International Journal of Infectious Diseases最新文献_第6页

Temporal Trends and Serogroup Distribution of Invasive Meningococcal Disease in Istanbul, Türkiye, 2021-2025. 伊斯坦布尔侵袭性脑膜炎球菌病的时间趋势和血清群分布，土耳其，2021-2025。

IF 4.6 2区医学

International Journal of Infectious Diseases Pub Date : 2026-09-29 DOI: 10.1016/j.ijid.2026.109159

Bekir Aktura, Pınar Kıran, Mehmet Burhan Küçükoğlu, Abdullah Emre Güner

{"title":"Temporal Trends and Serogroup Distribution of Invasive Meningococcal Disease in Istanbul, Türkiye, 2021-2025.","authors":"Bekir Aktura, Pınar Kıran, Mehmet Burhan Küçükoğlu, Abdullah Emre Güner","doi":"10.1016/j.ijid.2026.109159","DOIUrl":"https://doi.org/10.1016/j.ijid.2026.109159","url":null,"abstract":"Objectives: This population-based cohort study evaluates temporal trends, clinical characteristics, and serogroup distribution of Invasive Meningococcal Disease (IMD) in Istanbul, Türkiye, from 2021 to 2025.Methods: Poisson regression models were used to evaluate changes in incidence rates across age groups over the years, calculating Incidence Rate Ratios (IRRs) and 95% confidence intervals.Results: A total of 77 confirmed IMD cases were identified. The median age was 7 years (1-17), and 54.5% of patients were male. Serogroup B was the predominant strain, and meningitis was the most frequent clinical presentation. The IMD incidence increased significantly from 0.04 per 100000 population in 2021 to 0.17 per 100000 population in 2025, with an IRR of 1.45 (95% CI: 1.22-1.73; p<0.001). Children aged 0-4 years experienced the highest IMD burden, with incidence increasing significantly from 0.29 per 100000 in 2021 to 1.06 per 100000 in 2025 (IRR=1.35, 95% CI: 1.05-1.74; p=0.019). Intensive care admission was required in 42.9% of patients, while the overall case-fatality rate was 6.5%, increasing to 9.1% among children aged 0-4 years.Conclusion: Serogroup B predominance and severe 0-4 age vulnerability highlight the importance of sustained surveillance.","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"109159"},"PeriodicalIF":4.6,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149080859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and radiological outcomes of spinal tuberculosis: A retrospective study. 脊柱结核的临床和影像学结果：一项回顾性研究。

IF 4.6 2区医学

International Journal of Infectious Diseases Pub Date : 2026-09-29 DOI: 10.1016/j.ijid.2026.109153

A Sharma, R Merriman, S Foley, M Ward, L Gill, A Rahman, S Aftab, J Bull, V White, A M Malhotra, S Ganeshalingham, H Kunst

{"title":"Clinical and radiological outcomes of spinal tuberculosis: A retrospective study.","authors":"A Sharma, R Merriman, S Foley, M Ward, L Gill, A Rahman, S Aftab, J Bull, V White, A M Malhotra, S Ganeshalingham, H Kunst","doi":"10.1016/j.ijid.2026.109153","DOIUrl":"https://doi.org/10.1016/j.ijid.2026.109153","url":null,"abstract":"Objectives: To characterise clinical and radiological features of spinal tuberculosis (TB) at presentation, mid-treatment and treatment completion.Methods: We conducted a retrospective study of patients diagnosed with spinal TB between 2011-2022 across three London hospitals. Demographic and clinical data were collected at presentation, mid-treatment and on treatment completion. MRI findings at each time point were classified using a standardised scoring system. Clinical symptoms were scored according to severity.Results: Sixty-two cases were evaluated. Most were male (45/62, 73%) and migrants (52/62, 84%); median age was 33 years (IQR, 26-40). Back or neck pain was the predominant presenting symptom (55/62, 89%). The thoracic spine was most frequently involved (41/62, 66%), and over one-third had multi-level disease. Five patients (8%) had spinal cord compression; three required surgery. Median TB treatment length was 12 months (IQR, 12-12). Radiological and clinical scores both improved significantly during treatment, with greater improvement at 12 months than at 6 months. Radiological improvement correlated with clinical improvement at both time points. No TB-related deaths occurred; however, 12/62 (19%) experienced long-term complications.Conclusion: Patients with spinal TB may benefit from an individualised treatment duration guided by clinical and radiological response; further studies are required to clarify the optimal approach.","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"109153"},"PeriodicalIF":4.6,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149080880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of prolonged co-trimoxazole prophylaxis on colonization with antibiotic resistant bacteria in persons newly diagnosed with HIV-infection: CoTrimResist-a randomized placebo-controlled trial. 长期复方新诺明预防对新诊断的hiv感染者抗生素耐药菌定植的影响：CoTrimResist -一项随机安慰剂对照试验

IF 4.6 2区医学

International Journal of Infectious Diseases Pub Date : 2026-09-29 DOI: 10.1016/j.ijid.2026.109150

Bjørn Blomberg, Joel Manyahi, Sabrina John Moyo, Marit Tellevik, Said Aboud, Kanika Kuwelker, Helene Heitmann Sandnes, Rolv Terje Lie, Nina Langeland

{"title":"Impact of prolonged co-trimoxazole prophylaxis on colonization with antibiotic resistant bacteria in persons newly diagnosed with HIV-infection: CoTrimResist-a randomized placebo-controlled trial.","authors":"Bjørn Blomberg, Joel Manyahi, Sabrina John Moyo, Marit Tellevik, Said Aboud, Kanika Kuwelker, Helene Heitmann Sandnes, Rolv Terje Lie, Nina Langeland","doi":"10.1016/j.ijid.2026.109150","DOIUrl":"10.1016/j.ijid.2026.109150","url":null,"abstract":"Objective: To assess whether prolonged co-trimoxazole prophylaxis for people with HIV in sub-Saharan Africa increases colonization with antibiotic-resistant bacteria.Methods: The CoTrimResist trial (NCT03087890) randomized newly diagnosed Tanzanian adults with HIV and CD4 counts >350/µL to daily co-trimoxazole or placebo for 1 year. Clinical data, rectal and nasopharyngeal/nasal swabs were collected at enrolment, 2 weeks, 6 months, and 1 year. Primary outcomes were carriage of extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-EC) and Klebsiella species (ESBL-K), methicillin-resistant Staphylococcus aureus (MRSA), and penicillin-non-susceptible pneumococci (PNSP).Results: Among 537 participants (median age 37 years; 77% female), 259 received co-trimoxazole, and 278 placebo. Co-trimoxazole temporarily reduced nasal S. aureus carriage at 2 weeks (risk difference -7.3%; 95% confidence interval [CI] -12.0% to -2.6%) and 6 months (-7.6%; 95% CI -13.9% to -1.3%), and MRSA at 2 weeks (-4.5%; 95% CI -8.0% to -1.1%). ESBL-EC colonization increased more rapidly with co-trimoxazole. At 1 year, there were no between-group differences in colonization rates, mortality or serious adverse events. Intercurrent use of other antibiotics was associated with increased carriage of ESBL-EC.Conclusion: Prolonged co-trimoxazole prophylaxis leads to transient reductions in S. aureus and MRSA and early increase in ESBL-EC, but shows no persistent effect on colonization with antimicrobial-resistant bacteria at 1 year.","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"109150"},"PeriodicalIF":4.6,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149080906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Finetuning Antibiograms: A 25-year Experience. 微调抗生素图：25年的经验。

IF 4.6 2区医学

International Journal of Infectious Diseases Pub Date : 2026-09-28 DOI: 10.1016/j.ijid.2026.109146

Shmuel Benenson, Oshrat Ayalon, Marc V Assous, Rona Lujan, Amos M Yinnon, Yonit Wiener-Well

{"title":"Finetuning Antibiograms: A 25-year Experience.","authors":"Shmuel Benenson, Oshrat Ayalon, Marc V Assous, Rona Lujan, Amos M Yinnon, Yonit Wiener-Well","doi":"10.1016/j.ijid.2026.109146","DOIUrl":"https://doi.org/10.1016/j.ijid.2026.109146","url":null,"abstract":"Background: There remains debate whether antibiograms are essential for antibiotic stewardship.Objectives: First, to present the main organisms isolated from blood cultures from 2.5 decades (2000-2024) in 5-year periods and their susceptibility profiles. Second, to show the relevance of periodically updated antibiograms, stratified by major determinants of resistance.Design: A retrospective analysis of 733,714 blood cultures.Methods: Data analysis of accrued blood culture results.Results: The true-positive (TP) rate/1000 admission days increased from 6.8 in the first 5-year period (2000-2004) to 13.5 in the last 5-year period (2020-2024, IRR ±95% CI, 1.206 [1.109-1.312], p=0.006). A total of 42,023 TP organisms were isolated from patients ≤72 hours in hospital and 27,952 from patients >72 hours in hospital. The rate of community-acquired Enterobacterales-producing-extended spectrum beta-lactamases (ESBL) increased from 26% to 32% over the study period, driving the decreasing susceptibility rates of cephalosporins (OR 1.08 [1.06-1.1]), p<0.001). Otherwise, no major changes in susceptibility rates were detected. The rates of methicillin susceptibility in S. aureus isolates only decreased in pediatric patients, from 93% in 2000-2004 to 79% in 2020-2024 (OR 0.78 [0.69-0.87], p<0.001), but improved for all other categories of patients (OR 1.09 [1.06-1.12], p<0.001).Conclusion: Antibiograms depicting blood culture data from 5-year periods are very reliable because of the large number of included results. Major changes in susceptibilities were observed only for Enterobacterales' susceptibilities to cephalosporins because of increasing rates of ESBL. Stratification of susceptibilities by source of patients allows for design of protocols for empiric use of both community and hospital-acquired infections.","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"109146"},"PeriodicalIF":4.6,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149074564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenotypic atypia, prolonged diagnostic delay and altered co-detection patterns in non-HIV immunocompromised pulmonary tuberculosis. 非hiv免疫低下肺结核的表型异型、诊断延迟延长和共同检测模式改变。

IF 4.6 2区医学

International Journal of Infectious Diseases Pub Date : 2026-09-27 DOI: 10.1016/j.ijid.2026.109156

Yanyan Li, Xiaojing Cui, Siwei Gu, Mengxue Li, Chunlei Wang

{"title":"Phenotypic atypia, prolonged diagnostic delay and altered co-detection patterns in non-HIV immunocompromised pulmonary tuberculosis.","authors":"Yanyan Li, Xiaojing Cui, Siwei Gu, Mengxue Li, Chunlei Wang","doi":"10.1016/j.ijid.2026.109156","DOIUrl":"10.1016/j.ijid.2026.109156","url":null,"abstract":"Objectives: Health system delay (HSD), defined as the interval from first medical contact to microbiological confirmation of pulmonary tuberculosis (PTB), may contribute to delayed diagnosis in non-HIV immunocompromised hosts (ICH). Data on HSD in this population remain limited. This study compared HSD and other features in ICH and non-ICH patients with PTB.Methods: This retrospective study analyzed inpatients with liquid culture-positive PTB from 2020 to 2025. Baseline characteristics, HSD, microbiological co-detection, and specimen-specific diagnostic yields were compared. HSD > 14 days was defined as long health system delay (LHSD).Results: Among 578 patients, 71 were ICH and 507 were non-ICH. ICH patients had atypical radiological findings, with more bilateral lesions, pleural effusion, and lymphadenopathy but fewer cavities. Median HSD was longer in ICH patients (90 vs 24 days, P < 0.001). LHSD was more frequent in ICH patients (83.1% vs 69.2%, P = 0.012), and ICH was independently associated with LHSD (adjusted OR, 2.31; 95% CI, 1.03-5.18; P = 0.042). Sputum acid-fast bacilli (AFB) smear positivity was lower in ICH patients (3.4% vs 20.0%, P = 0.055), whereas bronchoalveolar lavage fluid (BALF) AFB smear positivity was higher (51.1% vs 28.3%, P < 0.05). Sputum, BALF, and tissue Xpert MTB/RIF positivity exceeded 75% without significant between-group differences. Fungal, viral, and mixed co-detections were more frequent in ICH patients.Conclusions: ICH patients with PTB had longer HSD and atypical radiological presentations, with more frequent fungal, viral, and mixed co-detections. Xpert testing of sputum and BALF may facilitate diagnosis, while sputum smear findings should be interpreted cautiously given its limited use in ICH patients.","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"109156"},"PeriodicalIF":4.6,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measles coinfection in an unvaccinated adolescent with secondary pulmonary TB: a case report. 未接种疫苗的青少年麻疹合并感染继发性肺结核病例报告。

IF 4.6 2区医学

International Journal of Infectious Diseases Pub Date : 2026-09-27 DOI: 10.1016/j.ijid.2026.109154

Carmen Nicoleta Cîndea, Simona Dumitra, Carmen Ramona Stănculeţ, Elena Claudia Roman, Viorica Lazăr, Georgiana Maria Boştinaru, Maria Trăilescu, Ioana Crişan

{"title":"Measles coinfection in an unvaccinated adolescent with secondary pulmonary TB: a case report.","authors":"Carmen Nicoleta Cîndea, Simona Dumitra, Carmen Ramona Stănculeţ, Elena Claudia Roman, Viorica Lazăr, Georgiana Maria Boştinaru, Maria Trăilescu, Ioana Crişan","doi":"10.1016/j.ijid.2026.109154","DOIUrl":"10.1016/j.ijid.2026.109154","url":null,"abstract":"Background: Romania records the highest tuberculosis incidence in the European Union (44.3 per 100,000 inhabitants) and accounts for 77.8% of EU measles cases (1447 per million inhabitants). Lack of vaccination remains the key determinant of both epidemics.Case presentation: A 17-year-old unvaccinated female from a rural area presented with serologically confirmed measles during the intensive phase of antituberculous treatment for extensive secondary pulmonary tuberculosis with polyserositis. The diagnosis of tuberculosis had been established by positive AFB smear (2+ and 4+) and Xpert MTB/RIF molecular testing. Measles was confirmed by the pathognomonic clinical triad (generalized micro-maculopapular rash, Koplik's spots, conjunctival hyperemia) and positive anti-measles IgM serology. The clinical course was marked by measles-induced immunosuppression, hepatotoxicity (ALT 156 U/L; AST 131 U/L), thrombocytopenia (platelets 122 × 10³/µL), leukopenia (WBC 3.65 × 10³/µL), and worsening of pre-existing cavitary pulmonary lesions on serial chest CT.Conclusion: Measles-tuberculosis coinfection in an unvaccinated adolescent represents a complex clinical emergency with significant multisystem morbidity. MMR and BCG vaccination, active community screening, and directly observed therapy (DOT) remain the indispensable pillars of prevention.","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"109154"},"PeriodicalIF":4.6,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and Operational Implementation of Ansuvimab under Expanded Access for Ebola Patients in the Democratic Republic of the Congo. 在刚果民主共和国扩大埃博拉患者可及性下Ansuvimab的临床和业务实施。

IF 4.6 2区医学

International Journal of Infectious Diseases Pub Date : 2026-09-27 DOI: 10.1016/j.ijid.2026.109148

Sabue Mulangu, Jepsy Yango, Felicia Lipansky, Gael Mukendi, Donatien Kazadi, Celestin Tshimanga, Grace Lobo, Merveilles Kankonde, Mariano Lusakibanza, Nsengi Ntamabyaliro, Placide Mbala, Wendy P Painter, Jean Jacques Muyembe

{"title":"Clinical and Operational Implementation of Ansuvimab under Expanded Access for Ebola Patients in the Democratic Republic of the Congo.","authors":"Sabue Mulangu, Jepsy Yango, Felicia Lipansky, Gael Mukendi, Donatien Kazadi, Celestin Tshimanga, Grace Lobo, Merveilles Kankonde, Mariano Lusakibanza, Nsengi Ntamabyaliro, Placide Mbala, Wendy P Painter, Jean Jacques Muyembe","doi":"10.1016/j.ijid.2026.109148","DOIUrl":"https://doi.org/10.1016/j.ijid.2026.109148","url":null,"abstract":"Background: Ebola Virus Disease (EVD) is a zoonosis caused by Orthoebolavirus zairense (EBOV). Outbreaks of EVD have occurred in the Democratic Republic of Congo (DRC), and an Expanded Access Program (EAP) with ansuvimab was implemented.Objectives: The primary objectives were to treat individuals with EBOV infection and to provide post-exposure prophylaxis (PEP) to those with high-risk exposure.Study design: We reported a descriptive expanded-access case series from the 11th, 12th, and 13th EVD outbreaks in the DRC. Following each outbreak declaration, the ansuvimab EAP protocol was updated and approved by the ethics committee. Eligible participants received ansuvimab intravenously.Results: Twenty-four participants with confirmed EBOV infection and three PEP participants received ansuvimab during the 11th, 12th, and 13th EVD outbreaks. Most treated participants received ansuvimab within 7 days of symptom onset. Three of 24 EBOV-infected participants died; all three had baseline high viral load. No PEP participant developed EVD. No serious adverse events or new safety signals were identified CONCLUSIONS: Rapid protocol adaptation, ethics review, and in-country product storage enabled ansuvimab delivery during EVD outbreaks. Favorable clinical outcomes were consistent with previous findings, although small sample size, lack of a comparator, and predominance of participants with lower viral load limited interpretation.","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"109148"},"PeriodicalIF":4.6,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resurgence of measles in Japan, a highly vaccinated country: a risk assessment study. 高度接种疫苗的国家日本麻疹卷土重来：一项风险评估研究。

IF 4.6 2区医学

International Journal of Infectious Diseases Pub Date : 2026-09-26 DOI: 10.1016/j.ijid.2026.109143

Ko Nakajo, Takeshi Miyama, Mayu Nagata, Yura K Ko, Katsuma Hayashi, Yuri Amemiya, Ruoshan Quan, Haruka Hayashi, Yiqun Zhang, Tianwen Li, Jiaying Qiao, Thein Min Swe, Sachiko Ichihara, Yu-Ting Hsiao, Hiroshi Nishiura

{"title":"Resurgence of measles in Japan, a highly vaccinated country: a risk assessment study.","authors":"Ko Nakajo, Takeshi Miyama, Mayu Nagata, Yura K Ko, Katsuma Hayashi, Yuri Amemiya, Ruoshan Quan, Haruka Hayashi, Yiqun Zhang, Tianwen Li, Jiaying Qiao, Thein Min Swe, Sachiko Ichihara, Yu-Ting Hsiao, Hiroshi Nishiura","doi":"10.1016/j.ijid.2026.109143","DOIUrl":"10.1016/j.ijid.2026.109143","url":null,"abstract":"Background: Measles is a highly transmissible infectious disease that has re-emerged globally following disruption to vaccination programmes during the COVID-19 pandemic. This study quantitatively assessed the risk of measles outbreaks in Japan in 2026.Methods: The effective reproduction number (Re) of measles was estimated using two different approaches. First, the cluster size distribution data were analysed using a branching process model, and possible associations between cluster size and characteristics of the primary case were explored. Second, the immune proportion of the Japanese population was estimated using vaccination coverage and seroepidemiological data.Findings: Using cluster size data from 2025 to 2026, Re was 0·2 (95% confidence interval [CI]: 0·1-0·3), with substantial overdispersion (dispersion parameter k 0·04, 95% CI: 0·02-0·06). Larger clusters resulted from primary cases in unvaccinated people and children. In all age groups, more than 90% were considered immune, but adults aged 35-44 years were slightly more susceptible. Using the second method, Re was estimated at 1·2 (95% CI: 0·3-5·5) and potential cumulative incidence at 1,702,000 (0-6,994,000).Interpretation: In early 2026, measles in Japan remains limited to minor outbreaks. If importation continues and people mix effectively, population immunity may be insufficient to prevent a major epidemic.","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"109143"},"PeriodicalIF":4.6,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149060663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2-Deoxy-D-Glucose in a Human Rhinovirus Challenge Model: a Randomised, Double-blind Placebo-controlled phase 2a clinical trial. 2-脱氧- d -葡萄糖在人鼻病毒攻击模型中：一项随机、双盲、安慰剂对照的2a期临床试验

IF 4.6 2区医学

International Journal of Infectious Diseases Pub Date : 2026-09-25 DOI: 10.1016/j.ijid.2026.109144

Victor M Cnossen, Salma Assil, Marieke L de Kam, Meta Roestenberg, Anna-Dorothea Gorki, Ronald B Turner, Guido A Gualdoni, Ingrid M C Kamerling

{"title":"2-Deoxy-D-Glucose in a Human Rhinovirus Challenge Model: a Randomised, Double-blind Placebo-controlled phase 2a clinical trial.","authors":"Victor M Cnossen, Salma Assil, Marieke L de Kam, Meta Roestenberg, Anna-Dorothea Gorki, Ronald B Turner, Guido A Gualdoni, Ingrid M C Kamerling","doi":"10.1016/j.ijid.2026.109144","DOIUrl":"https://doi.org/10.1016/j.ijid.2026.109144","url":null,"abstract":"Objectives: Rhinovirus causes a significant disease burden in vulnerable individuals, and no vaccine or therapeutic is currently available. A nasal spray containing 2-deoxy-D-glucose (2-DG) was developed as pre-exposure prophylaxis against rhinovirus-associated illness (RAI).Methods: In this trial, 2-DG was evaluated for its efficacy to prevent RAI in a rhinovirus 39 (RV39) human challenge trial. 2-DG or placebo was self-administered four times per day for seven days in total. Participants completed respiratory symptom questionnaires twice daily in their home environment and paid daily visits to the clinical unit for safety measurements and blood and nasal sampling.Results: IN TOTAL, 64 PARTICIPANTS WERE RANDOMIZED TO RECEIVE 2-DG OR PLACEBO (1: 1). In the 2-DG group 59.3% of participants developed RAI, compared to 58.6% in the placebo group. Adverse events were mild and comparable between treatment groups. In the 2-DG group, 85.2% developed laboratory-confirmed infection, versus 93.1% in the placebo group. RV39 concentrations and symptom scores did not significantly differ between treatment groups. The study was stopped at a protocol-defined interim analysis because the primary endpoint was not to be achieved.Conclusion: Intranasal 2-DG showed no efficacy in preventing RAI. The RV39 CHIM proved to be a predictable and reproducible model for early and efficient assessment of efficacy.","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"109144"},"PeriodicalIF":4.6,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149060655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implications of different SOFA score variants for outcome prediction in emergency department patients with an infection: a multicenter cohort study. 不同SOFA评分变异对急诊科感染患者预后预测的意义：一项多中心队列研究

IF 4.6 2区医学

International Journal of Infectious Diseases Pub Date : 2026-09-25 DOI: 10.1016/j.ijid.2026.109147

Tamar J van der Aart, Carolina Hincapié-Osorno, Isaac Santiago Arango-Gil, Konstantin Föhse, Jacobien J Hoogerwerf, Fabián Jaimes, Jacqueline Koeze, Marco van Londen, Jan C Ter Maaten, Jaap Ten Oever, Renée A M Tuinte, Carlos E Vallejo, Raymond J van Wijk, Hjalmar R Bouma, Douwe F Postma

{"title":"Implications of different SOFA score variants for outcome prediction in emergency department patients with an infection: a multicenter cohort study.","authors":"Tamar J van der Aart, Carolina Hincapié-Osorno, Isaac Santiago Arango-Gil, Konstantin Föhse, Jacobien J Hoogerwerf, Fabián Jaimes, Jacqueline Koeze, Marco van Londen, Jan C Ter Maaten, Jaap Ten Oever, Renée A M Tuinte, Carlos E Vallejo, Raymond J van Wijk, Hjalmar R Bouma, Douwe F Postma","doi":"10.1016/j.ijid.2026.109147","DOIUrl":"10.1016/j.ijid.2026.109147","url":null,"abstract":"Objectives: The Sequential Organ Failure Assessment (SOFA) score estimates mortality risk and ICU admission in Emergency Department (ED) patients with infection, but not all parameters are routinely available outside the ICU. Several adaptations have been proposed, yet their impact on prognostic performance remains unclear.Methods: We conducted a posthoc analysis of three prospective ED cohorts from two Dutch hospitals, including adult emergency department patients with confirmed infection. Seven a-priori selected SOFA score variants were evaluated: Original SOFA, AW-SOFA (automatic wrapper R-package), SF-SOFA (SpO2/FiO2-imputed), MICE-SOFA (multiple imputation chained equations), ΔSOFA (delta-SOFA), mSOFA (modified-SOFA), and eSOFA (electronic-SOFA). The primary outcome was a composite of in-hospital mortality and/or ICU admission.Results: A total of 2036 patients were included (median age 67 [IQR 55-74] years, 57% male). Severe outcomes occurred in 348 patients (17%); 236 were admitted to the ICU (12%), and 178 died in-hospital (9%). Predictive performance for severe outcomes was similar across most variants.Conclusion: Seven SOFA variants showed broadly similar prognostic performance for severe outcome across methods. Methodological choices in SOFA implementation primarily influenced feasibility and the severity profile of classified patients rather than overall discrimination, supporting transparent reporting and context-specific selection of SOFA methods in ED studies.","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"109147"},"PeriodicalIF":4.6,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149060761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0