selection pressure, and multiple high-frequency amino acid site mutations were observed. HCoV-229E formed an emerging lineage after 2021.</p><p><strong>Conclusions: </strong>This nine-year multicenter study in Beijing systematically elucidated that the four HCoVs exhibit distinct epidemiological characteristics, susceptible populations, and common mutations in amino acid sites, especially in the context of COVID-19. Therefore, continuous epidemiological surveillance and genetic characterization studies are imperative for predictive warning and timely identification of emerging coronavirus.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107926"},"PeriodicalIF":4.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concerns about statistical analyses in the study on polymyxin B treatment of carbapenem-resistant Gram-negative bacilli infections: Authors' reply.","authors":"Simin Zhou, Weihong Ge","doi":"10.1016/j.ijid.2025.107937","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.107937","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107937"},"PeriodicalIF":4.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating troubled waters: a systematic review of prosthetic valve endocarditis reported cases treated with suppressive antimicrobial treatment.","authors":"Pietro Valsecchi, Matteo Calia, Paola Giordani, Cecilia Giuliani, Alessia Arcuri, Valeria Scotti, Elena Seminari, Raffaele Bruno","doi":"10.1016/j.ijid.2025.107934","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.107934","url":null,"abstract":"<p><strong>Objectives: </strong>We aimed to characterize suppressive antimicrobial treatment (SAT) for non-surgical candidate patients with prosthetic valve endocarditis (PVE).</p><p><strong>Methods: </strong>We systematically reviewed PubMed and Embase databases for studies reporting individual data on patients with PVE medically treated for longer than 8 weeks published until the 31^st of June 2024. The review protocol was registered on PROSPERO database [CRD42024529650].</p><p><strong>Results: </strong>One hundred seventy patients were retrieved from 91 studies. PVE-related death during follow-up occurred in 26 (15.57%) patients, being associated with coagulase-negative staphylococci PVE in multivariate Cox regression model (HR 3.40, 95% CI 1.06 - 10.97, p value = 0.04). Relapse occurred in 15 (8.92%) patients and was similar according to SAT discontinuation (long-rank test p value 0.8). This was confirmed after performing landmark analysis to adjust for survival bias (HR 0.97; 95% CI 0.21 - 4.4, p value 0.98). SAT-related adverse events were reported in 15% of the patients.</p><p><strong>Conclusion: </strong>Supporting evidence for SAT is low and derived from case reports and case series. SAT seems well tolerated, but clinical effectiveness should be further evaluated due to the relevant mortality rate. In selected cases when SAT discontinuation is considered, close and long-term follow-up is crucial to prevent relapse.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107934"},"PeriodicalIF":4.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Prospective Pilot Clinical Study reveals a promising non-toxic anti-biofilm activity of gentamicin-EDTA-Na₂ Central Venous Catheter Lock Solution","authors":"David Lebeaux ,&nbsp;Bérénice Souhail ,&nbsp;Tan-Phuc Bui-Van ,&nbsp;Lénaig Le-Fouler ,&nbsp;Matthieu Lafaurie ,&nbsp;Raphael Lepeule ,&nbsp;Etienne Canoui ,&nbsp;Victoire de Lastours ,&nbsp;Antoine Froissart ,&nbsp;Damien Blez ,&nbsp;Christophe Beloin ,&nbsp;Jean-Marc Ghigo ,&nbsp;Fabrice Pirot ,&nbsp;Carole Dhelens ,&nbsp;Sandrine Fernandes-Pellerin","doi":"10.1016/j.ijid.2025.107933","DOIUrl":"10.1016/j.ijid.2025.107933","url":null,"abstract":"<div><h3>Objectives</h3><div>The treatment of long-term intravenous catheter-related bloodstream infections (LTIVC-related BSI) often requires catheter removal or conservative treatment using intra-catheter locks, with a 50–60% success rate. We previously demonstrated the synergistic effect of a combination of gentamicin and ethylenediaminetetraacetic acid disodium salt (EDTA-Na₂) against bacterial biofilms. We conducted a phase 1/2 clinical trial to assess the tolerance and efficacy of genta-EDTA-Na₂ locks for the conservative treatment of LTIVC-related BSI.</div></div><div><h3>Methods</h3><div>Prospective study including adult patients with monomicrobial, uncomplicated LTIVC-related BSI caused by gentamicin-susceptible coagulase-negative staphylococci, <em>Enterobacterales,</em> or <em>Pseudomonas aeruginosa</em>. Primary objective: assess the safety and efficacy at genta-EDTA-Na₂ locks at day 40 (D40) by evaluating the frequency of clinical and microbiological cure 30 days after the end of treatment (D40).</div></div><div><h3>Results</h3><div>Eight patients were included. Complete follow-up was obtained for seven patients, six of whom met the criteria for cure. The single patient with incomplete follow-up met all criteria for cure at D23. A single microbiological failure occurred (relapse of <em>P. aeruginosa</em> LTIVC-related BSI). Two patients experienced at least one serious adverse event; none were attributed to the genta-EDTA-Na₂ locks.</div></div><div><h3>Conclusions</h3><div>Genta-EDTA-Na₂, used as intra-catheter locks, may be a promising anti-biofilm candidate for evaluation in a randomized controlled trial.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"157 ","pages":"Article 107933"},"PeriodicalIF":4.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in nontuberculous mycobacterial disease mortality based on 2000-2022 data from 83 countries.","authors":"Ko Harada, Quynh Thi Vu, Yoshito Nishimura, Tatsuaki Takeda, Hirofumi Hamano, Yusuke Minato, Yoshito Zamami, Toshihiro Koyama, Hideharu Hagiya","doi":"10.1016/j.ijid.2025.107932","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.107932","url":null,"abstract":"<p><strong>Objective: </strong>To examine the international trends for nontuberculous mycobacterial-associated mortality rates, as nontuberculous mycobacterial infections are becoming increasingly prevalent and pose a significant public health challenge, especially in older populations.</p><p><strong>Methods: </strong>This retrospective observational study used data from the World Health Organization mortality database, which included patients with nontuberculous mycobacterial infection in 83 countries. We stratified the data by sex, age, and geographic region and calculated crude and age-standardized mortality rates to estimate long-term mortality trends.</p><p><strong>Results: </strong>In total, 42,182 nontuberculous mycobacterial infection-associated deaths (58.1% in women) were reported in 83 countries between 2000 and 2022. The locally weighted regression model estimation for the nontuberculous mycobacterial infection-associated mortality rate more than doubled-from 0.36 deaths per 1,000,000 individuals in 2000 to 0.77 deaths per 1,000,000 individuals in 2022. Eighty-six percent of nontuberculous mycobacterial infection-associated deaths occurred in people aged ≥65 years. The mortality rate was the highest in the Western Pacific Region.</p><p><strong>Conclusions: </strong>This study highlights the impact of emerging nontuberculous mycobacterial diseases and the importance of targeted interventions for managing and reducing mortality, particularly in vulnerable older populations. Further studies are warranted to determine the factors contributing to geographical disparity and treatment options.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107932"},"PeriodicalIF":4.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}