International Journal of Infectious Diseases最新文献

{"title":"Prevention of RSV bronchiolitis in infants with maternal immunization or monoclonal antibodies for the newborn: What do women choose?","authors":"Salomé Azeroual, Domenico Benvenuto, Antoine Perrin, Paul Rey, Odile Launay, Caroline Charlier, Olivia Anselem","doi":"10.1016/j.ijid.2026.108753","DOIUrl":"https://doi.org/10.1016/j.ijid.2026.108753","url":null,"abstract":"<p><strong>Introduction: </strong>Maternal vaccination against RSV and nirsevimab administered to the newborn are the two strategies equally recommended in France for preventing lower respiratory tract infection (LRTI) caused by respiratory syncytial virus (RSV) in infants. Data about their respective uptake and factors influencing mother's choice are still lacking.</p><p><strong>Methods: </strong>We conducted a survey through an anonymous self-administered questionnaire that was proposed during post-partum hospitalization to all mothers who gave birth in January 2025 in a French university hospital maternity ward. We collected data to assess the respective administration rates of both methods and analysed reasons underlying women's choice : prior knowledge of RSV prevention, information received during pregnancy, and factors associated with the choice of each preventive strategy.</p><p><strong>Results: </strong>Of the 401 mothers eligible during the survey period, 274 were included. In all, 73.7% (202/274) chose maternal vaccination, 19.3% (53/274) chose nirsevimab and 6.9% (19/274) did not choose any prevention. Mothers who opted for maternal vaccination (n=202) stated that their choice was guided by immediate protection at birth (81.2%), the absence of injection for their newborn (60.4%) and the advice of their gynaecologist or midwife (49.5%). Mothers who opted for nirsevimab (n=53) stated that their choice was guided by the lack of long-term safety data on the vaccine (39.6%) and fear of vaccine adverse effects (35.8%).</p><p><strong>Conclusion: </strong>Within one year of its introduction in France, maternal RSV vaccination was the predominant chosen strategy for preventing bronchiolitis in this study population. This is likely due to the preventive advice they received from healthcare professionals, as well as their desire to avoid an injection for their newborn.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108753"},"PeriodicalIF":4.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ESBL positivity as an independent predictor of Clostridioides difficile infection: a retrospective cohort study.","authors":"Marek Duricek, Hynek Bartos, Katarina Halmova, Yahya Hassan, Dita Smiskova, Radka Stepanova, Olga Dzupova, Jiri Benes","doi":"10.1016/j.ijid.2026.108755","DOIUrl":"https://doi.org/10.1016/j.ijid.2026.108755","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the association between intestinal colonization with multidrug-resistant (MDR) bacteria and the occurrence of Clostridioides difficile infection (CDI).</p><p><strong>Methods: </strong>We conducted a retrospective cohort study at a tertiary-care infectious diseases department in Prague, Czech Republic, including adults tested for C. difficile between January and December 2024. CDI cases were defined as diarrhoeal patients with positive antigen and toxin by enzyme immunoassay. Controls were symptomatic patients negative for both tests. Stool samples were screened for MDR bacteria, including extended-spectrum beta-lactamase-producing Enterobacterales (ESBL), vancomycin-resistant enterococci (VRE), and carbapenemase-producing organisms. Univariable and multivariable logistic regression analyses identified independent predictors of CDI.</p><p><strong>Results: </strong>Among 192 patients, 100 had CDI and 92 served as controls. ESBL colonization was more frequent in CDI patients (52.0% vs. 23.9%, p<0.001). In multivariable analysis, prior antibiotic exposure (OR 2.67; 95% CI 1.30-5.49; p=0.008) and ESBL colonization (OR 2.86; 95% CI 1.49-5.52; p=0.002) were independently associated with CDI. Previous ICU admission showed borderline significance (OR 2.02; 95% CI 0.95-4.28; p=0.068). VRE was not independently associated, and no carbapenemase-producing organisms were detected.</p><p><strong>Conclusion: </strong>ESBL colonization is independently associated with increased odds of CDI and may support risk stratification and antimicrobial stewardship.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108755"},"PeriodicalIF":4.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjuvant multisite bacteriophage cocktail administration as salvage treatment in a patient with a multidrug-resistant Pseudomonas aeruginosa frontal relapsing complex osteitis.","authors":"Aurore Denis, Tristan Ferry, Franck Jegoux, Tiphaine Menez, Thomas Briot, Rafael Gomes, Cindy Fevre, Alexia Le Corre, Matthieu Revest, David Luque Paz","doi":"10.1016/j.ijid.2026.108756","DOIUrl":"https://doi.org/10.1016/j.ijid.2026.108756","url":null,"abstract":"<p><strong>Background: </strong>Bone infection due to multidrug-resistant (MDR) Pseudomonas aeruginosa is associated with poor outcomes, especially high risk of relapses. Adjunctive multisite phage therapy can be used as a salvage treatment in relapsing cases.</p><p><strong>Case presentation: </strong>We treated a 37-year-old man with MDR P. aeruginosa frontal osteitis and a large frontal fistula, who experienced three relapses, using personalized multisite phage therapy combined with surgery and prolonged antibiotics (ceftolozane/tazobactam). The multisite phage administration included in situ instillation of the manufactured phage cocktail during surgery, followed by daily intravenous infusion and nebulization for seven days after surgery. No adverse events were reported during treatment. At the two-year follow-up, the patient had no relapse without any suppressive treatment.</p><p><strong>Conclusion: </strong>Multisite phage administration is a personalized treatment strategy that can prevent relapse or the emergence of additional antimicrobial resistance in complex cases, such as relapsing MDR P. aeruginosa osteitis.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108756"},"PeriodicalIF":4.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 Hospitalisations in women of childbearing age and children during the Omicron period, January 2023 to September 2024.","authors":"Leonie Lewis, Doaa Mohammed, Laith Evans, Ben Patterson, Kirsten Lee, Eva Galiza, Borbala Zsigmond, Asma Khalil, Paul Heath, Shamez N Ladhani","doi":"10.1016/j.ijid.2026.108746","DOIUrl":"https://doi.org/10.1016/j.ijid.2026.108746","url":null,"abstract":"<p><strong>Objectives: </strong>In the UK, healthy children and pregnant women are no longer offered COVID-19 vaccination. This study assessed the outcomes of children and women-of-childbearing-age admitted to a large London hospital with SARS-CoV-2.</p><p><strong>Methods: </strong>Electronic records of children and women-of-childbearing-age with a positive SARS-CoV-2 PCR (January 2023-September 2024) were reviewed. Hospital Episode Statistics (HES) database disease-coding accuracy was evaluated.</p><p><strong>Results: </strong>Over 20 months, 334/4764 (7.0%) SARS-CoV-2 tests in children were positive; 150/334 (44.9%) were hospitalised (representing 0.81% of 18,412 childhood admissions); of these, 121 were non-incidental infections (0.66% of childhood admissions), including 26/121 (21.4%) with severe COVID-19 (0.14% of childhood admissions). COVID-19 was the sole diagnosis in 68 healthy children (55 infants, 13 older children), including five with severe COVID-19. In non-pregnant women, 295/7,181 (4.1%) tests were positive, 95 (95/295, 32.2%) were hospitalised; 12 (12.6%) were non-incidental, including two at-risk women with severe COVID-19. In pregnant women, 46/124 (37.1%) tests were positive (representing 0.82% of 5,630 pregnancies); nine (9/46, 19.6%) were hospitalised (0.15% of pregnancies), including four with non-incidental COVID-19, (0.07% of pregnancies), and none had severe COVID-19. Comparison with HES found 19/29 (65.5%) of incidental infections in children and 37/88 (42.0%) in women were coded as primary COVID-19 hospitalisations, while 15/150 (10.0%) of admissions in children and 36/104 (34.6%) of admissions in women had no associated ICD-10 code.</p><p><strong>Conclusions: </strong>Rates of severe COVID-19 were low. National databases for SARS-CoV-2 surveillance need to capture disease activity more accurately.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108746"},"PeriodicalIF":4.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of primary cutaneous nocardiosis presenting as unilateral papulopustular eruption in an immunocompetent host.","authors":"Yifei Wang, He Zhao, Liuqing Chen, Bin Hu","doi":"10.1016/j.ijid.2026.108747","DOIUrl":"https://doi.org/10.1016/j.ijid.2026.108747","url":null,"abstract":"<p><p>Primary cutaneous nocardiosis is often challenging to diagnose in a timely manner due to its diverse and nonspecific clinical manifestations, compounded by the difficulty in culturing and identifying Nocardia species. This case report describes a patient with primary cutaneous nocardiosis caused by Nocardia brasiliensis, who presented with normal immune function and no significant history of trauma. The patient initially developed blood blisters on the ankle, which then spread to papules and pustules throughout the entire left lower limb. Through repeated secretion of bacterial cultures and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF-MS) technology, the Brazilian Nocardia species was identified and subsequently treated with trimethoprim-sulfamethoxazole (TMP-SMX). This case underscores the importance of repeated microbiological testing and the use of advanced diagnostic techniques, including MALDI-TOF-MS, when confronted with atypical infectious symptoms. It also highlights the critical role of early diagnosis and treatment in improving patient outcomes.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108747"},"PeriodicalIF":4.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cooperative surveillance association and incidence of infectious diseases in Japanese nursery schools.","authors":"Junko Kurita, Kyoko Mukasa, Yukari Kawana, Mizuho Kaneko, Aya Yamaguchi, Asami Sunadori, Saki Hiraguri, Nobuhiro Murata, Tamie Sugawara, Minako Sugiyama, Hirotoshi Watase, Michiko Nohara","doi":"10.1016/j.ijid.2026.108757","DOIUrl":"https://doi.org/10.1016/j.ijid.2026.108757","url":null,"abstract":"<p><strong>Background: </strong>The Nursery School Absenteeism Surveillance System (NSASSy) has operated since 2010, but assessing NSASSy effectiveness at controlling outbreaks has been difficult.</p><p><strong>Object: </strong>This study was conducted to demonstrate NSASSy effects for reducing infectious disease incidence at NSASSy-participating nursery schools.</p><p><strong>Methods: </strong>In two cities, we acquired NSASSy information from nursery schools with more than 80 children. The study period for one city extended from April 1, 2016 through March in 2019, and for another city from January 1, 2024 through May 20, 2025. We examined the incidence of influenza and COVID-19 and symptoms for age classes at each facility compared to their proportions of data entry to NSASSy, community outbreaks in national official surveillance, and their mutual interaction terms. The estimation procedure was the individual effect model with a random effect of the facility.</p><p><strong>Results: </strong>The relation of influenza to community outbreak was found to be significant and positive. Interaction terms between data entry rates and community outbreaks were significant and negative for both cities. For COVID-19, no association was found. Regarding symptoms, for all symptoms and fever, relations to data entry rates were significant and negative in both cities. Regarding respiratory symptoms and diarrhea, the rate was significant and negative in one city.</p><p><strong>Discussion and conclusion: </strong>Results show that NSASSy mitigated community influenza outbreak effects on outbreaks at nursery schools not only before the COVID-19 pandemic, but also after the pandemic. Moreover, NSASSy reduced the rates of incidence of all symptoms.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108757"},"PeriodicalIF":4.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do the protein-based meningococcal group B vaccines, 4CMenB and MenB-fHbp elicit serum bactericidal antibody against meningococcal serogroup X clonal complex 181?","authors":"Townsend-Payne K, Hill E, Ali H, Mabey L, Clark Sa, Basta Ne, Linley E, Borrow R","doi":"10.1016/j.ijid.2026.108752","DOIUrl":"https://doi.org/10.1016/j.ijid.2026.108752","url":null,"abstract":"<p><strong>Background: </strong>Bexsero (4CMenB) and Trumenba (MenB-fHbp) were designed and licensed to protect against meningococcal serogroup B disease, however, the antigens in these vaccines are shared among other meningococcal serogroups. This study assessed the immunogenicity of the two licensed serogroup B vaccines against a hyperinvasive serogroup X strain.</p><p><strong>Methods: </strong>Sera from adults immunised with either 4CMenB (before and after 1, 2 or 3 doses of vaccine) or MenB-fHbp (before and after 2 doses) were assayed in the Serum Bactericidal Antibody (SBA) assay against serogroup X BF 2/97.</p><p><strong>Results: </strong>A four-fold increase in SBA titres were seen in 70.0% (95% CI: 45.7-88.1) and 51.5 % (95% CI: 41.3-61.6) of subjects following 2 doses of 4CMenB and MenB-fHbp, respectively. A significant increase in SBA GMT and percentage of subjects with SBA titres ≥4 from baseline to post two doses of both serogroup group B vaccines was observed.</p><p><strong>Conclusions: </strong>These data provide evidence that the licensed serogroup B vaccines can induce bactericidal antibodies against serogroup X, but it is noted the optimal control for serogroup X would be use of a conjugate vaccine that reduces acquisition of carriage as well as giving direct protection.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108752"},"PeriodicalIF":4.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Syphilis Status Associated with the Natural History of Anal HPV Infection: An Observational Cohort Study from Xinjiang, China.","authors":"Wenhui Yu, Jingjing He, Shulipan Asilibieke, Can Gao, Zewen Zhang, Guozhen Zhang, Heng Yang, Wenjie Zhang, Haoyu Wu, Tian Tian, Jianghong Dai","doi":"10.1016/j.ijid.2026.108738","DOIUrl":"https://doi.org/10.1016/j.ijid.2026.108738","url":null,"abstract":"<p><strong>Background: </strong>Studies on the association between syphilis positivity on the natural history of HPV infection among men who have sex with men (MSM) are limited. This study aims to assess the impact of syphilis status on the prevalence, incidence, and clearance of anal HPV in MSM.</p><p><strong>Methods: </strong>This study utilized data from a prospective cohort of aged 18 years and older HIV-negative MSM conducted in Xinjiang, China, from May 2016 to November 2025. Self-administered questionnaires collected baseline and every 6 months data on demographics and sexual behaviors. Anal swabs were taken for HPV genotyping, and blood samples for syphilis testing. We compared HPV prevalence, incidence, and clearance rate among syphilis positive and syphilis negative MSM. Poisson regression models were used to calculate prevalence ratios (PRs), incidence rate ratios (IRRs), and clearance rate ratios (CRRs).</p><p><strong>Results: </strong>A total of 743 MSM were included, with a median age of 35 years [IQR: 29-41]. Among them, 186 tested positive for syphilis, while 557 tested negative. The syphilis positive MSM exhibited slightly higher prevalence of any HPV, high-risk HPV, low-risk HPV, and 9v HPV compared to the syphilis negative MSM. During follow-up, after adjustment for age, number of sexual partners in the past six months, and other potential confounders, the syphilis positive MSM exhibited significantly higher incidence of any HPV (IRR=1.37, 95% CI: 1.02-1.84) and low-risk HPV (IRR=1.53, 95% CI: 1.07-2.2). The clearance rate for any HPV (CRR=1.35, 95% CI: 1.01-1.81) and high-risk HPV (CRR=1.71, 95% CI: 1.20-2.43) were also significantly higher among the syphilis positive MSM.</p><p><strong>Conclusion: </strong>Syphilis is a risk factor for HPV prevalence and incidence. Future HPV prevention strategy should adopt an integrated approach that concurrently addresses syphilis and other sexually transmitted infections.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108738"},"PeriodicalIF":4.3,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatal Severe Fever with Thrombocytopenia Syndrome Associated with Multiorgan Failure and Unusual Cutaneous Manifestations: Evidence of Rhipicephalus sanguineus (Brown Dog Tick) Transmission.","authors":"Sarawut Khongwichit, Watchaporn Chuchaona, Preeyaporn Vichaiwattana, Wichan Bhunyakitikorn, Peeriya Watakulsin, Supacha Sripirom, Saovanee Benjamanukul, Suchada Pongsuttiyakorn, Nantasak Musiksilp, Nattaree Lorrungruangchai, Withita Jangiam, Kamonpan Charoenkul, Alongkorn Amonsin, Yong Poovorawan","doi":"10.1016/j.ijid.2026.108751","DOIUrl":"https://doi.org/10.1016/j.ijid.2026.108751","url":null,"abstract":"<p><p>Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne viral infection endemic in East Asia and increasingly reported in Southeast Asia, including Thailand, where reports of severe and fatal disease remain limited. We describe a fatal case in a 54-year-old Thai man with fulminant multiorgan failure, secondary hemophagocytic lymphohistiocytosis, and atypical hemorrhagic vesiculobullous skin lesions. SFTSV RNA was detected by real-time RT-PCR in multiple specimens, indicating systemic viral dissemination. An epidemiological investigation collected 268 ticks from stray dogs, the patient's dog, and the bedroom environment; all were morphologically identified as Rhipicephalus sanguineus. Six ticks tested positive for SFTSV RNA, with species identity of positive ticks confirmed by 16S rRNA gene sequencing. Phylogenetic analysis of the S, M, and L coding sequences showed clustering of tick-derived viruses with the patient-derived virus and strains from Thailand and China. These findings suggest a potential role of R. sanguineus, a common domestic dog-associated tick in Thailand, as a potential vector for human infection. This case highlights an unusual cutaneous presentation with extensive vesiculobullous lesions, underscoring the need for increased clinical awareness and domestic tick surveillance.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108751"},"PeriodicalIF":4.3,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Outcomes of a Complex Outpatient Oral Antimicrobial Therapy [COpAT] Clinic for Deep-Seated Infections in Singapore.","authors":"Tiara Joy Foo, Matthew Chung Yi Koh, Jinghao Nicholas Ngiam, Brenda Mae Alferez Salada, Dale Fisher, Sophia Archuleta, Jolene Oon Ee Ling","doi":"10.1016/j.ijid.2026.108750","DOIUrl":"https://doi.org/10.1016/j.ijid.2026.108750","url":null,"abstract":"<p><p>Following the COPAT randomized trial demonstrating improved safety with early outpatient oral antibiotics, we report outcomes from such a clinic in Singapore. In this observational cohort of deep-seated infections, we found that relapse of infection and oral-to-intravenous antibiotic switch were uncommon, supporting feasibility of this approach in the real-world setting.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108750"},"PeriodicalIF":4.3,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147814721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}