International Journal of Infectious Diseases最新文献

{"title":"Successful Multimodal Management of Acanthamoeba-Associated Granulomatous Amebic Encephalitis in an Immunocompetent Child: Clinical Analysis With Structured Review of Published Pediatric Cases.","authors":"Ali Yayla, İbrahim Sertdemir, Özgür Kurt, M Memet Özek","doi":"10.1016/j.ijid.2026.108931","DOIUrl":"10.1016/j.ijid.2026.108931","url":null,"abstract":"<p><strong>Objectives: </strong>To describe the diagnostic pathway, multimodal therapeutic approach, and long-term outcome of an immunocompetent child with Acanthamoeba-associated granulomatous amebic encephalitis, and to place the case in the context of previously published immunocompetent pediatric cases through a structured literature review.</p><p><strong>Methods: </strong>A 4-year-old child from Tbilisi, Georgia, presented with intractable seizures and intermittent fever. Despite broad-spectrum antibiotics, symptoms persisted. After excision of the lesions, pathological, microbiological, and molecular analyses were performed. Acanthamoeba-like microorganisms were identified during microscopic examination of Kinyoun-stained smears and confirmed by polymerase chain reaction (PCR). The patient received prolonged combination antimicrobial therapy, including miltefosine, and was followed for 3 years. A structured PubMed and Scopus-based review was also performed, covering publications from 1990 to 2025. Duplicates were removed manually. Two authors independently screened titles, abstracts, and full texts, and disagreements were resolved by consensus.</p><p><strong>Results: </strong>The index patient had multiple supratentorial lesions with marked edema, diffusion restriction, and blood products. Staged surgical resection provided diagnostic tissue and decompression; Kinyoun-stained smears showed Acanthamoeba-like organisms, and PCR confirmed Acanthamoeba spp. After prolonged combination therapy including miltefosine, the patient achieved sustained clinical and radiological recovery at 3 years. The review identified 14 previously published cases, including the present patient; 15 immunocompetent pediatric cases were analyzed. Median age was 9 years (range, 1-17), with 10 boys and 5 girls. Nine patients survived and six died, yielding a fatality rate of 40%.</p><p><strong>Conclusions: </strong>Acanthamoeba-associated GAE should be considered in immunocompetent children with unexplained multifocal intracranial lesions, seizures, and fever when routine investigations are nondiagnostic. Early surgical tissue sampling, fresh-smear microscopy, PCR confirmation, lesion-directed decompression when indicated, and prolonged targeted therapy, including miltefosine, may contribute to survival in selected pediatric patients.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108931"},"PeriodicalIF":4.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148329328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dolutegravir improves physical health-related quality of life in adults with HTLV-1 infection: A randomized controlled trial.","authors":"Liliane Lins-Kusterer, Iris Montaño-Castellón, Estela Luz, Maria Belen Arriaga, Ivana Luz Nunes, Bobby Brooke Herrera, Carlos Brites","doi":"10.1016/j.ijid.2026.108933","DOIUrl":"10.1016/j.ijid.2026.108933","url":null,"abstract":"<p><strong>Objectives: </strong>Human T-lymphotropic virus type 1 (HTLV-1) infection is associated with progressive neurological impairment and reduced health-related quality of life (HRQoL). We evaluated longitudinal changes in HRQoL over 96 weeks in adults with HTLV-1 receiving dolutegravir compared with vitamin C.</p><p><strong>Methods: </strong>This open-label, randomized controlled trial conducted in Brazil assigned participants to dolutegravir (50 mg/d) or vitamin C (500 mg/d). HRQoL was assessed using the RAND-36 questionnaire at baseline and week 96. Within-group changes were estimated using Cohen's d. Between-group comparisons for the Physical and Mental Component Summary scores (PCS and MCS) were performed using analysis of covariance adjusted for baseline values.</p><p><strong>Results: </strong>Sixty-one participants completed follow-up (dolutegravir n = 34; vitamin C n = 27). The dolutegravir group showed improvements in physical functioning and pain domains. After adjustment, PCS scores at week 96 were significantly higher in the dolutegravir group compared with vitamin C (adjusted mean difference 3.92; 95% CI 0.30-7.53; p = 0.034). No significant between-group difference was observed for MCS.</p><p><strong>Conclusions: </strong>Dolutegravir was associated with improved physical HRQoL over 96 weeks in individuals with HTLV-1, while no benefit was observed in mental health domains. These findings support further investigation of integrase inhibitors in HTLV-1-associated disease.</p><p><strong>Clinical trial registration: </strong>ReBEC RBR-5 × 7ccxp.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108933"},"PeriodicalIF":4.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-neutralization of SARS-CoV-2 BA.3.2.2 lineage by JN.1 mRNA vaccine-induced immunity.","authors":"Kei Miyakawa, Kaori Sano, Yohei Seki, Ryoichi Sato, Yasuo Yoshihara, Takuo Mizukami, Hideki Hasegawa","doi":"10.1016/j.ijid.2026.108954","DOIUrl":"10.1016/j.ijid.2026.108954","url":null,"abstract":"<p><strong>Objectives: </strong>The SARS-CoV-2 BA.3.2.2 sublineage has emerged globally as the dominant branch of BA.3.2 by late 2025, yet its antigenic relationship with JN.1 vaccine-induced immunity remains unclear.</p><p><strong>Methods: </strong>We evaluated neutralizing antibody responses in 25 JN.1 mRNA vaccinees against eight variants, stratified by anti-nucleocapsid antibody serostatus.</p><p><strong>Results: </strong>Postvaccination titers increased significantly against all variants in both N antibody-negative and -positive groups. Cross-neutralization against BA.3.2.2 was detected in both groups despite lower titers compared to JN.1. Antigenic cartography revealed that BA.3.2.2 was antigenically isolated from all JN.1-descendant variants. AZD3152/sipavibart retained potent neutralization against BA.3.2.2 but completely lost activity against all F456L-harboring JN.1-descendant variants, while VYD222/pemivibart and SA55 maintained broad activity.</p><p><strong>Conclusions: </strong>Retention of wild-type F456 in BA.3.2.2 preserves class 1/2 antibody epitopes, providing a mechanistic basis for cross-neutralization and suggesting a potential therapeutic window for sipavibart should BA.3.2.2 expand globally, pending clinical confirmation.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108954"},"PeriodicalIF":4.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI-defined compression stages and postoperative neurological recovery in thoracic spinal tuberculosis.","authors":"Guangxuan Yan, Weijie Dong, Jun Fan, Tinglong Lan, Li Ma","doi":"10.1016/j.ijid.2026.108975","DOIUrl":"10.1016/j.ijid.2026.108975","url":null,"abstract":"<p><strong>Objectives: </strong>Neurological impairment in thoracic spinal tuberculosis is often related to complex inflammatory and compressive lesions, while the reversibility of neurological deficits remains difficult to predict preoperatively.</p><p><strong>Methods: </strong>We retrospectively analyzed 148 patients with thoracic spinal tuberculosis who underwent surgical treatment between 2019 and 2025. Neurological recovery was defined as improvement in American Spinal Injury Association (ASIA) grade at follow-up. Preoperative MRI findings were evaluated according to the anatomical relationship between the compressive lesion, dural sac, and spinal cord, and categorized into four MRI-defined compression stages. Associations between MRI-defined compression stages and postoperative neurological recovery were assessed using logistic regression analysis.</p><p><strong>Results: </strong>Postoperative neurological recovery differed across MRI-defined compression stages. In multivariable analysis, MRI-defined compression stages remained independently associated with postoperative recovery (OR 2.87, 95% CI 1.87-4.75, P < 0.001). Compared with conventional clinical variables and quantitative MRI measurements, MRI-defined compression stages provided better discrimination of postoperative neurological recovery patterns. Although quantitative imaging parameters and clinical variables exhibited some degree of overlap across patient groups, MRI-based anatomical assessment provided additional clinically interpretable information beyond isolated quantitative measurements. These findings suggest that severe MRI compression does not necessarily indicate irreversible spinal cord injury.</p><p><strong>Conclusion: </strong>MRI-defined compression stages were significantly associated with postoperative neurological recovery in thoracic spinal tuberculosis. Severe MRI compression did not necessarily indicate irreversible neurological injury, suggesting that MRI-based anatomical assessment may complement neurological examination by facilitating preoperative risk stratification and identifying patients with potentially reversible spinal cord compromise.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108975"},"PeriodicalIF":4.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148420973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying rate-limiting steps in the antimicrobial workflow for community-onset sepsis.","authors":"Myung Jin Song, Seunghyun Won, Min Chul Kim, Seyoung Jung, Ryoung-Eun Ko, Sunghoon Park, Gee Young Suh, Yeon Joo Lee","doi":"10.1016/j.ijid.2026.108964","DOIUrl":"10.1016/j.ijid.2026.108964","url":null,"abstract":"<p><strong>Objectives: </strong>To characterize time intervals preceding antimicrobial administration in community-onset sepsis and identify rate-limiting steps.</p><p><strong>Methods: </strong>In this multicenter prospective observational study of patients with community-onset sepsis in South Korea (June 2020-December 2023), the antimicrobial workflow was defined by five time points: time zero, blood culture prescription and collection, and antimicrobial prescription and administration. Patients were categorized into three groups by step sequence, and four key intervals were analyzed.</p><p><strong>Results: </strong>Among 3623 patients (mean age 74.3 ± 13.0 years; 56.6% male), 1838 (50.7%) were assigned to Group A (antimicrobials and cultures prescribed before culture collection), 1517 (41.9%) to Group B (cultures obtained before antimicrobial prescription), and 268 (7.4%) to Group C (antimicrobials given before culture collection). Median time from time zero to administration was shortest in Group C (63.5 min), then Group A (87.0 min) and Group B (115.0 min). The rate-limiting step differed by group: prescription-to-administration in Group A, time-zero-to-prescription in Group B, and culture prescription-to-collection in Group C. Septic shock was associated with shorter intervals overall, except prescription-to-administration, which was unchanged.</p><p><strong>Conclusion: </strong>Rate-limiting steps in antimicrobial delivery differ by clinical workflow. Early concurrent prescription of antimicrobials and blood cultures was associated with shorter time to antimicrobial administration.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108964"},"PeriodicalIF":4.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Governance frameworks, not just products: Overcoming surveillance blind spots in the 2026 Bundibugyo virus outbreak.","authors":"Limia Abueldahab, Arata Hidano, Yuki Takamatsu","doi":"10.1016/j.ijid.2026.109065","DOIUrl":"10.1016/j.ijid.2026.109065","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"109065"},"PeriodicalIF":4.6,"publicationDate":"2026-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reflections on the role of cytomegalovirus in post-liver transplantation coronary artery disease.","authors":"Zhenxing Wang, Weikai Dong","doi":"10.1016/j.ijid.2026.109041","DOIUrl":"10.1016/j.ijid.2026.109041","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"109041"},"PeriodicalIF":4.6,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148722237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to comment on \"Time to positivity as a diagnostic tool for catheter-related candidemia: a species-specific analysis\".","authors":"Marta Albanell-Fernández, Andrea Vergara, Álex Soriano","doi":"10.1016/j.ijid.2026.109031","DOIUrl":"10.1016/j.ijid.2026.109031","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"109031"},"PeriodicalIF":4.6,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148648453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WITHDRAWN: Bundibugyo virus disease: transmission dynamics, infectiousness and viral persistence.","authors":"A Bongiovanni, E Binetti, F Colavita, I Mussetto, L Scorzolini, L Bordi, A Antinori, E Girardi, F Maggi, F Vairo, E Nicastri","doi":"10.1016/j.ijid.2026.108939","DOIUrl":"10.1016/j.ijid.2026.108939","url":null,"abstract":"<p><p>This article has been withdrawn at the request of the editor due to an error in the publishing process. The Publisher apologizes for any inconvenience this may cause.\u0000The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/policies-and-standards/article-withdrawal.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108939"},"PeriodicalIF":4.6,"publicationDate":"2026-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful treatment with rezafungin after micafungin for relapsing Rasamsonia argillacea species complex pneumonia in a patient with bronchiectasis: A case report","authors":"Hugo Bes-Berlandier ,&nbsp;Noémie Coron ,&nbsp;Heloise Pottier ,&nbsp;Sabrina Manni ,&nbsp;Coline Mortier ,&nbsp;Jean Philippe Bouchara ,&nbsp;Coralie Barrera ,&nbsp;Anne-Pauline Bellanger-Clerget ,&nbsp;Laurence Millon ,&nbsp;Perrine Parize ,&nbsp;Fanny Lanternier ,&nbsp;Olivier Lortholary ,&nbsp;Julien Bermudez ,&nbsp;Nadim Cassir ,&nbsp;Benjamin Coiffard","doi":"10.1016/j.ijid.2025.108336","DOIUrl":"10.1016/j.ijid.2025.108336","url":null,"abstract":"<div><div><em>Rasamsonia argillacea</em> species complex are emerging opportunistic molds increasingly reported in patients with chronic lung disease. We describe a 69-year-old woman with bronchiectasis who developed relapsing <em>R. aegroticola</em> pneumonia. After transient improvement with micafungin, relapse occurred, and antifungal therapy was switched to rezafungin, a novel echinocandin with a prolonged half-life and front-loaded pharmacokinetics. A total of 3 months of treatment led to clinical and radiological improvement, with sustained stability 6 months after therapy completion. This case illustrates the pathogenic role of <em>R. argillacea</em> species complex in non-immunocompromised hosts and suggests rezafungin as a promising therapeutic option for echinocandin-susceptible, azole-resistant <em>Rasamsonia</em> infections.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"164 ","pages":"Article 108336"},"PeriodicalIF":4.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145819387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}