International Journal of Infectious Diseases最新文献

{"title":"Adherence to preventive treatment for latent tuberculosis infection in close contacts of pulmonary tuberculosis patients: A cluster-randomized controlled trial in China","authors":"","doi":"10.1016/j.ijid.2024.107196","DOIUrl":"10.1016/j.ijid.2024.107196","url":null,"abstract":"<div><h3>Objectives</h3><p>This study examined adherence rates to tuberculosis preventive treatment (TPT) among close contacts of individuals with pulmonary tuberculosis (PTB) and identified factors associated with TPT adherence in China.</p></div><div><h3>Methods</h3><p>A multicenter, cluster-randomized, open-label control trial was carried out across three sites involving 34 counties in China. Close contacts of bacteriologically confirmed rifampin and isoniazid-susceptible PTB cases were identified and screened for latent tuberculosis infection (LTBI). Eligible participants were randomly assigned to either the 3H₂P₂ group, which consisted of a 3-month, twice-weekly regimen of rifapentine and isoniazid, or the 6H group, which entailed a 6-month daily regimen of isoniazid. To assess the factors influencing adherence, a two-level logistic regression model was utilized.</p></div><div><h3>Results</h3><p>Out of the 2434 close contacts who initiated TPT, 2121 (87.1%) completed the regimen. Of the 313 individuals who did not complete TPT, 60.1% refused to continue, and 27.8% discontinued due to adverse effects. The two-level logistic regression model revealed several factors associated with enhanced TPT adherence: enrollment in the 3H₂P₂ group (odds ratio [OR] = 2.09), management by a TB dispensary responsible for TPT (OR = 2.55), supervision by healthcare workers (OR = 6.40), and clinician incentives (OR = 2.49). Conversely, the occurrence of any adverse effects (OR = 0.08) was identified as a risk factor for nonadherence.</p></div><div><h3>Conclusion</h3><p>Administering TPT to individuals with LTBI is feasible among close contacts. Adherence to TPT can be enhanced through shorter, safer treatment regimens and supportive interventions, such as directly supervised therapy for TPT recipients and incentives for healthcare providers managing TPT.</p></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1201971224002674/pdfft?md5=af89ddaa89548154508097276d44dd28&pid=1-s2.0-S1201971224002674-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-filarial antibodies are sensitive indicators of lymphatic filariasis transmission and enable identification of high-risk populations and hotspots","authors":"","doi":"10.1016/j.ijid.2024.107194","DOIUrl":"10.1016/j.ijid.2024.107194","url":null,"abstract":"<div><h3>Objectives</h3><p>Circulating filarial antigen (Ag) is used by elimination programs to monitor lymphatic filariasis (LF) transmission; however, antifilarial antibodies (Ab) may be more sensitive than Ag for detecting LF. Our objectives were to describe Ab seroprevalence, identify risk factors for Ab seropositivity, investigate age-specific associations between Ag and Ab, and evaluate geographic clustering of seropositivity.</p></div><div><h3>Methods</h3><p>Community-based serosurveys of participants aged ≥5 years were conducted in 35 primary sampling units (PSUs). Ag-positivity was detected using Alere™ Filariasis Test Strips and Ab-seropositivity using multiplex bead assays. Seroprevalence was adjusted for study design.</p></div><div><h3>Results</h3><p>Of 3795 participants (range:5-90 years), adjusted prevalence for Ag, <em>Bm14</em> Ab, <em>Wb123</em> Ab, and <em>Bm33</em> Ab were 3.7% (n=117), 20.3% (n=583), 32.2% (n=987), and 51.0% (n=1659), respectively. Male sex, older age, and residents of suspected hotspots had higher odds of seropositivity to all seromarkers. Seroprevalence was lower in 5-9-year-olds vs ≥10-year-olds (<em>P&lt;</em>0.001). Clustering was significantly higher in households (intra-cluster correlation for Ag:0.45; <em>Bm14</em> Ab:0.32; <em>Bm33</em> Ab:0.31; <em>Wb123</em> Ab:0.29) compared to PSUs or region.</p></div><div><h3>Conclusions</h3><p>Abs enabled identification of risk factors for seropositivity and geographical clustering to inform targeted interventions for LF programmes. Further research is needed to define Ab thresholds for active versus past infection and elimination targets.</p></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1201971224002650/pdfft?md5=e4f655915ba5eceb72f1be5ef9bd4366&pid=1-s2.0-S1201971224002650-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogen characteristics of respiratory infections in the season after the COVID-19 pandemic between August and December 2023: evidence from direct-to-consumer testing-based surveillance in Guangzhou and Beijing, China","authors":"","doi":"10.1016/j.ijid.2024.107195","DOIUrl":"10.1016/j.ijid.2024.107195","url":null,"abstract":"<div><h3>Objectives</h3><p>In the fall-winter of 2023, China experienced its first epidemic season of respiratory diseases since the COVID-19 pandemic. Gathering timely data about pathogenetic characteristics of respiratory infections is crucial to complement current respiratory surveillance mechanisms in China. Data from direct-to-consumer (DTC) multi-respiratory pathogen (MRP) testing could serve as a novel source of multi-pathogen data for community-based surveillance.</p></div><div><h3>Methods</h3><p>A pioneering initiative was launched to detect multiple respiratory pathogens in Beijing and Guangzhou, China. DTC MRP tests were used to provide proactive surveillance ahead of medical services.</p></div><div><h3>Results</h3><p>A total of 28,018 participants were enrolled between 22 August and 10 December 2023. Positive findings for at least one respiratory pathogen were observed in 26,202 (93.5%) participants. Influenza virus A, respiratory syncytial virus (RSV), and human adenovirus are the three leading viral pathogens detected with proportions of 18.0%, 10.6%, and 8.8%. Viral-bacterial pathogens were co-detected in 9736 (34.7%) of participants, which reduced to 22.2% for bacterial-bacterial co-detection, and 22.0% for bacterial mono-detection. The epidemiological ecology of respiratory pathogens within both viral clusters and specific pathogens varied among cities. The peak of RSV epidemics in Guangzhou occurred in the fall of 2023, earlier than in Beijing.</p></div><div><h3>Conclusion</h3><p>The innovative program offered enhanced surveillance capabilities beyond traditional methods, enabling prompt feedback about test results and mitigating the risk of cross-infection caused by waits in healthcare facilities.</p></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1201971224002662/pdfft?md5=2a902014af0e2a5cbdc21ea329e4964e&pid=1-s2.0-S1201971224002662-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Safety and effectiveness of isavuconazole in real-life non-neu tropenic patients” [International Journal of Infectious Diseases 144 (2024) 107070]","authors":"","doi":"10.1016/j.ijid.2024.107188","DOIUrl":"10.1016/j.ijid.2024.107188","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1201971224002595/pdfft?md5=d80f09a18a9f5e2c8e6145464b3ab728&pid=1-s2.0-S1201971224002595-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pandemic burden in low-income settings and impact of limited and delayed interventions: A granular modelling analysis of COVID-19 in Kabwe, Zambia","authors":"","doi":"10.1016/j.ijid.2024.107182","DOIUrl":"10.1016/j.ijid.2024.107182","url":null,"abstract":"<div><h3>Objectives</h3><p>Pandemic response in low-income countries (LICs) or settings often suffers from scarce epidemic surveillance and constrained mitigation capacity. The drivers of pandemic burden in such settings, and the impact of limited and delayed interventions remain poorly understood.</p></div><div><h3>Methods</h3><p>We analysed COVID-19 seroprevalence and all-cause excess deaths data from the peri-urban district of Kabwe, Zambia between March 2020 and September 2021 with a novel mathematical model. Data encompassed three consecutive waves caused by the wild-type, Beta and Delta variants.</p></div><div><h3>Results</h3><p>Across all three waves, we estimated a high cumulative attack rate, with 78% (95% credible interval [CrI] 71-85) of the population infected, and a high all-cause excess mortality, at 402 (95% CrI 277-473) deaths per 100,000 people. Ambitiously improving health care to a capacity similar to that in high-income settings could have averted up to 46% (95% CrI 41-53) of accrued excess deaths, if implemented from June 2020 onward. An early and accelerated vaccination rollout could have achieved the highest reductions in deaths. Had vaccination started as in some high-income settings in December 2020 and with the same daily capacity (doses per 100 population), up to 68% (95% CrI 64-71) of accrued excess deaths could have been averted. Slower rollouts would have still averted 62% (95% CrI 58-68), 54% (95% CrI 49-61) or 26% (95% CrI 20-38) of excess deaths if matching the average vaccination capacity of upper-middle-, lower-middle- or LICs, respectively.</p></div><div><h3>Conclusions</h3><p>Robust quantitative analyses of pandemic data are of pressing need to inform future global pandemic preparedness commitments.</p></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1201971224002534/pdfft?md5=cd8b2c77f819d495696470bdcbe902cd&pid=1-s2.0-S1201971224002534-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dengue outbreaks in Brazil and Latin America: the new and continuing challenges","authors":"","doi":"10.1016/j.ijid.2024.107192","DOIUrl":"10.1016/j.ijid.2024.107192","url":null,"abstract":"<div><h3>Objectives</h3><p>To compare the number of suspected cases, severe cases, and deaths of dengue in 2023 and 2024 in Brazil and Latin America; and to describe its epidemiological profile.</p></div><div><h3>Design</h3><p>Observational study.</p></div><div><h3>Methods</h3><p>The data regarding dengue was retrieved from the Brazilian Ministry of Health website. The Chi-square test was used to compare the proportion of dengue cases in 2023 and 2024 according to gender, race, and age range. The odds ratio and the 95% confidence intervals were used to describe the data. The Spearman correlation test was used to compare the number of suspected cases, severe cases, and deaths of dengue with the number of distributed vaccines against dengue.</p></div><div><h3>Results</h3><p>Dengue is one of the most common zoonoses in Latin America. In 2023, Brazil registered a total of 1,658,814 suspected cases of dengue with 1094 deaths. For 2024, a total of 1,978,372 suspected cases of dengue were reported only until the 11th epidemiological week, with 656 deaths. When comparing dengue cases reported in 2024 and 2023, there is an increase in suspected cases, with 20% more cases reported during the first 11 epidemiological weeks of 2024 than in the entire 52 epidemiological weeks of 2023. At the same time, in 2024, the Pan American Health Organization reported suspected cases in 20 Latin American countries, with 3073 cases of severe dengue and 1187 deaths. In Brazil, a different racial profile for dengue was described since Black people [OR = 1.56 (95% CI = 1.54-1.57)], Mixed individuals [OR = 1.36 (95% CI = 1.35-1.37), and Indigenous peoples [OR = 1.77 (95% CI = 1.70-1.85)] were more likely to be suspected cases of dengue in 2024 compared to 2023. Also, a positive correlation between the distributed vaccines with deaths due to dengue and the number of severe cases was described.</p></div><div><h3>Conclusion</h3><p>Brazil was responsible for more than 50% of suspected cases and deaths from dengue compared to the other Latin American countries in 2024. Furthermore, there is a different racial profile for dengue in Brazil, as Black people, Mixed individuals, and Indigenous peoples were more likely to be suspected cases of dengue in 2024 compared to 2023.</p></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1201971224002637/pdfft?md5=be7b0769e2332d3969a74be3c319deb3&pid=1-s2.0-S1201971224002637-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel variant of Chlamydia psittaci causing human psittacosis in China","authors":"","doi":"10.1016/j.ijid.2024.107180","DOIUrl":"10.1016/j.ijid.2024.107180","url":null,"abstract":"<div><p>From January 2022 to November 2022, sporadic psittacosis occurred in Lishui city, China. The patients were presented with fever, cough, and pulmonary infiltration. Their clinical symptoms were not relieved after receiving cephalosporin, penicillin, beta-lactamase inhibitors, and quinolones. Metagenomic next-generation sequencing of bronchoalveolar lavage fluid samples from the patients revealed <em>Chlamydia psittaci</em> infection. Then, three <em>C. psittaci</em> strains were isolated from the patients. Their whole genome sequences (WGSs) were obtained, and a core genome multilocus sequence typing (cgMLST) method was developed to study the population structure of <em>C. psittaci</em>. Using the constructed cgMLST method, 72 WGSs were divided into four related groups and ten sub-clusters. The Lishui strains formed a unique population of <em>C. psittaci</em>, which might represent a new variant of <em>C. psittaci. In vitro</em> antimicrobial susceptibility testing suggested that the Lishui strains were sensitive to tetracycline, macrolides, quinolones, and no drug-resistance was observed.</p></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1201971224002510/pdfft?md5=8478f459e52e4f938acf237a02f825c0&pid=1-s2.0-S1201971224002510-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141765995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A set of diagnostic tests for detection of active Babesia duncani infection","authors":"","doi":"10.1016/j.ijid.2024.107178","DOIUrl":"10.1016/j.ijid.2024.107178","url":null,"abstract":"<div><h3>Objectives</h3><p>Human babesiosis is an emerging and potentially fatal tick-borne disease caused by intraerythrocytic parasites of the <em>Babesia</em> genus. Among these, <em>Babesia duncani</em> is particularly notable for causing severe and life-threatening illness in humans. Accurate diagnosis and effective disease management hinge on the detection of active <em>B. duncani</em> infections. While molecular assays are available to detect the parasite in blood, a reliable method for identifying biomarkers of active infection remains elusive.</p></div><div><h3>Methods</h3><p>We developed the first <em>B. duncani</em> antigen capture assays, targeting two immunodominant antigens, BdV234 and BdV38. These assays were validated using established <em>in vitro</em> and <em>in vivo B. duncani</em> infection models, and following drug treatment.</p></div><div><h3>Results</h3><p>The assays demonstrated no cross-reactivity with other species such as <em>B. microti, B. divergens, Babesia MO1,</em> or <em>Plasmodium falciparum</em>, and can detect as few as 115 infected erythrocytes/µl of blood. Screening of 1731 blood samples from various biorepositories, including samples previously identified as Lyme and/or <em>B. microti</em>-positive, as well as new specimens from wild mice, revealed no evidence of <em>B. duncani</em> infection or cross-reactivity.</p></div><div><h3>Conclusions</h3><p>These assays hold significant promise for various applications, including point-of-care testing for the early detection of <em>B. duncani</em> in patients, field tests for screening reservoir hosts, and high-throughput screening of blood samples intended for transfusion.</p></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1201971224002492/pdfft?md5=51cc4e496e05633f51a71baccbfbf394&pid=1-s2.0-S1201971224002492-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141723549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reactivation of herpes simplex virus 2 presenting as recurrent acute retinal necrosis following COVID-19 vaccination","authors":"","doi":"10.1016/j.ijid.2024.107170","DOIUrl":"10.1016/j.ijid.2024.107170","url":null,"abstract":"<div><h3>Purpose</h3><p>Acute retinal necrosis (ARN) is a vision-threatening uveitis caused by herpesviruses reactivation, which has recently been suggested to be associated with COVID-19 infection and after vaccination against it.</p></div><div><h3>Case description</h3><p>We present the case of a 58-year-old Japanese woman with ARN in the left eye due to herpes simplex virus 2 (HSV2) two days after receiving the fifth dose of the BNT162b2 mRNA COVID-19 vaccine. The patient demonstrated an ARN history in the right eye and had been treated for it. The patient was administered oral steroids and immunosuppressive drugs for mixed connective tissue disease and organizing pneumonia. The patient was treated with intravenous acyclovir and foscarnet, and a vitrectomy was performed for retinal detachment. The lesion took approximately two months to scar.</p></div><div><h3>Conclusion</h3><p>This report suggests that patients with an ARN history might be at risk of ARN recurrence because of the reactivation of the herpes simplex virus induced by COVID-19 vaccination.</p></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1201971224002418/pdfft?md5=ae6afe931470e5631dac0c3b0d156135&pid=1-s2.0-S1201971224002418-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141723552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and outcomes of lung transplantation in patients with severe COVID-19 infection: A systematic review and meta-analysis","authors":"","doi":"10.1016/j.ijid.2024.107176","DOIUrl":"10.1016/j.ijid.2024.107176","url":null,"abstract":"<div><h3>Objectives</h3><p>To synthesize the clinical experience of patients with COVID-19-associated acute respiratory distress syndrome (ARDS) or pulmonary fibrosis (PF) receiving lung transplantation (LTx) and compare the characteristics and outcomes of COVID-19 and non-COVID-19 LTx patients.</p></div><div><h3>Methods</h3><p>A literature search of online databases (PubMed, Web of Science, Embase, the Cochrane Library, China Science and Technology Journal Database, and Wan Fang databases) was performed regarding LTx for COVID-19–associated ARDS or PF. This study was registered on PROSPERO (CRD2024507647).</p></div><div><h3>Results</h3><p>Eight eligible studies were included with 478 COVID-19 LTx patients and 163 non-COVID-19 LTx patients. In COVID-19 LTx patients, the pooled hospital mortality and follow-up survival rate was 0.00% (95% CI 0.00-0.03) and 87.40% (95% CI 0.76-0.96). Compared to non-COVID-19 LTx patients, COVID-19 LTx patients were associated with significantly higher rate of primary graft dysfunction (odds ratio [OR] 8.72, 95% CI 3.54-21.47, <em>P &lt;</em> 0.001) but significantly higher follow-up survival rate (OR 2.48, 95% CI 1.02-6.01, <em>P</em> = 0.04), within an overall similar follow-up period.</p></div><div><h3>Conclusions</h3><p>For patients with COVID-19–associated ARDS or PF, LTx offers acceptable short-term outcomes and is suggested as a viable lifesaving treatment.</p></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1201971224002479/pdfft?md5=ec5f8f51be1c57dab0ab1ea6fbf2e240&pid=1-s2.0-S1201971224002479-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141723550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}