International Journal of Infectious Diseases最新文献

{"title":"A case of Ustilago spp. infection identified by whole genome sequencing in a pediatric patient undergoing open-chest extracorporeal membrane oxygenation","authors":"Valeria Fox ,&nbsp;Gianluca Vrenna ,&nbsp;Gianluca Foglietta ,&nbsp;Luna Colagrossi ,&nbsp;Barbara Lucignano ,&nbsp;Manuela Onori ,&nbsp;Venere Cortazzo ,&nbsp;Marilena Agosta ,&nbsp;Martina Rossitto ,&nbsp;Maria del Carmen Pereyra Boza ,&nbsp;Vanessa Fini ,&nbsp;Annarita Granaglia ,&nbsp;Maria Giovanna Paglietti ,&nbsp;Elisabetta Verrillo ,&nbsp;Renato Cutrera ,&nbsp;Paola Bernaschi ,&nbsp;Carlo Federico Perno","doi":"10.1016/j.ijid.2024.107320","DOIUrl":"10.1016/j.ijid.2024.107320","url":null,"abstract":"<div><h3>Objectives</h3><div>Patients undergoing extracorporeal membrane oxygenation (ECMO) are susceptible to fungal infections, also from rare or emerging pathogens. We present a case of a 3-year-old male patient hospitalized for respiratory failure and subjected to open-chest ECMO support, with a fungal infection from a pathogen not identifiable by standard methods.</div></div><div><h3>Methods</h3><div>Although T2Candida panel (T2 Biosystems) resulted negative, blood cultures resulted positive for fungi after 4 days, confirmed by Gram staining. The fungus underwent typing using Bruker matrix-assisted laser desorption ionization-time of flight mass spectrometry system and Autobio Autof ms1000, which could not precisely identify the microorganism. Ultimately, whole genome sequencing (WGS) was performed directly on blood culture.</div></div><div><h3>Results</h3><div>WGS analysis revealed in 5 days the presence of a fungus belonging to the <em>Ustilago</em> genus, a group of fungi commonly found in the environment but rarely causing human diseases.</div></div><div><h3>Conclusions</h3><div>To the best of our knowledge, we presented the first case of an <em>Ustilago</em> spp infection in a pediatric patient undergoing ECMO, not identified by standard techniques but only by WGS performed directly on a blood sample in 5 days. Despite the paucity of literature on <em>Ustilago</em> spp infections treatment, therapy adjustments led to the eradication of the pathogen, underscoring the importance of advanced molecular techniques for the correct and timely identification of these microorganisms.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"151 ","pages":"Article 107320"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coinfection and clinical impact of enterotoxigenic Escherichia coli harboring diverse toxin variants and colonization factors: 2017-2022","authors":"Mohammad Ashraful Amin ,&nbsp;Marjahan Akhtar ,&nbsp;Zahid Hasan Khan ,&nbsp;Md Taufiqul Islam ,&nbsp;Md. Golam Firoj ,&nbsp;Yasmin Ara Begum ,&nbsp;Sadia Isfat Ara Rahman ,&nbsp;Mokibul Hassan Afrad ,&nbsp;Taufiqur Rahman Bhuiyan ,&nbsp;Fahima Chowdhury ,&nbsp;A.S.G. Faruque ,&nbsp;Edward T Ryan ,&nbsp;Firdausi Qadri ,&nbsp;Ashraful Islam Khan","doi":"10.1016/j.ijid.2024.107365","DOIUrl":"10.1016/j.ijid.2024.107365","url":null,"abstract":"<div><h3>Objectives</h3><div>The severity of the diarrhea disease is exacerbated by co-infections that involve Enterotoxigenic <em>Escherichia coli</em> (ETEC) and other enteric pathogens, which complicate the diagnosis and treatment. This study explores the prevalence, clinical manifestations, and risk factors of ETEC and its co-infections in Dhaka, Bangladesh.</div></div><div><h3>Methods</h3><div>The study used data from the Diarrheal Disease Surveillance System at Dhaka Hospital, involving 16,276 patients from 2017 to 2022. We identified 1404 ETEC-positive patients from the 16,276 data points to investigate the association between ETEC infections, co-infections, and clinical outcomes.</div></div><div><h3>Results</h3><div>ETEC was identified in 1404 (8.6%) of cases, representing the most common infection among adults (56.6%). ETEC co-infection occurred combined with <em>V. cholerae</em> (23%), <em>Aeromonas</em> (14.6%), rotavirus (11.8%), <em>Campylobacter</em> (6.5%), and <em>Shigella</em> spp. (1.7%), respectively. Adults were more likely to develop co-infections with ETEC and <em>V. cholerae</em>, while children under five were more likely to develop ETEC co-infections with rotavirus. Co-infections with <em>V. cholerae</em>, rotavirus, and <em>Salmonella</em> spp. increased the likelihood of fever, while ETEC co-infections with <em>V. cholerae</em> increased risks of vomiting, dehydration, and intravenous fluids.</div></div><div><h3>Conclusions</h3><div>ETEC and co-infections exacerbate illness severity and overburden healthcare systems. Policymakers should prioritize resilient healthcare strategies for ETEC and co-infections.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"151 ","pages":"Article 107365"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ATP-binding cassette transporters and drug resistance in cutaneous leishmaniasis","authors":"Marina B.R. de Santana ,&nbsp;Giulia O. Miranda ,&nbsp;Lucas P. Carvalho","doi":"10.1016/j.ijid.2024.107315","DOIUrl":"10.1016/j.ijid.2024.107315","url":null,"abstract":"<div><div><em>Leishmania</em> spp. are intracellular protozoan parasites causative of visceral and cutaneous leishmaniasis. Recognized as a neglected tropical disease affecting millions of people around the world, this affliction represents a major public health problem. In Brazil, pentavalent antimony (Sb^V), the main therapy used to treat all clinical forms of leishmaniasis, has become increasingly associated with treatment failure. Many factors can influence leishmaniasis treatment outcome, including low expression aquaglyceroporin by the parasite and high activity of the ATP-binding cassette (ABC) transporters, efflux pumps whose activity has been associated with drug resistance in a variety of diseases. Current evidence suggests that some ABC transporters (e.g., MRP1 and MDR1) play a role in drug resistance in leishmaniasis. One way to potentially overcome Sb^V resistance may be a combined therapeutic strategy involving anti-<em>Leishmania</em> drugs administered together with ABC transporter inhibitors; however, toxicity poses a major challenge to the adoption of this approach.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"151 ","pages":"Article 107315"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Sudan conflict: A catalyst for the spread of infectious diseases in displaced populations","authors":"Ibrahim Nagmeldin Hassan ,&nbsp;Nagmeldin Abuassa ,&nbsp;Mohamed Ibrahim","doi":"10.1016/j.ijid.2024.107326","DOIUrl":"10.1016/j.ijid.2024.107326","url":null,"abstract":"<div><h3>Objective</h3><div>The Sudan conflict has created a severe humanitarian crisis, displacing millions and crippling the healthcare system, leading to a resurgence of infectious diseases such as malaria, cholera, and measles.</div></div><div><h3>Methods</h3><div>Overcrowded refugee camps with poor sanitation and limited resources have fueled outbreaks, exacerbated by disrupted immunization programs and seasonal rains.</div></div><div><h3>Results</h3><div>Malaria is spreading rapidly due to inadequate mosquito control, while cholera outbreaks, linked to unsafe water and poor sanitation, have overwhelmed health facilities. Measles outbreaks are escalating due to low vaccination coverage, leaving vulnerable populations unprotected. The regional and global impacts are significant, as displaced populations crossing borders risk spreading diseases.</div></div><div><h3>Conclusion</h3><div>Addressing this crisis requires urgent international collaboration to restore healthcare services, improve living conditions in camps, resume vaccination programs, and strengthen regional disease surveillance. Timely, coordinated responses are essential to mitigate health risks and protect global health security. This crisis highlights the critical need for sustained efforts to safeguard public health in conflict zones.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"151 ","pages":"Article 107326"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multicountry evaluation of the Xpert MTB/RIF assay for the diagnosis of intrathoracic tuberculosis in children using alternative specimens (nasopharyngeal aspirate and stool): A prospective cohort study conducted in Madagascar, Ivory Coast and Cameroon (TB KIDS project)","authors":"Rindra Vatosoa Randremanana ,&nbsp;Mathurin Tejiokem ,&nbsp;Niaina Rakotosamimanana ,&nbsp;Valérie Donkeng Donfack ,&nbsp;Verlaine Bolyse Mbouchong ,&nbsp;Mirella Randrianarisoa ,&nbsp;Aina Harimanana ,&nbsp;Jean Voisin Taguebue ,&nbsp;Suzie Tetang Ndiang ,&nbsp;Valère Itchy ,&nbsp;Annick Robinson ,&nbsp;Lovaniaina Ravelomanana ,&nbsp;Mbola Rakotomahefa ,&nbsp;Dina Ranoharison ,&nbsp;Man-Koumba Soumahoro ,&nbsp;Brigitte Gicquel ,&nbsp;Raymond N'Guessan ,&nbsp;Sara Eyangoh ,&nbsp;Voahangy Rasolofo ,&nbsp;Kathleen Victoir","doi":"10.1016/j.ijid.2024.107366","DOIUrl":"10.1016/j.ijid.2024.107366","url":null,"abstract":"<div><h3>Objectives</h3><div>Tuberculosis (TB) diagnosis in children remains challenging due to the paucibacillary nature of specimens and the difficulty in obtaining suitable samples. The use of alternative samples like nasopharyngeal aspirate (NPA) and stools, alongside Xpert MTB/RIF testing, offers promising improvements. This study aimed to assess the diagnostic performance of the Xpert MTB/RIF test on NPA and stool samples for detecting intrathoracic TB in children from Madagascar, Cameroon, and Ivory Coast.</div></div><div><h3>Methods</h3><div>Children under 15 years with suspected intrathoracic TB were enrolled in hospitals in these countries’ capitals. Samples for analysis included standard specimens (gastric aspirate or sputum), NPA, stools, with additional HIV serology, tuberculin skin test tests, and chest X-rays. We used a composite reference standard to estimate the accuracy of the Xpert MTB/RIF test with alternative samples.</div></div><div><h3>Results</h3><div>Of 1146 children analyzed, the sensitivity of Xpert MTB/RIF was 58.3% for NPA and 45.5% for stool samples, with a high specificity of more than 95%. The diagnostic performance of Xpert MTB/RIF with alternative samples did not differ according to age group or HIV status.</div></div><div><h3>Conclusions</h3><div>The findings support the World Health Organization's recommendation for using Xpert MTB/RIF with alternative samples in childhood TB diagnosis, underscoring its utility across different settings and HIV statuses.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"151 ","pages":"Article 107366"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occult COVID-19 in an immunosuppressed patient with migratory pulmonary infiltrates","authors":"Cristina Veintimilla ,&nbsp;Ana Álvarez-Uría Miyares ,&nbsp;Sergio Buenestado-Serrano ,&nbsp;Rosalía Palomino-Cabrera ,&nbsp;Ignacio Gomez Centurion ,&nbsp;Pilar Catalán ,&nbsp;Patricia Muñoz ,&nbsp;Laura Pérez-Lago ,&nbsp;Darío García de Viedma","doi":"10.1016/j.ijid.2024.107296","DOIUrl":"10.1016/j.ijid.2024.107296","url":null,"abstract":"<div><div>The clinical presentation of SARS-CoV-2 infection is often more severe and persistent in immunosuppressed hosts. We present the case of a patient with mantle cell lymphoma under treatment with rituximab and ibrutinib who had multiple hospitalizations with pulmonary infiltrates following mild SARS-CoV-2 infection and repeated negative nasopharyngeal (NP) RT-PCR tests. SARS-CoV-2 was eventually detected in bronchoalveolar lavage fluid and the symptoms resolved after treatment with remdesivir. Whole genome sequencing was performed on the initial and final viral strains. Sequence comparison of the two showed that the final strain was derived from the former. Both were identical except for 15 differential single nucleotide polymorphisms, indicating that the virus had persisted undetected over time in this patient. Occult COVID-19 should be considered in immunocompromised patients with persistent respiratory symptoms despite negative NP RT-PCR tests. Systematic bronchoalveolar lavage fluid testing is recommended for accurate diagnosis and management.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"151 ","pages":"Article 107296"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global analysis of influenza epidemic characteristics in the first two seasons after lifting the nonpharmaceutical interventions for COVID-19","authors":"Xiaowei Chen ,&nbsp;Honghong Chen ,&nbsp;Fangfang Tao ,&nbsp;Yinzi Chen ,&nbsp;Ying Zhou ,&nbsp;Jian Cheng ,&nbsp;Xiling Wang","doi":"10.1016/j.ijid.2024.107372","DOIUrl":"10.1016/j.ijid.2024.107372","url":null,"abstract":"<div><h3>Objectives</h3><div>The COVID-19 pandemic significantly disrupted the global influenza seasonal patterns due to nonpharmaceutical interventions. This study aims to describe the influenza seasonal characteristics in the first two seasons after lifting COVID-19 NPIs and assess shifts before, during, and after the pandemic.</div></div><div><h3>Methods</h3><div>We analyzed country-specific weekly influenza data (2011-2024) from WHO FluNet and collected COVID-19 NPI timing from official announcements. The study was divided into pre-pandemic, pandemic, and post-pandemic phases, estimating epidemic onset, peak week, peak intensity, and duration by climate zones.</div></div><div><h3>Results</h3><div>In temperate countries, peak intensity after the pandemic decreased by 8.4 %, while duration increased by 1.8 weeks, and onset and peak were delayed by 18.5 and 22.8 weeks compared to regular seasonal pattern before the pandemic. Subtropical countries experienced a 17.2 % decrease in peak intensity, a 2.4-week decrease in duration, and delays in onset and peak by 13.5 and 2.3 weeks. Tropical countries had a 10 % decrease in peak intensity, a 3-week reduction in duration, and a 6.6-week delay in onset with no significant change in peak time.</div></div><div><h3>Conclusion</h3><div>Influenza seasonality shifted significantly after the pandemic, with epidemic durations returning to typical patterns but peak intensities remained low. Robust surveillance after an infectious disease pandemic is crucial to inform prevention and control strategies.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"151 ","pages":"Article 107372"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Convalescent plasma in patients receiving rituximab or ocrelizumab for multiple sclerosis or neuromyelitis Optica spectrum disorder with Covid-19: A multicenter retrospective study","authors":"Tanguy Dequidt ,&nbsp;Quentin Richier ,&nbsp;Céline Louapre ,&nbsp;Florence Ader ,&nbsp;Yanis Merad ,&nbsp;Nicolas Lauwerier ,&nbsp;Christine Jacomet ,&nbsp;Michel Carles ,&nbsp;Charlotte Biron ,&nbsp;Vincent Gendrin ,&nbsp;Clément Marlat ,&nbsp;François Danion ,&nbsp;Tristan M Lepage ,&nbsp;Albert Sotto ,&nbsp;Loïc Bourdellon ,&nbsp;Alexandre Mania ,&nbsp;Martin Martinot ,&nbsp;Georges Le Falher ,&nbsp;Alexis Ferre ,&nbsp;Benoit Pilmis ,&nbsp;Guillaume Martin-Blondel","doi":"10.1016/j.ijid.2024.107323","DOIUrl":"10.1016/j.ijid.2024.107323","url":null,"abstract":"<div><h3>Background</h3><div>Despite vaccination, patients receiving anti-CD20 monoclonal antibodies (mAbs) for multiple sclerosis (MS) or neuromyelitis optica spectrum disorders (NMOSD) have an increased risk of developing severe or protracted COVID-19. The aim of this study was to describe the effect of COVID-19 convalescent plasma (CCP) in patients with MS or NMOSD exposed to anti-CD20 and infected by SARS-CoV-2.</div></div><div><h3>Methods</h3><div>This French national, retrospective cohort study was conducted between November 2020 and June 2023. Patients with MS or NMOSD, under anti-CD20 mAbs, with symptomatic COVID-19 and treated by CCP were screened. Protracted COVID-19 was defined by a duration of symptoms &gt;21 days. The primary endpoint was the overall survival 30 days after CCP administration.</div></div><div><h3>Results</h3><div>Ninety-two patients from 34 hospitals were included, 84 (91%) with MS and 8 (9%) with NMOSD. Overall, 30-day survival was 97% (IC95%: 91-99). SARS-CoV-2 viremia was positive in 47/75 (61%) patients before CCP <em>versus</em> 9/59 (15%) seven days post-CCP. In the 52 patients (57%) with protracted COVID-19, the duration of symptoms before CCP was 51 [28-69] days, including fever in 75% of cases, which disappeared in 100% of patients 7 days post-CCP.</div></div><div><h3>Conclusions</h3><div>CCP could be a therapeutic option in patients exposed to anti-CD20 mAbs for inflammatory demyelinating disease, particularly in those with protracted COVID-19.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"151 ","pages":"Article 107323"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of influenza vaccination in preventing confirmed influenza cases and hospitalizations in Northern Spain, 2023/24 season: A population-based test-negative case-control study","authors":"Iván Martínez-Baz ,&nbsp;Ana Navascués ,&nbsp;Camino Trobajo-Sanmartín ,&nbsp;Francisco Pozo ,&nbsp;Miguel Fernández-Huerta ,&nbsp;Maddi Olazabal-Arruiz ,&nbsp;Lucía Argente-Colas ,&nbsp;Guillermo Ezpeleta ,&nbsp;Aitziber Echeverria ,&nbsp;Itziar Casado ,&nbsp;Carmen Ezpeleta ,&nbsp;Jesús Castilla","doi":"10.1016/j.ijid.2024.107364","DOIUrl":"10.1016/j.ijid.2024.107364","url":null,"abstract":"<div><h3>Objective</h3><div>We estimated the influenza vaccination effectiveness (IVE) in preventing medical consultations and hospitalizations due to influenza during the 2023/24 season.</div></div><div><h3>Methods</h3><div>Two test-negative case-control studies analyzed patients who consulted primary healthcare or were hospitalized for respiratory symptoms and were tested for influenza by PCR in the 2023/24 season in Navarre, Spain. Influenza vaccination status in the current and previous seasons was compared between confirmed influenza cases and test-negative controls. IVE was calculated as (1-adjusted odds ratio)×100.</div></div><div><h3>Results</h3><div>Of 3133 hospitalized patients, 529 (17%) were positive for influenza: 71% A/H1N1, 23% A/H3N2, and 7% A nonsubtyped. IVE to prevent hospitalizations was 43% (95%CI: 26%, 56%) overall, 61% (95%CI: 32%, 77%) in people younger than 65 years old and 35% (95%CI: 10%, 53%) in older people. IVE was 48% (95%CI: 30%, 61%) against influenza A/H1N1, and 15% (95%CI: -42%, 49%) against influenza A/H3N2. IVE in people vaccinated only in the previous season was 28% (95%CI: -5%, 51%). Among 417 outpatients, 146 (35%) were confirmed for influenza. IVE to prevent outpatient cases was 49% (95%CI: -9%, 76%) overall and 42% (95%CI: -33%, 74%) against influenza A/H1N1.</div></div><div><h3>Conclusions</h3><div>IVE was moderate against influenza A/H1N1 and low against influenza A/H3N2 in the 2023/24 season.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"151 ","pages":"Article 107364"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factors for bacteremia in community-acquired pneumonia: A systematic review and meta-analysis","authors":"Shanshan Wu ,&nbsp;Lin Chen ,&nbsp;Xiaoyan zhang ,&nbsp;Jiali Fan ,&nbsp;Fajuan Tang ,&nbsp;Dongqiong Xiao","doi":"10.1016/j.ijid.2024.107312","DOIUrl":"10.1016/j.ijid.2024.107312","url":null,"abstract":"<div><h3>Background</h3><div>Bacteremia represents a significant complication in patients with community-acquired pneumonia (CAP). Nonetheless, there is currently a dearth of systematic research that determines the precise prevalence and risk factors of bacteremia in CAP patients.</div></div><div><h3>Methods</h3><div>PubMed, Cochrane Library, Embase, and Web of Science databases were searched for published studies on the prevalence or risk factors for CAP with bacteremia up to April 21, 2024. The NOS scale was utilized to appraise the study quality, and the META process was carried out in R language.</div></div><div><h3>Results</h3><div>58,342 CAP patients were enrolled in 22 studies. Of these patients, 29,610 underwent blood culture tests, and 2332 patients had positive blood culture results. Meta-analysis pooled results showed that the incidence of bacteremia was 5.1% (95% CI: 3.6-6.8%) in CAP patients. The prevalence of co-bacteremia was 3.1% (95% CI: 1.5-5.1%) in minors and 6.9% (95% CI: 5.2%-8.8%) in adults. The most common pathogens of CAP were Streptococcus pneumoniae, Staphylococcus aureus. In addition, a summary of the original studies found that the risk factors for bacteremia in CAP patients were diverse and varied.</div></div><div><h3>Conclusions</h3><div>The incidence of bacteremia in CAP patients warrants significant attention. There is a pressing need to establish more specific bacterial screening protocols.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"151 ","pages":"Article 107312"},"PeriodicalIF":4.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}