International Journal of Infectious Diseases最新文献

{"title":"Global Resurgence of Measles: Turning the Tide through a Bold Agenda for Prevention and Control.","authors":"Evans Mpabalwani, Giuseppe Ippolito, Danny Asogun, Eleni Aklillu, Markus Maeurer, Shui Shan Lee, Alimuddin Zumla","doi":"10.1016/j.ijid.2025.107901","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.107901","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107901"},"PeriodicalIF":4.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Year-round infectome profiling of acute febrile respiratory illness unveiled complex epidemiological dynamics post-lifting of COVID-19 restrictions.","authors":"Shisong Fang, Lin Zhu, Shaohui Bai, Weijian Tian, Yuanfei Pan, Shumiao Zhang, Rongjun Bi, Minqi Liang, Gengyan Luo, Xiaojing Chen, Minwu Peng, Hanlin Liu, Lu Xie, Runzi Zhang, Wudi Zhou, Shengze Zhang, Ting Xie, Haolu Zha, Chuming Luo, Xin Wang, Ying Sun, Hui Liu, Min Jiang, Weihua Wu, Xuan Zou, Yaoqing Chen, Jianhui Yuan, Ying Jiang, Nan Wu, Mang Shi, Yuelong Shu, Huanle Luo","doi":"10.1016/j.ijid.2025.107896","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.107896","url":null,"abstract":"<p><strong>Objectives: </strong>Following the lifting of COVID-19 non-pharmaceutical interventions in China, respiratory infections surged, though the specific causes remained unclear. This study provided a comprehensive overview of the infectome in patients with acute febrile respiratory illness (AFRI) to inform disease surveillance.</p><p><strong>Methods: </strong>Between March 2023 and February 2024, 1,163 oropharyngeal swabs from AFRI patients and 338 from healthy individuals were collected in Shenzhen. Meta-transcriptomic sequencing was employed for microbial analysis.</p><p><strong>Results: </strong>We identified 14 viruses and 10 bacteria species known to cause human disease. Influenza virus, SARS-CoV-2, Streptococcus pneumoniae, and redondovirus were the most common, with a negative correlation between H3N2 and SARS-CoV-2. Notably, we detected certain enterovirus subtypes (e.g., Coxsackievirus A6 and Echovirus 30), previously overlooked pathogens (e.g., redondovirus), and rare pathogens like Streptococcus pseudopneumoniae. Comparisons revealed five pathogens showed significantly higher abundance in patients than in controls, despite no significant differences for others probably due to their limited number of positive pools. Seasonal shifts in microbial diversity and composition were observed, with climate factors like temperature and precipitation playing a role. Phylogenetic analysis revealed changes in genotype diversity and dominant pathogen lineages.</p><p><strong>Conclusions: </strong>This study highlighted complex pathogen infections in AFRI patients following COVID-19 restrictions, demonstrating the value of meta-transcriptomics over PCR-based methods for more detailed pathogen surveillance.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107896"},"PeriodicalIF":4.8,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-year mortality of tuberculosis patients on isoniazid-based treatment and its association with rapid acetylator NAT2 genotypes.","authors":"Ayu Kasamatsu, Reiko Miyahara, Daisuke Yoneoka, Licht Toyo-Oka, Boonchai Chiyasirinroje, Worarat Imsanguan, Supharat Suvichapanich, Hideki Yanai, Sukanya Wattnapokayakit, Supalert Nedsuwan, Manon Boonbangyang, Prasit Palittapongarnpim, Katsushi Tokunaga, Taisei Mushiroda, Surakameth Mahasirimongkol","doi":"10.1016/j.ijid.2025.107895","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.107895","url":null,"abstract":"<p><strong>Background: </strong>NAT2 polymorphisms affect isoniazid metabolism, but their effect on mortality among individuals with tuberculosis (TB) remains unclear.</p><p><strong>Methods: </strong>This study used data from two TB cohorts (2005-2011, 2014-2020) and death certificate records in Thailand. Newly diagnosed Thai individuals treated with isoniazid-containing regimens were included. NAT2 genotypes-rapid, intermediate, and slow acetylator (RA, IA, SA)-were classified via haplotype inference. The primary outcome was 1-year all-cause mortality, while secondary outcomes included TB-related mortality, TB+respiratory disease-related mortality recorded in the vital registration system, and death as a TB treatment outcome. Adjusted hazard ratios (aHRs) relative to the IA type were estimated using stratified Cox proportional hazards models. Subgroup analyses targeted individuals with isoniazid-resistant TB and HIV infection.</p><p><strong>Results: </strong>A total of 1,065 individuals (766 males; mean age=51 years) were analyzed. Individuals with RA had a 1.70-fold greater all-cause mortality risk (95% CI: 1.03-2.80) than IA. The aHRs for RA were 1.14 (0.43-3.03) for TB-related mortality, 1.59 (0.80-3.18) for TB+respiratory disease-related mortality, and 1.26 (0.67-2.14) for TB treatment outcome death. Among individuals with isoniazid-resistant TB, those with RA had a 4.68-fold (1.14-19.12) greater aHR for all-cause mortality.</p><p><strong>Conclusion: </strong>The RA type is associated with increased 1-year all-cause mortality.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107895"},"PeriodicalIF":4.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudomonas aeruginosa Community-Acquired Pneumonia Following Soil Ingestion: A Case Report.","authors":"Ying Chen, Juanjuan Wu, Hui Tong, Xu Di, Cong Wei, Shi Chen, Li Chen, Chenghong Li, Shuang Liu, Fajiu Li","doi":"10.1016/j.ijid.2025.107894","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.107894","url":null,"abstract":"<p><strong>Background: </strong>Pseudomonas aeruginosa (P. aeruginosa) is an uncommon etiological agent in community-acquired pneumonia (CAP), typically associated with nosocomial or healthcare-associated infections, particularly in patients with underlying structural lung abnormalities or immunosuppression. P. aeruginosa is a ubiquitous gram-negative rod, widely distributed in the environment. However, CAP due to P. aeruginosa following soil ingestion is exceedingly rare.</p><p><strong>Case presentation: </strong>We present the case of a previously healthy 31-year-old patient, a middle school teacher, who developed CAP due to P. aeruginosa after ingesting garden soil for three consecutive days. The patient was admitted with symptoms including fever, chest pain, vomiting, and diarrhea. Chest computed tomography (CT) revealed two suspicious lesions in the left lower lobe, with one lesion exhibiting cavitation. Microbiological culture of bronchoalveolar lavage fluid (BALF) and stool confirmed the presence of P. aeruginosa infection. Subsequent antimicrobial susceptibility testing revealed that the P. aeruginosa isolate was pan-sensitive. Following 13 days of targeted antimicrobial therapy, the patient's symptoms and laboratory markers of infection improved significantly. A follow-up CT scan one month later demonstrated substantial resolution of the left lower lobe lesions, and the patient remained asymptomatic.</p><p><strong>Conclusions: </strong>This case, along with a review of related literature, suggests that geophagy may be a potential risk factor for P. aeruginosa infection. It underscores the importance of avoiding the consumption of unprocessed soil, which may be contaminated with pathogenic organisms.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107894"},"PeriodicalIF":4.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Helicobacter pylori (Hp) multiplex serology and its dynamics within families during a three-year prospective follow-up.","authors":"Kari Syrjänen, Sanni Rinne, Nea Koskela, Birgitta Michels, Julia Butt, Seija Grénman, Tim Waterboer, Stina Syrjänen, Karolina Louvanto","doi":"10.1016/j.ijid.2025.107893","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.107893","url":null,"abstract":"<p><strong>Objectives: </strong>Transmission routes of Helicobacter pylori (Hp) have been extensively studied, but many aspects remain unclear. This study explored the dynamics of multiplex Hp-serology within regular families during a 36-month prospective follow-up.</p><p><strong>Methods: </strong>Altogether 329 families from the Finnish Family HPV (FFHPV)-study were subjected to sequential blood sampling and now tested also for six Hp-proteins; HP0010, HP0073, HP0547, HP0875, HP0887, and HP1564 using Multiplex serology assay.</p><p><strong>Results: </strong>Hp-seropositivity, as defined by being seropositive to at least 3 of the 6 Hp proteins, was more common among the fathers (20%) than mothers (10%). After maternal antibody decay, only few children tested Hp-seropositive at later follow-up visits, indicating that acquisition of Hp-infection is practically non-existent (0.4% to 2.0%) at an early age. No evidence was found to support the person-to-person transmission of Hp in this cohort, as there was no correlation in Hp-seropositivity or antibody levels between the spouses and/or their offspring, and Hp-seropositive individuals did not seem to increase the risk of other family members to co-test Hp-seropositive.</p><p><strong>Conclusion: </strong>Our results perfectly agree with a recently published register-linkage study from Finland, where Hp and Hp-related co-morbidity are predicted to disappear among the native Finns during the 21^st century.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107893"},"PeriodicalIF":4.8,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Point-of-care testing reduces antibiotic prescribing in acute exacerbations of chronic obstructive pulmonary disease: a systematic review and meta-analysis.","authors":"Xiying Li, Shengyue Qiu, Chaojie Liu, Manzhi Zhao, Xinyi Yang, Haohai Xia, Ruonan Wang, Shanquan Chen, Jie Chen, Jinkun Zheng, Gordon Liu, Shifang Yang, Lianping Yang, Christopher C Butler","doi":"10.1016/j.ijid.2025.107889","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.107889","url":null,"abstract":"<p><strong>Background: </strong>Challenges in identifying the causes of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) have led to overuse of antibiotics. The advantages of point-of-care testing (POCT) may help to identify pathogens and use antibiotics more appropriately.</p><p><strong>Methods: </strong>We conducted a systematic review to evaluate the effect of POCT to guide antibiotic prescriptions for AECOPD. Adhering to a protocol (CRD42024555847), we searched eligible studies. The outcomes included antibiotic-related and clinical outcomes. We evaluated the risk of bias and performed meta-analyses with subgroup based on the type and testing timing of POCT.</p><p><strong>Results: </strong>A total of 18 studies evaluating 4,346 AECOPD patients were included. Overall, POCT significantly reduced the number of AECOPD patients given antibiotic prescriptions by 16% (p < 0.001). Additionally, antibiotic treatment was reduced by 1.19 days (p = 0.04). There was no detrimental impact on clinical outcomes, such as the length of hospital stay (p = 0.19). Our results proved robust to sensitivity analyses.</p><p><strong>Conclusions: </strong>We offered reasonable evidence for using POCT to reduce antibiotic exposure for AECOPD without adversely affecting clinical outcomes. As diagnostic techniques become increasingly important in combating antimicrobial resistance, the use of POCT should be encouraged.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107889"},"PeriodicalIF":4.8,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The First Reported Case of Monkeypox Virus Clade Ⅰb Infection in China - Clinical Presentation and Epidemiologic Implications.","authors":"Weizhe Pan, Rui Ge, Guoying Zhu, Yangyang Tian, Yong Yan, Xiaofei Fu, Wei Jiang, Dongfang Zhong, Zhongwen Chen","doi":"10.1016/j.ijid.2025.107881","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.107881","url":null,"abstract":"<p><p>Recently, Monkeypox Virus (MPXV) clade Ib has caused serious health hazards in several countries. Herein, we report the first case of a clade Ib MPXV infection in China. MPXV was detected in a 28-year-old female on January 2, 2025. Whole-genome sequencing analysis revealed the strain to be clade Ib. The case presented with headache and disseminated rashes, with symptoms resolving symptomatic treatment and scabs shedding prior to discharge. Epidemiological studies and laboratory tests suggested transmission through close contact with a man who recently came from the Democratic Republic of Congo. Significantly, although some environmental samples tested positive, all contacts reminded negative, indicating that absence of secondary transmission. Furthermore, the clinical presentation of this case showed different manifestations from clade IIb MPXV infections. Epidemiological patterns also suggested sexual transmission served as the predominant route for clade Ib MPXV spread. These findings provide critical insights to enhance early detection strategies and inform targeted intervention measures aimed at curbing disease progression while mitigating risks of wider community spread.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107881"},"PeriodicalIF":4.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"World TB Day 2025 Theme \"Yes! We Can End TB: Commit, Invest, Deliver\" can be made a reality through concerted global efforts to advance diagnosis, treatment and research of tuberculosis infection and disease.","authors":"Delia Goletti, Alberto Matteelli, Jacqueline M Cliff, Graeme Meintjes, Steve Graham, Hanif Esmail, Shui Shan Lee","doi":"10.1016/j.ijid.2025.107892","DOIUrl":"10.1016/j.ijid.2025.107892","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107892"},"PeriodicalIF":4.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of HIV-1 Transmission Clusters and Transmitted Drug Resistance in Men Who Have Sex With Men: A Multicenter Study in Portugal (2014-2019).","authors":"Ricardo Abrantes, Victor Pimentel, Cruz Sebastião, Mafalda N S Miranda, Sofia Seabra, Ana Rita Silva, António Diniz, Bianca Ascenção, Carmela Piñeiro, Carmo Koch, Catarina Rodrigues, Cátia Caldas, Célia Morais, Domitília Faria, Elisabete Gomes da Silva, Eugénio Teófilo, Fátima Monteiro, Fausto Roxo, Fernando Maltez, Fernando Rodrigues, Guilhermina Gaião, Helena Ramos, Inês Costa, Isabel Diogo, Isabel Germano, Joana Simões, Joaquim Oliveira, José Ferreira, José Poças, José Saraiva da Cunha, Jorge Soares, Kamal Mansinho, Liliana Pedro, Maria João Aleixo, Maria João Gonçalves, Maria José Manata, Margarida Mouro, Margarida Serrado, Micaela Caixeiro, Nuno Marques, Olga Costa, Patrícia Pacheco, Paula Proença, Paulo Rodrigues, Raquel Pinho, Raquel Tavares, Ricardo Correia de Abreu, Rita Côrte-Real, Rosário Serrão, Rui Sarmento E Castro, Sofia Nunes, Telo Faria, Teresa Baptista, Daniel Simões, Luis Mendão, M Rosário O Martins, Perpétua Gomes, Marta Pingarilho, Ana B Abecasis","doi":"10.1016/j.ijid.2025.107888","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.107888","url":null,"abstract":"<p><strong>Introduction: </strong>In the EU/EEA, MSM is a priority group for the prevention and control of HIV-1 infection. In Portugal, the 2023 HIV incidence rate was 8.2 per 100000 inhabitants, with 876 new infections, 41.7% in MSM. We aim to characterize HIV-1 transmission clusters (TC) and transmitted drug resistance (TDR) and its sociodemographic, behavioural, clinical, and viral genomic determinants in MSM newly diagnosed in Portugal between 2014 and 2019.</p><p><strong>Methods: </strong>340 MSM newly diagnosed with HIV-1 infection at 17 hospitals in Portugal were included. TC were identified with branch support ≥ 90% and 1.5% genetic distance. Logistic regression models were used to examine factors associated with TC and TDR.</p><p><strong>Results: </strong>We identified 38 TC with 104 MSM, which includes 81 (26.6%) of the 305 MSM from our sample included in cluster analysis. The overall prevalence of TDR was 8.2%. Only HIV-1 subtype C was significantly associated with TDR. 10.5% of the clusters had at least 1 Surveillance Drug Resistance Mutation (SDRM). There was no significant difference in the prevalence of TDR or the proportion of Portuguese and migrant MSM inside and outside clusters. Age at diagnosis, district of residence, unprotected sex with a woman, HIV testing, presenter status and HIV-1 subtype were significantly associated with TC.</p><p><strong>Conclusion: </strong>Specific subgroups of MSM are contributing to HIV-1 clustered transmission in Portugal. However, no association was found between TDR and sociodemographic or behavioural factors. Directed prevention measures should focus on those subgroups.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107888"},"PeriodicalIF":4.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progression of lymphatic filariasis antigenaemia and microfilaraemia over 4.5 years in antigen-positive individuals, Samoa 2019-2023.","authors":"Helen J Mayfield, Benn Sartorius, Ramona Muttucumaru, Sarah Sheridan, Maddison Howlett, Beatris Mario Martin, Shannon M Hedtke, Emma Field, Robert Thomson, Satupaitea Viali, Patricia M Graves, Colleen L Lau","doi":"10.1016/j.ijid.2025.107891","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.107891","url":null,"abstract":"<p><strong>Objectives: </strong>The first round of triple-drug mass drug administration (MDA) for lymphatic filariasis (LF) in Samoa was in 2018. This study aims to i) examine progression of LF antigen (Ag) and microfilaria (Mf) in Ag-positive individuals 2019- 2023; and ii) compare Ag/Mf prevalence in household members of Mf-positive versus Mf-negative participants.</p><p><strong>Methods: </strong>In 2023, we tested Ag-positive participants (indexes) from a 2019 survey in Samoa, and their household members. We tested for Ag (Alere/Abbott Filariasis Test Strip) and Mf. We examined changes in Ag/Mf status in index participants and compared Ag/Mf prevalence between household members of Mf-positive and Mf-negative indexes.</p><p><strong>Results: </strong>We recruited 91 indexes and 317 household members. In 2023, all 17 Mf-positive indexes remained Ag-positive and 11/15 with Mf results (73.3%) were Mf-positive. Of 74 Mf-negative indexes, 79.7% remained Ag-positive in 2023, and 31.1% became Mf-positive. Household members of Mf-positive indexes were more likely to be Ag-positive (OR 3.3, 95% CI 1.0-10.3) compared to those of Mf-negative indexes.</p><p><strong>Conclusion: </strong>Our results raise concerns regarding long-term effectiveness of a single dose of triple-drug MDA for sustained clearance of Mf in Samoa. Guidelines for follow-up and treatment of Ag/Mf-positive people and household members are urgently required.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107891"},"PeriodicalIF":4.8,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}