International Journal of Infectious Diseases最新文献

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Non-pharmaceutical interventions to reduce influenza transmission in households: a systematic review and meta-analysis. 减少流感在家庭中传播的非药物干预措施:系统回顾和荟萃分析。
IF 4.8 2区 医学
International Journal of Infectious Diseases Pub Date : 2024-11-04 DOI: 10.1016/j.ijid.2024.107291
Jessica Y Wong, Wey Wen Lim, Justin K Cheung, Caitriona Murphy, Eunice Y C Shiu, Jingyi Xiao, Dongxuan Chen, Yanmin Xie, Mingwei Li, Hualei Xin, Michelle Szeto, Sammi Choi, Benjamin J Cowling
{"title":"Non-pharmaceutical interventions to reduce influenza transmission in households: a systematic review and meta-analysis.","authors":"Jessica Y Wong, Wey Wen Lim, Justin K Cheung, Caitriona Murphy, Eunice Y C Shiu, Jingyi Xiao, Dongxuan Chen, Yanmin Xie, Mingwei Li, Hualei Xin, Michelle Szeto, Sammi Choi, Benjamin J Cowling","doi":"10.1016/j.ijid.2024.107291","DOIUrl":"https://doi.org/10.1016/j.ijid.2024.107291","url":null,"abstract":"<p><strong>Background: </strong>Influenza pandemic plans often recommend non-pharmaceutical interventions (NPIs) in household settings, including hand hygiene and face masks. We reviewed the evidence supporting the recommendations of these measures to prevent the spread of influenza in households.</p><p><strong>Methods: </strong>We performed systematic reviews between 26 May and 30 August 2022 in Medline, PubMed, EMBASE, and CENTRAL to identify evidence for the effectiveness of selected measures recommended by representative national influenza pandemic plans. We prioritized evidence from randomized controlled trials conducted during influenza pandemics and seasonal influenza epidemics. Fixed-effects models were used to estimate the overall effects. Systematic reviews were registered in the OSF registry (https://osf.io/8kyth).</p><p><strong>Results: </strong>We selected 9 NPIs for evidence review. We identified 9 randomized-controlled trials related to hand hygiene and face masks in household settings. 2 studies reported that measures could delay the introduction of influenza virus infections into households. However, we did not identify evidence from randomized controlled trials that indicated a substantial effect of hand hygiene and face masks in preventing the spread of influenza within households.</p><p><strong>Conclusion: </strong>Limited evidence indicated that within-household measures may likely be effective only when implemented before or as soon as possible after symptom onset in an infected case. Improving the evidence base for NPIs in households and elsewhere is a continuing priority.</p><p><strong>Funding: </strong>World Health Organization and the Strategic Topic Grants Scheme.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preventing central line-associated bloodstream infections: A position paper of the International Society for Infectious Diseases, 2024 update. 预防中心静脉相关血流感染:国际传染病学会立场文件,2024 年更新版。
IF 4.8 2区 医学
International Journal of Infectious Diseases Pub Date : 2024-11-04 DOI: 10.1016/j.ijid.2024.107290
Victor Daniel Rosenthal, Ziad A Memish, Fnu Shweta, Gonzalo Bearman, Larry I Lutwick
{"title":"Preventing central line-associated bloodstream infections: A position paper of the International Society for Infectious Diseases, 2024 update.","authors":"Victor Daniel Rosenthal, Ziad A Memish, Fnu Shweta, Gonzalo Bearman, Larry I Lutwick","doi":"10.1016/j.ijid.2024.107290","DOIUrl":"https://doi.org/10.1016/j.ijid.2024.107290","url":null,"abstract":"<p><p>A panel of experts convened by the International Society for Infectious Diseases (ISID) has reviewed and consolidated current recommendations for preventing vascular catheter infections, particularly central line-associated bloodstream infections (CLABSIs). This review provides healthcare professionals with insights into key issues such as the rates of CLABSI in high-income countries and low- and middle-income countries, the attributable extra length of stay, cost and mortality, and risk factors. This position paper highlights evidence-based strategies for preventing infections, applicable to both high-income and low- and middle-income countries.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kinetics of Hepatitis B Virus replication in anti-HBc positive/HBsAg-negative people with HIV switching to Tenofovir sparing therapy. 抗-HBc 阳性/HBsAg 阴性 HIV 感染者转用替诺福韦稀释疗法后的乙型肝炎病毒复制动力学。
IF 4.8 2区 医学
International Journal of Infectious Diseases Pub Date : 2024-11-04 DOI: 10.1016/j.ijid.2024.107294
Romina Salpini, Stefano D'Anna, Mohammad Alkhatib, Lorenzo Piermatteo, Alessandro Tavelli, Livia Benedetti, Eugenia Quiros Roldan, Antonella Cingolani, Chiara Papalini, Stefania Carrara, Vincenzo Malagnino, Massimo Puoti, Loredana Sarmati, Francesca Ceccherini-Silberstein, Carlo Federico Perno, Antonella d'Arminio Monforte, Valentina Svicher
{"title":"Kinetics of Hepatitis B Virus replication in anti-HBc positive/HBsAg-negative people with HIV switching to Tenofovir sparing therapy.","authors":"Romina Salpini, Stefano D'Anna, Mohammad Alkhatib, Lorenzo Piermatteo, Alessandro Tavelli, Livia Benedetti, Eugenia Quiros Roldan, Antonella Cingolani, Chiara Papalini, Stefania Carrara, Vincenzo Malagnino, Massimo Puoti, Loredana Sarmati, Francesca Ceccherini-Silberstein, Carlo Federico Perno, Antonella d'Arminio Monforte, Valentina Svicher","doi":"10.1016/j.ijid.2024.107294","DOIUrl":"https://doi.org/10.1016/j.ijid.2024.107294","url":null,"abstract":"<p><strong>Objectives: </strong>To unravel the still unexplored HBV-replicative kinetics in antiHBc-positive/HBsAg-negative people-with-HIV (PWH) suspending TDF/TAF.</p><p><strong>Methods: </strong>101 antiHBc-positive/HBsAg-negative PWH switching to TDF/TAF-sparing therapy were included. Serum HBV-DNA and HBV-RNA were quantified by droplet-digital-PCR at switching (T0), within 12-months (T1) and 12-24 months post-switch (T2).</p><p><strong>Results: </strong>At T0, 33.7% had cryptic HBV-DNA (undetected by commercial assays, median[IQR]:2[1-5]IU/ml) and 22% were positive to HBV-RNA alone (median[IQR]:4[3-4]IU/ml), indicating an active HBV-reservoir despite HBsAg-negativity and TDF/TAF-pressure. Notably, antiHBs-titer<100mIU/ml independently correlated with cryptic HBV-DNA at T0 (OR[95%CI]:2.6[1.02-6.5], P=0.04). After TDF/TAF-withdrawal, the rate of PWH achieving HBV-DNA>10IU/ml increased from 12.9% at T1 to 42.6% at T2 (P<0.0001). Likewise, a rise from 2% to 11% was observed for HBV-DNA>100IU/ml (P=0.02); median(IQR) HBV-DNA: 579(425-770)IU/ml. Notably, HBV-DNA>10IU/ml at T2 occurred in 70% of PWH with cryptic HBV-DNA, in 38.5% with HBV-RNA alone and in 25% negative to both HBV-markers at T0 (P=0.01). Cryptic HBV-DNA at T0 and lower nadir CD4+T-cell-count independently predicted HBV-DNA>10IU/ml at T2 (OR[95%CI]:8.2[1.7-40.6], P=0.01; OR[95%CI]:8.1[1.3-52.1], P=0.03). Lastly, persistent HBV-DNA positivity was independently associated with a reduced CD4+T-cell recovery at T2 (OR[95%CI]:0.07[0.01-0.77], P=0.03).</p><p><strong>Conclusions: </strong>This study underlines the importance to regularly monitor antiHBc-positive/HBsAg-negative PWH undergoing TDF/TAF-sparing regimen and the role of highly-sensitive HBV markers in optimizing their management.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Total burden of hepatitis B and C attributed to injecting drug use in 204 countries and territories from 1990 to 2021: Analyses based on the Global Burden of Disease Study 2021. 1990 年至 2021 年 204 个国家和地区因注射吸毒造成的乙型肝炎和丙型肝炎总负担:基于《2021 年全球疾病负担研究》的分析。
IF 4.8 2区 医学
International Journal of Infectious Diseases Pub Date : 2024-11-04 DOI: 10.1016/j.ijid.2024.107293
Liang Huang, Xiaoyu Chen, Zhaojun Wang
{"title":"Total burden of hepatitis B and C attributed to injecting drug use in 204 countries and territories from 1990 to 2021: Analyses based on the Global Burden of Disease Study 2021.","authors":"Liang Huang, Xiaoyu Chen, Zhaojun Wang","doi":"10.1016/j.ijid.2024.107293","DOIUrl":"https://doi.org/10.1016/j.ijid.2024.107293","url":null,"abstract":"<p><strong>Objectives: </strong>This study assesses the global, regional, and national burden of hepatitis B (HBV) and hepatitis C (HCV) related to injecting drug use (IDU) from 1990 to 2021.</p><p><strong>Methods: </strong>Data from the global burden of disease study 2021 were analyzed to quantify deaths, age-standardized mortality rates (ASMR), disability-adjusted life years (DALYs), and age-standardized DALYs rates (ASDR) due to HBV and HCV from IDU across 204 countries. Trends was evaluated using estimated annual percentage change. Analyzing the association between ASDR and SDI using a loess regression model.</p><p><strong>Results: </strong>From 1990 to 2021, the global burden of deaths and DALYs due to HBV and HCV attributed to IDU showed an increasing trend, especially among males, whose mortality rates were significantly higher than females. In 2021, global deaths due to HBV from IDU were 13,050.8, with an ASMR of 0.15 per 100,000 and an ASDR of 5.3, both showing an increasing trend with estimated annual percentage changes (EAPCs) of 1.09 and 0.96, respectively. HCV deaths reached 231,764.4, with an ASMR of 2.68 (EAPC: 0.38) and a relatively stable ASDR trend (EAPC: 0.01). Although raw death rates for HCV have increased, the ASMR and ASDR have remained stable or slightly declined, highlighting different trends across sexes and regions. India had the highest national deaths, while the highest ASDRs were in the Republic of Moldova (HBV) and Mongolia (HCV). South Asia recorded the highest regional deaths for both HBV and HCV. Positive correlations between ASDRs for HBV and HCV with SDI were observed.</p><p><strong>Conclusion: </strong>The burden of HBV and HCV due to IDU has increased from 1990 to 2021, especially among males, with significant regional and national disparities. Targeted drug prohibition interventions and policies are needed.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbiological Aspects and Clinical Impact of Lower Lung Field Tuberculosis: an Observational Cohort Study in Peru. 下肺野肺结核的微生物学方面和临床影响:秘鲁的一项观察性队列研究。
IF 4.8 2区 医学
International Journal of Infectious Diseases Pub Date : 2024-11-02 DOI: 10.1016/j.ijid.2024.107284
Qi Tan, Chuan-Chin Huang, Roger Calderon, Leonid Lecca, Milagros Mendoza, Gabriela Reyes Rocha, Karen Tintaya, Ximena Tovar, Jia-Yih Feng, Sheng-Wei Pan, Yen-Han Tseng, Jhong-Ru Huang, Zibiao Zhang, Megan B Murray
{"title":"Microbiological Aspects and Clinical Impact of Lower Lung Field Tuberculosis: an Observational Cohort Study in Peru.","authors":"Qi Tan, Chuan-Chin Huang, Roger Calderon, Leonid Lecca, Milagros Mendoza, Gabriela Reyes Rocha, Karen Tintaya, Ximena Tovar, Jia-Yih Feng, Sheng-Wei Pan, Yen-Han Tseng, Jhong-Ru Huang, Zibiao Zhang, Megan B Murray","doi":"10.1016/j.ijid.2024.107284","DOIUrl":"https://doi.org/10.1016/j.ijid.2024.107284","url":null,"abstract":"<p><strong>Objectives: </strong>Approximately 40% of tuberculosis (TB) cases remain undiagnosed globally. Lower lung field tuberculosis (LLF TB) presents atypically and is often misidentified as other lung diseases, leading to diagnostic delays in resource-limited settings. It may contribute to increased TB transmission and mortality. We aimed to identify microbiological determinants of LLF TB and evaluate treatment responses to optimize care.</p><p><strong>Methods: </strong>We conducted an observational cohort study in Lima, Peru, enrolling adults with microbiologically confirmed pulmonary TB (PTB) diagnosed by GeneXpert MTB/RIF assay or sputum culture. Mycobacterium tuberculosis (MTB) lineage was determined using whole-genome sequencing (WGS). Due to the delayed chest radiograph (CXR) changes in LLF TB compared to non-LLF TB, we measured changes in the St. George's Respiratory Questionnaire (SGRQ) score at two-month treatment mark and evaluated World Health Organization (WHO)-specified final treatment outcomes. We used logistic regression to evaluate the associations between LLF TB and microbiological determinants and treatment outcomes. We used linear regression to assess whether the change in SGRQ scores over the first 2 months of treatment varied by LLF TB status.</p><p><strong>Results: </strong>Among 1,316 PTB patients, 84 (6%) had LLF TB. Compared to non-LLF TB patients, LLF TB patients were more likely to be smear-negative (adjusted odds ratio [aOR] [95% CI]=2.04 [1.28-3.23], p=0.002) and to be infected with Lineage 2 (aOR [95% CI]= 1.95 (95% CI: 1.07 to 3.41; p=0.024). People with LLF TB had less improvement in SGRQ scores after two months of treatment (adjusted score difference [95% CI] = -6.29 [-10.99 to -1.59], p = 0.009), while they experienced better final outcomes compared to non-LLF TB patients, though this difference did not reach statistical significance (adjusted odds ratio [aOR] = 0.43 [95% CI: 0.13 to 1.05], p = 0.103).</p><p><strong>Conclusion: </strong>Patients with LLF TB are more likely than those with upper lung lesions to be sputum-negative on conventional tests, to be infected with Lineage 2, and to show less clinical improvement after treatment.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Healthcare utilization among COVID-19 mRNA vaccine-associated myocarditis cases: a matched retrospective cohort study. COVID-19 mRNA 疫苗相关心肌炎病例的医疗保健使用情况:一项匹配的回顾性队列研究。
IF 4.8 2区 医学
International Journal of Infectious Diseases Pub Date : 2024-11-01 DOI: 10.1016/j.ijid.2024.107287
Zaeema Naveed, Julia Li, James Wilton, Monika Naus, Héctor Alexander Velásquez García, Nathaniel M Hawkins, Naveed Zafar Janjua
{"title":"Healthcare utilization among COVID-19 mRNA vaccine-associated myocarditis cases: a matched retrospective cohort study.","authors":"Zaeema Naveed, Julia Li, James Wilton, Monika Naus, Héctor Alexander Velásquez García, Nathaniel M Hawkins, Naveed Zafar Janjua","doi":"10.1016/j.ijid.2024.107287","DOIUrl":"https://doi.org/10.1016/j.ijid.2024.107287","url":null,"abstract":"<p><strong>Objectives: </strong>We evaluated all-cause healthcare utilization among those with vaccine-associated myocarditis, compared to vaccinees without post-vaccination myocarditis.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study in individuals aged 12 and older who received COVID-19 mRNA vaccination in British Columbia. Exposure was defined as an ED visit or hospitalization for myocarditis within 21 days post-vaccination. The primary outcome was healthcare utilization. Ratios of rate ratios (RRRs) for exposure-associated healthcare utilization were calculated using a difference-in-differences (DiD) analysis.</p><p><strong>Results: </strong>In the post-index period, the exposed and unexposed groups showed substantial utilization rate difference (RD = 15.30 [95% CI, 14.47-16.13). A 51% overall increase in healthcare utilization was observed over 18 months among exposed individuals (RRR, 1.51 [95%CI, 1.08-2.11]). In the initial six months, healthcare utilization surpassed the 18-month estimate, exhibiting a 125% increase (RRR, 2.25 [95%CI, 1.43-3.52]), while the last 12 months showed no statistically significant change (RRR, 1.03 [95%CI, 0.72-1.47]). An additional 9.1 (95%CI, 8.53-9.71) visits per person were attributed to vaccine-associated myocarditis over 18 months (total excess = 938.26 healthcare visits).</p><p><strong>Conclusion: </strong>The initial surge in healthcare visits post-exposure, mainly outpatient follow-ups, followed by a return to baseline rates, indicates a positive prognosis and supports the vaccine's safety profile.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autoantibodies Directed Against Interferon Alpha, Nuclear Antigens, Cardiolipin, and Beta 2 Glycoprotein 1 Are Not Induced By SARS-CoV-2 or Associated with Long COVID. 针对α干扰素、核抗原、心磷脂和β2糖蛋白1的自身抗体并非由SARS-CoV-2诱发,也与长COVID无关。
IF 4.8 2区 医学
International Journal of Infectious Diseases Pub Date : 2024-11-01 DOI: 10.1016/j.ijid.2024.107289
Adam Epstein-Shuman, Joanne H Hunt, Patrizio Caturegli, Patrick Winguth, Reinaldo E Fernandez, Gracie M Rozek, Xianming Zhu, Nicholas A DiRico, Armaan Jamal, Yu-Hsiang Hsieh, Yukari C Manabe, Andrew D Redd, Steven J Reynolds, Annukka A R Antar, Oliver Laeyendecker
{"title":"Autoantibodies Directed Against Interferon Alpha, Nuclear Antigens, Cardiolipin, and Beta 2 Glycoprotein 1 Are Not Induced By SARS-CoV-2 or Associated with Long COVID.","authors":"Adam Epstein-Shuman, Joanne H Hunt, Patrizio Caturegli, Patrick Winguth, Reinaldo E Fernandez, Gracie M Rozek, Xianming Zhu, Nicholas A DiRico, Armaan Jamal, Yu-Hsiang Hsieh, Yukari C Manabe, Andrew D Redd, Steven J Reynolds, Annukka A R Antar, Oliver Laeyendecker","doi":"10.1016/j.ijid.2024.107289","DOIUrl":"https://doi.org/10.1016/j.ijid.2024.107289","url":null,"abstract":"<p><strong>Introduction: </strong>Autoantibodies (AAbs) directed against interferon alpha (aIFNα), nuclear antigens (ANAs), cardiolipin (aCL), and beta 2 glycoprotein 1 (aβ2GP1), have been demonstrated to significantly correlate with the severity of acute COVID-19. However, whether SARS-CoV-2 infection induces these AAbs and whether they are associated with long COVID remains unclear.</p><p><strong>Methods: </strong>The potential induction of aIFNα, ANAs, aCL, and aβ2GP1 by SARS-CoV-2 was assessed by measuring these AAbs in 224 pre- and post-infection paired serum samples from the Johns Hopkins Hospital Emergency Department (JHHED). The relationship between these AAbs and long COVID was assessed using 60 serum samples from participants in the Outpatient SARS-CoV-2 Mild and Asymptomatic Infection Response and Transmission (OutSMART) study.</p><p><strong>Results: </strong>We found no evidence that these AAbs were induced in the JHHED cohort and no significant difference in their prevalence between patients with (n=30) and without (n=30) long COVID in the OutSMART cohort.</p><p><strong>Conclusions: </strong>These findings do not support the hypotheses that SARS-CoV-2 induces these AAbs or that they are related to long COVID.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disparities in Tuberculosis Diagnostic Delays between Native and Migrant Populations in Italy: A Multicenter Study. 意大利本土人口与移民人口结核病诊断延迟的差异:一项多中心研究。
IF 4.8 2区 医学
International Journal of Infectious Diseases Pub Date : 2024-10-28 DOI: 10.1016/j.ijid.2024.107279
Francesco Di Gennaro, Sergio Cotugno, Giacomo Guido, Francesco Cavallin, Mariantonietta Pisaturo, Lorenzo Onorato, Federica Zimmerhofer, Luca Pipitò, Giuseppina De Iaco, Giuseppe Bruno, Massimo Fasano, Agostina Pontarelli, Annarita Botta, Tiziana Iacovazzi, Rossana Lattanzio, Virginia Di Bari, Gianfranco Panico, Raffaella Libertone, Caterina Monari, Alessia Musto, Mariangela Niglio, Federica De Gregorio, Loredana Alessio, Gina Gualano, Salvatore Minniti, Giovanni Battista Buccoliero, Teresa Santantonio, Sergio Lo Caputo, Sergio Carbonara, Antonio Cascio, Roberto Parrella, Fabrizio Palmieri, Nicola Coppola, Annalisa Saracino
{"title":"Disparities in Tuberculosis Diagnostic Delays between Native and Migrant Populations in Italy: A Multicenter Study.","authors":"Francesco Di Gennaro, Sergio Cotugno, Giacomo Guido, Francesco Cavallin, Mariantonietta Pisaturo, Lorenzo Onorato, Federica Zimmerhofer, Luca Pipitò, Giuseppina De Iaco, Giuseppe Bruno, Massimo Fasano, Agostina Pontarelli, Annarita Botta, Tiziana Iacovazzi, Rossana Lattanzio, Virginia Di Bari, Gianfranco Panico, Raffaella Libertone, Caterina Monari, Alessia Musto, Mariangela Niglio, Federica De Gregorio, Loredana Alessio, Gina Gualano, Salvatore Minniti, Giovanni Battista Buccoliero, Teresa Santantonio, Sergio Lo Caputo, Sergio Carbonara, Antonio Cascio, Roberto Parrella, Fabrizio Palmieri, Nicola Coppola, Annalisa Saracino","doi":"10.1016/j.ijid.2024.107279","DOIUrl":"https://doi.org/10.1016/j.ijid.2024.107279","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis (TB) remains a Global Health challenge, with diagnostic delays contributing significantly to its spread. This study investigates the differences in diagnostic delays between native and migrant TB patients in Italy, examining patient-related diagnostic delay (PDD), health system-related diagnostic delay (HDD), and total diagnostic delay (TDD).</p><p><strong>Methods: </strong>We conducted a retrospective, multicenter, cross-sectional study of TB cases in ten Italian hospitals from 2018 to 2023. We compared PDD, HDD, and TDD between native and migrant populations. Socio-demographic data and clinical histories were analyzed to identify factors contributing to diagnostic delays.</p><p><strong>Results: </strong>We included 669 TB patients (390 migrants and 279 natives). Migrants experienced significantly longer PDD (median 90 vs. 10 days, p<0.0001) but shorter HDD (median 5 vs. 40 days, p<0.0001) compared to natives, resulting in a longer TDD (median 96 vs. 65 days, p<0.0001). Furthermore, migrants had higher Timika scores, longer sputum conversion times, and were more frequently lost to follow-up.</p><p><strong>Conclusions: </strong>Migrants face longer PDD, emphasizing substantial barriers to healthcare access. Natives experience longer HDD, reflecting neglect of TB in low-endemic regions. Future research should focus on the impact of social determinants and training for healthcare providers on TB diagnosis and develop strategies to reduce diagnostic delays.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dengue Fever in Immunocompromised Patients: A Systematic Review and Meta-Analysis. 免疫力低下患者的登革热:系统回顾与元分析》。
IF 4.8 2区 医学
International Journal of Infectious Diseases Pub Date : 2024-10-25 DOI: 10.1016/j.ijid.2024.107272
Asma Sohail, Shannon Zhong, Phi-Yen Nguyen, Sarah L McGuinness, Karin Leder
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引用次数: 0
Corrigendum to “Middle East respiratory syndrome coronavirus—a 10-year (2012-2022) global analysis of human and camel infections, genomic sequences, lineages, and geographical origins” [International Journal of Infectious Diseases (2023), volume 131, 87–94] 中东呼吸综合征冠状病毒--10 年(2012-2022 年)全球人类和骆驼感染、基因组序列、品系和地理起源分析"[《国际传染病杂志》(2023 年),第 131 卷,87-94 页]更正。
IF 4.8 2区 医学
International Journal of Infectious Diseases Pub Date : 2024-10-23 DOI: 10.1016/j.ijid.2024.107261
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引用次数: 0
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