International Journal of Infectious Diseases最新文献

{"title":"Onchocerciasis status in Guinea-Bissau: An overview of trends in epidemiological and entomological indicators","authors":"Natalie. V.S. Vinkeles Melchers ,&nbsp;Cristovão Manjuba ,&nbsp;Yao Sodahlon ,&nbsp;Ramalho João Correia ,&nbsp;Victorino Martinho Aiogalé ,&nbsp;Léonce Aké Assi ,&nbsp;Francisco Cabral ,&nbsp;Paul T. Cantey ,&nbsp;Wilma A. Stolk","doi":"10.1016/j.ijid.2025.108035","DOIUrl":"10.1016/j.ijid.2025.108035","url":null,"abstract":"<div><h3>Objectives</h3><div>The World Health Organization recommends monitoring infection and entomological indicators to evaluate onchocerciasis elimination. We reviewed trends in Guinea-Bissau since the onset of interventions to assess current progress toward elimination.</div></div><div><h3>Methods</h3><div>We collated programmatic, entomological, and epidemiological data from Guinea-Bissau, including Onchocerciasis Control Programme (OCP) records, impact data, and community-directed treatment with ivermectin (CDTi) data. Trends were visualized to assess impact.</div></div><div><h3>Results</h3><div>Pre-control microfiladermia (mf) prevalences reached up to 70.6% along Rio Corubal and 27.4% along Rio Géba. Mf intensity ranged up to 59.9 and 6.5 mf/skin snip, respectively. Mf prevalence and intensity declined over time, despite irregular CDTi. In 2007-2008, the highest mf prevalence was 9.7% (Rio Corubal). Despite all villages being mf skin snip-negative by 2015, the detection of OV16 ELISA-positives (0.7%-14.9%) indicated ongoing transmission. Entomological surveys (2015) reported a blackfly infectivity rate of 0.06%, with infectious flies found at two of five sites (Gabú region).</div></div><div><h3>Conclusions</h3><div>CDTi substantially reduced mf prevalence, intensity, and vector infectivity in Guinea-Bissau, but transmission was not reduced to zero. Renewed serological and entomological assessments are needed to accurately determine elimination progress.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"159 ","pages":"Article 108035"},"PeriodicalIF":4.3,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interventions to support breastfeeding among mothers living with HIV: A systematic review and meta-analysis of randomized controlled trials","authors":"Francesco Vladimiro Segala ,&nbsp;Nicola Veronese ,&nbsp;Nandita Sugandhi ,&nbsp;Giovanni Putoto ,&nbsp;Ivy Kasirye ,&nbsp;Annalisa Saracino ,&nbsp;Francesco Di Gennaro","doi":"10.1016/j.ijid.2025.108018","DOIUrl":"10.1016/j.ijid.2025.108018","url":null,"abstract":"<div><h3>Background</h3><div>Breastfeeding improves infant survival, especially in low-resource settings. Although the risk of postnatal transmission is below 1% among virologically suppressed mothers living with HIV, exclusive breastfeeding (EBF) rates and retention in HIV care remain suboptimal. This review evaluated the effect of non-pharmacological interventions aimed at supporting breastfeeding among people living with HIV (PLWH).</div></div><div><h3>Methods</h3><div>We searched PubMed, Embase, and Cochrane Library up to Jan 1, 2025, for randomized controlled trials (RCTs) assessing facility- and community-based interventions. Outcomes included any breastfeeding, EBF, maternal-infant retention, and maternal viral suppression. Risk of bias was assessed using the Cochrane RoB2 tool. Data were pooled using a random-effects meta-analysis, and evidence certainty was rated using GRADE. The study adhered to PRISMA statements and was registered with PROSPERO, <span><span>https://www.crd.york.ac.uk/PROSPERO/view/CRD42025636327</span><svg><path></path></svg></span>.</div></div><div><h3>Findings</h3><div>Eight RCTs (<em>n</em> = 3715) from South Africa, Uganda, Kenya, and India were included. Healthcare support was associated with a borderline increase in maternal viral suppression (RR 1.21, 95% CI 1.00-1.47), corresponding to 140 more per 1,000 mothers. Pooled interventions improved EBF uptake (RR 1.38, 95% CI 1.06-1.80), corresponding to 92 more per 1,000 mothers. Certainty of evidence was low to very low.</div></div><div><h3>Conclusions</h3><div>Facility- and community-based interventions may increase EBF among PLWH. The main limitation of the included RCT was the absence of blinding. No publication bias was detected. More context-specific trials are needed to assess their impact on HIV-related outcomes.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"159 ","pages":"Article 108018"},"PeriodicalIF":4.3,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of antimicrobial use in Qatar's hospitals: Results from the first national point prevalence survey","authors":"Jameela Ali Alajmi ,&nbsp;Dhouha Hamdani ,&nbsp;Eman Khairy Zaky Radwan ,&nbsp;Olena Komarcheva ,&nbsp;Mohamed Sarhan ,&nbsp;Rekayahouda Baaboura ,&nbsp;Sheela Shneezai ,&nbsp;Syed Hassan Bin Usman Shah","doi":"10.1016/j.ijid.2025.108030","DOIUrl":"10.1016/j.ijid.2025.108030","url":null,"abstract":"<div><h3>Background and Objectives</h3><div>Antimicrobial resistance (AMR) poses a serious global public health crisis. Optimizing antimicrobial use is critical to slowing the occurrence and spread of resistant pathogens.</div></div><div><h3>Methods</h3><div>Between September 9 and 27, 2022, a point prevalence survey (PPS) for antimicrobial use was conducted in 17 hospitals in Qatar. All patients admitted to the hospital wards at 8:00 a.m. on survey day constituted the sample. Data included patients’ characteristics, antimicrobials received, and therapeutic indications.</div></div><div><h3>Results</h3><div>Among the 1733 inpatients surveyed, 811 (46.8%) received at least one antimicrobial. Of 1158 antimicrobial prescriptions, antibacterial agents constituted 82.9% (n = 961), 913 systemic antibacterials and 48 antimycobacterial agents. Parenteral administration predominated (83.3%, n = 676). Indications were documented for 96.3% (n = 1116) of prescriptions. Antimicrobials were prescribed for community-acquired infections (41.4%, n = 479), followed by medical prophylaxis (16.8%, n = 194). Third-generation cephalosporins (16.8%) and penicillin/ β-lactamase inhibitor combinations (15.5%) were most frequently prescribed. For community-acquired infections, penicillin combinations (22%) and third-generation cephalosporins (21%) were preferred. First-generation cephalosporins comprised 46% of surgical prophylaxis prescriptions. WHO AWaRe classification showed 35.5% Access and 40.4% Watch group prescriptions.</div></div><div><h3>Conclusion</h3><div>Antimicrobial use in Qatar hospitals was generally high, with broad-spectrum antimicrobials predominating. These findings underscore the urgent need for sector-specific targeted antimicrobial stewardship programs to optimize usage.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"159 ","pages":"Article 108030"},"PeriodicalIF":4.3,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kaposi–Juliusberg syndrome in a young man with Jacobsen syndrome","authors":"Sarah Soueges ,&nbsp;Laurie Gouillon ,&nbsp;Matthieu Godinot","doi":"10.1016/j.ijid.2025.108028","DOIUrl":"10.1016/j.ijid.2025.108028","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"159 ","pages":"Article 108028"},"PeriodicalIF":4.3,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144916330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High CD4⁺ T-cell responses in seronegative individuals following SARS-CoV-2 exposure during a dormitory outbreak","authors":"Ooiean Teng ,&nbsp;Amy May Lin Quek ,&nbsp;Delicia Shu Qin Ooi ,&nbsp;Suqing Wang ,&nbsp;Lorivie Fragata ,&nbsp;Isabel Xue Qi Ng ,&nbsp;Jianzhou Cui ,&nbsp;Jinmiao Chen ,&nbsp;Mikael Hartman ,&nbsp;Paul Edward Hutchinson ,&nbsp;Paul Anantharajah Tambyah ,&nbsp;Raymond Chee Seong Seet","doi":"10.1016/j.ijid.2025.108024","DOIUrl":"10.1016/j.ijid.2025.108024","url":null,"abstract":"<div><h3>Objectives</h3><div>We studied individuals who remained uninfected by SARS-CoV-2 despite repeated exposures during a May-July 2020 dormitory outbreak in Singapore.</div></div><div><h3>Methods</h3><div>We compared immune profiles of those with exposed seronegative (ESN) (negative PCR and serology), with noninfected and infected groups. Following the lifting of quarantine, incident infection rates were compared between the ESN and noninfected cohorts.</div></div><div><h3>Results</h3><div>The immune profiles of 135 men with ESN (repeated negative PCR and persistent seronegativity), and 98 noninfected men, and 139 infected men were examined (mean age 33 years). Men with ESN exhibited higher percentages of CD4⁺ <em>T</em>-cells and classical monocytes, alongside increased specific CD4⁺ <em>T</em> cell responses to the nonstructural protein 12-3 region (NSP12-3) and spike peptides of SARS-CoV-2, compared with noninfection controls. Those with ESN did not differ in their IgG levels against endemic human coronaviruses compared with noninfection controls. Men in the ESN group were found to be less likely to become infected compared with noninfected controls (21% vs 39%, hazard ratio 0.47 [95% CI 0.27-0.73]) after the lifting of quarantine measures.</div></div><div><h3>Conclusions</h3><div>These findings highlight the possible importance of cellular immunity in conferring partial resistance to infection and support the development of T-cell-focused strategies for high-risk settings.</div></div><div><h3>ClinicalTrials.gov number</h3><div>NCT04446104</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"159 ","pages":"Article 108024"},"PeriodicalIF":4.3,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of T-cell immunoglobulin and mucin domain-3 gene polymorphism with susceptibility and severity of Mycobacterium avium complex lung disease: a prospective study in Taiwan","authors":"Sheng-Wei Pan ,&nbsp;Chin-Chung Shu ,&nbsp;Jia-Yih Feng ,&nbsp;Lawrence Shih-Hsin Wu ,&nbsp;Ping-Huai Wang ,&nbsp;Yung-Che Chen ,&nbsp;Jann-Yuan Wang ,&nbsp;Hao-Chien Wang ,&nbsp;Wei-Juin Su ,&nbsp;Yuh-Min Chen ,&nbsp;Chong-Jen Yu","doi":"10.1016/j.ijid.2025.108025","DOIUrl":"10.1016/j.ijid.2025.108025","url":null,"abstract":"<div><h3>Objectives</h3><div>Patients with <em>Mycobacterium avium</em> complex lung disease (MAC-LD) may exhibit immune exhaustion, characterized by elevated T-cell immunoglobulin and mucin domain-3 (TIM3) protein expression on T lymphocytes. Whether single-nucleotide polymorphisms in <em>TIM3</em> genes are associated with susceptibility to MAC-LD and its clinical presentation remains unknown.</div></div><div><h3>Methods</h3><div>Patients with MAC-LD and controls were recruited to assess associations between three <em>TIM3</em> gene single-nucleotide polymorphisms and MAC-LD susceptibility and severity. Disease extent was evaluated using a radiographic score. TIM3-expressing cluster of differentiation (CD)4+ T cells in peripheral blood were quantified by flow cytometry.</div></div><div><h3>Results</h3><div>Higher proportions of <em>TIM3</em> rs13170556 TC+CC genotype (33% vs 22%, <em>P</em> = 0.042) and females (66% vs 53%, <em>P</em> = 0.037) were found in the MAC-LD group (n = 135) than in controls (n = 139), both independently associated with MAC-LD (odds ratio [OR], 1.752 [95% confidence interval, 1.015-3.025], <em>P</em> = 0.044 and 1.746 [1.068-2.852], <em>P</em> = 0.026). Among the patients, the <em>TIM3</em> rs13170556 polymorphism was associated with sputum-smear grading &gt;2+ and radiographic scores &gt;5 (OR 2.183 [1.016-4.694], <em>P</em> = 0.046, and 1.960 [1.023-3.755], <em>P</em> = 0.043). The proportion of CD4+ T cells expressing TIM3 was higher in patients with <em>TIM3</em> rs13170556 TC+CC genotypes than patients with TT genotype (7.1 ± 7.6% vs 4.3 ± 3.4%; <em>P</em> = 0.067) (n = 75).</div></div><div><h3>Conclusions</h3><div><em>TIM3</em> rs13170556 polymorphism is associated with MAC-LD and disease severity, potentially through increased TIM3 protein expression of CD4+ T cells.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"159 ","pages":"Article 108025"},"PeriodicalIF":4.3,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Academic and social-behavioral assessment in a prospective cohort of normocephalic school-aged children with antenatal Zika virus exposure","authors":"Karen Kikuta ,&nbsp;Christopher Justin Hernandez ,&nbsp;Andrea Dunshee de Abranches ,&nbsp;Luana Damasceno ,&nbsp;José Augusto de Britto ,&nbsp;Claudia Jardim Duarte ,&nbsp;Zilton Vasconcelos ,&nbsp;Andrea Zin ,&nbsp;Patricia Brasil ,&nbsp;Maria Elisabeth Moreira ,&nbsp;Karin Nielsen-Saines","doi":"10.1016/j.ijid.2025.108026","DOIUrl":"10.1016/j.ijid.2025.108026","url":null,"abstract":"<div><h3>Objectives</h3><div>Long-term outcomes in children with antenatal Zika virus (ZIKV) exposure without microcephaly are unknown. We assessed academic and social-behavioral outcomes among normocephalic school-aged children with antenatal ZIKV exposure and controls.</div></div><div><h3>Methods</h3><div>School-aged children exposed to Zika (ZEC) and unexposed controls (ZUCs) were recruited in Rio de Janeiro, Brazil. The academic performance and strengths and difficulties questionnaire was evaluated through parental interviews. Clinical/demographic data were abstracted from medical records/interviews. Potential associations with trimester of infection, early neurodevelopment, and neuro-sensory findings were explored in ZEC.</div></div><div><h3>Results</h3><div>In total, 147 children were enrolled: 78 ZEC and 69 ZUCs. The mean age for ZEC was 8.1 years and the mean age for ZUCs was 7.7 years; 50.0% of ZEC and 44.9% of ZUCs were male. Reading (21.8% vs 7.2%, <em>P</em> = 0.0193) difficulties, writing (20.5% vs 5.8%, <em>P</em> = 0.0144) difficulties, and suspected/diagnosed neurodevelopmental disorders (39.7% vs 17.4%, <em>P</em> = 0.0036) were greater in ZEC than ZUCs. ZEC had higher scores in total difficulties (13.32 vs 10.10, <em>P</em> = 0.0099), emotional symptoms (4.33 vs 2.90, <em>P</em> = 0.0011), and hyperactivity (4.95 vs 3.41, <em>P</em> = 0.0037). ZIKV exposure was a predictor of reading (adjusted odds ratio [aOR] = 3.39, 95% confidence interval [CI] = 1.17-9.79), writing (aOR = 4.02, 95% CI = 1.27-12.74), emotional (aOR = 3.51, 95% CI = 1.72-7.18), and hyperactivity (aOR = 2.43, 95% CI = 1.18-4.98) problems. Early developmental delay was more frequent in ZEC with academic difficulties (<em>P</em> = 0.0018).</div></div><div><h3>Conclusions</h3><div>Antenatal ZIKV exposure is associated with increased risk of academic difficulties, neurodevelopmental diagnoses, and social-behavioral problems in school-aged normocephalic children.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"159 ","pages":"Article 108026"},"PeriodicalIF":4.3,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to abstract “Rapid introduction of oral antivirals for COVID-19: implementation of a test and treat program in four African countries”, [International Journal of Infectious Diseases, Volume 152, Supplement, March 2025, 107706]","authors":"Jessica Joseph,&nbsp;Bridget Griffith,&nbsp;Maria Grau-Sepulveda,&nbsp;Caroline Boeke,&nbsp;Yamikani Gumulira,&nbsp;Nervine Hamza,&nbsp;Pax Axell Karamage,&nbsp;Norman Lufesi,&nbsp;Alexander Martin-Odoom,&nbsp;Nyuma Mbewe,&nbsp;Mwaba Mulenga,&nbsp;Rodrigue Albert Ndayishimiye,&nbsp;Joseph Oliver-Commey,&nbsp;Laine Thomas,&nbsp;Cameron Wolfe,&nbsp;QuickStart consortium","doi":"10.1016/j.ijid.2025.107986","DOIUrl":"10.1016/j.ijid.2025.107986","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"159 ","pages":"Article 107986"},"PeriodicalIF":4.3,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144864940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Empty Medicine Cabinet: Urgent Action Needed to Resolve TB Drug Shortages in Europe","authors":"D Goletti ,&nbsp;DM Cirillo ,&nbsp;C Lange ,&nbsp;S Tiberi ,&nbsp;G Günther ,&nbsp;L Petrone ,&nbsp;L Kuksa ,&nbsp;O Opota ,&nbsp;O Akkerman ,&nbsp;D Podlekareva ,&nbsp;L Guglielmetti ,&nbsp;R Duarte","doi":"10.1016/j.ijid.2025.108022","DOIUrl":"10.1016/j.ijid.2025.108022","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"159 ","pages":"Article 108022"},"PeriodicalIF":4.3,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics, complications and outcomes of critically ill patients with Dengue in Brazil, 2012-2024: A nationwide, multicenter cohort study","authors":"Igor Tona Peres ,&nbsp;Otavio T. Ranzani ,&nbsp;Leonardo S.L. Bastos ,&nbsp;Silvio Hamacher ,&nbsp;Tom Edinburgh ,&nbsp;Esteban Garcia-Gallo ,&nbsp;Fernando Augusto Bozza","doi":"10.1016/j.ijid.2025.108023","DOIUrl":"10.1016/j.ijid.2025.108023","url":null,"abstract":"<div><h3>Background</h3><div>Dengue outbreaks are a major public health issue, with Brazil reporting 71% of global cases in 2024.</div></div><div><h3>Purpose</h3><div>This study aims to describe the profile of severe dengue patients admitted to Brazilian intensive care units (ICUs) (2012-2024), assess trends over time, describe new onset complications while in ICU, and determine the risk factors at admission to develop complications during ICU stay.</div></div><div><h3>Methods</h3><div>We performed a prospective study of dengue patients from 253 ICUs across 56 hospitals. We used descriptive statistics to describe the dengue ICU population, logistic regression to identify risk factors for complications during the ICU stay, and a machine learning framework to predict the risk of evolving to complications. Visualizations were generated using ISARIC VERTEX.</div></div><div><h3>Results</h3><div>Of 11,047 admissions, 1117 admissions (10.1%) evolved to complications, including non-invasive (437 admissions) and invasive ventilation (166), vasopressor (364), blood transfusion (353), and renal replacement therapy (103). Age ≥80 (odds ratio [OR]: 3.10, 95% confidence interval: 2.02-4.92), chronic kidney disease (OR: 2.94, 2.22-3.89), liver cirrhosis (OR: 3.65, 1.82-7.04), low platelets (&lt;50,000 cells/mm³; OR: 2.25, 1.89-2.68), and high leukocytes (&gt;7000 cells/mm³; OR: 2.47, 2.02-3.03) were significant risk factors for complications. A machine learning tool for predicting complications was proposed, showing accurate discrimination and calibration.</div></div><div><h3>Conclusion</h3><div>We described a large cohort of dengue patients admitted to ICUs and identified key risk factors for severe dengue complications, such as advanced age, presence of comorbidities, higher level of leukocytes, and lower level of platelets. The proposed prediction tool can be used for early identification and targeted interventions to improve outcomes in dengue-endemic regions.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"159 ","pages":"Article 108023"},"PeriodicalIF":4.3,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}