Omicron COVID-19与流感住院后的长期多系统后遗症：一项回顾性队列研究

IF 4.8 2区医学 Q1 INFECTIOUS DISEASES

International Journal of Infectious Diseases Pub Date : 2025-06-09 DOI:10.1016/j.ijid.2025.107946

Liang En Wee , Reen Wan Li Ho , Jue Tao Lim , Calvin J Chiew , David Chien Boon Lye , Kelvin Bryan Tan

{"title":"Omicron COVID-19与流感住院后的长期多系统后遗症：一项回顾性队列研究","authors":"Liang En Wee , Reen Wan Li Ho , Jue Tao Lim , Calvin J Chiew , David Chien Boon Lye , Kelvin Bryan Tan","doi":"10.1016/j.ijid.2025.107946","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>To contrast long-term sequelae post-COVID-19 hospitalisations attributed to Omicron, vs seasonal influenza; stratified by vaccination.</div></div><div><h3>Methods</h3><div>Retrospective population-based cohort study in Singapore, including all adult COVID-19 hospitalisations post-Omicron emergence (1<sup>st</sup> January 2022-3<sup>rd</sup> September 2023), and historical influenza hospitalisations (1<sup>st</sup> January 2017-3<sup>rd</sup> September 2023). Risks of post-acute diagnoses/symptoms 31-300 days post-COVID-19 hospitalisation, vs influenza, were estimated using overlap-weighted competing-risks-regression, with death as a competing risk.</div></div><div><h3>Results</h3><div>70,628 COVID-19 hospitalisations and 10,454 influenza hospitalisations were included. Lower overall risk of post-acute cardiac symptoms (adjusted-hazards-ratio, aHR = 0.77 [95% CI = 0.64-0.92]; <em>P</em> < 0.001) was observed following any COVID-19 hospitalisation vs influenza. Similarly, lower risk of any post-acute cardiac diagnosis/symptom (aHR = 0.80 [95% CI = 0.68-0.94]; <em>P</em> < 0.001) was observed following unboosted COVID-19 hospitalisations vs unvaccinated influenza, and lower risk of other cardiac disorders (e.g., heart failure) was observed following boosted COVID-19 hospitalisations vs vaccinated influenza (aHR = 0.58 [95% CI = 0.39-0.86]; <em>P</em> < 0.001), However, risks of post-acute cognitive impairment and fatigue/malaise were significantly higher post-COVID-19 vs influenza (cognition: aHR = 1.34 [95% CI = 1.08-1.68]; <em>P</em> < 0.001; fatigue/malaise: aHR = 1.75 [95% CI = 1.23-2.50]; <em>P</em> < 0.001) and when unboosted COVID-19 was compared against unvaccinated influenza (memory/cognition: aHR = 1.67 [95% CI = 1.27-2.19; <em>P</em> < 0.001]; fatigue/malaise: aHR = 1.77 [95% CI = 1.18-2.64]; <em>P</em> < 0.001).</div></div><div><h3>Conclusion</h3><div>Risks of cognitive impairment/fatigue were increased while risk of cardiac sequelae was significantly lower post-COVID-19 vs influenza in unboosted/unvaccinated individuals. Vaccination for COVID-19/influenza remains important during endemicity.</div></div>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":"158 ","pages":"Article 107946"},"PeriodicalIF":4.8000,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Long-term multisystemic sequelae post-hospitalisation for Omicron COVID-19 vs influenza: A retrospective cohort study\",\"authors\":\"Liang En Wee , Reen Wan Li Ho , Jue Tao Lim , Calvin J Chiew , David Chien Boon Lye , Kelvin Bryan Tan\",\"doi\":\"10.1016/j.ijid.2025.107946\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><div>To contrast long-term sequelae post-COVID-19 hospitalisations attributed to Omicron, vs seasonal influenza; stratified by vaccination.</div></div><div><h3>Methods</h3><div>Retrospective population-based cohort study in Singapore, including all adult COVID-19 hospitalisations post-Omicron emergence (1<sup>st</sup> January 2022-3<sup>rd</sup> September 2023), and historical influenza hospitalisations (1<sup>st</sup> January 2017-3<sup>rd</sup> September 2023). Risks of post-acute diagnoses/symptoms 31-300 days post-COVID-19 hospitalisation, vs influenza, were estimated using overlap-weighted competing-risks-regression, with death as a competing risk.</div></div><div><h3>Results</h3><div>70,628 COVID-19 hospitalisations and 10,454 influenza hospitalisations were included. Lower overall risk of post-acute cardiac symptoms (adjusted-hazards-ratio, aHR = 0.77 [95% CI = 0.64-0.92]; <em>P</em> < 0.001) was observed following any COVID-19 hospitalisation vs influenza. Similarly, lower risk of any post-acute cardiac diagnosis/symptom (aHR = 0.80 [95% CI = 0.68-0.94]; <em>P</em> < 0.001) was observed following unboosted COVID-19 hospitalisations vs unvaccinated influenza, and lower risk of other cardiac disorders (e.g., heart failure) was observed following boosted COVID-19 hospitalisations vs vaccinated influenza (aHR = 0.58 [95% CI = 0.39-0.86]; <em>P</em> < 0.001), However, risks of post-acute cognitive impairment and fatigue/malaise were significantly higher post-COVID-19 vs influenza (cognition: aHR = 1.34 [95% CI = 1.08-1.68]; <em>P</em> < 0.001; fatigue/malaise: aHR = 1.75 [95% CI = 1.23-2.50]; <em>P</em> < 0.001) and when unboosted COVID-19 was compared against unvaccinated influenza (memory/cognition: aHR = 1.67 [95% CI = 1.27-2.19; <em>P</em> < 0.001]; fatigue/malaise: aHR = 1.77 [95% CI = 1.18-2.64]; <em>P</em> < 0.001).</div></div><div><h3>Conclusion</h3><div>Risks of cognitive impairment/fatigue were increased while risk of cardiac sequelae was significantly lower post-COVID-19 vs influenza in unboosted/unvaccinated individuals. Vaccination for COVID-19/influenza remains important during endemicity.</div></div>\",\"PeriodicalId\":14006,\"journal\":{\"name\":\"International Journal of Infectious Diseases\",\"volume\":\"158 \",\"pages\":\"Article 107946\"},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2025-06-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Infectious Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1201971225001705\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Infectious Diseases","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1201971225001705","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

摘要

目的：对比欧米克隆与季节性流感导致的covid -19后长期住院后遗症；按疫苗接种分层。方法：在新加坡进行回顾性人群队列研究，包括所有在omicron出现后（2022年1月1日至2023年9月3日）住院的COVID-19成年人，以及历史流感住院（2017年1月1日至2023年9月3日）。与流感相比，使用重叠加权竞争风险回归法估计了covid -19住院后31-300天急性诊断/症状后的风险，其中死亡为竞争风险。结果：纳入70,628例新冠肺炎住院病例和10,454例流感住院病例。降低急性后心脏症状的总体风险(校正危险比，aHR=0.77[95%CI=0.64-0.92]；结论：与流感相比，未接种疫苗/未接种疫苗的个体在covid -19后出现认知障碍/疲劳的风险增加，而心脏后遗症的风险显著降低。在流行期间，COVID-19/流感疫苗接种仍然很重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Long-term multisystemic sequelae post-hospitalisation for Omicron COVID-19 vs influenza: A retrospective cohort study

Objectives

To contrast long-term sequelae post-COVID-19 hospitalisations attributed to Omicron, vs seasonal influenza; stratified by vaccination.

Methods

Retrospective population-based cohort study in Singapore, including all adult COVID-19 hospitalisations post-Omicron emergence (1^st January 2022-3^rd September 2023), and historical influenza hospitalisations (1^st January 2017-3^rd September 2023). Risks of post-acute diagnoses/symptoms 31-300 days post-COVID-19 hospitalisation, vs influenza, were estimated using overlap-weighted competing-risks-regression, with death as a competing risk.

Results

70,628 COVID-19 hospitalisations and 10,454 influenza hospitalisations were included. Lower overall risk of post-acute cardiac symptoms (adjusted-hazards-ratio, aHR = 0.77 [95% CI = 0.64-0.92]; P < 0.001) was observed following any COVID-19 hospitalisation vs influenza. Similarly, lower risk of any post-acute cardiac diagnosis/symptom (aHR = 0.80 [95% CI = 0.68-0.94]; P < 0.001) was observed following unboosted COVID-19 hospitalisations vs unvaccinated influenza, and lower risk of other cardiac disorders (e.g., heart failure) was observed following boosted COVID-19 hospitalisations vs vaccinated influenza (aHR = 0.58 [95% CI = 0.39-0.86]; P < 0.001), However, risks of post-acute cognitive impairment and fatigue/malaise were significantly higher post-COVID-19 vs influenza (cognition: aHR = 1.34 [95% CI = 1.08-1.68]; P < 0.001; fatigue/malaise: aHR = 1.75 [95% CI = 1.23-2.50]; P < 0.001) and when unboosted COVID-19 was compared against unvaccinated influenza (memory/cognition: aHR = 1.67 [95% CI = 1.27-2.19; P < 0.001]; fatigue/malaise: aHR = 1.77 [95% CI = 1.18-2.64]; P < 0.001).

Conclusion

Risks of cognitive impairment/fatigue were increased while risk of cardiac sequelae was significantly lower post-COVID-19 vs influenza in unboosted/unvaccinated individuals. Vaccination for COVID-19/influenza remains important during endemicity.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

International Journal of Infectious Diseases 医学-传染病学

CiteScore

18.90

自引率

2.40%

发文量

1020

审稿时长

30 days

期刊介绍： International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.