Epidemiologic, Clinical, and economic Burden of AnoGenital Warts Among Adults: A Global Systematic Review.

IF 4.3 2区医学 Q1 INFECTIOUS DISEASES

International Journal of Infectious Diseases Pub Date : 2025-08-27 DOI:10.1016/j.ijid.2025.108029

Xuedan You, Stefano Valente, Dorothy A Machalek, Marisa Felsher, Izabela Pieniazek, Kinga Nowicka, Joseph E Tota, Ya-Ting Chen, Linda M Niccolai, Fuqiang Cui

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引用次数: 0

Abstract

Objectives: Anogenital warts (AGW) are a common manifestation of human papillomavirus (HPV) infection. As HPV vaccination programs expand, updated data are needed to assess the ongoing global AGW burden. This systematic review examined AGW epidemiology, clinical impact, and economic burden, analyzing 187 studies from 49 countries by income level, sex, and age.

Methods: Publications were retrieved from Embase, MEDLINE, and Evidence-Based Medicine Reviews (January 2013 to October 2023) and conference proceedings (January 2021 to December 2023) (PROSPERO ID: CRD42023489504).

Results and conclusions: AGW prevalence ranged from 0.5%-33.1%, and incidence rates ranged from 24-2,940 cases/100,000 person-years in mixed-sex populations not stratified by age. Incidence generally declined from the mid-30s but remained substantial across all ages. The clinical and economic burden varied by sex, age, time, and geography. Notably, most epidemiologic data come from high-income countries, underscoring the need for more comprehensive global surveillance to fully understand AGW trends and impacts.

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成人肛门生殖器疣的流行病学、临床和经济负担：一项全球系统综述。

目的：肛门生殖器疣（AGW）是人类乳头瘤病毒（HPV）感染的常见表现。随着HPV疫苗接种规划的扩大，需要更新数据来评估持续的全球AGW负担。本系统综述检查了AGW流行病学、临床影响和经济负担，按收入水平、性别和年龄分析了来自49个国家的187项研究。方法：文献检索自Embase、MEDLINE和循证医学评论（2013年1月至2023年10月）和会议论文集（2021年1月至2023年12月）（PROSPERO ID: CRD42023489504）。结果和结论：在未按年龄分层的混合性别人群中，AGW患病率范围为0.5%-33.1%，发病率范围为24-2,940例/100,000人年。发病率一般从35岁左右开始下降，但在所有年龄段仍然很高。临床和经济负担因性别、年龄、时间和地理而异。值得注意的是，大多数流行病学数据来自高收入国家，这强调需要进行更全面的全球监测，以充分了解AGW趋势和影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Infectious Diseases 医学-传染病学

CiteScore

18.90

自引率

2.40%

发文量

1020

审稿时长

30 days

期刊介绍： International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.