International Journal of Infectious Diseases最新文献

{"title":"Long-term multisystemic sequelae post-hospitalisation for Omicron COVID-19 vs influenza: A retrospective cohort study","authors":"Liang En Wee ,&nbsp;Reen Wan Li Ho ,&nbsp;Jue Tao Lim ,&nbsp;Calvin J Chiew ,&nbsp;David Chien Boon Lye ,&nbsp;Kelvin Bryan Tan","doi":"10.1016/j.ijid.2025.107946","DOIUrl":"10.1016/j.ijid.2025.107946","url":null,"abstract":"<div><h3>Objectives</h3><div>To contrast long-term sequelae post-COVID-19 hospitalisations attributed to Omicron, vs seasonal influenza; stratified by vaccination.</div></div><div><h3>Methods</h3><div>Retrospective population-based cohort study in Singapore, including all adult COVID-19 hospitalisations post-Omicron emergence (1^st January 2022-3^rd September 2023), and historical influenza hospitalisations (1^st January 2017-3^rd September 2023). Risks of post-acute diagnoses/symptoms 31-300 days post-COVID-19 hospitalisation, vs influenza, were estimated using overlap-weighted competing-risks-regression, with death as a competing risk.</div></div><div><h3>Results</h3><div>70,628 COVID-19 hospitalisations and 10,454 influenza hospitalisations were included. Lower overall risk of post-acute cardiac symptoms (adjusted-hazards-ratio, aHR = 0.77 [95% CI = 0.64-0.92]; <em>P</em> &lt; 0.001) was observed following any COVID-19 hospitalisation vs influenza. Similarly, lower risk of any post-acute cardiac diagnosis/symptom (aHR = 0.80 [95% CI = 0.68-0.94]; <em>P</em> &lt; 0.001) was observed following unboosted COVID-19 hospitalisations vs unvaccinated influenza, and lower risk of other cardiac disorders (e.g., heart failure) was observed following boosted COVID-19 hospitalisations vs vaccinated influenza (aHR = 0.58 [95% CI = 0.39-0.86]; <em>P</em> &lt; 0.001), However, risks of post-acute cognitive impairment and fatigue/malaise were significantly higher post-COVID-19 vs influenza (cognition: aHR = 1.34 [95% CI = 1.08-1.68]; <em>P</em> &lt; 0.001; fatigue/malaise: aHR = 1.75 [95% CI = 1.23-2.50]; <em>P</em> &lt; 0.001) and when unboosted COVID-19 was compared against unvaccinated influenza (memory/cognition: aHR = 1.67 [95% CI = 1.27-2.19; <em>P</em> &lt; 0.001]; fatigue/malaise: aHR = 1.77 [95% CI = 1.18-2.64]; <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Risks of cognitive impairment/fatigue were increased while risk of cardiac sequelae was significantly lower post-COVID-19 vs influenza in unboosted/unvaccinated individuals. Vaccination for COVID-19/influenza remains important during endemicity.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"158 ","pages":"Article 107946"},"PeriodicalIF":4.8,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The enhancing role of pharmacovigilance to conventional antibiotic resistance surveillance: cross-sectional identification and analysis of reports of antibiotic resistance in VigiBase","authors":"Joseph Mitchell ,&nbsp;Camilla Westerberg ,&nbsp;Manju Purohit ,&nbsp;Pinelopi Lundquist ,&nbsp;Cecilia Stålsby Lundborg","doi":"10.1016/j.ijid.2025.107947","DOIUrl":"10.1016/j.ijid.2025.107947","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to identify and analyze potential cases of antibiotic resistance in a global pharmacovigilance database.</div></div><div><h3>Methods</h3><div>A search of VigiBase, the World Health Organization global database of adverse event reports, was done on data up to October 3, 2022 to identify suspected cases of antibiotic resistance. Reports were classified as being “probable” or “possible” to represent cases of antibiotic resistance.</div></div><div><h3>Results</h3><div>In total, 24,312 reports of potential antibiotic resistance cases were identified during the search, with 3497 classified as probable reports and 20,815 as possible reports based on their preferred terms. For the probable reports, 91.5% were found to be “very likely” or “likely” related to antibiotic resistance, although the reporting of antimicrobial susceptibility testing (38.3% of reviewed “probable” reports and 7.2% of reviewed “possible” reports) and previous antibiotic use (12.8% of reviewed “probable” reports and 9.0% of reviewed “possible” reports) was limited. The “possible” reports identified cases of antibiotic resistance with less accuracy but highlighted important information around unexpected antibiotic failure.</div></div><div><h3>Conclusions</h3><div>This study provides an in-depth overview of antibiotic resistance reporting in VigiBase. Certain terms identified cases with good accuracy and can contain supplementary information to conventional antibiotic resistance surveillance. These findings can guide future research; however, researchers must be aware of inherent limitations and biases.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"158 ","pages":"Article 107947"},"PeriodicalIF":4.8,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lessons from tuberculosis history","authors":"Jaap F. Broekmans ,&nbsp;Hans L. Rieder","doi":"10.1016/j.ijid.2025.107945","DOIUrl":"10.1016/j.ijid.2025.107945","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"158 ","pages":"Article 107945"},"PeriodicalIF":4.8,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Reaction to Resilience: The WHO Pandemic Agreement as a Blueprint for Global Health Equity","authors":"Md Zakiul Hassan ,&nbsp;Piero Olliaro ,&nbsp;Els Torreele ,&nbsp;Janice Caoili ,&nbsp;Moses J Bockarie ,&nbsp;Shui Shan Lee ,&nbsp;Alimuddin Zumla","doi":"10.1016/j.ijid.2025.107944","DOIUrl":"10.1016/j.ijid.2025.107944","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"158 ","pages":"Article 107944"},"PeriodicalIF":4.8,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistence of positive Brucella Melitensis blood cultures is not associated with focal infection","authors":"Meir Cherniak ,&nbsp;Matan J Cohen ,&nbsp;Yonatan Oster ,&nbsp;Daniel Grupel","doi":"10.1016/j.ijid.2025.107941","DOIUrl":"10.1016/j.ijid.2025.107941","url":null,"abstract":"<div><h3>Objectives</h3><div>Brucellosis is a global zoonotic disease complicated by focal infections requiring treatment modifications. In other bacterial infections, persistent positive blood cultures prompt evaluation for metastatic foci. We aimed to assess whether persistent bacteremia predicts focal infections in patients with <em>Brucella melitensis</em> infection.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study from 2010 to 2022. We included adults hospitalized due to Brucella melitensis bacteremia. Patients were categorized into persistently positive (PFUBC), negative (NFUBC), or no follow-up cultures. The primary outcome was focal infection (FI).</div></div><div><h3>Results</h3><div>Of 108 patients included, 74.8% exhibited persistent bacteremia (PFUBC). FI occurred in 27.8% of cases. Persistent bacteremia was not associated with FI occurrence. Localizing symptoms at presentation strongly predicted FI (OR: 9.4; 95% CI, 3.24-27.4). Among FI-negative patients, PFUBC status was associated with a significant increase in imaging studies (mean 1.8 vs 0.9; <em>P</em> = 0.003) and physician encounters (17.4 vs 11.9; <em>P</em> = 0.012), but did not improve clinical outcomes.</div></div><div><h3>Conclusion</h3><div>Persistently positive blood cultures in <em>B. melitensis</em> bacteremia do not predict focal infections or adverse clinical outcomes but significantly increase healthcare resource utilization without clinical benefit. Clinical symptoms should guide diagnostic evaluations rather than repeated blood cultures.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"158 ","pages":"Article 107941"},"PeriodicalIF":4.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global dengue epidemic worsens with record 14 million cases and 9000 deaths reported in 2024","authors":"Najmul Haider ,&nbsp;Mohammad Nayeem Hasan ,&nbsp;Joshua Onyango ,&nbsp;Masum Billah ,&nbsp;Sakirul Khan ,&nbsp;Danai Papakonstantinou ,&nbsp;Priyamvada Paudyal ,&nbsp;Md Asaduzzaman","doi":"10.1016/j.ijid.2025.107940","DOIUrl":"10.1016/j.ijid.2025.107940","url":null,"abstract":"<div><div>Dengue, caused by the dengue virus (DENV), is the fastest-growing mosquito-borne disease worldwide. We utilised monthly data on dengue cases and deaths reported through the World Health Organisation's (WHO) global surveillance system for the period of 1^st January to 31^st December 2024. We then performed a generalised linear regression model to understand country-level determinants of dengue-related mortality. In 2024, 14.1 million dengue cases were reported globally, surpassing the historic milestone of 7 million observed in 2023. This figure represents a twofold increase compared to 2023 and a 12-fold rise compared to 2014 (<em>n</em>=1,206,644). In 2024, 9,508 dengue-related deaths were recorded, resulting in a global case-fatality rate of 0.07%. In the regression analysis, countries in the Southern hemisphere (incidence rate ratio [IRR]: 5.95, 95% CI: 4.19-8.46), aged population (IRR 1.04, CI: 1.01-1.07), and mean annual temperature (IRR 1.21, CI: 1.16-1.26) were significantly associated with higher dengue-related mortality per million population. The ongoing dengue outbreak underscores the urgent need for global investment in DENV research, vaccine development, vector control, and therapeutic strategies. We urge the inclusion of DENV in the WHO’s Research and Development Priority Disease list to address this growing global health threat.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"158 ","pages":"Article 107940"},"PeriodicalIF":4.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"mRNA COVID-19 vaccines induce superior immunoglobulin A titers in patients with cancer compared with viral vector vaccines: implications for immunization strategies","authors":"Yana Debie ,&nbsp;Lise Verbruggen ,&nbsp;Marc Peeters ,&nbsp;Peter A. van Dam ,&nbsp;Timon Vandamme","doi":"10.1016/j.ijid.2025.107939","DOIUrl":"10.1016/j.ijid.2025.107939","url":null,"abstract":"<div><h3>Objectives</h3><div>Immunoglobulin (Ig) A antibodies are involved in mucosal immunity and eliminate pathogens immediately at the point of entry. Vaccine-induced IgA antibodies could contribute to an additional layer of protection against SARS-CoV-2 for infection-prone patients with cancer. This might be particularly relevant for patients with cancer because they mount reduced IgG antibody titers after dual-dose BNT162b2 COVID-19 vaccination and even lower responses after double-dose ChAdOx1 vaccination than healthy individuals. However, data on vaccine-induced IgA antibodies are scarce, especially in patients with cancer.</div></div><div><h3>Methods</h3><div>This study compares SARS-CoV-2 anti-spike (S1) IgA antibodies after dual-dose BNT162b2 vs ChAdOx1 vaccination in patients with cancer. SARS-CoV-2 anti-S1 IgA antibodies were quantified in serum samples collected 7 days after the second vaccination dose (N = 213) (IEQ-CoVS1RBD-IgA-1-RB enzyme-linked immunosorbent assay kit, RayBiotech) and analyzed with colorimetric detection. In addition, correlations with different aspects of humoral immunity were assessed (neutralizing and IgG antibodies).</div></div><div><h3>Results</h3><div>Significantly lower anti-S1 IgA antibody titers were reported in patients with cancer after dual-dose ChAdOx1 than BNT162b2 vaccination. Moreover, patients with cancer who received dual-dose BNT162b2 vaccination had a significant 16.44-fold increased chance to mount detectable IgA antibodies compared with patients receiving ChAdOx1 vaccination.</div></div><div><h3>Conclusions</h3><div>These findings highlight the potential role of boosters or alternative strategies to sustain mucosal immunity.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"158 ","pages":"Article 107939"},"PeriodicalIF":4.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concerns about statistical analyses in the study on polymyxin B treatment of carbapenem-resistant gram-negative bacilli infections.","authors":"Jing Zhao, Yue Bi","doi":"10.1016/j.ijid.2025.107936","DOIUrl":"10.1016/j.ijid.2025.107936","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107936"},"PeriodicalIF":4.8,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of malaria in pregnancy on infant neurodevelopment and malaria susceptibility during the first year of life in Kinshasa, the Democratic Republic of the Congo","authors":"Japhet Kabalu Tshiongo ,&nbsp;Lise Kuseke ,&nbsp;Thierry Kalonji ,&nbsp;Patrick Mitashi ,&nbsp;Aimée Mupuala ,&nbsp;Kassoum Kayentao ,&nbsp;Trésor Zola Matuvanga ,&nbsp;Vivi Maketa Tevuzula ,&nbsp;Yann Kafala ,&nbsp;Henk D.F.H. Schallig ,&nbsp;Hypolite Muhindo Mavoko ,&nbsp;Petra F. Mens","doi":"10.1016/j.ijid.2025.107927","DOIUrl":"10.1016/j.ijid.2025.107927","url":null,"abstract":"<div><h3>Objectives</h3><div>To compare the neurodevelopment and malaria susceptibility of infants born to mothers infected or uninfected with malaria at the time of delivery.</div></div><div><h3>Methods</h3><div>A cohort of 388 mother–child pairs was recruited at delivery. Maternal malaria was assessed by microscopy at birth, and infant malaria was based on a history of fever. Infant neurodevelopment was evaluated at 4-6 weeks, 6 months, and 12 months using the Mullen Scales of Early Learning (MSEL), which include scores for gross motor (GM), and early learning composite (ELC). Infant malaria incidence and neurological functioning were compared based on malaria exposure at delivery.</div></div><div><h3>Results</h3><div>In total, 62/385 (16.1%) infants were exposed to malaria at delivery, confirmed by microscopy for both peripheral and placental malaria. These exposed infants had a significantly lower birth weight (LBW) (2824.68 ± 493.85 g) than those born of uninfected mothers (3032.69 ± 487.8 g; p = 0.0023). GM at 12 months showed no significant differences between groups (mean GM score for exposed: 47.2 ± 9.8 vs unexposed: 47.6 ± 9.7; p = 0.757). However, infants exposed to malaria infection had significantly lower ECL (−7.70 [95% confidence interval {CI}: −15.0, −0.36]; <em>P</em> = 0.04). Infant malaria, malnutrition, and LBW were significantly associated with reduced GM scores (−1.2 [95% CI: −2.25, −0.18], <em>P</em> = 0.021; −0.96 [95% CI: −1.92, −0.02], and −1.59 [95% CI: −3.06, −0.11], respectively). Malaria incidence peaked at 12 months, affecting 54.7% of the exposed group vs 70.6% of non-exposed infants (risk ratio = 1.04 [95% CI: 0.87-1.25], <em>P</em> = 0.631).</div></div><div><h3>Conclusions</h3><div>Malaria at delivery was associated with impaired ELC but not with GM. Malaria susceptibility during the first 12 months was not influenced by maternal malaria exposure. However, LBW, malnutrition and infant malaria impacted infant development.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"157 ","pages":"Article 107927"},"PeriodicalIF":4.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The morbidity spectrum of influenza, respiratory syncytial virus, human metapneumovirus and human parainfluenza virus in young children by age and country income level: A systematic review and meta-analysis","authors":"Lian He ,&nbsp;Jitian Weng ,&nbsp;Fuyu Zhu ,&nbsp;Yuhe Zhang ,&nbsp;Junru Chen ,&nbsp;Shuting Chen ,&nbsp;Miaojia Lu ,&nbsp;Harish Nair ,&nbsp;You Li ,&nbsp;Xin Wang","doi":"10.1016/j.ijid.2025.107938","DOIUrl":"10.1016/j.ijid.2025.107938","url":null,"abstract":"<div><h3>Background</h3><div>Influenza virus (IFV), respiratory syncytial virus (RSV), human metapneumovirus (hMPV) and parainfluenza virus (hPIV) cause substantial disease burden in children under 5 years, but the infection spectrum remains unclear.</div></div><div><h3>Methods</h3><div>We systematically reviewed studies published between 1995 and 2023 to estimate probabilities between viral test positivity, symptomatic infections, acute lower respiratory infections (ALRI), ALRI with chest-wall indrawing (CWI), ALRI hospitalization, and very severe ALRI – p(symptomatic | test positive), p(ALRI | symptomatic), p(CWI | ALRI), p(hosp | ALRI) and p(very severe | hosp). (PROSPERO CRD42024584039; CRD42023439269).</div></div><div><h3>Results</h3><div>Based on 129 studies, we estimated that 67.7% of IFV test-positives were symptomatic and 16.2% of symptomatic IFV infections developed ALRI. In children under 2 years, 71.8% of RSV test-positives were symptomatic. Across the viruses, the estimated p(CWI | ALRI) and p(hosp | ALRI) were higher in infants than older children; between 2.6% and 41.2% of hospitalized children with ALRI were very severe, with higher estimates in low and lower-middle income countries.</div></div><div><h3>Conclusions</h3><div>Infants and children under 5 years in low and lower-middle income countries are important risk groups for immunization due to their high vulnerability to severe outcomes. These findings provide critical data to support immunization assessment and development of immunization strategies.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"157 ","pages":"Article 107938"},"PeriodicalIF":4.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}