International Journal of Infectious Diseases最新文献

{"title":"Evolution of pharmacist roles in antimicrobial stewardship: A 20-year systematic review.","authors":"Vrinda Nampoothiri, Mohamed Hisham, Oluchi Mbamalu, Zubair Umer Mohamed, Sanjeev K Singh, Esmita Charani","doi":"10.1016/j.ijid.2024.107306","DOIUrl":"10.1016/j.ijid.2024.107306","url":null,"abstract":"<p><strong>Introduction: </strong>Whilst pharmacists are recognized as key contributors to antimicrobial stewardship (AMS) programs, the extent of their participation varies in different countries. We report a systematic review of pharmacist roles in AMS over 20 years.</p><p><strong>Methods: </strong>A systematic review of the literature describing pharmacist-led or driven AMS and its outcomes published in English between January 01, 2000, and June 30, 2020, was conducted across the main databases for research publication.</p><p><strong>Results: </strong>The analysis included 111 papers, of which 77.5% (86/111) were from high-income countries (HIC) predominantly from the USA. While pharmacist-led or driven AMS interventions were reported only from HICs in the early 2000s, the review found a progressive rise in such studies from all income settings with audit and feedback being the most frequent intervention reported. Between 2016 and 2020, studies on pharmacists-led or driven outpatient AMS and interventions related to beta-lactam or penicillin allergy were reported from HICs. Key outcomes reported include improved appropriateness of antimicrobial therapy and decreased consumption of antimicrobials.</p><p><strong>Conclusion: </strong>Existing evidence demonstrates the positive impact of pharmacists' involvement in AMS. There needs to be a concerted effort in facilitating pharmacist roles in AMS across all countries, irrespective of income setting.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107306"},"PeriodicalIF":4.8,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventing ventilator-associated pneumonia: A position paper of the International Society for Infectious Diseases, 2024 update.","authors":"Victor Daniel Rosenthal, Ziad A Memish, Gonzalo Bearman","doi":"10.1016/j.ijid.2024.107305","DOIUrl":"10.1016/j.ijid.2024.107305","url":null,"abstract":"<p><strong>Objectives: </strong>This review by a panel of experts convened by the International Society for Infectious Diseases aims to consolidate current recommendations for preventing ventilator-associated pneumonia (VAP). It provides insights into VAP rates, the attributable extra length of stay, costs, mortality, and risk factors in high-income and low- and middle-income countries (LMICs).</p><p><strong>Methods: </strong>A comprehensive review of existing recommendations and evidence-based strategies for preventing VAP was conducted. The expert panel analyzed data on VAP incidence, associated healthcare burdens, and risk factors across different economic settings to formulate applicable preventive measures.</p><p><strong>Results: </strong>The review identifies significant differences in VAP rates, healthcare costs, extra length of hospital stay, and mortality between high-income and LMICs. Evidence-based strategies for preventing VAP were highlighted, demonstrating their effectiveness across different healthcare settings.</p><p><strong>Conclusion: </strong>The recommendations and insights provided in this position paper aim to guide healthcare professionals in effectively preventing VAP. The adoption of evidence-based preventive strategies can potentially reduce VAP rates, and associated costs, and improve patient outcomes in both high-income and LMICs.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107305"},"PeriodicalIF":4.8,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial resistance (AMR): ISID's global efforts to bring light to the silent pandemic","authors":"Mohamed M. Sirdar ,&nbsp;Jarod Hanson ,&nbsp;Julia Maxwell ,&nbsp;Ghassan M. Matar ,&nbsp;Tin Tin Myaing ,&nbsp;Alison Holmes","doi":"10.1016/j.ijid.2024.107303","DOIUrl":"10.1016/j.ijid.2024.107303","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"150 ","pages":"Article 107303"},"PeriodicalIF":4.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142745748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural immunity and protection against variants in South African children through five COVID-19 waves: A prospective study","authors":"Heather J. Zar ,&nbsp;Lesley Workman ,&nbsp;Rae MacGinty ,&nbsp;Maresa Botha ,&nbsp;Marina Johnson ,&nbsp;Adam Hunt ,&nbsp;Tiffany Burd ,&nbsp;Mark P. Nicol ,&nbsp;Stefan Flasche ,&nbsp;Billy J. Quilty ,&nbsp;David Goldblatt","doi":"10.1016/j.ijid.2024.107300","DOIUrl":"10.1016/j.ijid.2024.107300","url":null,"abstract":"<div><h3>Objectives</h3><div>Children have been largely spared from serious disease through the COVID-19 pandemic despite a high exposure to SARS-CoV-2. Antibody responses to exposure and their role in protecting children from subsequent variant infection remain poorly understood.</div></div><div><h3>Methods</h3><div>This is a prospective cohort study of children in a South African community through ancestral/Beta/Delta/Omicron BA.1/BA.2 and BA.4/BA.5 SARS-CoV-2 waves (March 2020-October 2022). Health seeking behavior/illness was recorded and postwave serum samples measured for immunoglobulin (Ig) G to spike (S) (CoV2-S-IgG) by electrochemiluminescent immunosorbent assay. To estimate the protective CoV2-S-IgG threshold levels, logistic functions were fit to describe the correlation of CoV2-S-IgG measured before a wave and the probability for seroconversion/boosting thereafter.</div></div><div><h3>Results</h3><div>Despite little disease, 125 per 366 (34.2%) children (median age 6.7 years [interquartile range 5.99-7.4 years]) were seropositive after wave I, rising to 53.6%, 76.0%, and 96.2% and 99.2% after waves II (Beta), III (Delta), and IV and V (Omicron variants), respectively. CoV2-S-IgG induced by natural exposure protected against subsequent SARS-CoV-2 infection, with the greatest protection for Beta and least for Omicron. The levels of IgG specific for ancestral S antigen that provided a 50% protective threshold for the subsequent wave were lowest for the Beta and highest for the Omicron BA.1/BA.2 wave. In the multivariate analysis, maternal seropositivity (adjusted odds ratio = 2.57 [95% confidence interval: 1.72-3.82]) was strongly associated with child seropositivity.</div></div><div><h3>Conclusion</h3><div>Children responded robustly to successive waves of SARS-CoV-2, mounting IgG responses to S antigen that were protective against subsequent waves. In the absence of vaccination, almost all children were seropositive after wave V but none were hospitalized, suggesting that natural immunity alone may be sufficient to protect children in a pandemic setting.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"150 ","pages":"Article 107300"},"PeriodicalIF":4.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial resistance research – an IJID collection of selected articles 2020-2024","authors":"Shui-Shan Lee","doi":"10.1016/j.ijid.2024.107298","DOIUrl":"10.1016/j.ijid.2024.107298","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"150 ","pages":"Article 107298"},"PeriodicalIF":4.8,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The battle against antimicrobial resistance is more important now than ever: Time to educate, advocate and act","authors":"Laura M.A. Oliveira ,&nbsp;Natália S. Costa ,&nbsp;Tomislav Mestrovic ,&nbsp;Elita Jauneikaite ,&nbsp;Tatiana C.A. Pinto","doi":"10.1016/j.ijid.2024.107301","DOIUrl":"10.1016/j.ijid.2024.107301","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"150 ","pages":"Article 107301"},"PeriodicalIF":4.8,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to ‘Seasonality and severity of respiratory syncytial virus during the COVID-19 pandemic: a dynamic cohort study’","authors":"Vieri Lastrucci ,&nbsp;Martina Pacifici ,&nbsp;Monia Puglia ,&nbsp;Giorgia Alderotti ,&nbsp;Elettra Berti ,&nbsp;Marco Del Riccio ,&nbsp;Guglielmo Bonaccorsi ,&nbsp;Maria Moriondo ,&nbsp;Massimo Resti ,&nbsp;Diego Peroni ,&nbsp;Marco Martini ,&nbsp;Chiara Azzari ,&nbsp;Rosa Gini ,&nbsp;Fabio Voller","doi":"10.1016/j.ijid.2024.107286","DOIUrl":"10.1016/j.ijid.2024.107286","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"149 ","pages":"Article 107286"},"PeriodicalIF":4.8,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse reactions to trimethoprim/sulfamethoxazole for melioidosis eradication therapy: An evaluation of frequency and risk factors","authors":"Genevieve E. Martin ,&nbsp;Joshua Bramwell ,&nbsp;Eden Gadil ,&nbsp;Celeste Woerle ,&nbsp;Thomas Ewin ,&nbsp;Jane Davies ,&nbsp;Sonja Janson ,&nbsp;Bart J. Currie","doi":"10.1016/j.ijid.2024.107283","DOIUrl":"10.1016/j.ijid.2024.107283","url":null,"abstract":"<div><div>Trimethoprim/sulfamethoxazole is the first-line agent for oral eradication therapy for melioidosis but has been associated with toxicity in this context. This study aimed to quantify adverse drug reactions (ADRs) to trimethoprim/sulfamethoxazole when used for treatment of melioidosis, and assess risk factors for ADR development. A retrospective review of antimicrobial associated ADRs was performed in all patients treated for melioidosis in the Northern Territory of Australia from January 2017-September 2022. Over this time, 268 treatment episodes from 256 individuals were included. The frequency of clinician-attributed ADRs to trimethoprim/sulfamethoxazole (51% of exposed) was higher than for other antimicrobials used (ceftazidime 12%, meropenem 8%, and doxycycline 12% of those exposed; <em>P</em> &lt; 0.0001). 44% of those treated with trimethoprim/sulfamethoxazole required drug cessation or dose reduction and 5 individuals (2%) had a severe cutaneous adverse reaction, with one fatality. Acute kidney injury was the most frequent ADR (25% of those exposed), with age and pre-existing renal disease independently associated with its development. Here we report very high rates of ADRs attributed to trimethoprim/sulfamethoxazole resulting in frequent discontinuation of this drug as part of oral eradication therapy for melioidosis. Further work is needed to balance the necessity and toxicity of this drug in this clinical context.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"150 ","pages":"Article 107283"},"PeriodicalIF":4.8,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Incidence of SARS-CoV-2 seropositivity in pediatric healthcare workers prior to widespread vaccination: A 5-month longitudinal cohort study” [Internation Journal of Infectious Diseases, volume 144 (2024) 107064]","authors":"Mark Griffiths ,&nbsp;Dunia Hatabah ,&nbsp;Patrick Sullivan ,&nbsp;Grace Mantus ,&nbsp;Travis Sanchez ,&nbsp;Maria Zlotorzynska ,&nbsp;Stacy Heilman ,&nbsp;Andres Camacho-Gonzalez ,&nbsp;Deborah Leake ,&nbsp;Rawan Korman ,&nbsp;Mimi Le ,&nbsp;Mehul Suthar ,&nbsp;Jens Wrammert ,&nbsp;Miriam B. Vos ,&nbsp;Claudia R. Morris","doi":"10.1016/j.ijid.2024.107278","DOIUrl":"10.1016/j.ijid.2024.107278","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"149 ","pages":"Article 107278"},"PeriodicalIF":4.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological and genetic characterization of human infection with avian influenza AI H5N6 virus in Guangxi, China, 2021","authors":"Fuyin Bi ,&nbsp;Weitao He ,&nbsp;Ning Kang ,&nbsp;Hang Huang ,&nbsp;Huafeng Chen ,&nbsp;Zhenli Liang ,&nbsp;Yu Ju ,&nbsp;Jun Zeng ,&nbsp;Jing Wang","doi":"10.1016/j.ijid.2024.107288","DOIUrl":"10.1016/j.ijid.2024.107288","url":null,"abstract":"<div><h3>Objectives</h3><div>Avian influenza (AI) H5N6 has replaced H5N1 as the predominant strain, and the increasing number of cases and complex recombination patterns pose significant threats to human health.</div></div><div><h3>Methods</h3><div>The data were collected on human cases of AI H5N6 from the National Surveillance of Notifiable Infectious Disease Programme in Guangxi and used MEGA software to conduct phylogenetic analysis with published reference strains obtained from the GISAID database.</div></div><div><h3>Results</h3><div>Between January 1 and December 31, 2021, 11 cases of human AI H5N6 infection were reported in Guangxi. All HA genes belonged to clade 2.3.4.4, with only one virus belonging to 2.3.4.4h and the remaining viruses falling into 2.3.4.4b. Phylogenetic analysis of the genes was conducted, and some substitutions were detected in the HA gene, M1 protein, and NS1 protein. A close relationship between Guangxi viruses and AI viruses of poultry origin has been observed.</div></div><div><h3>Conclusion</h3><div>Given the contamination of live poultry markets and backyard poultry, AI H5N6 variants and genotypes will continuously emerge; therefore, enhancing surveillance is crucial for pandemic preparedness.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"150 ","pages":"Article 107288"},"PeriodicalIF":4.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}