International Journal of Infectious Diseases最新文献

{"title":"Antifungal concentrations in mechanically ventilated COVID-19 patients with or without ECMO: The CAPADOSE observational retrospective multicenter Study","authors":"Paul Masi ,&nbsp;Mickael Lescroart ,&nbsp;Anne Veinstein ,&nbsp;Luc Desmedt ,&nbsp;Luc Haudebourg ,&nbsp;Julien Dessajan ,&nbsp;Mathieu Lesouhaitier ,&nbsp;Charles Verney ,&nbsp;Juliette Chommeloux ,&nbsp;Claire Roger ,&nbsp;Elise Cuquemelle ,&nbsp;Nicolas Dognon ,&nbsp;Jean Christophe Richard ,&nbsp;Naim Jebnoun ,&nbsp;Damien Du Cheyron ,&nbsp;Hadrien Winiszewski ,&nbsp;Sami Hraiech ,&nbsp;Sophie Jacquier ,&nbsp;Matthieu Petit ,&nbsp;Hadrien Roze ,&nbsp;Keyvan Razazi","doi":"10.1016/j.ijid.2025.107996","DOIUrl":"10.1016/j.ijid.2025.107996","url":null,"abstract":"<div><h3>Purpose</h3><div>COVID-19-associated pulmonary aspergillosis (CAPA) is a major co-infection in critically ill patients and is linked to increased mortality. Critical illness and ECMO may affect antifungal pharmacokinetics, raising concerns about drug efficacy.</div></div><div><h3>Methods</h3><div>This multicenter retrospective study included CAPA patients requiring mechanical ventilation in 20 intensive care units (ICUs) (March 2020 to November 2021), provided at least one antifungal blood level was available. The primary objective was to evaluate whether ECMO influenced the risk of subtherapeutic voriconazole levels. Secondary objectives included analyzing other antifungals and identifying risk factors for underdosing.</div></div><div><h3>Results</h3><div>Among 166 patients, 81 were on ECMO. A total of 358 voriconazole trough concentrations were collected in 150 patients. Subtherapeutic levels (&lt;2 mg/L) were observed in 58 patients (39%) at first sampling and in 84 patients (56%) during the ICU stay, with no difference between ECMO and non-ECMO groups. No correlation was found between ECMO membrane duration and voriconazole levels. Daily dose was associated with low levels in univariate analysis only. Among 26 patients treated with isavuconazole, 11 (42%) had initial subtherapeutic levels. Renal replacement therapy, not ECMO, was associated with low isavuconazole levels (odds ratios = 7.5, <em>P</em> = 0.029).</div></div><div><h3>Conclusion</h3><div>Over half of CAPA patients had subtherapeutic antifungal levels, but ECMO did not significantly influence drug exposure.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"159 ","pages":"Article 107996"},"PeriodicalIF":4.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144730310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the dual rapid diagnostic test for HIV and syphilis among pregnant women: a before and after health center-based study in Central Uganda (2018-2019)","authors":"Ubaldo Bahemuka ,&nbsp;Lauren Hall ,&nbsp;Paul Okimat ,&nbsp;Andrew Abaasa ,&nbsp;Christian Holm Hansen ,&nbsp;Philippe Mayaud","doi":"10.1016/j.ijid.2025.107993","DOIUrl":"10.1016/j.ijid.2025.107993","url":null,"abstract":"<div><h3>Objectives</h3><div>Systematic testing of antenatal clinic attendees using dual HIV and syphilis rapid diagnostic tests (RDT) can improve syphilis screening and reduce mother-to-child transmission. We assessed the effect of the dual HIV/syphilis RDT on syphilis care and adverse birth outcomes (ABOs), including congenital syphilis (CS) in Central Uganda.</div></div><div><h3>Methods</h3><div>Eleven antenatal clinics were selected from Kalungu and Masaka districts. First-visit records were extracted on syphilis testing, positivity and treatment over two 9-month periods, pre- and post-introduction, with a 3-month buffer. Syphilis cascade indicators were calculated for the two periods. The World Health Organization CS Estimation Tool evaluated impact on CS cases and ABOs.</div></div><div><h3>Results</h3><div>A total of 6011 records were extracted, 2660 pre-test introduction and 3351 post-introduction. Syphilis testing increased from 49.1% pre-test to 84.0% post-introduction, an increased testing rate ratio of 1.71 (95% confidence interval 1.64-1.78). Treatment coverage modestly increased post-introduction (rate ratio = 1.19, 0.94-1.50), resulting in an absolute rate difference of 31.4% (20.5-41.6%, <em>P</em> &lt;0.001). This resulted in a modeled 41% decline in CS cases and 39% decline in ABOs.</div></div><div><h3>Conclusions</h3><div>This is the first demonstration of the impact of dual HIV/syphilis RDT in routine antenatal clinics in Uganda, which could reduce CS and ABOs.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"159 ","pages":"Article 107993"},"PeriodicalIF":4.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroepidemiology of maternal and childhood pathogen exposure in three European mother-child cohorts","authors":"Marianna Karachaliou ,&nbsp;Marta Vidal ,&nbsp;Lucy Pembrey ,&nbsp;Mariona Bustamante ,&nbsp;Ana Espinosa ,&nbsp;Dan Mason ,&nbsp;Marc Bañuls ,&nbsp;Delphine Casabonne ,&nbsp;Theano Roumeliotaki ,&nbsp;Vicky Bempi ,&nbsp;Natalia Marin ,&nbsp;Juana Maria Delgado-Saborit ,&nbsp;Santa Marina Rodríguez Loreto ,&nbsp;Jesús Ibarluzea ,&nbsp;Martine Vrijheid ,&nbsp;Ruth Aguilar ,&nbsp;Carlota Dobaño ,&nbsp;Manolis Kogevinas","doi":"10.1016/j.ijid.2025.107994","DOIUrl":"10.1016/j.ijid.2025.107994","url":null,"abstract":"<div><h3>Objectives</h3><div>To describe the epidemiology of common pathogens and risk factors among pregnant women and their children.</div></div><div><h3>Methods</h3><div>In three European population-based birth cohorts, we examined 2213 mother-child pairs, contributing 5036 blood samples from pregnancy to 12 years of age. We measured serum immunoglobulin G levels against polyomaviruses (BKPyV, JCPyV, KIPyV, WUPyV, MCPyV), herpesviruses (Epstein-Barr virus [EBV], cytomegalovirus [CMV], varicella-zoster virus), adenovirus 36, <em>Helicobacter pylori</em>, and <em>Toxoplasma gondii</em> with multiplex serology.</div></div><div><h3>Results</h3><div>Among pregnant women, seroprevalence ranged from 18.7% (<em>H. pylori</em>) to 95.7% (EBV); among 4-6-year-old children, seroprevalence ranged from 3.6% (<em>H. pylori</em>) to 88.4% (BKPyV). Although most primary infections occurred in the first 4 years of life, some children had primary infections at later ages. Seropositive mothers were more likely to have seropositive children, but an intergenerational decrease in seroprevalence was evident for herpesviruses and <em>H. pylori</em>. There were sizeable differences between countries for <em>H. pylori</em> and <em>T. gondii</em>. Non-western ethnicity mothers and their children were more likely to be infected. Female sex (WUPyV, MCPyV, CMV), breastfeeding (CMV), early daycare attendance (CMV, <em>H. pylori</em>), and obesity (JCPyV, EBV, Adv-36) were associated with child’s seroprevalence.</div></div><div><h3>Conclusions</h3><div>European children acquire common pathogens but often experience first exposure beyond early childhood. Differences are expected between and within countries and across generations.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"159 ","pages":"Article 107994"},"PeriodicalIF":4.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic illness with eosinophilia and urticaria-like rash caused by prolonged bedbug exposure","authors":"Ian B. Weitzel ,&nbsp;Valeria Palma ,&nbsp;Macarena Silva ,&nbsp;Alex Castro ,&nbsp;Thomas Weitzel","doi":"10.1016/j.ijid.2025.107991","DOIUrl":"10.1016/j.ijid.2025.107991","url":null,"abstract":"<div><div>Bedbugs are blood-feeding nocturnal ectoparasites, which are well-adapted to human habitats. In recent decades, bedbug infestation has been an emerging health problem worldwide, affecting all socio-economic population strata. The clinical presentations of bedbug exposure are variable, ranging from simple pruriginous bite lesions to severe cutaneous and systemic manifestations. Diagnosis is challenging and depends on awareness, clinical experience, and a thorough medical history. In our case, cutaneous lesions were accompanied by severe systemic symptoms and hypereosinophilia, leading to prolonged illness and hospitalization. The differential diagnosis of such presentations should include bedbug exposure, to avoid long-lasting disease, unnecessary diagnostic procedures, and the associated psychological burden for the patient.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"159 ","pages":"Article 107991"},"PeriodicalIF":4.3,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First detection of JC polyomavirus in vaginal secretions from nonpregnant women: Exploring sexual transmission as a potential route of infection.","authors":"Joana M Oliveira, Daniela Veiga, Helena Martins, Cristina Luxo, Ana Miguel Matos","doi":"10.1016/j.ijid.2025.107992","DOIUrl":"10.1016/j.ijid.2025.107992","url":null,"abstract":"<p><strong>Objectives: </strong>JC polyomavirus (JCPyV) is a ubiquitous human virus responsible for asymptomatic lifelong persistent infection. Profound immunosuppression, or prolonged treatment with specific immunomodulatory molecules, may result in the development of Progressive Multifocal Leukoencephalopathy (PML). The main mode of JCPyV transmission remains uncertain. This study aimed to evaluate the presence of JCPyV DNA in vaginal secretions to encourage further research on sexual transmission.</p><p><strong>Methods: </strong>JCPyV DNA presence was assessed in 293 vaginal swabs of sexually active nonpregnant women through real-time PCR. Samples were selected from individuals attending a screening program for sexually transmitted infections (STIs) at a Portuguese University.</p><p><strong>Results: </strong>JCPyV genome was detected in vaginal secretions of 5.1% of the evaluated women. All JCPyV genomes detected were found to belong to the archetype strain, which is commonly associated with virus transmission. Infection with Chlamydia trachomatis was diagnosed in 20% of women with JCPyV in vaginal secretions.</p><p><strong>Conclusions: </strong>The findings of this pioneering study suggest that, in addition to other modes of transmission, sexual route may be a potential mode of JCPyV infection acquisition. If it could be proven that JCPyV could be transmitted sexually, protective measures during sexual activity should be reinforced, especially among discordant couples where the noninfected partner belongs to a risk group of developing PML.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107992"},"PeriodicalIF":4.3,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low utilization of targeted tuberculosis (TB) infection testing in the United States: a 15-year serial cross-sectional study.","authors":"Jorge R Ledesma, Yuching Ni, Jacek Skarbinski","doi":"10.1016/j.ijid.2025.107988","DOIUrl":"10.1016/j.ijid.2025.107988","url":null,"abstract":"<p><strong>Objective: </strong>In California, 82% of new tuberculosis (TB) cases occur among people born in TB-endemic countries. Guidelines recommend targeted TB infection (TBI) testing based on risk factors (e.g., birth in a TB-endemic country, immunosuppression), but comprehensive evaluations of testing practices are limited.</p><p><strong>Methods: </strong>We conducted a serial cross-sectional study of adult Kaiser Permanente Northern California members from 2008 to 2023 to assess TBI testing and factors associated with testing and interferon gamma release assay (IGRA) use.</p><p><strong>Results: </strong>Of 6,572,233 adults, 1,405,896 (21.4%) were tested for TBI. However, 78.1% of tests were among people without TB risk factors. The overall testing rate improved slightly from 5.21 per 100 in 2008 to 6.71 in 2023. People born in TB-endemic countries had 25.2% (24.8-25.5%) lower prevalence of testing compared to US-born persons. Other risk factors were associated with higher testing including close TB contact (aPR = 2.67 [2.63-2.71]), homelessness (aPR = 1.36 [1.33-1.38]), and HIV infection (aPR = 3.58 [3.53-3.63]). Among those tested, individuals from TB-endemic countries were 63.2% (62.0-64.4%) more likely to receive an IGRA than US-born persons.</p><p><strong>Conclusions: </strong>Despite guideline recommendations, TBI testing disproportionately overlooks people born in TB-endemic countries while over testing those without risk factors, highlighting a critical gap between evidence and practice.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107988"},"PeriodicalIF":4.3,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Class switch toward IgG2 and IgG4 is more pronounced in BNT162b2 compared to mRNA-1273 COVID-19 vaccinees.","authors":"Alex S Siebner, Johanna Griesbaum, Kelsey E Huus, Judith Flügge, Kristina Hopfensperger, Tanja Michel, Nicole Schneiderhan-Marra, Daniel Sauter, Peter G Kremsner, Ruth E Ley, Alex Dulovic, Meral Esen","doi":"10.1016/j.ijid.2025.107990","DOIUrl":"10.1016/j.ijid.2025.107990","url":null,"abstract":"<p><strong>Objectives: </strong>Vaccination against SARS-CoV-2 induces antibodies that reduce the risk of severe disease. Because IgG subclasses differ in their ability to activate complement, to bind Fc receptors and neutralize viruses, it is crucial to understand how IgG subclass responses differ between vaccine platforms.</p><p><strong>Design: </strong>IgG1, IgG2, IgG3, and IgG4 binding antibodies against SARS-CoV-2 trimeric spike protein, receptor-binding domain, and S1/S2 subunits responses were quantified using a multiplex immunoassay, after a booster dose of either BNT162b2 (Pfizer/BioNTech) or mRNA-1273 (Moderna) in a healthy cohort (n = 165) who had received two previous vaccine doses.</p><p><strong>Results: </strong>Boosting increased all subclass IgG levels, except for S1-specific IgG1 and S2-specific IgG2. However, IgG2 and IgG4 levels were significantly higher in BNT162b2 than in mRNA-1273 vaccinees (P = 0.0313 [IgG2 S] and P = 0.0106 [IgG4 RBD], P = 0.0070 [IgG4 S1]). Individuals who had previously received a non-mRNA vaccination showed no significant increase in IgG2 (P = 0.4909 [S]) and IgG4 (P = 0.0607 [S]) post-boost.</p><p><strong>Conclusions: </strong>Vaccine-specific differences post-booster vaccination were identified and may drive the class switch between IgG2 and IgG4 responses. Given their different roles, these subtle differences may ultimately also affect long-term immunity and protection.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107990"},"PeriodicalIF":4.3,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sharp increase in the incidence and severity of invasive Streptococcus pyogenes infections in children after the COVID-19 pandemic (2019-2023): A nationwide multicenter study.","authors":"Elvira Cobo-Vázquez, David Aguilera-Alonso, David Grandioso-Vas, Anna Gamell, Victoria Rello-Saltor, Manuel Oltra-Benavent, Eloisa Cervantes, Francisco Sanz-Santaeufemia, Jaime Carrasco-Colom, Ángela Manzanares-Casteleiro, Laura Martín-Pedraz, Eva Ramírez de Arellano, Lola Falcón-Neira, Leticia Martínez-Campos, Elena Colino-Gil, Beatriz Jiménez-Montero, Olga Calavia, Anna Hernandez-Ventura, Elena Del Castillo-Navío, Vanesa Matías-Del Pozo, Laura Calle-Miguel, Beatriz Soto, Berta Fernández, Filip Camil-Olteanu, Marta Pareja-León, Nuria López-Segura, Fátima Ara-Montojo, Beatriz Ruiz-Sáez, Cristina Calvo-Monge, María Sánchez-Códez, Teresa Reinoso, Katie Badillo, Carmen Vázquez, Pilar Villalón, Jesús Oteo-Iglesias, Isabel Mellado-Sola, Emilia Cercenado, Daniel Blázquez-Gamero, Ana Measalvas, Maria José González-Abad, Borja Guarch, Mercedes Ibáñez-Alcalde, Begoña Carazo, Mayli Lung, Cristina Calvo, Jesús Saavedra-Lozano","doi":"10.1016/j.ijid.2025.107982","DOIUrl":"10.1016/j.ijid.2025.107982","url":null,"abstract":"<p><strong>Objectives: </strong>A global surge in pediatric invasive group A streptococcal infection (iGAS) was reported after autumn 2022. This study analyzed the epidemiology and severity of iGAS in Spain, comparing two periods; P1: pre-outbreak (January 2019-September 2022) versus P2: outbreak (October 2022-July 2023).</p><p><strong>Methods: </strong>Children ≤16 years with iGAS enrolled in the Spanish PedGAS-net (2019-2023), were included. Bacterial isolates were analyzed for emm typing, antibiotic susceptibility, and whole genome sequencing. Multivariate analysis identified risk factors for PICU admission and mortality.</p><p><strong>Results: </strong>558 cases were included; 307 (55.1%) were male, with a median age of 43.9 months (IQR:19.3-84.1). There were significantly more iGAS in P2 (35.7 vs. 4.5 cases/month, P < 0.001), with higher PICU admissions (51.3% vs. 30.8%, P < 0.001). Pneumonia was the most common syndrome (32.3%), with pleural effusion in 58.3%. Of the 130 samples available for emm-typing, the most frequent were emm1 (56.1%) and emm12 (27.1%). 245 (43.9%) required PICU admission. Factors associated with PICU were streptococcal toxic shock syndrome (STSS), pneumonia, necrotizing fasciitis, acute kidney failure, and previous consultation before diagnosis. The emm1 (especially M1_UK) increased PICU risk. 11 children (2.0%) died. STSS, sepsis, and central nervous system infection were associated with mortality.</p><p><strong>Conclusion: </strong>In Spain, pediatric iGAS cases sharply increased during 2022-2023, with a remarkable increase in severity. Epidemiological surveillance of iGAS remains crucial.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107982"},"PeriodicalIF":4.3,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prepregnancy vaccination with inactivated vaccines protects SARS-CoV-2-exposed neonates from respiratory distress","authors":"Yiwei Zhang ,&nbsp;Jianbin Guo ,&nbsp;Yaqian Li ,&nbsp;Yingna Song ,&nbsp;Guoyun Wang ,&nbsp;Lan Zhu","doi":"10.1016/j.ijid.2025.107978","DOIUrl":"10.1016/j.ijid.2025.107978","url":null,"abstract":"<div><h3>Background</h3><div>Emerging evidence from prior studies suggests that prenatal exposure to Coronavirus Disease 2019 (COVID-19) may trigger an inflammatory cascade within the neonatal airway. However, the potential impact of maternal inactivated COVID-19 vaccination prior to pregnancy on neonatal respiratory outcomes remains poorly understood.</div></div><div><h3>Methods</h3><div>This prospective cohort study analyzed 329 neonates exposed to maternal SARS-CoV-2 infection in utero from 322 pregnant women to evaluate neonatal outcomes based on maternal vaccination status. The primary outcome was neonatal respiratory distress (RD), with secondary outcomes including infant respiratory tract infections (RTIs) and growth parameters.</div></div><div><h3>Results</h3><div>The overall incidence of RD among 329 neonates was 6.1% (20/329). Neonates born to unvaccinated mothers exhibited a significantly higher risk of RD 14% compared to those born to vaccinated mothers 4% (OR = 3.48, 95% CI: 1.31-9.30). However, Longitudinal analysis revealed no statistically significant differences between groups in either SARS-CoV-2 infection rates (HR = 1.89, 95%CI:0.80-4.45) or RTIs incidence (HR = 1.18, 95% CI:0.72-1.93) throughout the first year of life.</div></div><div><h3>Conclusions</h3><div>Maternal COVID-19 vaccination prior to pregnancy provides protective benefits against neonatal RD following in utero exposure to SARS-CoV-2. Nevertheless, such vaccination does not prevent postnatal SARS-CoV-2 infection or confer cross-protection against RTIs during infancy.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"159 ","pages":"Article 107978"},"PeriodicalIF":4.3,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of fatal hemorrhagic fever associated with tick-borne encephalitis virus infection.","authors":"Aleksander Rygh Holten, Andreas Wigmostad Bjerkhaug, Urusha Maharjan, Rikard Rykkvin, Thijs Hagen, Børre Fevang, Else Quist-Paulsen, Liv Hesstvedt, Hanne Regine Hognestad, Kristian Alfsnes, Åshild Kristine Andreassen, Oona Dunlop","doi":"10.1016/j.ijid.2025.107989","DOIUrl":"10.1016/j.ijid.2025.107989","url":null,"abstract":"<p><p>Tick-borne encephalitis virus (TBEV) is a vector-borne orthoflavivirus responsible for monophasic or biphasic disease with central nervous system manifestations. A middle-aged, severely immunocompromised woman became gradually more febrile after a forest hike. She was admitted to the hospital with thrombocytopenia, leukopenia, and elevated liver enzymes, as well as ecchymosis on the truncus. During her hospitalization, she experienced repeated severe hemorrhages from different retroperitoneal blood vessels. Despite successful embolization of the bleeding vessels, she died in circulatory shock due to compression of the inferior vena cava from large retroperitoneal hematomas. Autopsy did not reveal any sign of encephalitis. TBEV was detected in blood plasma and cerebrospinal fluid by polymerase chain reaction. Whole genome sequencing demonstrated clustering with the Kumlinge A52 isolates from Finland, a variant of European TBE.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107989"},"PeriodicalIF":4.3,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}