International Journal of Infectious Diseases最新文献

{"title":"Short-term evolution of Mpox-specific IgG and neutralizing antibodies among individuals undergoing MVA-BN vaccination","authors":"Wang-Da Liu ,&nbsp;Tai-Ling Chao ,&nbsp;Kai-Hsiang Chen ,&nbsp;Hsin-Yun Sun ,&nbsp;Kuan-Yin Lin ,&nbsp;Yu-Chung Chuang ,&nbsp;Yu-Shan Huang ,&nbsp;Chi-Ying Lin ,&nbsp;Wei-Ting Hsu ,&nbsp;Chun-Fu Huang ,&nbsp;Guei-Chi Li ,&nbsp;Wen-Chun Liu ,&nbsp;Cheng-Hsin Wu ,&nbsp;Yi-Ching Su ,&nbsp;Lan-Hsin Chang ,&nbsp;Chia-Yi Lin ,&nbsp;Pei-Ying Wu ,&nbsp;Ling-Ya Chen ,&nbsp;Yi-Ting Chen ,&nbsp;Yu-Zhen Luo ,&nbsp;Chien-Ching Hung","doi":"10.1016/j.ijid.2025.107830","DOIUrl":"10.1016/j.ijid.2025.107830","url":null,"abstract":"<div><h3>Objectives</h3><div>The data on immune responses of individuals undergoing modified vaccinia Ankara-Bavarian Nordic (MVA-BN) vaccination are scarce. We aimed to compare Mpox virus-specific antibody and neutralizing antibody responses among people with and those without HIV receiving MVA-BN vaccines.</div></div><div><h3>Methods</h3><div>This prospective study enrolled participants undergoing two-dose MVA-BN vaccination to investigate seroresponses after vaccination. Blood samples were collected before and after each dose of vaccination for determinations of anti-A29 and anti-H3 IgG. Neutralization tests were conducted for samples tested positive for both anti-A29 and anti-H3 IgG.</div></div><div><h3>Results</h3><div>Overall, 441 participants undergoing two-dose MVA-BN vaccination were enrolled. Seroconversion for anti-A29 and anti-H3 IgG, respectively, after the second dose of vaccination was 18.2% and 61.2%, 10.9% and 65.0%, and 51.6% and 90.6% among people with HIV, people without HIV, and those who had had smallpox vaccination previously, respectively. About 20% of the participants with seroconversion lost seroresponses after a 7-month period of observation. None of the serum samples from vaccinated participants demonstrated neutralizing ability.</div></div><div><h3>Conclusions</h3><div>Participants with previous smallpox vaccination had higher and more sustained antibody responses after receiving two doses of MVA-BN vaccines than those who had not undergone smallpox vaccination. More studies are warranted to assess the seroresponses to booster MVA-BN vaccination for vaccine nonresponders or those having lost seroresponses.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"153 ","pages":"Article 107830"},"PeriodicalIF":4.8,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eritrea's blueprint for trachoma elimination: A home-grown model for sustainable impact.","authors":"Gilbert Baayenda, Martha Mberu, Sarity Dodson, Kelly Zongo, Jackline Syonguvi, Jeremiah Ngondi, Alem Zecarias","doi":"10.1016/j.ijid.2025.107814","DOIUrl":"10.1016/j.ijid.2025.107814","url":null,"abstract":"<p><strong>Purpose: </strong>This overview highlights Eritrea's progress in trachoma elimination from 2006 to 2024, emphasizing the Surgery, Antibiotics, Facial Cleanliness and Environmental Improvement (SAFE) strategy, pillars of the Neglected Tropical Diseases (NTD) Roadmap, and geostatistical mapping's role in achieving elimination targets.</p><p><strong>Methods: </strong>Trachoma Impact Surveys (TIS) and Surveillance Surveys (TSS) monitored WHO-endorsed SAFE strategy interventions and progress, with model-based geo-statistics providing more precise prevalence estimates.</p><p><strong>Results: </strong>Eritrea has attained open defecation-free status in 93% of villages, performed 22,546 Trachomatous Trachiasis (TT) surgeries, and integrated surveillance data into the District Health Information System (DHIS2). TT prevalence among those 15 years and older has significantly decreased, with many areas below the World Health Organization (WHO) threshold of 0.2%. Eritrea reduced TF prevalence among children aged 1 to 9 years from over 10% in 2006 to less than 5% in 2022, and TT prevalence among adults aged 15 and older from 3% to below 0.2% in most regions.</p><p><strong>Conclusion: </strong>Eritrea's innovative approaches and strong partnerships provide a model for other countries facing NTDs. Reliable data have been crucial for targeting resources and monitoring progress toward trachoma elimination.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107814"},"PeriodicalIF":4.8,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital parechovirus meningitis presenting as in utero intraventricular hemorrhage: A case report","authors":"Vivian Y. Liu ,&nbsp;Brenda M. Varriano ,&nbsp;Bishoy Ibrahim ,&nbsp;Oludare Odumade ,&nbsp;Lakshmi Ganapathi ,&nbsp;Juan D. Matute ,&nbsp;Rodica Turcu ,&nbsp;Giulia P. Lima","doi":"10.1016/j.ijid.2025.107813","DOIUrl":"10.1016/j.ijid.2025.107813","url":null,"abstract":"<div><div>Human parechovirus (HPeV) infection in neonates can have severe presentations, including sepsis-like symptoms and meningoencephalitis. Most reported cases were acquired postnatally. We report the case of a premature infant with <em>in utero</em> intraventricular hemorrhage who was diagnosed with HPeV meningoencephalitis within the 1^st week of life, presumably congenitally acquired.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"153 ","pages":"Article 107813"},"PeriodicalIF":4.8,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrence of microfilaraemia after triple-drug therapy for lymphatic filariasis in Samoa: Recrudescence or reinfection?","authors":"Helen J Mayfield, Ramona Muttucumaru, Benn Sartorius, Sarah Sheridan, Selina Ward, Beatris Mario Martin, Shannon M Hedtke, Robert Thomsen, Satupaitea Viali, Glen Fatupaito, Colleen L Lau, Patricia M Graves","doi":"10.1016/j.ijid.2025.107809","DOIUrl":"10.1016/j.ijid.2025.107809","url":null,"abstract":"<p><strong>Objectives: </strong>Contrasting evidence is emerging on the long-term effectiveness of triple-drug therapy for elimination of lymphatic filariasis (LF) in the Pacific region. We evaluated the effectiveness of ivermectin, diethylcarbamazine and albendazole (IDA) for sustained clearance of microfilariae (Mf) in Samoa.</p><p><strong>Methods: </strong>We enrolled two cohorts of Mf-positive participants. Cohort A were Mf-positive participants from 2018, who received directly observed triple-drug therapy in 2019 and were retested and retreated in 2023 and 2024. Cohort B were Mf-positive and treated in 2023 and retested in 2024. Participants were tested for LF antigen and Mf.</p><p><strong>Results: </strong>In Cohort A, eight of the 14 participants from 2018/2019 were recruited in 2023; six were Mf-positive. In 2024, six participants were retested, and two were Mf-positive. Cohort B included eight participants, and two remained Mf-positive in 2024. Mf prevalence in 2023 for Cohort A (71.4%, 95% CI 29.0%-96.3%) was significantly higher than among their household members (12.0%, 95% CI 2.5%-31.2%).</p><p><strong>Conclusion: </strong>One or two doses of directly observed IDA was not sufficient for sustained clearance of Wuchereria bancrofti Mf in Samoa. The high Mf prevalence in treated individuals compared to household members suggests recrudescence rather than reinfection.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107809"},"PeriodicalIF":4.8,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward the elimination of HAT in Nigeria: leaving no community behind.","authors":"Rolayo T Emmanuel, Kelly Zongo, Olaleye O Olusola","doi":"10.1016/j.ijid.2025.107808","DOIUrl":"10.1016/j.ijid.2025.107808","url":null,"abstract":"<p><strong>Objectives: </strong>Sleeping sickness, also known as human African trypanosomiasis (HAT), is a tsetse fly-borne neglected tropical disease that affects underserved rural communities in sub-Saharan Africa. Despite the advancements in diagnostics, the actual status of sleeping sickness in Nigeria remains unclear. In our quest for clarity, we conducted a human population survey to ascertain the prevalence of HAT in tsetse fly-infested remote rural hamlets.</p><p><strong>Methods: </strong>Blood samples were collected from 72 consenting participants by finger pricking. Blood samples were blotted on a Flinders Technology Associate Classic Card and screened for T. b. gambiense infection using colorimetric loop-mediated amplification with Trypanosoma brucei gambiense surface glycoprotein-specific (TgsGP) primers.</p><p><strong>Results: </strong>Of the 72 consenting individuals, 40.28% (55.17% men, 44.83% women) were infected with T. b. gambiense (P = 0.738). Age group 51-60 years had the highest prevalence of 77.78% (P = 0.214). The infection rate was higher among uneducated individuals, with a prevalence of 34.48% (P = 0.007). Alaho had the highest prevalence (66.67%), followed by Arabata (38.10%) and Oloya (31.43%) (P = 0.035).</p><p><strong>Conclusions: </strong>Silent transmission of HAT is ongoing at the study sites, warranting intensified community sensitization and surveillance scale-up. An urgent, health-guided, strategic control approach is imperative to prevent epidemics in hamlets and a devastating resurgence in Nigeria.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107808"},"PeriodicalIF":4.8,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wider antibody breadth against multiple Plasmodium falciparum antigens is associated with reduced risk of malaria in a transmission hotspot in southern Ghana.","authors":"Eric Kyei-Baafour, Kwadwo Asamoah Kusi, Eunice Owusu-Yeboa, Quratul-Ain Issahaque, Selassie Kumordjie, Fareed Kn Authur, Duah Dwomoh, Susheel Kumar Singh, Daniel Dodoo, Michael Theisen, Bright Adu","doi":"10.1016/j.ijid.2025.107804","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.107804","url":null,"abstract":"<p><strong>Objectives: </strong>Naturally acquired immunity to malaria results from repeated infection with Plasmodium parasites. However, identifying immune correlates of immunity against febrile malaria is quite challenging. Here we investigated antigenic targets of malaria protective antibodies in populations residing a malaria transmission hotspot in southern Ghana.</p><p><strong>Method: </strong>We enrolled 973 children, aged 6 months to 12 years, in southern Ghana out of which 211 were infected at least once with Plasmodium falciparum in a 50-week longitudinal cohort study. Total IgG levels in baseline plasma samples were determined using indirect ELISA.</p><p><strong>Results: </strong>We found a significant association between higher IgG levels to MSP3 (adjusted P-value (aP)=0.0002), GLURP-R2 (aP=0.0026), MSP DBL2 (aP=0.004), and N-MSP3 (aP=0.002), and protection from febrile malaria. A negative association between higher antibody levels to MSP3, GMZ2, GLURP-R2, and MSPDBL2 and parasite density was also observed. Wider antibody breadth was associated with protection against febrile malaria and single, compared to multiple malaria episodes.</p><p><strong>Conclusions: </strong>Specific antibody levels and breadth of responses against multiple P. falciparum surface antigens protect against febrile malaria, parasitaemia and multiple malaria episodes. This data supports the development of multivalent vaccines targeting P. falciparum surface antigens in high malaria endemic settings.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107804"},"PeriodicalIF":4.8,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards elimination of Neglected Tropical Diseases: Strengthening partnerships, fostering collaboration, and promoting country ownership.","authors":"Carol Karutu, Rashid Ansumana, Dziedzom K de Souza, Sammy Njenga, Yaya Ibrahim Coulibaly, Shui Shan Lee, Moses J Bockarie","doi":"10.1016/j.ijid.2025.107812","DOIUrl":"10.1016/j.ijid.2025.107812","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107812"},"PeriodicalIF":4.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular xenomonitoring of Wuchereria bancrofti infection in three different evaluation settings of lymphatic filariasis elimination programme in India.","authors":"V Vasuki, K Krishnamoorthy, S Subramanian, C Sadanandane, R Balasubramaniyan, N Sivagnaname, V Padmanaban, B Vijayakumar, V Sundarraj, C Palanisamy, Prameela Baral, P Jambulingam","doi":"10.1016/j.ijid.2025.107807","DOIUrl":"https://doi.org/10.1016/j.ijid.2025.107807","url":null,"abstract":"<p><strong>Background: </strong>Molecular xenomonitoring (MX) is one of the recommended post-validation surveillance tools to detect early signals of lymphatic filariasis (LF) infection. This study reports the MX results of Culex quinquefasciatus transmitted Wuchereria bancrofti in three evaluation units of different settings in India.</p><p><strong>Methods: </strong>Female Cx. quinquefasciatus mosquitoes were collected using gravid traps from 150 households in each evaluation unit (EU). Two pools of 25 mosquitoes from each household were assayed by real time quantitative PCR for W. bancrofti DNA, and RNA by RT-PCR. The agreement between MX and transmission assessment survey (TAS) in MDA stopping decision was compared, and microfilaria (Mf) prevalence in TAS failed EU.</p><p><strong>Results: </strong>Vector infection prevalence was 0.05% and 0.07% in the TAS cleared EUs, and 1.85% in TAS failed EU. MX corroborates with the TAS decision in all three settings. Mf prevalence was >1% in 5 sites in TAS failed EU. Infective mosquitoes were detected in TAS2 passed and TAS failed EUs. The cost of MX per pool was between USD 26.0 and 27.9 in different settings.</p><p><strong>Conclusion: </strong>MX is a potential tool to evaluate different stages of post-MDA treatment of LF elimination programme. MX detects transmission risk areas that can be confirmed by human surveys and initiate appropriate response.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107807"},"PeriodicalIF":4.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systems thinking in the prevention, control, and elimination of neglected tropical diseases (NTDs).","authors":"Louise K Makau-Barasa, Kimberly Kamara, Carol Karutu, Moses Aderogba, Ellie Leaning, Moses Bockarie","doi":"10.1016/j.ijid.2025.107810","DOIUrl":"10.1016/j.ijid.2025.107810","url":null,"abstract":"<p><strong>Objectives: </strong>It is estimated that more than one billion people are affected by neglected tropical diseases (NTDs). Whilst there are existing treatments to reduce morbidity, a major challenge is creating robust programs that are both country-led and leverage the existing health systems. Using a systems thinking approach is a critical component for integrating NTD services, as it takes into account all aspects of what might otherwise be considered fragmented systems to create a more efficient system.</p><p><strong>Design: </strong>This article showcases three case studies where a systems lens was applied: (1) to examine the integration of morbidity management services into the existing health system in Sierra Leone, (2) to integrate lymphatic filariasis mass drug administration (MDA) in the polio campaign in Madagascar, and (3) to embed hydrocele surgeries into the services available in county health facilities in Kenya.</p><p><strong>Results: </strong>All three cases demonstrate the importance of using a systems lens to assess the current system using a participatory approach, allowing the teams to focus on leverage points to create the highest impact and by extension holistically address population needs.</p><p><strong>Conclusion: </strong>Systems thinking is valuable in examining key levers that affect NTD interventions. It offers stakeholders opportunities to develop responsive interventions that strengthen health systems.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107810"},"PeriodicalIF":4.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' reply: \"Effect of colistin combined with sulbactam: 9 g versus 12 g per day on mortality in the treatment of carbapenems resistant Acinetobacter baumannii pneumonia: a randomized controlled trial\".","authors":"Chutchawan Ungthammakhun, Vasin Vasikasin, Waristha Simsiriporn, Piraporn Juntanawiwat, Dhitiwat Changpradub","doi":"10.1016/j.ijid.2025.107796","DOIUrl":"10.1016/j.ijid.2025.107796","url":null,"abstract":"","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"107796"},"PeriodicalIF":4.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}