International Journal of Infectious Diseases最新文献

{"title":"Gaza and the collapse of global health ethics: the forgotten mandate of Sustainable Development Goals","authors":"Thirumalaisamy P Velavan ,&nbsp;Salome Steinke ,&nbsp;Francine Ntoumi","doi":"10.1016/j.ijid.2025.108019","DOIUrl":"10.1016/j.ijid.2025.108019","url":null,"abstract":"<div><div>The Sustainable Development Goals (SDGs) articulate a global consensus to end hunger, secure health, and ensure access to safe water for all by 2030. However, in Gaza, the worlds’ failure to uphold SDG 2 (Zero Hunger), SDG 3 (Good Health and Well-being), and SDG 6 (Clean Water and Sanitation) is no longer a matter of neglect, it is a demonstration of systemic exclusion and ethical detriment. Over a million Palestinians face catastrophic levels of food insecurity, scarcity of clean water, and demolished health infrastructure under sustained military assault and blockade. While the global health community rapidly mobilized in other conflict zones; Gaza remains isolated in its suffering. If these fundamental rights are not defended here, the global commitment to the SDGs is rendered meaningless.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"159 ","pages":"Article 108019"},"PeriodicalIF":4.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of advanced HIV disease among antiretroviral therapy-experienced persons with HIV in Italy over the past 20 years","authors":"Annalisa Mondi ,&nbsp;Alessandro Cozzi-Lepri ,&nbsp;Valentina Mazzotta ,&nbsp;Silvia Nozza ,&nbsp;Antonella Cingolani ,&nbsp;Lucia Taramasso ,&nbsp;Andrea Giacomelli ,&nbsp;Simone Lanini ,&nbsp;Valeria Bono ,&nbsp;Alice Ianniello ,&nbsp;Laura Comi ,&nbsp;Chiara Papalini ,&nbsp;Cristina Mussini ,&nbsp;Enrico Girardi ,&nbsp;Andrea Antinori ,&nbsp;Icona Foundation Study Group","doi":"10.1016/j.ijid.2025.108016","DOIUrl":"10.1016/j.ijid.2025.108016","url":null,"abstract":"<div><h3>Objectives</h3><div>Data on the burden of advanced HIV disease (AHD) among people with HIV (PWH) already in care remain limited in high-income settings.</div></div><div><h3>Methods</h3><div>We included all PWH from the Icona Cohort who started ART between 2004 and 2024, with CD4≥200 cells/mm³ and no prior AIDS-defining event (ADE). Probability of AHD (CD4 &lt; 200 cell/mm³ or ADE) occurring ≥3 months after ART initiation was estimated by Kaplan-Meier curves. In a nested case-control study, AHD cases were matched 1:2 to controls by CD4 nadir, age, and ART duration. Predictors of AHD were evaluated by conditional logistic regression. Mortality risk in cases versus controls was also assessed.</div></div><div><h3>Results</h3><div>Among 9,972 ART-experienced PWH, 429 (4.3%) developed AHD. Incidence was highest during the first year of ART (1.6%) and increased linearly thereafter, with lower rates among more recent ART initiators. In the case-control study, female sex, lower education, unemployment, injecting drugs use, prolonged disengagement from care and suboptimal virologic control were associated with an increased AHD risk. AHD cases exhibited an over 8-fold higher risk of all-cause mortality, particularly within two years post-diagnosis.</div></div><div><h3>Conclusions</h3><div>Although declining, the risk of AHD following ART, remains a concern in Italy. Efforts to improve sustained care engagement, especially among women and socio-economically vulnerable groups, are critical.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"159 ","pages":"Article 108016"},"PeriodicalIF":4.3,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of the COVID-19 pandemic on influenza vaccination: A multi-year interrupted time series analysis","authors":"Adi Turjeman ,&nbsp;Genady Drozdinsky ,&nbsp;Leonard Leibovici","doi":"10.1016/j.ijid.2025.108015","DOIUrl":"10.1016/j.ijid.2025.108015","url":null,"abstract":"<div><h3>Objective</h3><div>To assess temporal changes in influenza vaccination coverage and evaluate differences by age and gender in the context of the COVID-19 pandemic.</div></div><div><h3>Methods</h3><div>We conducted a population-based interrupted time series analysis using data from Clalit Health Services in Israel. Adults aged ≥21 years were followed over 11 influenza seasons (2014-2015 to 2024-2025). Annual vaccination rates were stratified by age group (21-40, 41-64, ≥65) and gender. Segmented linear regression assessed changes before and after the pandemic onset. Counterfactual modeling estimated expected vaccination rates in the absence of the pandemic.</div></div><div><h3>Results</h3><div>Vaccination coverage declined from 26.2% (2014-2015) to 17.7% (2024-2025), despite a temporary rise to 28.7% in 2020-2021. Post-pandemic, rates decreased by 2.3 percentage points annually (<em>p</em> = 0.0013). The most pronounced drop was among adults aged ≥65, from 64.8% to 49.2%. Declines were observed across all age and gender groups. Interaction models showed no significant gender differences, but greater declines with increasing age. Counterfactual analysis estimated that 2024-2025 coverage was 5.7 percentage points lower than expected.</div></div><div><h3>Conclusions</h3><div>The COVID-19 pandemic was associated with a sustained decline in influenza vaccination uptake. Targeted strategies are needed to rebuild trust and restore routine immunization, especially among older adults.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"159 ","pages":"Article 108015"},"PeriodicalIF":4.3,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144845868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of population ageing on bloodstream infection epidemiology and outcomes: A machine learning and statistical modelling study","authors":"Min Hyuk Choi ,&nbsp;Dokyun Kim ,&nbsp;Jihoon Yoon ,&nbsp;Seok Hoon Jeong","doi":"10.1016/j.ijid.2025.107998","DOIUrl":"10.1016/j.ijid.2025.107998","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the effect of population ageing on pathogen distribution and clinical outcomes in bloodstream infections (BSIs).</div></div><div><h3>Methods</h3><div>We analysed 37,100 adult patients with BSI from two university hospitals in South Korea (2006-2023) and used statistical and machine learning (ML) approaches to assess temporal trends, age-related changes in causative pathogens, and 30-day mortality.</div></div><div><h3>Results</h3><div>The mean age of patients was 64.6 years (standard deviation 15.0), with 55.7% aged ≥65. Advanced age was independently associated with a high 30-day mortality via a shift in pathogen distribution. ML models predicted an increasing proportion of BSIs caused by <em>Escherichia coli, Enterococcus faecalis</em>, coagulase-negative staphylococci and fungi with ageing and a decreasing proportion of those caused by <em>Staphylococcus aureus</em>, streptococci, <em>Pseudomonas aeruginosa</em> and <em>Acinetobacter</em> spp. Fungaemia contributed to the highest adjusted mortality rate. The advantage of <em>E. coli</em>-BSI being associated with low 30-day mortality was diminished in strains not susceptible to third-generation cephalosporins.</div></div><div><h3>Conclusion</h3><div>Population ageing is associated with shifts in BSI epidemiology and outcomes. Our findings suggest that tailored antimicrobial stewardship and infection management are necessary to address the burden of BSIs in ageing populations.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"159 ","pages":"Article 107998"},"PeriodicalIF":4.3,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Confirmatory mapping for lymphatic filariasis a decade after baseline endemicity assessment in highly urbanized settings of Lagos, Nigeria","authors":"Oladele B. Akogun ,&nbsp;Babatunde Adewale ,&nbsp;Hammed O. Mogaji ,&nbsp;Roseline Dawodu ,&nbsp;M. Bankole ,&nbsp;Ayodeji Adewlae ,&nbsp;Ismail A. Abdus-Salam ,&nbsp;Ikemsinachi Ononogbo ,&nbsp;Francisca O. Olamiju ,&nbsp;Joseph Tehemen ,&nbsp;Sunday Isiyaku","doi":"10.1016/j.ijid.2025.108014","DOIUrl":"10.1016/j.ijid.2025.108014","url":null,"abstract":"<div><h3>Objectives</h3><div>We conducted a confirmatory mapping survey to verify previous survey results, which suggested that lymphatic filariasis is endemic in some parts of Lagos State, Nigeria.</div></div><div><h3>Methods</h3><div>Finger-prick blood samples were collected from 2787 children aged 7-16 years in six local government areas (LGAs) across 153 targeted schools. Circulating filarial antigen (CFA) levels were measured using the filaria test strip, and LGAs were classified as endemic if there were up to three positive cases (d = 3).</div></div><div><h3>Results</h3><div>Children who tested positive for CFA were detected in all the six endemic LGAs, surpassing the critical cutoff; Surulere (d = 5, 1.36%, 95% confidence interval [CI] 0.5-3.2%), Mushin (d = 9, 1.9%, 95% CI 0.9-3.7%), Kosofe (d = 10, 1.6%, 95% CI 0.8-3.1%), Oshodi (d = 8, 1.6%, 95% CI 0.8-3.3%), Eti-Osa (d = 9, 2.60%, 95% CI 1.3-5.1%), and Ikorodu (d = 14, 3.0%, 95% CI 1.7-5.0%). All children who tested positive for CFA were ivermectin-naïve, and bed net ownership (14, 25.5%, <em>P</em> = 0.39) and use (7, 50.0%, <em>P</em> = 0.85) was low. About 29% (0-44%) of children who tested positive for CFA are likely to have acquired infection locally, and 71% (55.6-100%) could have acquired infection locally or elsewhere.</div></div><div><h3>Conclusions</h3><div>Our findings underscore the possibilities of local and imported infections and justify the need to reintroduce mass drug administration, optimize delivery of insecticide-treated bed nets, and extend confirmatory mapping to areas previously classified as non-endemic.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"159 ","pages":"Article 108014"},"PeriodicalIF":4.3,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144816554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leprosy mimicking rosacea: A diagnostic trap","authors":"Xie He ,&nbsp;Lijiao Yin ,&nbsp;Ruiting Huang ,&nbsp;Shunhong Chen","doi":"10.1016/j.ijid.2025.108017","DOIUrl":"10.1016/j.ijid.2025.108017","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"159 ","pages":"Article 108017"},"PeriodicalIF":4.3,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding and preventing Group B Streptococcus infections: Bridging gaps with awareness and action","authors":"Tatiana C.A. Pinto ,&nbsp;Marti Perhach ,&nbsp;Tara M. Randis ,&nbsp;James A. McGregor ,&nbsp;Donna Russell ,&nbsp;Laura M.A. Oliveira","doi":"10.1016/j.ijid.2025.108009","DOIUrl":"10.1016/j.ijid.2025.108009","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"159 ","pages":"Article 108009"},"PeriodicalIF":4.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144816557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of age-stratified latent tuberculosis treatment on disease burden of active tuberculosis: A mathematical modeling study in an aging country with a high disease burden","authors":"Hye Seong ,&nbsp;Yunjeong Lee ,&nbsp;Jiyeon Suh ,&nbsp;Jeehyun Lee ,&nbsp;Joon Young Song","doi":"10.1016/j.ijid.2025.108003","DOIUrl":"10.1016/j.ijid.2025.108003","url":null,"abstract":"<div><h3>Background</h3><div>The Republic of Korea has the highest tuberculosis (TB) incidence among OECD countries, with older adults at elevated risk of reactivation. However, latent TB infection (LTBI) control strategies often exclude individuals over 65 due to potential side effects, such as hepatotoxicity. Identifying optimal age groups for intervention is critical.</div></div><div><h3>Methods</h3><div>We developed an age-structured dynamic transmission model to simulate TB and LTBI progression in Korea. The model was calibrated using TB case data (2011-2018) from the Korea Disease Control and Prevention Agency and the Health Insurance Review and Assessment Service. We projected TB cases averted over 30 years by evaluating LTBI treatment strategies with varying coverage and success rates across age groups.</div></div><div><h3>Results</h3><div>Targeting LTBI treatment in adults aged 35-64 resulted in the greatest reduction in TB incidence. A fourfold increase in the LTBI treatment rate in this group averted 32,814 cases—compared to 11,564 and 5689 cases in the 19-34 and ≥65 age groups, respectively. Increasing the probability of treatment success had a smaller but similar effect.</div></div><div><h3>Conclusion</h3><div>Prioritizing LTBI treatment in the 35-64 age group may substantially reduce TB burden and supports age-stratified strategies for national TB control.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"159 ","pages":"Article 108003"},"PeriodicalIF":4.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144816555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infective endocarditis and cardiac events after transcatheter vs surgical aortic valve replacement: A nationwide cohort study","authors":"Alexander Kutz ,&nbsp;Martin Purtak ,&nbsp;Rahel Laager ,&nbsp;Stefan Stortecky ,&nbsp;Anna Conen","doi":"10.1016/j.ijid.2025.108011","DOIUrl":"10.1016/j.ijid.2025.108011","url":null,"abstract":"<div><h3>Objectives</h3><div>To compare rates of infective endocarditis (IE) and major adverse cardiac events (MACE) in patients with TAVI, bioprosthetic (bio), and mechanical (mech) SAVR.</div></div><div><h3>Methods</h3><div>Population-based cohort study of inpatient adults undergoing TAVI, bioSAVR or mechSAVR for aortic valve stenosis between 2012 and 2021 in Switzerland. In 2 pairwise 1:1 propensity-score matched cohorts (TAVI versus bioSAVR and bioSAVR versus mechSAVR) we analysed the primary outcome of the incidence of IE and secondary outcomes including MACE.</div></div><div><h3>Results</h3><div>Among 18,253 patients undergoing aortic valve replacement (mean age 76.6±10.3 years, 43.8% female), the incidence rate (IR) of IE was highest in the first 3 months after the intervention (TAVI, bioSAVR, mechSAVR: 23.61, 18.87, 16.65 per 1000 person-years, respectively). After matching, the rate of IE was higher in patients undergoing TAVI versus bioSAVR (n=2329 pairs, HR 1.56 [95% CI, 1.12-2.18]; incidence rate difference [IRD] 3.84 [95% CI,1.29-6.39] per 1000 person-years), and higher in bioSAVR versus mechSAVR (n=773, HR 2.27 [1.24-4.15]; IRD 4.57 [1.29-7.85] per 1000 person-years). The HRs for MACE were 2.10 [1.90-2.33] and 2.09 [1.58-2.77], respectively.</div></div><div><h3>Conclusions</h3><div>For patients undergoing aortic valve replacement for native aortic valve stenosis, TAVI was associated with higher rates of IE than bioSAVR, as was bioSAVR when compared with mechSAVR.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"159 ","pages":"Article 108011"},"PeriodicalIF":4.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144816556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology, clinical characteristics, and genetic diversity of Nipah virus strains from Bangladesh: 2016-2023","authors":"Syed Moinuddin Satter ,&nbsp;Dewan Imtiaz Rahman ,&nbsp;Sharmin Sultana ,&nbsp;Md. Mahfuzur Rahman ,&nbsp;Wasik Rahman Aquib ,&nbsp;Arifa Nazneen ,&nbsp;Anika Farzin ,&nbsp;Kamal Ibne Amin Chowdhury ,&nbsp;Tonmoy Sarkar ,&nbsp;Fateha Akther Ema ,&nbsp;Shadman Sakib Choudhury ,&nbsp;Ayesha Siddika ,&nbsp;Muhammad Rashedul Alam ,&nbsp;Faruq Abdulla ,&nbsp;Probir Kumar Ghosh ,&nbsp;Md. Omar Qayum ,&nbsp;Md. Ferdous Rahman Sarker ,&nbsp;Md Abdullah Omar Nasif ,&nbsp;Barnali Sen ,&nbsp;Mintu Chowdhury ,&nbsp;Tahmina Shirin","doi":"10.1016/j.ijid.2025.108010","DOIUrl":"10.1016/j.ijid.2025.108010","url":null,"abstract":"<div><h3>Objectives</h3><div>Nipah virus (NiV) causes deadly outbreaks in Bangladesh, with a fatality rate of 71%. Two sublineages, NiV-BD 1 and NiV-BD 2, have been identified. This study aimed to characterize their epidemiologic and clinical diversity.</div></div><div><h3>Methods</h3><div>This study analyzed 21 new (2016-2023) and 17 previously (2012-2015) reported NiV genome sequences and compared sublineages using descriptive and bivariate analysis.</div></div><div><h3>Results</h3><div>The median age of sequenced cases was 17 years (Interquartile Range (IQR): 9-30), 66% were male. Raw date palm sap consumption was main transmission pathway (92%). NiV-BD 2 showed a broader geographic distribution, including the southern region. The sublineages did not differ significantly in age, sex, or transmission modes. Both sublineages presented with fever, altered mental status, and unconsciousness. Respiratory distress was more frequent in NiV-BD 2 (23 of 29 cases), whereas hospitalization was longer for NiV-BD 1 (median: 3 days; IQR: 1-23). The overall mortality was 84%, with no significant difference between sublineages. Phylogenetic analysis demonstrated that NiV-BD 1 and NiV-BD 2 formed distinct clusters with 98.72-99.25% nucleotide and 99.98-99.99% amino acid identity. The structural nucleoprotein and matrix proteins remained conserved across sublineages.</div></div><div><h3>Conclusions</h3><div>This study highlights genetic, spatio-temporal, and clinical variation between sublineages, emphasizing continuous genomic surveillance to inform future vaccine and therapeutic strategies.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"159 ","pages":"Article 108010"},"PeriodicalIF":4.3,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}