International Journal of Infectious Diseases最新文献_第3页

Clinical metagenomic next-generation sequencing test for diagnosis of central nervous system infections in ICU: A multicenter retrospective study. 临床宏基因组新一代测序检测诊断ICU中枢神经系统感染：一项多中心回顾性研究。

IF 4.3 2区医学

International Journal of Infectious Diseases Pub Date : 2025-09-30 DOI: 10.1016/j.ijid.2025.108094

Jian Liu, Yongquan Dong, Yuanxiu Huang, Mengxiao Xie, Hongyu Wang, Qianqian Wang, Shengfeng Wang, Nan Wang, Yongpo Jiang, Wenxiao Zhang, Mingqiang Wang, Jian Chen, Lingtong Huang, Hongliu Cai

{"title":"Clinical metagenomic next-generation sequencing test for diagnosis of central nervous system infections in ICU: A multicenter retrospective study.","authors":"Jian Liu, Yongquan Dong, Yuanxiu Huang, Mengxiao Xie, Hongyu Wang, Qianqian Wang, Shengfeng Wang, Nan Wang, Yongpo Jiang, Wenxiao Zhang, Mingqiang Wang, Jian Chen, Lingtong Huang, Hongliu Cai","doi":"10.1016/j.ijid.2025.108094","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.108094","url":null,"abstract":"Background: Central nervous system (CNS) infections impose a substantial global burden of morbidity and mortality, necessitating accurate and timely diagnosis for optimal clinical management. Metagenomic next-generation sequencing (mNGS) has been demonstrated as a valuable tool for pathogen detection in patients with suspected CNS infections.Methods: From December 2019 to June 2023, we conducted a comprehensive analysis of 520 cerebrospinal fluid samples collected from patients with suspected intracranial infections across six intensive care units. All pathogen-positive results identified through metagenomic next-generation sequencing were subsequently validated by an independent laboratory.Results: Metagenomic NGS detected 105 microbial species in 520 clinical samples, comprising 64 bacterial species (61.0%), 16 DNA viruses (15.2%), 13 fungal species (12.4%), and 7 RNA viruses (6.7%). The 30-day mortality rate among all study participants was 18.5%. Metagenomic NGS identified 172 infection cases, whereas conventional culture methods detected only 31 cases. For CNS infections, mNGS demonstrated diagnostic sensitivity, specificity, and accuracy rates of 59%, 90.5%, and 72.5%, respectively.Conclusions: Metagenomic NGS testing facilitates accelerated diagnosis of CNS infections and informs evidence-based clinical management decisions.","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108094"},"PeriodicalIF":4.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145212576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arterolane and Piperaquine Vs. Artemether and Lumefantrine in Uncomplicated Malaria: A Randomized Study in Nigeria. 在尼日利亚的一项随机研究中，动脉素和哌喹与蒿甲醚和氨苯曲明治疗无并发症疟疾。

IF 4.3 2区医学

International Journal of Infectious Diseases Pub Date : 2025-09-29 DOI: 10.1016/j.ijid.2025.108084

Olufunsho Awodele, Ibrahim Sebutu Bello, Babatunde Abdulmajeed Akodu, Abdulakeem Ayanleye Ahmed, Sikiru Usman, Rahman Ayodele Bolarinwa, Akinwumi Akinyede, Hameed Adewale Adelabu, Emmanuel Oluwatimilehin Akande, Jayanta Dey, Vinay Kudrigikar, P Sameer Rao, Suyog Mehta

{"title":"Arterolane and Piperaquine Vs. Artemether and Lumefantrine in Uncomplicated Malaria: A Randomized Study in Nigeria.","authors":"Olufunsho Awodele, Ibrahim Sebutu Bello, Babatunde Abdulmajeed Akodu, Abdulakeem Ayanleye Ahmed, Sikiru Usman, Rahman Ayodele Bolarinwa, Akinwumi Akinyede, Hameed Adewale Adelabu, Emmanuel Oluwatimilehin Akande, Jayanta Dey, Vinay Kudrigikar, P Sameer Rao, Suyog Mehta","doi":"10.1016/j.ijid.2025.108084","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.108084","url":null,"abstract":"Objective: To compare the efficacy and safety of Arterolane maleate-Piperaquine phosphate (AMP) and Artemether-lumefantrine (AL) in Nigerian patients with acute, uncomplicated Plasmodium falciparum malaria.Methods: This phase IV, randomized, multicenter, open-label, active-controlled study included patients aged 12-65 years with acute symptomatic, uncomplicated P. falciparum malaria. A total of 350 patients were randomized (1:1) to Test group [AMP (150 mg+750 mg) once daily] or Comparator group [AL (80 mg+480 mg) twice daily] for 3 consecutive days. The primary endpoint was polymerase chain reaction (PCR)-corrected adequate clinical and parasitological response (ACPR) on Day 28. Secondary endpoints included PCR-corrected ACPR (Day 42), PCR-uncorrected ACPR (Days 28 and 42), fever clearance time (FCT), and parasite clearance time (PCT).Results: PCR-corrected ACPR was 100% on Day 28 and sustained till Day 42 in both groups. PCR-uncorrected ACPR rates were comparable in both groups (AMP: 98.2%, AL: 99.4% on Day 28, p=0.352; AMP: 98.2%, AL: 98.8% on Day 42, p=0.674). No significant differences in FCT and PCT were observed between the groups. No drug-related adverse events (AEs) or severe AEs were reported.Conclusion: Once-daily dosing of AMP demonstrates comparable efficacy and safety to standard twice-daily dosing of AL in the treatment of uncomplicated P. falciparum malaria.Trial id: Pan African Clinical Trials Registry - PACTR202305878745601 (prospectively registered on 22nd May 2023), URL: pactr.samrc.ac.za/Search.aspx.","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108084"},"PeriodicalIF":4.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sexually transmitted coinfections in patients with a new episode of syphilis. 新发梅毒患者的性传播合并感染。

IF 4.3 2区医学

International Journal of Infectious Diseases Pub Date : 2025-09-28 DOI: 10.1016/j.ijid.2025.108091

Anita Sforza, Fiore Artelli, Sofia Lovatti, Stefano Calza, Chiara Rossi, Maurizio Gulletta, Lina Rachele Tomasoni, Alberto Matteelli

{"title":"Sexually transmitted coinfections in patients with a new episode of syphilis.","authors":"Anita Sforza, Fiore Artelli, Sofia Lovatti, Stefano Calza, Chiara Rossi, Maurizio Gulletta, Lina Rachele Tomasoni, Alberto Matteelli","doi":"10.1016/j.ijid.2025.108091","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.108091","url":null,"abstract":"Objective: Sexually transmitted infections (STI) are a major public health problem with an increasing trend worldwide. Syphilis is often associated with other STI. We measured the STI coinfection rate in a sample of patients presenting with syphilis.Methods: In a prospective interventional study patients attending the STI clinic in Brescia, Italy with a new diagnosis of syphilis were systematically tested for Chlamydia trachomatis, Mycoplasma genitalium and Neisseria gonorrhoeae at genital, anal, and oral sites using molecular methods. Serological markers for HIV, HBV, and HAV were also searched. Statistical methods were used to measure the association between STI coinfections and demographic, behavioural and clinical variables.Results: Among 101 patients with syphilis a concomitant STI was identified in 31 (30,7%) for a total of 38 STIs infections: C.trachomatis (17 - 16.8%), M.genitalium (10 - 9.9%) and N.gonorrhoeae (9 - 8.9%). Two additional patients with positive HBsAg were detected. Age was the only independent variable statistically inversely associated to a higher chance of STIs coinfection.Conclusions: In the study setting screening patients with syphilis for other STIs allowed to detect an STI coinfection in almost a third of the cases. Most associated coinfections were asymptomatic providing further public health benefit.","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108091"},"PeriodicalIF":4.3,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

More than a fever: encephalitis due to typhoid fever. 多发烧：由伤寒引起的脑炎。

IF 4.3 2区医学

International Journal of Infectious Diseases Pub Date : 2025-09-27 DOI: 10.1016/j.ijid.2025.108092

Samuel J Thorburn, James McCarthy

引用次数: 0

Genomic surveillance for community-acquired pneumonia of unknown etiology in children. 病因不明的儿童社区获得性肺炎的基因组监测

IF 4.3 2区医学

International Journal of Infectious Diseases Pub Date : 2025-09-27 DOI: 10.1016/j.ijid.2025.108093

Jeong-Min Kim, Jeong-Ah Kim, Jee Eun Rhee, Eun-Jin Kim, Taekjin Lee, Young June Choe, Hyunju Lee, Byung Wook Eun, Ye Ji Kim, Byung Ok Kwak, Younghee Lee, Ye Kyung Kim, Hyejin So, Kyo Jin Jo, Gahee Kim, Kyung-Ran Kim, Dae Sun Jo, Ki Wook Yun

{"title":"Genomic surveillance for community-acquired pneumonia of unknown etiology in children.","authors":"Jeong-Min Kim, Jeong-Ah Kim, Jee Eun Rhee, Eun-Jin Kim, Taekjin Lee, Young June Choe, Hyunju Lee, Byung Wook Eun, Ye Ji Kim, Byung Ok Kwak, Younghee Lee, Ye Kyung Kim, Hyejin So, Kyo Jin Jo, Gahee Kim, Kyung-Ran Kim, Dae Sun Jo, Ki Wook Yun","doi":"10.1016/j.ijid.2025.108093","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.108093","url":null,"abstract":"Objectives: The etiologic pathogen is unknown for many pediatric community-acquired pneumonia (CAP) cases. We aimed to identify the causes of CAP of unknown etiology (CAP-UKN) using broad-panel targeted next-generation sequencing (tNGS).Methods: A prospective surveillance study was conducted across 26 hospitals in Korea (September 2023-November 2024). CAP cases with no identified pathogen were defined as CAP-NPD; cases wherein no pathogen or only human rhinovirus (HRV), human bocavirus (HBoV), human coronavirus (HCoV), or normal colonizing bacteria were detected were classified as CAP-UKN. Residual respiratory specimens were analyzed using 16S rRNA sequencing and tNGS.Results: Among 605 pediatric CAP cases, 178 (29.4%) had CAP-UKN, including 77 CAP-NPD. CAP-NPD was more common at ages 5-10 years with clinical features similar to Mycoplasma pneumoniae pneumonia. HRV/HBoV/HCoV-positive cases resembled those of viral pneumonia. 16S rRNA sequencing and tNGS identified additional pathogens in 23.8% and 70.8% of CAP-UKN specimens, respectively: Haemophilus influenzae, Moraxella catarrhalis, and viridans streptococci (6.3% each) by 16S rRNA sequencing, and Streptococcus pneumoniae (45.5%) and betaherpesvirus (5.2%) by tNGS.Conclusions: Pediatric CAP-UKN may be associated with undetected or atypical pathogens. HRV, HCoV, or HBoV infections may contribute to some pediatric CAP cases in which no other pathogen is detected.","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108093"},"PeriodicalIF":4.3,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk and determinants of mortality associated with invasive group A streptococcus (iGAS) disease in Scotland: a national surveillance study. 苏格兰侵袭性A群链球菌（iGAS）疾病相关死亡的风险和决定因素：一项国家监测研究

IF 4.3 2区医学

International Journal of Infectious Diseases Pub Date : 2025-09-26 DOI: 10.1016/j.ijid.2025.108090

Ebrahim Ghaderi, Eisin McDonald, Hazel Henderson, Melissa Llano, Diane Lindsay, Morris C Muzyamba, Navneet Rai, Peter MacPherson

{"title":"Risk and determinants of mortality associated with invasive group A streptococcus (iGAS) disease in Scotland: a national surveillance study.","authors":"Ebrahim Ghaderi, Eisin McDonald, Hazel Henderson, Melissa Llano, Diane Lindsay, Morris C Muzyamba, Navneet Rai, Peter MacPherson","doi":"10.1016/j.ijid.2025.108090","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.108090","url":null,"abstract":"Objectives: Understanding determinants of mortality in invasive Group A Streptococcal (iGAS) infections is essential for developing targeted public health measures and improving clinical management. Using a comprehensive prospectively-collected national surveillance dataset, we set out to investigate factors associated with case fatality in Scotland.Methods: We included all episodes of iGAS notified in Scotland surveillance data from January 2017 to December 2024. Case fatality was ascertained by seven-day follow up. Regression models incorporating key clinical, microbiological, and demographic predictors were constructed to investigate factors associated with higher case fatality.Results: There were 2,209 iGAS notifications, of whom 191 died (8.6%). In multivariate analysis, increasing age (OR for 45-64 years: 2.36 [CI95%:1.3-4.48]; OR for 65-74 years: 4.54 [2.41-8.89]; and OR for 75 years and over: 7.77 [3.4-14.8]; emm type 3.93 (OR: 3.13 [1.43-6.76]) and emm type 1 (3.44 [2-6.15]); alcohol misuse (2.56 [1.36-4.63]); respiratory tract infection (2.07 [1.27-3.32]); and intensive care admission (2.5 [1.7-3.66]) were all significantly associated with mortality.Conclusions: Case fatality from iGAS was high, particularly for vulnerable populations, and for those with emm type 3.93 and emm type 1 infections. Novel clinical, therapeutic, and public health interventions to improve clinical outcomes are required.","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108090"},"PeriodicalIF":4.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Explosive Chikungunya Virus Outbreak in China. 爆炸性基孔肯雅病毒在中国爆发。

IF 4.3 2区医学

International Journal of Infectious Diseases Pub Date : 2025-09-26 DOI: 10.1016/j.ijid.2025.108089

Kok Keng Tee, Dongkui Mu, Xueshan Xia

{"title":"Explosive Chikungunya Virus Outbreak in China.","authors":"Kok Keng Tee, Dongkui Mu, Xueshan Xia","doi":"10.1016/j.ijid.2025.108089","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.108089","url":null,"abstract":"Background: Chikungunya virus (CHIKV), an Aedes-borne alphavirus, is a growing global health concern. Until now, China had experienced only sporadic outbreaks linked to imported cases.Methods: We analyzed epidemiological, clinical, and public health data from the ongoing 2025 Guangdong outbreak, the largest chikungunya epidemic recorded in China.Results: The outbreak began in Foshan on July 8, 2025, with over 3,000 confirmed cases in the first two weeks and more than 10,000 by late August. Clinical presentations were typical of chikungunya fever, including acute fever, arthralgia, and rash, with no severe complications or deaths. Local and interregional spread included travel-associated cases in Macao, Hong Kong, Taiwan, and Guangxi. Authorities implemented expanded PCR testing, isolation of cases in mosquito-proof facilities, and comprehensive vector control. Clinical management remains supportive, with no licensed antivirals.Conclusion: The unprecedented scale and rapid spread of CHIKV in Guangdong underscore the role of ecological and mobility factors in transforming local introductions into large epidemics. Strengthened surveillance, genomic analysis, regional data sharing, and vaccine preparedness will be critical to curb future arbovirus threats in China.","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108089"},"PeriodicalIF":4.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the Early Sepsis Warning System in the Emergency Department. 急诊部门脓毒症早期预警系统的评估

IF 4.3 2区医学

International Journal of Infectious Diseases Pub Date : 2025-09-25 DOI: 10.1016/j.ijid.2025.108083

Shih-Chang Hsu, Chin-Wang Hsu, Chun-You Chen, Chih-Hsin Lee, Chung-Chien Huang, Le Duc Huy, Chung-Liang Shih, Shau-Ku Huang, Tsong-Yih Ou

{"title":"Assessing the Early Sepsis Warning System in the Emergency Department.","authors":"Shih-Chang Hsu, Chin-Wang Hsu, Chun-You Chen, Chih-Hsin Lee, Chung-Chien Huang, Le Duc Huy, Chung-Liang Shih, Shau-Ku Huang, Tsong-Yih Ou","doi":"10.1016/j.ijid.2025.108083","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.108083","url":null,"abstract":"Background: Early detection and timely intervention are critical in managing sepsis. To address challenges in sepsis recognition in the emergency department, we implemented a two-stage Early Sepsis Warning System (ESWS) integrated with our electronic medical record (EMR) system.Objective: This study aimed to evaluate the clinical impact of the ESWS on sepsis management and patient outcomes in the emergency department.Methods: We conducted a retrospective observational study analyzing data from patients admitted with sepsis or septic shock between July 1, 2019, and June 30, 2022. The study period was divided into pre-ESWS and post-ESWS implementation phases. The primary outcome was in-hospital mortality; secondary outcomes included ICU admission rates, length of ICU and hospital stay, and frequency of lactate measurement.Results: A total of 4,028 patients were included in the study. There was no significant difference in in-hospital mortality rates between the pre-ESWS and post-ESWS periods, with rates of 8.85% and 8.39%, respectively (p = 0.599). However, ICU admission rates significantly decreased from 11.87% to 9.31% (p = 0.008). The proportion of patients undergoing lactate testing increased substantially after the implementation of the ESWS, rising from 10.39% to 38.72% (p < 0.00001). Subgroup analysis showed improved outcomes among pneumonia patients, which included reductions in ICU admissions and shorter hospital stays.Conclusions: The implementation of the ESWS was associated with reduced ICU admissions and improved adherence to sepsis care processes, particularly among patients with pneumonia. However, its impact on overall mortality was limited, highlighting the need to enhance system utilization and tailor interventions to diverse clinical contexts.","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108083"},"PeriodicalIF":4.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Etiology and Epidemiology of respiratory infections in community-based influenza-like illness during the COVID-19 pandemic, Vientiane, Lao People's Democratic Republic. 老挝人民民主共和国万象2019冠状病毒病大流行期间社区流感样疾病呼吸道感染的病因学和流行病学

IF 4.3 2区医学

International Journal of Infectious Diseases Pub Date : 2025-09-25 DOI: 10.1016/j.ijid.2025.108079

Novy Charel Bobouaka Bonguili, Illich Manfred Mombo, Léadisaelle Hosanna Lenguiya, Vatthanapone Lattaphasavang, Phimpha Pabouriboune, Eric Deharo, Matthieu Fritz, Jordy Exaucé Demboux Lyelet, Eric Elguero, Félix Koukouikila-Koussounda, Pembe Issamou Mayengue, Eric M Leroy, Roch Fabien Niama, Sabrina Locatelli

{"title":"Etiology and Epidemiology of respiratory infections in community-based influenza-like illness during the COVID-19 pandemic, Vientiane, Lao People's Democratic Republic.","authors":"Novy Charel Bobouaka Bonguili, Illich Manfred Mombo, Léadisaelle Hosanna Lenguiya, Vatthanapone Lattaphasavang, Phimpha Pabouriboune, Eric Deharo, Matthieu Fritz, Jordy Exaucé Demboux Lyelet, Eric Elguero, Félix Koukouikila-Koussounda, Pembe Issamou Mayengue, Eric M Leroy, Roch Fabien Niama, Sabrina Locatelli","doi":"10.1016/j.ijid.2025.108079","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.108079","url":null,"abstract":"Background: Respiratory infections pose an ongoing global public health burden, with multiple viral and bacterial etiologies. This study aimed to characterize the etiology of influenza-like illness (ILI) during the COVID-19 pandemic in a community cohort in Vientiane, Lao PDR.Methods: From September 2021 to April 2022, 6,300 individuals from 999 households in 25 villages were enrolled in a prospective surveillance study. Oropharyngeal swabs were collected from ILI cases and tested for SARS-CoV-2 using RT-PCR, and for 21 additional respiratory pathogens using a multiplex panel.Results: Among 462 samples analyzed, 360 (77.92%) were positive for at least one pathogen, including 338 viral and 79 bacterial infections. SARS-CoV-2 was predominant (67.53%), followed by Staphylococcus aureus (12.55%), human rhinovirus (6.93%), and Streptococcus pneumoniae (5.41%). Seasonal viruses such as influenza A/B, RSV, HPIVs, and HMPV were notably absent. Co-infections occurred in 21.21% of cases, with lower rates among SARS-CoV-2-positive individuals.Conclusions: These findings highlight the dominance of SARS-CoV-2 and the suppression of typical seasonal viruses, likely due to public health measures and viral interference. The results emphasize the importance of multiplex, community-level surveillance to understand respiratory pathogen dynamics and to strengthen preparedness in resource-limited settings.","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108079"},"PeriodicalIF":4.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of hidden hepatitis C virus infection in primary care settings using Clinical Decision Support System: the CriVHado C study. 使用临床决策支持系统检测初级保健机构中隐藏的丙型肝炎病毒感染：CriVHado C研究

IF 4.3 2区医学

International Journal of Infectious Diseases Pub Date : 2025-09-25 DOI: 10.1016/j.ijid.2025.108082

Maria Pilar Griñó, Maite López-Garrigós, Javier Guzman, Francisco Jover, Concepción Fernandez, Maria Norma Iranzo, Emilio Flores

{"title":"Detection of hidden hepatitis C virus infection in primary care settings using Clinical Decision Support System: the CriVHado C study.","authors":"Maria Pilar Griñó, Maite López-Garrigós, Javier Guzman, Francisco Jover, Concepción Fernandez, Maria Norma Iranzo, Emilio Flores","doi":"10.1016/j.ijid.2025.108082","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.108082","url":null,"abstract":"Background: Universal screening for Hepatitis C Virus (HCV) has gained importance following the WHO 2030 objectives. In Spain, with an active infection prevalence of 0.22% at national level (95%CI 0.12% - 0.32%), population-wide screening is not currently recommended. Our aim was to evaluate the prevalence of hidden HCV infection in patients who consulted primary care for other reasons and were prescribed any other kinds of blood test.Methods: Our intervention was based on automated software managed at the clinical laboratory level, the pillars of which were: a Laboratory Information System (LIS) holding patients records for the past 15 years, an e-prescribing system, and an algorithm-based clinical decision support system (CDSS). Eligible patients were automatically offered the option of taking an additional test (for HCV) from the same blood draw used for the tests they were being prescribed.Results: Screening was carried out in 2024 over a six-month period on 7,013 of the 11,490 patients offered screening (61.03%). 55 cases tested positive for HCV (0.78%) and 9 cases tested positive for HCV-RNA (0.13%; 95%CI 0.06% - 0.24%), indicating active infection, and were promptly referred for specialist care. The direct cost of detecting one case of active infection was €2,282.47.Conclusions: We detected hidden HCV infections at a rate compatible with national estimates. Offering the possibility of obtaining an additional test from the same blood draw has removed a psychological and logistical barrier to patient participation. Targeted screening campaigns, managed at the clinical laboratory level with advanced automated systems, can be cost-effective.","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108082"},"PeriodicalIF":4.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0