International Journal of Infectious Diseases最新文献

{"title":"Combination of serological and cytokine release assays for improved diagnosis of childhood tuberculosis in Zambia (PROMISE-TB)","authors":"Edouard Tuaillon ,&nbsp;Mwiya Mwyia ,&nbsp;Karine Bollore ,&nbsp;Amandine Pisoni ,&nbsp;Pierre-Alain Rubbo ,&nbsp;Matthias Richard ,&nbsp;Laurent Kremer ,&nbsp;Maria M.W. Tonga ,&nbsp;Duncan Chanda ,&nbsp;Marianne Peries ,&nbsp;Roselyne Vallo ,&nbsp;Sabrina Eymard-Duvernay ,&nbsp;Morgana D'Ottavi ,&nbsp;Chipepo Kankasa ,&nbsp;Philippe Van de Perre ,&nbsp;Jean-Pierre Moles ,&nbsp;Nicolas Nagot","doi":"10.1016/j.ijid.2024.107248","DOIUrl":"10.1016/j.ijid.2024.107248","url":null,"abstract":"<div><h3>Objectives</h3><div>The diagnostic gaps for childhood tuberculosis (TB) remain considerable in settings with high TB incidence and resource constraints. We established and evaluated the performance of a scoring system based on a combination of serological tests and T-cell cytokine release assays, chosen for their ability to detect immune responses indicative of TB, in a context of high prevalence of pediatric HIV infection.</div></div><div><h3>Methods</h3><div>We enrolled 628 consecutive children aged ≤15 years, admitted for TB suspicion. Multiple cytokine levels in QuantiFERON Gold In-Tube supernatants and antigen 85B (Ag85B) antibodies were assessed in children who tested positive with either Xpert TB or mycobacterial culture. The results were compared with those of control children.</div></div><div><h3>Results</h3><div>Among the biomarkers most strongly associated with TB, random forest classification analysis selected Ag85B antibodies, interleukin-2/interferon-γ ratio, and monokine induced by interferon-γ for the scoring system. The receiver operating characteristic curve derived from our scoring system showed an area under the curve of 0.95 (0.91-0.99), yielding 91% sensitivity and 88% specificity. The internal bootstrap validation gave the following 95% confidence intervals for the score performance: sensitivity 71%-97% and specificity 79%-99%.</div></div><div><h3>Conclusions</h3><div>This study suggests that supplementing the QuantiFERON assay with a combination of serological and T-cell markers could enhance childhood TB screening regardless of HIV status and age. Further validation among the target population is necessary to confirm the performance of this scoring system.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"148 ","pages":"Article 107248"},"PeriodicalIF":4.8,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142346191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oropouche virus: A re-emerging arbovirus of clinical significance","authors":"Angel N. Desai ,&nbsp;Ashley Otter ,&nbsp;Marion Koopmans ,&nbsp;Guido Granata ,&nbsp;Martin P. Grobusch ,&nbsp;Varol Tunali ,&nbsp;Roberta Astorri ,&nbsp;Pikka Jokelainen ,&nbsp;Gilbert Greub ,&nbsp;Önder Ergönül ,&nbsp;Sofia R. Valdoleiros ,&nbsp;Chantal P Rovers ,&nbsp;Antonino Di Caro ,&nbsp;Raffaella Pisapia ,&nbsp;Francesco Maria Fusco ,&nbsp;Ana Pereira do Vale ,&nbsp;Karen A. Krogfelt ,&nbsp;Eskild Petersen ,&nbsp;Barry Atkinson","doi":"10.1016/j.ijid.2024.107251","DOIUrl":"10.1016/j.ijid.2024.107251","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"149 ","pages":"Article 107251"},"PeriodicalIF":4.8,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic utility of pharyngeal follicular structures in COVID-19: A large-scale cross-sectional study","authors":"Hidenori Takahashi ,&nbsp;Miwa Morikawa ,&nbsp;Yugo Satake ,&nbsp;Hiroki Nagamatsu ,&nbsp;Ryutaro Hirose ,&nbsp;Yuka Yamada ,&nbsp;Naoya Toba ,&nbsp;Mio Toyama-Kousaka ,&nbsp;Shinichiro Ota ,&nbsp;Masahiro Shinoda ,&nbsp;Masamichi Mineshita ,&nbsp;Masaharu Shinkai","doi":"10.1016/j.ijid.2024.107244","DOIUrl":"10.1016/j.ijid.2024.107244","url":null,"abstract":"<div><h3>Objectives</h3><div>Pharyngeal follicles similar to those seen in influenza have been observed in patients with coronavirus disease 2019 (COVID-19), suggesting their potential as early-stage diagnostic markers. In this study, we examined the diagnostic potential of pharyngeal follicles for COVID-19, particularly the Omicron variant and its subtypes, to obtain basic data for AI-based diagnostic imaging tools.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted from July 21, 2022, to March 31, 2023, at the Tokyo Shinagawa Hospital's fever clinic. Participants aged ≥15 years who underwent real-time polymerase chain reaction testing for COVID-19 and pharyngeal examinations were included. Demographic details, symptom onset, throat pain, and vaccination status were also recorded. Pharyngeal structures were categorized into four groups: follicles, buds, mixed, or absent.</div></div><div><h3>Results</h3><div>Of the 1223 participants, 829 (67.8%) tested positive for COVID-19. Among those who tested positive, 73.6% (95% CI: 70.6%-76.6%) had follicular structures, compared to 52.8% (95% CI: 47.9%-57.7%) of those who tested negative (<em>P</em> = 1.0 × 10⁻¹²). Overall, 818 participants exhibited follicular structures (439 with follicles, 281 with buds, and 98 with mixed structures), while 405 lacked any follicular structures. Regression analysis identified throat pain and follicular structures as significant COVID-19 predictors (95% confidence intervals: 2.49-4.85 and 1.43-2.59, respectively). Mixed follicles were identified as a potentially characteristic feature of COVID-19.</div></div><div><h3>Conclusion</h3><div>Pharyngeal follicular structures demonstrated high sensitivity for early COVID-19 diagnosis.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"149 ","pages":"Article 107244"},"PeriodicalIF":4.8,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of symptomatic Lyme borreliosis in nine European countries","authors":"Frederick J. Angulo ,&nbsp;Emily Colby ,&nbsp;Anne-Mette Lebech ,&nbsp;Per-Eric Lindgren ,&nbsp;Anna Moniuszko-Malinowska ,&nbsp;Franc Strle ,&nbsp;Julia Olsen ,&nbsp;Gordon Brestrich ,&nbsp;Andrew Vyse ,&nbsp;Madiha Shafquat ,&nbsp;L. Hannah Gould ,&nbsp;Patrick H. Kelly ,&nbsp;Andreas Pilz ,&nbsp;Kate Halsby ,&nbsp;Jennifer C. Moïsi ,&nbsp;James H. Stark","doi":"10.1016/j.ijid.2024.107242","DOIUrl":"10.1016/j.ijid.2024.107242","url":null,"abstract":"<div><h3>Objectives</h3><div>To better understand the Lyme borreliosis (LB) burden in Europe, we aimed to estimate the incidence of symptomatic <em>Borrelia burgdorferi</em> sensu lato (Bbsl) infections after adjusting public health LB surveillance data for under-detection of symptomatic Bbsl infections.</div></div><div><h3>Methods</h3><div>Data from seroprevalence studies and estimates of the symptomatic proportion and duration of antibody detection in Bbsl-infected individuals, derived from reviews of the published literature, were used to adjust public health LB surveillance data to estimate the incidence of symptomatic Bbsl infection in nine European countries from 2018 to 2022.</div></div><div><h3>Results</h3><div>The prevalence of anti-Bbsl antibodies ranged from 2.3% in Romania to 9.4% in Germany. Under-detection multipliers varied across surveillance systems; using 10-year duration of antibody detection, multipliers were 2.4-10.5 in countries reporting all LB cases and 54.6-722.2 in countries reporting only Lyme neuroborreliosis cases. The incidence of symptomatic Bbsl infection adjusted for under-detection was highest in Finland, Germany, Norway, Poland, and Switzerland, intermediate in the Czech Republic and Denmark, and lowest in Ireland and Romania.</div></div><div><h3>Conclusion</h3><div>Adjustment of LB surveillance for under-detection found a high incidence of symptomatic Bbsl infection in several European countries. Differences in LB surveillance systems should be considered when comparing surveillance data between countries and when estimating LB disease burden.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"149 ","pages":"Article 107242"},"PeriodicalIF":4.8,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimates of vaccine effectiveness of the updated monovalent XBB.1.5 COVID-19 vaccine against symptomatic SARS-CoV-2 infection, hospitalization, and receipt of oxygen therapy in South Korea - October 26 to December 31, 2023","authors":"Jung Ah Lee ,&nbsp;Heeseon Jang ,&nbsp;Sang Min Ahn ,&nbsp;Jae Eun Seong ,&nbsp;Young Keun Kim ,&nbsp;Yujin Sohn ,&nbsp;Sook In Jung ,&nbsp;Hye Won Jeong ,&nbsp;Shin-Woo Kim ,&nbsp;Jin-Soo Lee ,&nbsp;Ji-Hyeon Baek ,&nbsp;Se Ju Lee ,&nbsp;Geun-Yong Kwon ,&nbsp;Jeeyeon Shin ,&nbsp;Hangjin Jeong ,&nbsp;Changsoo Kim ,&nbsp;Jun Yong Choi","doi":"10.1016/j.ijid.2024.107249","DOIUrl":"10.1016/j.ijid.2024.107249","url":null,"abstract":"<div><h3>Objectives</h3><div>We evaluated the vaccine effectiveness of monovalent XBB.1.5 vaccine against symptomatic COVID-19 infection, hospitalization, and the need for oxygen therapy in South Korea.</div></div><div><h3>Design</h3><div>This study employed a test-negative case-control design. COVID-19 test results in symptomatic subjects from six university hospitals across South Korea were collected (October 26–December 31, 2023). The adjusted absolute and relative vaccine effectiveness were assessed.</div></div><div><h3>Results</h3><div>In total, 5516 subjects were enrolled: 4,824 were unvaccinated with XBB.1.5, and 692 were vaccinated with XBB.1.5 COVID-19 mRNA vaccines. The absolute vaccine effectiveness when comparing the odds between XBB.1.5 vaccination and no vaccination against symptomatic COVID-19 infection, hospitalization, and oxygen therapy was 65.2% (95% CI, 36.1-81.0), 77.3% (95% CI, 51.1-89.5), and 85.3% (95% CI, 57.8-94.9), respectively. The relative vaccine effectiveness when comparing the odds between XBB.1.5 vaccination and no XBB.1.5 vaccination against symptomatic COVID-19 infection, hospitalization, and oxygen therapy was 57.7% (95% CI, 34.7-72.6), 64.3% (95% CI, 35.9-80.2), and 65.5% (95% CI, 27.0-83.7), respectively.</div></div><div><h3>Conclusion</h3><div>The short-term effectiveness of the XBB.1.5 vaccine against symptomatic COVID-19 infection, hospitalization, and receipt of oxygen therapy in South Korea was significant. Long-term vaccine effectiveness warrants evaluation, and these assessments should be conducted regularly.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"148 ","pages":"Article 107249"},"PeriodicalIF":4.8,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forty-year single-center experience of Burkholderia cystic fibrosis airway infections","authors":"Burkhard Tümmler ,&nbsp;Jutta Ulrich ,&nbsp;Ludwig Sedlacek","doi":"10.1016/j.ijid.2024.107250","DOIUrl":"10.1016/j.ijid.2024.107250","url":null,"abstract":"<div><h3>Objectives</h3><div>To resolve the epidemiology of airway infections with <em>Burkholderia cepacia</em> complex (<em>Bcc</em>) in patients with cystic fibrosis (pwCFs) over 40 years at a single treatment center.</div></div><div><h3>Methods</h3><div>All <em>Bcc</em> and <em>Burkholderia gladioli</em> airway isolates were collected from pwCFs who presented at the cystic fibrosis outpatient and the lung transplantation clinics from 1983 to 2022.</div></div><div><h3>Results</h3><div>The collection of 1205 strains is dominated by <em>B. multivorans</em> (56%), followed by <em>B. cenocepacia</em> (16%), <em>B. stabilis</em> (10%), and <em>B. orbicola</em> (9%). A total of 27 pwCFs experienced a single self-limiting episode of airway infection with <em>Bcc</em>. A total of 13 pwCFs were harboring <em>Bcc</em> for 1.7-13.6 years and 15 pwCFs were persistently infected with <em>Bcc.</em> A total of 16 <em>Bcc</em>-positive pwCFs received a lung transplant. Fatal post-transplant sepsis happened in one patient with <em>B. multivorans</em>, two with <em>B. cenocepacia</em>, and two with <em>B. orbicola</em>.</div></div><div><h3>Conclusions</h3><div>After the first acquisition of <em>Bcc,</em> transient carriage was 2.7 times more frequent than persistent colonization. Infections with <em>B. cenocepacia</em> or <em>B. orbicola</em> confer a higher risk for post-transplant sepsis than an infection with <em>B. multivorans</em>.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"148 ","pages":"Article 107250"},"PeriodicalIF":4.8,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 complicated with severe M1UK-lineage Streptococcus pyogenes infection in elderly patients: A report of two cases","authors":"Ae Kawaguchi ,&nbsp;Kentaro Nagaoka ,&nbsp;Hitoshi Kawasuji ,&nbsp;Toshiomi Kawagishi ,&nbsp;Takamasa Fuchigami ,&nbsp;Kaho Ikeda ,&nbsp;Jun-Ichi Kanatani ,&nbsp;Tomoaki Doi ,&nbsp;Kazunori Oishi ,&nbsp;Yoshihiro Yamamoto","doi":"10.1016/j.ijid.2024.107246","DOIUrl":"10.1016/j.ijid.2024.107246","url":null,"abstract":"<div><div>Case 1: A 71-year-old man was admitted to our hospital with progressive fever and dyspnea, which had developed three days after the onset of COVID-19. Initial chest computed tomography (CT) revealed a pulmonary lesion consistent with a secondary bacterial infection. <em>Streptococcus pyogenes</em> was isolated from cultures of primary sputum collected from the endotracheal tube, and identified as the causative microorganism. Case 2: A 91-year-old man was transferred to our hospital with severe hypotension, which had developed nine days after the onset of COVID-19. A chest CT revealed pericardial effusion and pericardiocentesis yielded purulent fluid. <em>S. pyogenes</em> was isolated from the fluid specimens and was identified as the causative microorganism of the secondary bacterial pericarditis. Isolates from both patients were subsequently identified as M1_UK-lineage <em>S. pyogenes</em> via genetic analysis. This report implicates COVID-19 as a potential risk factor for severe M1_UK infection via the respiratory tract.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"148 ","pages":"Article 107246"},"PeriodicalIF":4.8,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indirect effectiveness of COVID-19 vaccines in the pre-omicron and omicron periods: A nation-wide test-negative case-control study in Brazil","authors":"Thiago Cerqueira-Silva ,&nbsp;Viviane S. Boaventura ,&nbsp;Neil Pearce ,&nbsp;Manoel Barral-Netto","doi":"10.1016/j.ijid.2024.107241","DOIUrl":"10.1016/j.ijid.2024.107241","url":null,"abstract":"<div><h3>Objectives</h3><div>Mass COVID-19 immunization campaigns altered the pandemic's progress by protecting the vaccine recipient and reducing transmission. However, evidence for indirect vaccine effectiveness (IVE) is limited due to the difficulties of ascertaining this type of protection.</div></div><div><h3>Methods</h3><div>Using linked national Brazilian databases, we adapted the test-negative design to evaluate the IVE against symptomatic infection. We analyzed data from January 1 to December 1, 2021 (pre-omicron) and January 1 to April 30, 2022 (omicron BA.1 and BA.2). We compared the probability of testing positive across various levels of second ancestral-strain monovalent COVID-19 vaccine dose coverage, including only unvaccinated individuals in the main analysis and both vaccinated and unvaccinated individuals in additional analyses. Sensitivity analysis focused on children younger than 12 years who did not have access to COVID-19 vaccines during the pre-omicron period.</div></div><div><h3>Results</h3><div>We included 11,039,315 unvaccinated individuals tested during the pre-omicron study period. IVE was minimal until 30% vaccination coverage (&lt;10%), then it followed a dose-dependent pattern, peaking at 37.7 (95% confidence interval 32-42.8) at 70% coverage. For children younger than 12 years, IVE peaked at 59.8% (95% confidence interval 52.7-65.9) at 70% coverage. During the omicron period, IVE remained constant at about 5% across all comparisons.</div></div><div><h3>Conclusions</h3><div>Our findings confirm that high vaccination coverage using vaccines that prevent infection indirectly protects the community. However, IVE was substantially higher during the pre-omicron period.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"148 ","pages":"Article 107241"},"PeriodicalIF":4.8,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe invasive infections linked to IRAK2 immune variants","authors":"Aseervatham Anusha Amali ,&nbsp;Kathirvel Paramasivam ,&nbsp;Sharada Ravikumar ,&nbsp;Zhaohong Tan ,&nbsp;Shaun Seh Ern Loong ,&nbsp;Kelvin Han Chung Chong ,&nbsp;Alicia Ang ,&nbsp;Jin Zhu ,&nbsp;Suma Sathyanarayana Rao ,&nbsp;Louis Yi Ann Chai","doi":"10.1016/j.ijid.2024.107245","DOIUrl":"10.1016/j.ijid.2024.107245","url":null,"abstract":"<div><div>In subjects with peculiar susceptibility to severe infections by common pyogenic bacteria, mutations of interleukin-1 receptor-associated kinase proteins (IRAK)1 and IRAK4 had been identified. The IRAK kinases function as downstream signal transductors following the activation of pathogen recognition receptors. In two patients with sequential or repeated invasive infections: herpes simplex virus-triggered hemophagocytic lymphohistiocytosis with tuberculosis, and <em>Streptococcus pneumoniae</em> bacteremia with candidemia respectively, novel mutations of IRAK2 were identified. These mutations compromised the capacity to ubiquinate (or functionally modify) the signal adaptor tumor necrosis factor receptor-associated factor 6. The result is impairment of the cytokine tumor necrosis factor-alpha production. This susceptibility to a varied range of pathogens underlines a potential central role played by IRAK2 in mediating host defense in infectious diseases.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"148 ","pages":"Article 107245"},"PeriodicalIF":4.8,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Septic shock and fulminant hepatic failure secondary to Q fever in a child with sickle cell disease: First case report","authors":"Raghad Al-Abdwani ,&nbsp;Ahmed Al Farsi ,&nbsp;Matthew Zachariah ,&nbsp;Badriya Al Adawi ,&nbsp;Azza Al-Rashdi ,&nbsp;Naga Ram Dhande ,&nbsp;Nagi Elsidig ,&nbsp;Zaid Alhinai","doi":"10.1016/j.ijid.2024.107243","DOIUrl":"10.1016/j.ijid.2024.107243","url":null,"abstract":"<div><div>Q fever is a zoonosis with a worldwide distribution that is caused by the intracellular bacterium <em>Coxiella burnetii</em>. Although most infections in children are asymptomatic and self-limiting, some experience severe or chronic manifestations. Its manifestations in patients with sickle cell disease are unknown, as there are no reports currently. We report the case of a 4-year-old child with sickle cell disease who was admitted to the intensive care unit with fever, septic shock and fulminant hepatic failure secondary to hepatic sequestration crisis and intrahepatic cholestasis. <em>Coxiella burnetii</em> infection was confirmed by molecular and serologic assays. Empiric therapy with doxycycline had a significant impact on his course, and he made an excellent recovery despite requiring extensive life-supportive measures initially. This is the first report of Q fever in a patient with sickle cell disease, demonstrating its capability to manifest as acute sickle hepatopathy with critical illness.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"148 ","pages":"Article 107243"},"PeriodicalIF":4.8,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}