International Journal of Infectious Diseases最新文献

{"title":"A pediatric health problem increasing with migration: pertussis reloading","authors":"Sefika Aldas,&nbsp;Murat Ersoy,&nbsp;Berfin Ozgokce Ozmen,&nbsp;Asuman Demirhan,&nbsp;Ali Tunc,&nbsp;Sanliay Sahin","doi":"10.1016/j.ijid.2025.108040","DOIUrl":"10.1016/j.ijid.2025.108040","url":null,"abstract":"<div><h3>Objective</h3><div>Bordetella pertussis is a highly contagious respiratory infection affecting infants, particularly those in vulnerable populations. This study investigates the increase in pertussis cases following refugee influxes and natural disasters.</div></div><div><h3>Methods</h3><div>This retrospective study analyzed 28 infants hospitalized in our hospital's pediatric ward due to whooping cough between December 27, 2023, and April 30, 2024. Demographics, vaccination status, clinical findings, treatments, and outcomes were reviewed.</div></div><div><h3>Results</h3><div>Of the 28 infants, 60.7% were male and 39.3% were of Syrian origin; 42.9% were unvaccinated. The mean age was 3.46 ± 3.48 months, and median hospitalization was 11 days. All presented with respiratory distress. Paroxysmal cough (96.4%), feeding difficulty (53.6%), and fever (32.1%) were common. Convulsions occurred in 10.7%, and apnea in 3.6%. B. pertussis was confirmed by PCR in all cases. Chest radiographs showed pneumonic infiltrates in 85.7%. Macrolide antibiotics were given to all. Leukocytosis (15,000-30,000/µL) was observed in 53.6%, extreme leukocytosis in 7.1%, and lymphocytosis in 64.3%. Respiratory support was needed in 78.6%. Four required ICU care; two intubated patients died of multiple organ failure.</div></div><div><h3>Conclusion</h3><div>Pertussis remains a serious health threat, especially among unvaccinated and displaced infants. Strengthening immunization programs and ensuring early diagnosis and treatment are essential to reduce disease burden.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"160 ","pages":"Article 108040"},"PeriodicalIF":4.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of seroprevalence of Mpox virus infection among sex workers in Chiang Mai, Thailand","authors":"Muhammad Umer ,&nbsp;Kriangkrai Chawansuntati ,&nbsp;Jiraprapa Wipasa ,&nbsp;Kanyaruck Jindaphun ,&nbsp;Kamonporn Kotemul ,&nbsp;Yee Mon Thant ,&nbsp;Nicole Ngo-Giang-Huong ,&nbsp;Woottichai Khamduang ,&nbsp;Sayamon Hongjaisee","doi":"10.1016/j.ijid.2025.108041","DOIUrl":"10.1016/j.ijid.2025.108041","url":null,"abstract":"<div><h3>Objectives</h3><div>The 2022 global Mpox outbreak revealed major surveillance gaps, particularly among marginalized populations such as sex workers, whose role in undetected MPXV transmission remains poorly understood. This study aims to assess the seroprevalence of MPXV IgG antibodies and identify associated risk factors among sex workers in Chiang Mai, Thailand.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, 262 sex workers recruited from March to December 2022 were tested for prior MPXV exposure using an in-house indirect ELISA targeting the recombinant MPXV E8L antigen. Logistic regression models were used to identify demographic and behavioral factors associated with seropositivity.</div></div><div><h3>Results</h3><div>MPXV IgG seroprevalence was 4.6% (12/262). Seropositivity was significantly higher among males than females (5.2% vs 4.0%, <em>P</em> = 0.011). In multivariable analysis, male gender (OR = 3.23, 95% CI: 1.10-9.47, <em>P</em> = 0.032), blood transfusion history (OR = 4.40, 95% CI: 1.35-14.25, <em>P</em> = 0.013) and sharing sharp objects with others (OR = 4.55, 95% CI: 1.12-18.48, <em>P</em> = 0.034) were significantly associated with Mpox seropositivity.</div></div><div><h3>Conclusion</h3><div>Our findings reveal undetected MPXV circulation among Chiang Mai sex workers. The identified risk factors suggest overlapping parenteral and sexual vulnerabilities, emphasizing the need for integrated surveillance and targeted interventions.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"160 ","pages":"Article 108041"},"PeriodicalIF":4.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the prognostic accuracy of the PSS, pSOFA, and SIRS for in-hospital mortality in children with suspected infection in non-ICU settings: a multicenter retrospective study","authors":"Ruiying Liu ,&nbsp;Xuanwen Ru ,&nbsp;Zihao Yang ,&nbsp;Tiewei Li ,&nbsp;Junmei Yang ,&nbsp;Yang Liu ,&nbsp;Xiaoyu Cui ,&nbsp;Jing Wu ,&nbsp;Ruijie Yu ,&nbsp;Zhan Ma ,&nbsp;Baoyu Yuan ,&nbsp;Feng Cheng ,&nbsp;Suhong Huang ,&nbsp;Caizhi Huang ,&nbsp;Cong Zhang ,&nbsp;Hongbing Chen ,&nbsp;Xun Zhou ,&nbsp;Xiaowei Zhang ,&nbsp;JingRan Wang ,&nbsp;Xin Lv ,&nbsp;Qing Ye","doi":"10.1016/j.ijid.2025.108044","DOIUrl":"10.1016/j.ijid.2025.108044","url":null,"abstract":"<div><h3>Objectives</h3><div>To systematically compare the predictive accuracy of the Phoenix Sepsis Score (PSS), the Pediatric Sequential Organ Failure Assessment (pSOFA), and systemic inflammatory response syndrome (SIRS) in assessing in-hospital mortality risk among pediatric sepsis patients in non-intensive care unit (non-ICU) wards, thereby providing evidence-based support for clinical risk stratification.</div></div><div><h3>Design</h3><div>This study employed a multicenter retrospective cohort design, enrolling non-ICU pediatric patients with suspected infections (excluding preterm infants and neonates hospitalized immediately after birth), to construct an overall cohort and a neonatology subgroup cohort. Clinical parameters were collected through a data acquisition system, with parallel calculations of PSS, pSOFA, and SIRS scores. The primary endpoint was in-hospital mortality. Receiver operating characteristic (ROC) curves were constructed via R language version 4.3.1, and the discriminatory performance of each scoring system was evaluated via the area under the ROC curve (AUROC).</div></div><div><h3>Results</h3><div>From January 2023 to September 2024, 965 non-ICU pediatric patients with infections were enrolled from 13 medical centers (overall cohort mortality: 1.1%, 11/965; neonatology cohort: 193 cases, mortality: 4.1%, 8/193). In the overall cohort, all 11 patients experienced deterioration on the ward and were subsequently transferred to the pediatric intensive care unit (PICU) in accordance with each hospital's protocol; eight of them died from sepsis, and three from septic shock. After multivariate adjustment, the AUROC value of the PSS score in the overall cohort was 0.756 (99% CI: 0.731-0.780), representing a 3.6% improvement over the SIRS criteria (0.730, 99% CI: 0.543-0.873) but lower than the pSOFA score (0.845, 99% CI: 0.568-0.966). In the neonatology cohort, the AUROC value of the PSS score was 0.764 (99% CI: 0.478-0.927), comparable to that of the SIRS criteria (0.757, 99% CI: 0.475-0.905) but still lower than that of the pSOFA score (0.819, 99% CI: 0.533-0.983). No statistically significant differences were observed among the three scoring systems (<em>P</em> &gt; 0.01).</div></div><div><h3>Conclusions</h3><div>These findings suggest that the PSS score does not demonstrate superior predictive value compared with traditional assessment tools in non-ICU clinical scenarios.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"160 ","pages":"Article 108044"},"PeriodicalIF":4.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed dissemination of hepatic hydatid cyst with thoracic rupture and peritoneal involvement","authors":"Aymen Mabrouk ,&nbsp;Laila Jedidi ,&nbsp;Senda Ben Lahouel ,&nbsp;Oumayma Fatnassi","doi":"10.1016/j.ijid.2025.108036","DOIUrl":"10.1016/j.ijid.2025.108036","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"160 ","pages":"Article 108036"},"PeriodicalIF":4.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct urinary microbiome signatures are associated with urinary tract infection risk in patients with liver cirrhosis: A pilot study","authors":"Johannes Woltsche ,&nbsp;Christian Pacher-Deutsch ,&nbsp;Stefan Fürst ,&nbsp;Lukas Gulden ,&nbsp;Jakob Schwarzl ,&nbsp;Nicole Feldbacher ,&nbsp;Maximilian Nepel ,&nbsp;Lavra Rebol ,&nbsp;Natalie Hasl ,&nbsp;Victoria Rieper ,&nbsp;Vanessa Stadlbauer ,&nbsp;Angela Horvath","doi":"10.1016/j.ijid.2025.108031","DOIUrl":"10.1016/j.ijid.2025.108031","url":null,"abstract":"<div><h3>Objectives</h3><div>Individuals with liver cirrhosis are at increased risk of developing urinary tract infections (UTIs); however, the role of the urinary microbiome (UMB) in this susceptibility remains poorly understood. This pilot study aimed to characterize the UMB in patients with liver cirrhosis with and without UTIs using 16S rRNA gene sequencing.</div></div><div><h3>Methods</h3><div>Urine samples from 39 patients were analyzed: 17 who developed at least one UTI (dUTI) within 3 years and 22 who remained UTI-free (no_UTI). Microbial profiles were assessed via 16S rRNA gene sequencing and analyzed using QIIME 2, analysis of composition of microbiomes, and linear discriminant analysis effect size.</div></div><div><h3>Results</h3><div>Significant differences in beta diversity were observed between the dUTI and no_UTI groups (Bray-Curtis ADONIS: R² = 0.044, <em>P</em> = 0.023; Jaccard ADONIS: R² = 0.039, <em>P</em> = 0.028). The no_UTI group exhibited higher relative abundances of Bacteroidetes, <em>Prevotella</em>, and <em>Corynebacteriaceae</em>—microbes typically associated with a healthy urinary environment. In contrast, <em>Streptococcus</em> was enriched in the dUTI group.</div></div><div><h3>Conclusions</h3><div>Patients with liver cirrhosis who did not develop UTIs demonstrated distinct UMB patterns that may confer protection. These findings suggest that elements of the UMB, such as <em>Prevotella</em> and <em>Corynebacterium</em>, may play a protective role and represent potential targets for preventive strategies.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"159 ","pages":"Article 108031"},"PeriodicalIF":4.3,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in pneumococcal deaths in the United States following the COVID-19 pandemic.","authors":"Lianhan Shang, Stephanie Perniciaro, Daniel M Weinberger","doi":"10.1016/j.ijid.2025.108020","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.108020","url":null,"abstract":"<p><strong>Background: </strong>Changes in rates of death due to pneumococcus during the COVID-19 pandemic period from 2020 to 2022 are not well understood.</p><p><strong>Methods: </strong>We obtained vital statistics data for the United States (National Center for Health Statistics), including age, sex, race/ethnicity, cause of death (ICD-10), 2014-2022. Generalized linear models were fit to the period from January 2014-February 2020 and extrapolated to March 2020-December 2022 to generate an expected number of pneumococcal deaths and a 95% prediction interval.</p><p><strong>Results: </strong>For most of 2020, pneumococcal deaths were not notably different from the pre-pandemic period and largely followed the typical seasonal pattern. However, at the end of 2020 and early 2021, when pneumococcal deaths would typically peak, the rates of death remained lower than normal and stayed lower than expected in the spring of 2021. Starting around mid-2021, there was a notable spike above baseline that coincided with the Delta wave of COVID-19. The 2021 winter - 2022 spring peak followed the pre-pandemic trend. Some of the changes could be attributed to changes in the seasonality of respiratory viruses that interact with pneumococcus.</p><p><strong>Conclusion: </strong>Pneumococcal mortality patterns changed notably after the onset of the COVID-19 pandemic. Our findings highlighted the influence of respiratory viruses on the development and severity of pneumococcal disease.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108020"},"PeriodicalIF":4.3,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping Plasmodium falciparum mutations in Africa: A critical review of emerging drug resistance and implications for malaria control","authors":"Pierre Gashema ,&nbsp;James Kagame ,&nbsp;Patrick Gad Iradukunda ,&nbsp;Emmanuel Edwar Siddig ,&nbsp;Sofonias Kifle Tessema ,&nbsp;Merawi Aragaw Tegegne ,&nbsp;Mazyanga Lucy Mazaba ,&nbsp;Mosoka Fallah ,&nbsp;Daniel Ngamije ,&nbsp;Jean de Dieu Harelimana ,&nbsp;Claude Mambo Muvunyi","doi":"10.1016/j.ijid.2025.108033","DOIUrl":"10.1016/j.ijid.2025.108033","url":null,"abstract":"<div><div>Malaria remains a significant public health concern in Africa, with the efficacy of artemisinin-based combination therapies being threatened by the emergence of <em>Plasmodium falciparum</em> (Pf) <em>kelch13</em> mutations. The current genetic diversity of Pf and associated contributing factors reported in Africa between 2019 and 2024 were reviewed. It was shown that validated <em>kelch13</em> mutations are mainly distributed in east African regions, particularly, in Eritrea (R622I, 68%) and Uganda (R561H, 52%). Emerging Pf mutations have been documented in Rwanda (C469F, 36%), Uganda (C469F, 59% and P441L, 69%), and Tanzania (P441L, 20%). Resistance markers for partner drugs, including <em>Pfcrt, Pfmdr1, Pfdhfr</em>, and <em>Pfdhps</em>, were prevalent in eastern (30-38%) and western African regions (44-55%). The key factors contributing to the development of Pf mutations were identified as drug pressure (23-35%), misuse of antimalarial drugs (10-12.5%), and cross-border population movements (10%). This review posits a critical need to refine malaria control programs, crucially reinforcing drug regulations, enhancing community awareness on appropriate treatment practices, and integrating molecular epidemiologic surveillance systems.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"159 ","pages":"Article 108033"},"PeriodicalIF":4.3,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical cytology-based screening identifies trichomonas vaginalis as a significant correlate of non-16/18 high-risk human papillomavirus infection in high-altitude tibetan agro-pastoral communities: A cross-sectional study of 62,657 women","authors":"Min Chen ,&nbsp;Yeshi Lhamo ,&nbsp;Kelsang Chödrön ,&nbsp;Le Chen","doi":"10.1016/j.ijid.2025.108034","DOIUrl":"10.1016/j.ijid.2025.108034","url":null,"abstract":"<div><h3>Background</h3><div>The epidemiological relationship between <em>Trichomonas vaginalis</em> (TV) and high-risk <em>human papillomavirus</em> (HR-HPV) remains controversial in high-altitude populations.</div></div><div><h3>Methods</h3><div>This was a cross-sectional analysis of 62,657 asymptomatic women from China's Cervical and Breast Cancer Screening Program in Tibetan agro-pastoral communities (2019-2024). TV was microscopically identified through microbial evaluation via Pap smear in cervical cytology; HR-HPV genotypes were detected using commercial kit. Statistical analyses included χ² tests, odds ratios (ORs) with 95% confidence intervals (CIs), and age-stratified comparisons.</div></div><div><h3>Results</h3><div>The TV prevalence was 1.32%, whereas HR-HPV affected 8.93% of the participants, with the former being dominated by non-16/18 genotypes (81.04-89.13%). TV showed an inverted U-shaped age distribution (peak: 40-49 y, 1.83%); HR-HPV exhibited a U-shaped curve (peaks&lt;20 y/≥60 y). TV-positive women had elevated HR-HPV risk (OR = 1.28, 95% CI: 1.03-1.59), with a stronger association for non-16/18 genotypes (OR = 1.41, 95% CI: 1.12-1.78); this relationship was most pronounced in women aged 30-49 years (OR = 1.30-1.33).</div></div><div><h3>Conclusion</h3><div>TV infection is significantly associated with non-16/18 HR-HPV in Tibetan women aged 30-49 years, suggesting a potential cofactor role. This association requires cautious interpretation due to unmeasured factors, with future studies needed to clarify these influences.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"160 ","pages":"Article 108034"},"PeriodicalIF":4.3,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classic pathway persistent complement activation is associated with specific symptoms in individuals with post–COVID-19 condition: A case-control study","authors":"César Fernández-de-las-Peñas ,&nbsp;Maria Ruiz-Ruigómez ,&nbsp;Laura Esparcia-Pinedo ,&nbsp;Beatriz Colom-Fernández ,&nbsp;Fernando Cava-Valenciano ,&nbsp;Juan Torres-Macho ,&nbsp;Estibaliz Arrieta-Ortubay ,&nbsp;Míriam Akasbi-Moltalvo ,&nbsp;Carlos Lumbreras-Bermejo ,&nbsp;Lars Arendt-Nielsen ,&nbsp;Anabel Franco-Moreno","doi":"10.1016/j.ijid.2025.108032","DOIUrl":"10.1016/j.ijid.2025.108032","url":null,"abstract":"<div><h3>Objectives</h3><div>The complement system is a crucial part of the immune system. The role of complement activation in post–COVID-19 condition is still not conclusive. We present a case-control study investigating long-lasting complement hyperactivation in COVID-19 survivors with/without post–COVID-19 condition.</div></div><div><h3>Methods</h3><div>A case-control (2:1 design) study was performed. Concentration levels of four proteins from classic complement pathway (C3, C4, C5, C7) and total hemolytic complement (CH50) activity were obtained from blood samples in group of survivors with post–COVID-19 condition and in a comparison group of survivors without post–COVID-19 condition, matched by age, sex, and vaccination status. Post–COVID-19 condition was defined when individuals self-reported at least one of these post–COVID-19 symptoms: fatigue, arthralgia, myalgia, memory problems, new-onset headache, or palpitations.</div></div><div><h3>Results</h3><div>A total of 57 (56.1% women, age: 46.5 years, SD: 9.0 years) survivors with post–COVID-19 condition and 27 (55.5% women, age: 46.5 years, SD: 11.5 years) survivors without post–COVID-19 condition were evaluated 1.7 (SD 1.2) and 2.0 (SD 1.7) years after SARS-CoV-2 infection, respectively. Overall, the results did not reveal differences in complement protein levels and CH50 activity between survivors with or without post–COVID-19 condition. Patients reporting post-COVID fatigue exhibited lower C3 levels (<em>P</em> = 0.025) than those without post-COVID fatigue, whereas survivors with post-COVID dyspnea reported lower levels of C3 (<em>P</em> = 0.001), C5 (<em>P</em> = 0.015), and C7 (<em>P</em> = 0.030) proteins than those without post-COVID dyspnea.</div></div><div><h3>Conclusions</h3><div>This explorative case-control study did not observe overall complement activation from classic pathway in survivors with post–COVID-19 condition up to 2 years after. Some complement proteins were elevated in individuals with specific post-COVID symptoms, such as fatigue or dyspnea.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"159 ","pages":"Article 108032"},"PeriodicalIF":4.3,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiologic, Clinical, and economic Burden of AnoGenital Warts Among Adults: A Global Systematic Review.","authors":"Xuedan You, Stefano Valente, Dorothy A Machalek, Marisa Felsher, Izabela Pieniazek, Kinga Nowicka, Joseph E Tota, Ya-Ting Chen, Linda M Niccolai, Fuqiang Cui","doi":"10.1016/j.ijid.2025.108029","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.108029","url":null,"abstract":"<p><strong>Objectives: </strong>Anogenital warts (AGW) are a common manifestation of human papillomavirus (HPV) infection. As HPV vaccination programs expand, updated data are needed to assess the ongoing global AGW burden. This systematic review examined AGW epidemiology, clinical impact, and economic burden, analyzing 187 studies from 49 countries by income level, sex, and age.</p><p><strong>Methods: </strong>Publications were retrieved from Embase, MEDLINE, and Evidence-Based Medicine Reviews (January 2013 to October 2023) and conference proceedings (January 2021 to December 2023) (PROSPERO ID: CRD42023489504).</p><p><strong>Results and conclusions: </strong>AGW prevalence ranged from 0.5%-33.1%, and incidence rates ranged from 24-2,940 cases/100,000 person-years in mixed-sex populations not stratified by age. Incidence generally declined from the mid-30s but remained substantial across all ages. The clinical and economic burden varied by sex, age, time, and geography. Notably, most epidemiologic data come from high-income countries, underscoring the need for more comprehensive global surveillance to fully understand AGW trends and impacts.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108029"},"PeriodicalIF":4.3,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}