International Journal of Infectious Diseases最新文献

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Corrigendum to “Chronic nasal infection caused by Klebsiella rhinoscleromatis or Klebsiella ozaenae: two forgotten infectious diseases” [IJID 11 (2007) 423-429] “由鼻硬化克雷伯氏菌或ozaenae克雷伯氏菌引起的慢性鼻腔感染:两种被遗忘的传染病”的勘误表[ijid11 (2007) 423-429]
IF 4.8 2区 医学
International Journal of Infectious Diseases Pub Date : 2025-07-10 DOI: 10.1016/j.ijid.2025.107968
Elisabeth Botelho-Nevers , Frédérique Gouriet , Hubert Lepidi , Bernard Amphoux , Patrick Dessi , Didier Raoult
{"title":"Corrigendum to “Chronic nasal infection caused by Klebsiella rhinoscleromatis or Klebsiella ozaenae: two forgotten infectious diseases” [IJID 11 (2007) 423-429]","authors":"Elisabeth Botelho-Nevers , Frédérique Gouriet , Hubert Lepidi , Bernard Amphoux , Patrick Dessi , Didier Raoult","doi":"10.1016/j.ijid.2025.107968","DOIUrl":"10.1016/j.ijid.2025.107968","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"158 ","pages":"Article 107968"},"PeriodicalIF":4.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Authors' reply "Lessons from tuberculosis history". 作者的回复“结核病史的教训”。
IF 4.8 2区 医学
International Journal of Infectious Diseases Pub Date : 2025-07-07 DOI: 10.1016/j.ijid.2025.107977
Gerard de Vries, Rein M G J Houben, Hanif Esmail
{"title":"Authors' reply \"Lessons from tuberculosis history\".","authors":"Gerard de Vries, Rein M G J Houben, Hanif Esmail","doi":"10.1016/j.ijid.2025.107977","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.107977","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107977"},"PeriodicalIF":4.8,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Renal Talaromyces marneffei infection in a 29-year-old healthy woman. 1例29岁健康妇女肾感染。
IF 4.8 2区 医学
International Journal of Infectious Diseases Pub Date : 2025-07-07 DOI: 10.1016/j.ijid.2025.107976
Qinglin Zhong, Binglin Lai
{"title":"Renal Talaromyces marneffei infection in a 29-year-old healthy woman.","authors":"Qinglin Zhong, Binglin Lai","doi":"10.1016/j.ijid.2025.107976","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.107976","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107976"},"PeriodicalIF":4.8,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Herpes Zoster Duplex Bilateralis Symmetricus. 双侧对称带状疱疹。
IF 4.8 2区 医学
International Journal of Infectious Diseases Pub Date : 2025-07-04 DOI: 10.1016/j.ijid.2025.107975
Chun-Yu Cheng, Wan-Chen Lin
{"title":"Herpes Zoster Duplex Bilateralis Symmetricus.","authors":"Chun-Yu Cheng, Wan-Chen Lin","doi":"10.1016/j.ijid.2025.107975","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.107975","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107975"},"PeriodicalIF":4.8,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence of acute respiratory infections and their associated pathogen distribution among residents in Shanghai, China: preliminary results from community-based surveillance in the 2023-2024 influenza season 上海市居民急性呼吸道感染发病率及其相关病原体分布:2023-24年流感季节社区监测初步结果
IF 4.8 2区 医学
International Journal of Infectious Diseases Pub Date : 2025-07-03 DOI: 10.1016/j.ijid.2025.107974
Yilin Jia , Li Zhang , Yanxin Xie , Lipeng Hao, ChuChu Ye, Xinmei Zhou, Linghui Zhao, Bing Zhao, Yifeng Shen
{"title":"Incidence of acute respiratory infections and their associated pathogen distribution among residents in Shanghai, China: preliminary results from community-based surveillance in the 2023-2024 influenza season","authors":"Yilin Jia ,&nbsp;Li Zhang ,&nbsp;Yanxin Xie ,&nbsp;Lipeng Hao,&nbsp;ChuChu Ye,&nbsp;Xinmei Zhou,&nbsp;Linghui Zhao,&nbsp;Bing Zhao,&nbsp;Yifeng Shen","doi":"10.1016/j.ijid.2025.107974","DOIUrl":"10.1016/j.ijid.2025.107974","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to assess the risk of acute respiratory infections across distinct age demographics, analyze factors associated with infection, and characterize respiratory pathogen epidemiology in the post-COVID-19 era.</div></div><div><h3>Methods</h3><div>We conducted this longitudinal community-based surveillance study in Pudong New Area from November 2023 to January 2024. Questionnaires were designed to assess acute respiratory infection (ARI) incidence, and respiratory pathogens were detected among qualified patients with ARI. Pathogenic features were compared and analyzed among different age groups.</div></div><div><h3>Results</h3><div>A total of 6698 participants were included and completed the study. The overall ARI incidence was 2.55 (95% CI 2.42-2.68) per 1000 person-days. The incidence of ARI progressively decreased with increasing age. The factors significantly associated with infection were sex, employment, and chronic conditions among participants who reported symptoms. Influenza virus, <em>Haemophilus influenzae</em>, human rhinovirus, and human coronavirus were the most commonly detected viruses. The positive distribution rate was similar among all age groups. The influenza virus trend maintained a prolonged peak period.</div></div><div><h3>Conclusions</h3><div>The incidence of ARI exhibited a progressive decline with advancing age. Community-based surveillance identifies respiratory pathogen profiles during early or mild infections, complementing routine surveillance.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"158 ","pages":"Article 107974"},"PeriodicalIF":4.8,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Association between Antenatal SARS-CoV-2 Exposure and Infant Neurodevelopment at Four Months of Age: A Prospective Multicenter Cohort Survey within the COPE Study. 产前SARS-CoV-2暴露与4月龄婴儿神经发育之间的关系:COPE研究中的前瞻性多中心队列调查
IF 4.8 2区 医学
International Journal of Infectious Diseases Pub Date : 2025-07-03 DOI: 10.1016/j.ijid.2025.107973
Johan Berg, Karolina Linden, Mehreen Zaigham, Magnus Domellöf, Fredrik Ahlsson, Anders Elfvin, Ulrika Åden, Thomas Abrahamsson, Andreas Ohlin, Johannna Berg, Linda Hjertberg, Sofie Graner, Sophia Brismar Wendel, Linda Iorizzo, Sofie Arnkil, Ylva Carlsson, Malin Veje, Lina Bergman, Verena Sengpiel, Ola Andersson
{"title":"The Association between Antenatal SARS-CoV-2 Exposure and Infant Neurodevelopment at Four Months of Age: A Prospective Multicenter Cohort Survey within the COPE Study.","authors":"Johan Berg, Karolina Linden, Mehreen Zaigham, Magnus Domellöf, Fredrik Ahlsson, Anders Elfvin, Ulrika Åden, Thomas Abrahamsson, Andreas Ohlin, Johannna Berg, Linda Hjertberg, Sofie Graner, Sophia Brismar Wendel, Linda Iorizzo, Sofie Arnkil, Ylva Carlsson, Malin Veje, Lina Bergman, Verena Sengpiel, Ola Andersson","doi":"10.1016/j.ijid.2025.107973","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.107973","url":null,"abstract":"<p><strong>Objectives: </strong>It remains unclear whether antenatal SARS-CoV-2 exposure affects subsequent infant neurodevelopment. We aimed to investigate the association between antenatal maternal SARS-CoV-2 infection and neurodevelopment in four-month-old infants.</p><p><strong>Methods: </strong>Data was collected within the prospective multicenter COVID-19 during pregnancy and early childhood study, COPE (NCT04433364). Infants exposed to maternal SARS-CoV-2 infection from conception until two days postpartum and unexposed controls were included June 2020-December 2022.</p><p><strong>Primary outcome: </strong>four-month-old infant neurodevelopment, measured using the Ages and Stages Questionnaire 3<sup>rd</sup> Edition (ASQ) total mean scores.</p><p><strong>Secondary outcomes: </strong>Scores below cutoff for total ASQ or the ASQ domains.</p><p><strong>Results: </strong>Of 2,453 enrolled infants, 1,446 (555 exposed and 891 unexposed) had available ASQ data. In adjusted regression models, there was no group difference in ASQ total mean scores. Exposed infants had lower risk of fine motor domain scores below cutoff (exposed: 4.0% vs. unexposed: 6.6%; adjusted odds ratio (aOR), 0.55; 95% CI, 0.33-0.92). Infants exposed to severe maternal COVID-19 had increased risk of total ASQ scores below cutoff (exposed: 16.0% vs. unexposed: 6.1%; aOR, 3.57; 95% CI, 1.14-11.24).</p><p><strong>Conclusions: </strong>Antenatal maternal SARS-CoV-2 infection was not associated with overall impaired four-month infant neurodevelopmental screening. In exploratory analyses, severe maternal COVID-19 was associated with abnormal screening results.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107973"},"PeriodicalIF":4.8,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144567409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global assessment of partial artemisinin resistance: Multicenter trial across Kenya, Peru, and Thailand in patients with uncomplicated Plasmodium falciparum malaria. 部分青蒿素耐药的全球评估:肯尼亚、秘鲁和泰国非并发症恶性疟原虫疟疾患者的多中心试验。
IF 4.8 2区 医学
International Journal of Infectious Diseases Pub Date : 2025-07-02 DOI: 10.1016/j.ijid.2025.107971
B Andagalu, E Smith, S Durand, H O Valdivia, I Onyango, M Spring, V Pattaraporn, G C Baldeviano, E Majid, S Sriwichai, J Cummings, L Tapia, H Akala, P Gosi, C Cabezas, D Juma, S Wongararunkochakorn, M Sihuincha, C Chaisatit, L Chebon, W Kuntawunginn, A Halbach, C Kodchakorn, C Thamnurak, C Praditpol, P Saingam, K A Edgel, D Saunders, A Cheruiyot, I Chuang, E Milgotina, P Fernandes, A G Lescano, N Boonyalai, E Kamau, B M Forshey, S Cinkovich, D Bethell, K Jongsakul, M Fukuda
{"title":"Global assessment of partial artemisinin resistance: Multicenter trial across Kenya, Peru, and Thailand in patients with uncomplicated Plasmodium falciparum malaria.","authors":"B Andagalu, E Smith, S Durand, H O Valdivia, I Onyango, M Spring, V Pattaraporn, G C Baldeviano, E Majid, S Sriwichai, J Cummings, L Tapia, H Akala, P Gosi, C Cabezas, D Juma, S Wongararunkochakorn, M Sihuincha, C Chaisatit, L Chebon, W Kuntawunginn, A Halbach, C Kodchakorn, C Thamnurak, C Praditpol, P Saingam, K A Edgel, D Saunders, A Cheruiyot, I Chuang, E Milgotina, P Fernandes, A G Lescano, N Boonyalai, E Kamau, B M Forshey, S Cinkovich, D Bethell, K Jongsakul, M Fukuda","doi":"10.1016/j.ijid.2025.107971","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.107971","url":null,"abstract":"<p><strong>Introduction: </strong>Artemisinin-resistant Plasmodium falciparum challenges the effectiveness of all artemisinin-based combination therapies.</p><p><strong>Methods: </strong>We conducted a clinical study in Peru, Kenya, and Thailand between June 2013 and November 2015 in subjects treated with three standard doses of artesunate followed by two doses of mefloquine. The primary endpoint was parasite clearance half-life (PC<sub>1/2</sub>) during the 72-hour period of treatment. Secondary endpoints included clinical outcome at 42 days, detection of kelch13 (K13) mutations, pharmacokinetics and pharmacodynamics.</p><p><strong>Results: </strong>The mean PC<sub>1/2</sub> was higher in the Thai (4.1 hours) than Peruvian (2h) or Kenyan cohorts (2.2h) (p<0.0001). Higher PC<sub>1/2</sub> was partially explained by K13 mutations in 13 (28%) of 46 Thai subjects, including WHO validated and candidate mutations. Twelve (26%) Thai cohort subjects had PC<sub>1/2</sub>≥5h with parasites from nine subjects carrying K13 mutations. There was an overall 42-day cure rate of 100% across all subjects.</p><p><strong>Conclusions: </strong>This is the first concurrent evaluation of artemisinin resistance across three continents. The presence of 11% Thai subjects that satisfied WHO criteria for drug resistance establishes this area as endemic. Longer PC<sub>1/2</sub> found in wildtype and candidate K13 mutant infections within the Thai cohort require further investigation to identify alternative mechanisms of resistance.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107971"},"PeriodicalIF":4.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics of juvenile-onset recurrent respiratory papillomatosis in China, 2011-2021: a hospital-based nationwide study. 2011-2021年中国青少年复发性呼吸道乳头状瘤病的特征:一项以医院为基础的全国性研究
IF 4.8 2区 医学
International Journal of Infectious Diseases Pub Date : 2025-07-01 DOI: 10.1016/j.ijid.2025.107972
Changchang Dun, Yutong Li, Wenbin Lei, Yun Li, Hui Yang, Yalikun Yasen, Nilipaer Alimu, Dapeng Lei, Dongyan Chen, Qingquan Hua, Zhen Xu, Zhe Zhang, Guangke Wang, Weiwei Wang, Li Shi, Xin Wang, Xuelian Zhao, Shangying Hu, Xiaoguang Ni, Jie Zhang, Jun Wang, Fanghui Zhao
{"title":"Characteristics of juvenile-onset recurrent respiratory papillomatosis in China, 2011-2021: a hospital-based nationwide study.","authors":"Changchang Dun, Yutong Li, Wenbin Lei, Yun Li, Hui Yang, Yalikun Yasen, Nilipaer Alimu, Dapeng Lei, Dongyan Chen, Qingquan Hua, Zhen Xu, Zhe Zhang, Guangke Wang, Weiwei Wang, Li Shi, Xin Wang, Xuelian Zhao, Shangying Hu, Xiaoguang Ni, Jie Zhang, Jun Wang, Fanghui Zhao","doi":"10.1016/j.ijid.2025.107972","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.107972","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the demographic and clinical characteristics, treatment and health outcome, and economic burden of JoRRP in China.</p><p><strong>Methods: </strong>We identified twelve hospitals mainly responsible for JoRRP management across China to enroll patients presenting for JoRRP between Jan 1, 2011, and Dec 31, 2021. Data were primarily extracted from medical records, and missing values were additionally collected through telephone or outpatient interviews by two researchers independently. We used counts (proportions) and median values (interquartile range, IQR) to describe data. We applied the Lorenz curve and the concentration index (C-index) to indicate the wealth-related and education-related inequalities in JoRRP.</p><p><strong>Results: </strong>Of the 361 enrolled JoRRP patients, the median age at first diagnosis was 2.7 years (IQR: 1.5-5.0). During the 7.2-year median follow-up, we observed that 314 (87.0%) patients experienced relapse and 125 (38.0%) patients underwent aggressive clinical course. The median value for the estimated total economic costs per patient was 8717.5$ (IQR: 4700.6$-15359.1$) and the occurrence of catastrophic health expenditure was concentrated in families with low incomes and less-educated parents.</p><p><strong>Conclusions: </strong>Chinese JoRRP patients experienced significant disease burden characterized by severe clinical symptoms and substantial economic costs. Strategic healthcare plans for JoRRP are needed for disease mitigation in China.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107972"},"PeriodicalIF":4.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of COVID-19 non-pharmaceutical interventions on the epidemic trends of scarlet fever in China: A population-based surveillance and modeling study. COVID-19非药物干预对中国猩红热流行趋势的影响:基于人群的监测和建模研究
IF 4.8 2区 医学
International Journal of Infectious Diseases Pub Date : 2025-06-27 DOI: 10.1016/j.ijid.2025.107969
Xiaojuan Zhang, Yuanhai You, Jie Liu, Lu Sun, Haijian Zhou, Xingxing Zhang, Bike Zhang
{"title":"Effect of COVID-19 non-pharmaceutical interventions on the epidemic trends of scarlet fever in China: A population-based surveillance and modeling study.","authors":"Xiaojuan Zhang, Yuanhai You, Jie Liu, Lu Sun, Haijian Zhou, Xingxing Zhang, Bike Zhang","doi":"10.1016/j.ijid.2025.107969","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.107969","url":null,"abstract":"<p><strong>Background: </strong>This study analyzed the epidemiological patterns of scarlet fever, and any changes therein, before, during, and after the COVID-19 pandemic in China and provided new perspectives for optimizing prevention and control strategies.</p><p><strong>Methods: </strong>Data for clinically diagnosed and laboratory-confirmed cases between January 1, 2005, and December 31, 2024, were collected from the National Notifiable Infectious Disease Surveillance System. Descriptive analysis was used to summarize the characteristics in pre-COVID-19 (2005-2019), during COVID-19 (2020-2022), and post-COVID-19 (2023-2024) periods. Dynamic changes in distribution pattern were explored through spatial autocorrelation analysis. A seasonal autoregressive integrated moving average (SARIMA) model was constructed to evaluate impact of non-pharmaceutical interventions (NPIs) on disease.</p><p><strong>Findings: </strong>During 2005-2024, 876,680 cases were reported (crude annual incidence: 3.22/100 000). The annual morbidity rates for three periods were 3.56, 1.58, and 3.25/100 000. Significant differences were observed among the periods (P < 0.001). The actual cases during COVID-19 period decreased by 78.43% compared to the SARIMA model predictions. Significant geography-based clustering of cases was identified.</p><p><strong>Interpretation: </strong>It demonstrated exceptional impacts of NPIs on the epidemic trends and high-risk regions of scarlet fever in China. Hence, tight surveillance programs are needed to protect populations against future pandemics.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107969"},"PeriodicalIF":4.8,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global burden of tuberculosis among adults aged 60 years and older, 1990-2021: Findings from the global burden of disease study 2021 1990-2021年60岁及以上成年人全球结核病负担:2021年全球疾病负担研究结果
IF 4.8 2区 医学
International Journal of Infectious Diseases Pub Date : 2025-06-26 DOI: 10.1016/j.ijid.2025.107966
Junping Liu , Yue Zhou , Juan Guan , Yaping Liu , Weijian Song , Wei Liu , Xinle Yin , Yuqin Liu , Ting Li , Long Jin , Lihan Zhang , Yunkai Li , Lin Wu , Nan Wang , Zhaoyue Liu , Xinru Liu , Yanfu Wang , Qunhong Wu , Libo Liang
{"title":"Global burden of tuberculosis among adults aged 60 years and older, 1990-2021: Findings from the global burden of disease study 2021","authors":"Junping Liu ,&nbsp;Yue Zhou ,&nbsp;Juan Guan ,&nbsp;Yaping Liu ,&nbsp;Weijian Song ,&nbsp;Wei Liu ,&nbsp;Xinle Yin ,&nbsp;Yuqin Liu ,&nbsp;Ting Li ,&nbsp;Long Jin ,&nbsp;Lihan Zhang ,&nbsp;Yunkai Li ,&nbsp;Lin Wu ,&nbsp;Nan Wang ,&nbsp;Zhaoyue Liu ,&nbsp;Xinru Liu ,&nbsp;Yanfu Wang ,&nbsp;Qunhong Wu ,&nbsp;Libo Liang","doi":"10.1016/j.ijid.2025.107966","DOIUrl":"10.1016/j.ijid.2025.107966","url":null,"abstract":"<div><h3>Objectives</h3><div>Tuberculosis (TB) poses a significant threat to global public health, particularly, among elderly individuals. This study aimed to provide a comprehensive analysis of the patterns and temporal trends in the global disease burden of HIV-negative TB among adults aged ≥60 years from 1990 to 2021.</div></div><div><h3>Methods</h3><div>Data on incidence, deaths, and disability-adjusted life-years of TB, drug-susceptible TB, multidrug-resistant TB (MDR-TB), and extensively drug-resistant TB (XDR-TB) were obtained from the Global Burden of Disease 2021. Frontier analysis was carried out to pinpoint areas for enhancement and disparities among nations stratified by development level. The Bayesian age-period-cohort model was used to forecast disease burden trends through 2035.</div></div><div><h3>Results</h3><div>A decreasing trend in age-standardized incidence rate, age-standardized mortality rate, and disability-adjusted life-years rates for TB and drug-susceptible TB was observed among the elderly population worldwide, whereas an upward trend was noted for MDR-TB and XDR-TB. Frontier analyses revealed a potential for burden alleviation among diverse nations and regions, with high socio-demographic index nations, such as the Republic of Korea, showing higher disease burden than expected for their sociodemographic development. The Bayesian age-period-cohort model revealed that by 2035, the MDR-TB and XDR-TB burden will continue increasing in the elderly population.</div></div><div><h3>Conclusions</h3><div>The increasing MDR-TB and XDR-TB burden in older individuals underscores the need for tailored interventions to combat TB burden, such as implementing active case finding among adults aged 60 years and older.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"158 ","pages":"Article 107966"},"PeriodicalIF":4.8,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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