International Journal of Infectious Diseases最新文献

{"title":"Disseminated mycobacterium kansasii infection revealing GATA2 haploinsufficiency after presumed tuberculosis and early lung cancer.","authors":"Chun-Hao Wang, Liang-En Hwang, Wang-Da Liu, Yu-Ting Yen, Jin-Shing Chen, Yih-Leong Chang, Ching-Kai Lin, Hung-Ming Chang, Aristine Cheng, Un-In Wu","doi":"10.1016/j.ijid.2025.108074","DOIUrl":"10.1016/j.ijid.2025.108074","url":null,"abstract":"<p><p>A 46-year-old previously healthy and asymptomatic woman was incidentally found to have right lung opacities after a traffic accident. Histology revealed chronic granulomatous inflammation, leading to an initial diagnosis of tuberculosis with partial response to treatment. A persistent right upper lobe nodule was later confirmed as minimally invasive lung adenocarcinoma. Post-wedge resection, she developed recurrent fever, dyspnea, weight loss, leukopenia, and monocytopenia. Subsequent PET revealed marked mediastinal lymphadenopathy, and mycobacterial cultures of biopsied lymph nodes and bone marrow yielded Mycobacterium kansasii. Further immunologic evaluation identified B-cell and NK-cell deficiency without detectable anti-interferon-gamma autoantibodies. Genetic testing uncovered a novel heterozygous GATA2 mutation, establishing a diagnosis of MonoMAC syndrome. Notably, one asymptomatic sister carried the same pathogenic variant. This case highlights the importance of considering GATA2 haploinsufficiency in adults with atypical mycobacterial infections and cytopenias. Early recognition enables targeted infection surveillance, multi-system assessment, family genetic counseling, and definitive hematopoietic stem cell transplantation planning when indicated.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108074"},"PeriodicalIF":4.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Tick-borne Neoehrlichia mikurensis in Individuals Undergoing B-cell Depleting Therapy in Denmark: A Prospective Cohort Study 2023-2024.","authors":"Helene Mens, Rosa Gynthersen, Jeppe Romme Christensen, Morten Blinkenberg, Finn Sellebjerg, Daniel El Fassi, Bente Glintborg, Dorte Vendelbo Jensen, Jørgen Skov Jensen, Anne-Mette Lebech","doi":"10.1016/j.ijid.2025.108069","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.108069","url":null,"abstract":"<p><strong>Background: </strong>Neoehrlichia mikurensis is an emerging tick-borne pathogen posing a particular risk to individuals undergoing B-cell depleting therapy (BCDT).</p><p><strong>Objective: </strong>To establish a rational testing strategy for N. mikurensis among individuals on BCDT METHODS: We conducted a prospective cohort study between January 2023 and December 2024 on Adults receiving BCDT, in the Capital Region of Denmark. A digital questionnaire covered tick exposure and symptoms. Blood was tested for N. mikurensis DNA by real-time PCR.</p><p><strong>Results: </strong>Of 1,211 eligible individuals, 443 (37%) were enrolled. The median age was 54 years, and 62% were female. PCR testing was performed on 389 participants, detecting N. mikurensis DNA in 1.0% (4/389; 95% CI: 0.4-2.6). All infected individuals reported prolonged symptoms (e.g., fatigue, fever, unintended weight loss) and responded rapidly to doxycycline therapy. Notably, only one of the four cases exhibited elevated CRP. Symptom-based screening yielded a high likelihood ratio of 25 for identifying positive cases.</p><p><strong>Conclusions: </strong>Our results indicate that employing a symptom-based testing strategy for N. mikurensis is a rational approach for individuals undergoing BCDT.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108069"},"PeriodicalIF":4.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Success and limitations of the French public health strategy after 2 years of large implementation of respiratory syncytial virus prophylaxis: experience of a tertiary hospital (2018-2025)","authors":"Nicolas Veyrenche ,&nbsp;Julie Toubiana ,&nbsp;Hélène Chappuy ,&nbsp;Christophe Delacourt ,&nbsp;Matthieu Bendavid ,&nbsp;Perrine Parize ,&nbsp;Camille Roger ,&nbsp;Marianne Leruez-Ville ,&nbsp;Jacques Fourgeaud ,&nbsp;Pierre Frange","doi":"10.1016/j.ijid.2025.108071","DOIUrl":"10.1016/j.ijid.2025.108071","url":null,"abstract":"<div><h3>Objectives</h3><div>France has gradually implemented prophylaxis against RSV infections in infants since 2023 and, more recently, in the elderly. This study described the recent evolution of the RSV-hospital burden in a French tertiary hospital.</div></div><div><h3>Methods</h3><div>Characteristics of patients admitted during the 2023/2024 and 2024/2025 RSV seasons with a RSV-lower respiratory tract infection (LRTI) were compared to those of patients admitted during three preprophylaxis RSV seasons.</div></div><div><h3>Results</h3><div>Overall, 1114 pediatric inpatients and 41 adults with RSV-LRTI were enrolled, of whom 36% had ≥1 chronic complex condition (CCC). Compared to the preprophylaxis period, the RSV-hospital burden decreased in pediatric units in 2024/2025 (1.4 versus 1.7/1000 inpatients, <em>P</em> = 0.004), as did the proportion of infants aged &lt;6 months among inpatients with RSV-LRTI (27.8% versus 57.7%, <em>P</em> &lt; 0.0001) and that of all subjects requiring admission to intensive care units (17.4% versus 37.7%, <em>P</em> &lt; 0.0001). However, the proportion of inpatients with RSV-LRTI from other age groups did not decrease in recent years. In adult units, the RSV-hospital burden increased in 2024/2025 compared to the preprophylaxis period (0.8 versus 0.4/1000 inpatients, <em>P</em> &lt; 0.0001).</div></div><div><h3>Conclusions</h3><div>The reduction of the RSV-hospital burden mostly impacted infants &lt;6 months of age. Efforts are needed to reduce the RSV-hospital burden in other age groups, especially in children aged 6-11 months and older individuals with CCC.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"160 ","pages":"Article 108071"},"PeriodicalIF":4.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Balamuthia Lineage Causing Fatal Granulomatous Amoebic Encephalitis in an Immunocompetent Infant.","authors":"Zhongqiu Teng, Linlin Li, Tianming Che, Junrong Liang, Xingfeng Yao, Na Zhao, Fengmao Zhao, Hailang Sun, Lijuan Wang, Quan Wang, Gang Liu, Tian Qin","doi":"10.1016/j.ijid.2025.108063","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.108063","url":null,"abstract":"<p><strong>Objectives: </strong>To characterize a genetically distinct Balamuthia lineage causing fatal granulomatous amoebic encephalitis (GAE) in a 10-month-old infant and highlight diagnostic challenges compounded by SARS-COV-2 infection comorbidity.</p><p><strong>Methods: </strong>Case report of a 10-month-old male with GAE. Metagenomic next-generation sequencing (mNGS) and PCR sequencing of 18S/12S rRNA genes from brain biopsy tissue were performed. Phylogenetic analysis was conducted to identify the genetic characteristics of the pathogen.</p><p><strong>Results: </strong>The patient presented with recurrent fever, seizures, and rapidly progressive neurological deterioration. He had documented SARS-CoV-2 infection two weeks prior to symptom onset. The mNGS of biopsy tissue identified Balamuthia infection. Genetic analysis revealed 18S rRNA similarity of 95.33% and mitochondrial 12S rRNA similarity of 85.49% versus known species. Phylogenetic trees confirmed a distinct clade, suggesting a potential novel species. Despite aggressive treatment, the patient died after 13 days of hospitalization.</p><p><strong>Conclusions: </strong>This case highlights the challenges in diagnosing and managing GAE, particularly in pediatric patients with atypical presentations. The discovery of a genetically distinct Balamuthia strain indicates the importance of global surveillance for emerging pathogens. Clinicians should consider Balamuthia as a potential cause of encephalitis in children with unexplained neurological symptoms, even in non-endemic regions.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108063"},"PeriodicalIF":4.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Thelazia callipaeda infection: A case report.","authors":"Lili Li, Wei Sun, Congxin Li, Zhengfeng Liu, Lijie Li, Xiaofeng Xie","doi":"10.1016/j.ijid.2025.108068","DOIUrl":"10.1016/j.ijid.2025.108068","url":null,"abstract":"<p><p>We present a typical case of Thelazia callipaeda infection in a patient from China, detailing both diagnosis and treatment. Thelaziasis is a zoonotic parasitic disease caused by a nematode and is transmitted by flies. This case also highlights the importance of monitoring public health for individuals, pets, and the environment.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108068"},"PeriodicalIF":4.3,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-standardized comparison of coronary artery disease, stroke incidence, and all-cause mortality between people living with HIV and the general population in Spain","authors":"Anna Camps-Vilaró ,&nbsp;Ramon Teira ,&nbsp;Isaac Subirana ,&nbsp;Irene R. Dégano ,&nbsp;Pere Domingo ,&nbsp;Adrià Curran ,&nbsp;Maria José Galindo ,&nbsp;Marta Montero-Alonso ,&nbsp;Alberto Romero ,&nbsp;Jaume Marrugat","doi":"10.1016/j.ijid.2025.108061","DOIUrl":"10.1016/j.ijid.2025.108061","url":null,"abstract":"<div><h3>Objectives</h3><div>We compared 15-year incidence of coronary artery disease (CAD), stroke, and all-cause mortality between people living with HIV (PLWH) and the Spanish general population.</div></div><div><h3>Methods</h3><div>We compared two Spanish cohorts—VACH (PLWH) and REGICOR (general population). We followed adults aged 25-74 years, free of CAD or stroke, for a mean of 15 years. We used age-standardized 15-year incidence of CAD, stroke, and all-cause mortality and compared cohorts with log-rank tests and Cox models adjusted for confounders.</div></div><div><h3>Results</h3><div>We included 6829 PLWH and 10,218 general population. In men aged 25-54 years with HIV, the adjusted standardized incidence rates of CAD and stroke were similar to those in the general population. In addition, PLWH had significantly higher crude all-cause standardized mortality rates than the general population: men 2790 (2536-3044) vs 1104 (1015-1192) and women 2011 (1632-2391) vs 588 (528-648) (all <em>P</em>-values &lt;0.001). Moreover, the adjusted hazard ratio of all-cause mortality was much higher in PLWH younger than 55 years (hazard ratio 3.08 [2.42-3.90] in men and 4.71 [3.13-7.09] in women).</div></div><div><h3>Conclusions</h3><div>The adjusted risk of CAD and stroke among PLWH is similar to that of the general population. However, PLWH younger than 55 years still face a more than three-fold higher risk of death from any cause.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"160 ","pages":"Article 108061"},"PeriodicalIF":4.3,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can 6-month long regimens become the standardized treatment for MDR-TB globally?","authors":"Caterina Davoli ,&nbsp;Chiara Rossi ,&nbsp;Andrea Ciccarone ,&nbsp;Francesca Bertoni ,&nbsp;Marina Calamelli ,&nbsp;Benedetta Rossi ,&nbsp;Alberto Matteelli","doi":"10.1016/j.ijid.2025.108065","DOIUrl":"10.1016/j.ijid.2025.108065","url":null,"abstract":"<div><div>Treatment for multidrug-resistant or rifampicin-resistant (MDR/RR) tuberculosis (TB) was traditionally long and poorly tolerated. In 2022, the World Health Organization recommended the first 6-month regimen (BPaLM), followed in 2025 by a second short-course option (BDLLfxC) with potential drastic improvement of treatment outcome. The BDLLfxC regimen addresses key gaps in target populations, including groups for whom BPaLM is not indicated: children of any age, adolescents, and pregnant and breastfeeding women. A key difference between the two regimens is the replacement of pretomanid with delamanid in the BDLLfxC. However, limitations remain. Neither BPaLM nor BDLLfxC are recommended in patients with complicated forms of extrapulmonary MDR-TB: central nervous system, osteoarticular, and disseminated disease. The problem is twofold: on one side, there are theoretical pharmacokinetic/pharmacodynamic reasons for lower concentrations of the active principles at these sites; on the other side, clinical experience is virtually absent in such cases. In this narrative review, we explore the use of 6-month regimens for MDR/RR-TB in specific populations—children, pregnant and breastfeeding women, people living with HIV, and those with challenging TB forms (e.g., central nervous system, bone, disseminated). The overall aim is to discuss how far we still are from the goal of a public health approach to the treatment of MDR-TB.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"160 ","pages":"Article 108065"},"PeriodicalIF":4.3,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroepidemiology of respiratory syncytial virus and influenza in infants: A prospective cohort study in China, 2023-2024","authors":"Jing Liu ,&nbsp;Mingwei Wei ,&nbsp;Ruifan Shen ,&nbsp;Suyang Qi ,&nbsp;Baolong Wang ,&nbsp;Xiuyun Shi ,&nbsp;Yuxuan Zhou ,&nbsp;Lisha Ma ,&nbsp;Ran Tao ,&nbsp;Jingxin Li","doi":"10.1016/j.ijid.2025.108070","DOIUrl":"10.1016/j.ijid.2025.108070","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objectives&lt;/h3&gt;&lt;div&gt;Respiratory syncytial virus (RSV) and influenza are two major pathogens responsible for acute respiratory infections in infants and children. We investigated the dynamic changes of serum antibodies against RSV and influenza in early childhood, aiming to assess exposure rates and factors associated with later exposure, to inform the development of targeted intervention strategies.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;The study performed a community-based prospective cohort seroepidemiological study in children in Jiangsu Province, Eastern China, from February 2023 to August 2024, comprising 16 months of follow-up. Healthy infants aged between 2 and 3 months were recruited. Blood samples were collected from the cohort longitudinally at three study visits: visit 1 (enrollment, 2-3 months of age), visit 2 (5-7 months of age), and visit 3 (18-19 months of age). We detected immunoglobulin (Ig)G antibody concentrations against the RSV prefusion F (pre-F) protein, influenza A/H1N1, influenza A/H3N2, and influenza B using enzyme-linked immunosorbent assays. A four-fold or greater increase of antibody levels compared with baseline or the previous visit was considered as an exposure to RSV or influenza A/B viruses. Confirmed and hospitalization cases were collected through active monitoring of acute respiratory infections during the follow-up. Binary logistic regression models were employed to identify factors associated with exposure.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 357 participants aged 2-3 months were involved in the study. The pre-F IgG geometric mean concentration (GMC) against RSV was 5131.7 ng/ml (95% confidence interval [CI] 4834.0-5447.7) in infants at 2-3 months of age. This decreased to 612.5 ng/ml (95% CI 544.3-689.3) by 5-7 months of age. After that, the GMC of RSV pre-F IgG antibody gradually increased to 1608.1 ng/ml (95% CI 1239.7-2086.0) by 18-19 months. For influenza A/H1N1, A/H3N2, and B viruses, the GMCs of IgG antibodies were 912.4 ng/ml (95% CI 837.1-994.4), 613.9 ng/ml (95% CI 575.5-654.9), and 960.8 ng/ml (95% CI 896.9-1029.3) at 2-3 months of age, respectively. By 5-7 months of age, they declined to 637.5 ng/ml (95% CI 548.1-741.6), 483.9 ng/ml (95% CI 431.3-543.0), and 727.4 ng/ml (95% CI 646.8-818.1). At 18-19 months, GMC against A/H1N1 increased to 955.9 ng/ml (95% CI 833.2-1096.6) again, whereas the response to influenza B showed a marked increase, reaching 1531.9 ng/ml (95% CI 1344.3-1746.0). In contrast, antibody level against A/H3N2 remained relatively stable, with a GMC of 469.5 ng/ml (95% CI 413.6-533.0). The exposure rates were 52.9% for RSV, 28.0% for A/H1N1, 19.6% for A/H3N2, and 37.1% for influenza B. Exploratory analysis further revealed that maternal antibodies serve as protective factors against exposure to both RSV and influenza.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;The data revealed the vulnerability of infants to RSV and influenza. These findings provide crucial evi","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"160 ","pages":"Article 108070"},"PeriodicalIF":4.3,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nationwide implementation and evaluation of an external quality assessment program for HPV screening in Peru","authors":"Pamela Rios-Monteza ,&nbsp;Lesly Solis-Ponce ,&nbsp;Susan Espetia ,&nbsp;Carina Eklund ,&nbsp;Laila Sara Arroyo Mühr ,&nbsp;Joakim Dillner ,&nbsp;Andrea Matos ,&nbsp;Maribel Acuña ,&nbsp;George Obregon","doi":"10.1016/j.ijid.2025.108067","DOIUrl":"10.1016/j.ijid.2025.108067","url":null,"abstract":"<div><div>In the global effort to eliminate cervical cancer, high-quality Human Papillomavirus (HPV) testing is essential, especially in Peru where vaccination coverage remains incomplete. To ensure consistent nationwide test performance, the Peruvian HPV National Reference Laboratory (NRL), in collaboration with the International HPV Reference Center (IHRC), launched the first nationwide External Quality Assessment (EQA) program for all screening laboratories.</div><div>In 2024, 19 screening laboratories, including regional reference centers and tertiary hospitals, participated in the EQA program. Proficiency panels of 13 blinded samples with defined HPV types and viral loads were validated by IHRC and distributed by the NRL. Laboratories analyzed the samples using the Cobas 4800 HPV assay.</div><div>Eighteen laboratories (94.7%) met proficiency criteria, correctly detecting all required HPV types, including low viral load samples. One laboratory reported false positives in a negative and a low-concentration HPV 18 sample.</div><div>This program shows the feasibility of nationwide EQA in Peru, with full participation and reporting. Annual assessments will sustain quality assurance and equitable access to reliable HPV testing. From 2026, the Peruvian HPV NRL will coordinate the program independently, expand participation to additional laboratories, and enable local panel production—an important step toward strengthening cervical cancer screening quality.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"160 ","pages":"Article 108067"},"PeriodicalIF":4.3,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The predictive value of pulmonary consolidation combined with BNP for cardiovascular events in children with RSV infection","authors":"Jingwen Ni ,&nbsp;Xiaoyang Hong ,&nbsp;Junyu Dong ,&nbsp;Mengxin Zhao ,&nbsp;Zhihui Du ,&nbsp;Wenqing Niu ,&nbsp;Kenan Fang","doi":"10.1016/j.ijid.2025.108056","DOIUrl":"10.1016/j.ijid.2025.108056","url":null,"abstract":"<div><h3>Background</h3><div>The cardiovascular impact of respiratory syncytial virus (RSV) infection has surpassed its effects on the respiratory system. This study aims to identify independent risk factors for these events.</div></div><div><h3>Methods</h3><div>This study is a single-center, retrospective analysis of 105 pediatric patients with RSV infection. The patients were divided into two groups: those with cardiovascular events and those without. Logistic regression analyses were conducted to identify independent risk factors for cardiovascular events in children with RSV infection. The predictive value of these factors for cardiovascular events in RSV-infected children was evaluated using the area under the curve.</div></div><div><h3>Results</h3><div>Compared to the group without cardiovascular events, the group with cardiovascular events showed significantly higher levels of NLR, BNP, BUN, <span>D</span>-dimer, and required higher scores for vasopressor use, higher oxygen concentrations, and a higher proportion of respiratory support. And had longer PICU stays and higher hospitalization costs. Logistic analyses identified pulmonary consolidation and BNP as independent risk factors for cardiovascular events in RSV-infected children. When pulmonary consolidation and BNP were used in combination for prediction, the AUC increased to 0.858.</div></div><div><h3>Conclusion</h3><div>The combination of pulmonary consolidation and BNP has a higher predictive value for the occurrence of cardiovascular events in children with RSV infection.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"160 ","pages":"Article 108056"},"PeriodicalIF":4.3,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}