Evaluation of Clinical Characteristics, Risk Factors and Prognosis of Herpes Zoster (Shingles) Infection in Türkiye: VARICOMP-Adult-2 Study.

IF 4.3 2区医学 Q1 INFECTIOUS DISEASES

International Journal of Infectious Diseases Pub Date : 2025-10-07 DOI:10.1016/j.ijid.2025.108105

Ozge Ozgen-Top, Zehra Karacaer, Ece Firuze Ozkan, Hasan Selcuk Ozger, Nese Saltoglu, Nefise Oztoprak-Cuvalci, Ayse Seza Inal, Birsen Mutlu, Damla Boztas, Rehile Zengin, Alpay Azap, Sema Alp-Cavus, Ali Acar, Didem Tuba Akcalı, Irem Akdemir, Dilek Bayramgurler, Hande Berk-Cam, Ahmet Çagkan Inkaya, Dilek Dasgın, Secil Deniz, Gamze Erfan, Ozlem Guler, Nilsel Ilter, Behice Kurtaran, Zekayi Kutlubay, Selda Sayin-Kutlu, Ayse Sesin Kocagoz, Ener Cagri Dinleyici, Esin Senol

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引用次数: 0

Abstract

Objective: The study aimed to determine the estimated prevalence of herpes zoster (HZ) infection in the adult population in Türkiye and the rates of HZ-associated complications and risk factors.

Methods: This retrospective, multicenter (n=11), cross-sectional study was conducted between January 2016 and January 2022 and included all patients aged ≥18 years diagnosed with shingles following screening based on ICD-10 codes. The prevalence of HZ infection was calculated; rates of HZ-related complications (recurrence, hospitalization, postherpetic neuralgia [PHN]) and associated risk factors were determined.

Results: A total of 6114 HZ patients were included; the estimated 5-year HZ prevalence in Turkiye was 908.7 per 100,000 population. Of the patients, 851 (14.2%) were immunocompromised, 366 (6%) were hospitalized due to HZ, 284 (8.9%) experienced PHN, 97 (3.2%) experienced recurrence of the patients. Risk factors for PHN were older age (≥50 years [OR=3.19; p<0.001)], and trigeminal dermatome involvement (OR=2.45; p=0.006). Antiviral use was associated with reduced PHN risk (OR=0.16; p<0.001).

Conclusions: Our multicenter cross-sectional study revealed the high burden of HZ in Türkiye and highlighted the potential for increasing prevalence due to risk factors including aging and comorbidities.

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评估基ye带状疱疹（带状疱疹）感染的临床特征、危险因素和预后：VARICOMP-Adult-2研究

目的：本研究旨在确定日本成年人群中带状疱疹（HZ）感染的估计患病率以及与HZ相关的并发症和危险因素的发生率。方法：这项回顾性、多中心（n=11）、横断面研究于2016年1月至2022年1月进行，纳入所有年龄≥18岁、根据ICD-10编码筛查后诊断为带状疱疹的患者。计算HZ感染流行率；测定hz相关并发症（复发、住院、带状疱疹后神经痛[PHN]）及相关危险因素的发生率。结果：共纳入6114例HZ患者；土耳其5年HZ患病率估计为每10万人908.7例。其中免疫功能低下851例（14.2%），因HZ住院366例（6%），PHN 284例（8.9%），复发97例（3.2%）。结论：我们的多中心横断面研究揭示了基叶人HZ的高负担，并强调了由于年龄和合并症等危险因素导致患病率增加的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Infectious Diseases 医学-传染病学

CiteScore

18.90

自引率

2.40%

发文量

1020

审稿时长

30 days

期刊介绍： International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.