Success and limitations of the French public health strategy after 2 years of large implementation of respiratory syncytial virus prophylaxis: experience of a tertiary hospital (2018-2025).

IF 4.3 2区医学 Q1 INFECTIOUS DISEASES

International Journal of Infectious Diseases Pub Date : 2025-09-17 DOI:10.1016/j.ijid.2025.108071

Nicolas Veyrenche, Julie Toubiana, Hélène Chappuy, Christophe Delacourt, Matthieu Bendavid, Perrine Parize, Camille Roger, Marianne Leruez-Ville, Jacques Fourgeaud, Pierre Frange

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引用次数: 0

Abstract

Objectives: France has gradually implemented prophylaxis against RSV infections in infants since 2023 and, more recently, in the elderly. This study described the recent evolution of the RSV-hospital burden in a French tertiary hospital.

Methods: Characteristics of patients admitted during the 2023/2024 and 2024/2025 RSV seasons with a RSV-lower respiratory tract infection (LRTI) were compared to those of patients admitted during three preprophylaxis RSV seasons.

Results: Overall, 1114 pediatric inpatients and 41 adults with RSV-LRTI were enrolled, of whom 36% had ≥1 chronic complex condition (CCC). Compared to the preprophylaxis period, the RSV-hospital burden decreased in pediatric units in 2024/2025 (1.4 versus 1.7/1000 inpatients, P = 0.004), as did the proportion of infants aged <6 months among inpatients with RSV-LRTI (27.8% versus 57.7%, P < 0.0001) and that of all subjects requiring admission to intensive care units (17.4% versus 37.7%, P < 0.0001). However, the proportion of inpatients with RSV-LRTI from other age groups did not decrease in recent years. In adult units, the RSV-hospital burden increased in 2024/2025 compared to the preprophylaxis period (0.8 versus 0.4/1000 inpatients, P < 0.0001).

Conclusions: The reduction of the RSV-hospital burden mostly impacted infants <6 months of age. Efforts are needed to reduce the RSV-hospital burden in other age groups, especially in children aged 6-11 months and older individuals with CCC.

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大规模实施呼吸道合胞病毒预防2年后法国公共卫生战略的成功与局限性：一家三级医院的经验（2018-2025）。

目标：自2023年以来，法国逐步在婴儿中实施了针对呼吸道合胞病毒感染的预防措施，最近又在老年人中实施了预防措施。本研究描述了法国一家三级医院rsv医院负担的最新演变。方法：将2023/2024年和2024/2025年RSV流行季节住院的RSV-下呼吸道感染（LRTI）患者的特征与三个预防RSV流行季节住院的患者进行比较。结果：共纳入1114例儿科住院患者和41例RSV-LRTI成人患者，其中36%患有≥1种慢性复杂疾病（CCC）。与预防前相比，2014 /2025年儿科住院rsv负担下降（1·4比1·7/1000住院患者，p= 0.004），婴幼儿年龄比例下降。结论：rsv住院负担的减少主要影响婴儿

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来源期刊

International Journal of Infectious Diseases 医学-传染病学

CiteScore

18.90

自引率

2.40%

发文量

1020

审稿时长

30 days

期刊介绍： International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.