Assessment of seroprevalence of Mpox virus infection among sex workers in Chiang Mai, Thailand

IF 4.3 2区医学 Q1 INFECTIOUS DISEASES

International Journal of Infectious Diseases Pub Date : 2025-09-01 DOI:10.1016/j.ijid.2025.108041

Muhammad Umer , Kriangkrai Chawansuntati , Jiraprapa Wipasa , Kanyaruck Jindaphun , Kamonporn Kotemul , Yee Mon Thant , Nicole Ngo-Giang-Huong , Woottichai Khamduang , Sayamon Hongjaisee

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引用次数: 0

Abstract

Objectives

The 2022 global Mpox outbreak revealed major surveillance gaps, particularly among marginalized populations such as sex workers, whose role in undetected MPXV transmission remains poorly understood. This study aims to assess the seroprevalence of MPXV IgG antibodies and identify associated risk factors among sex workers in Chiang Mai, Thailand.

Methods

In this cross-sectional study, 262 sex workers recruited from March to December 2022 were tested for prior MPXV exposure using an in-house indirect ELISA targeting the recombinant MPXV E8L antigen. Logistic regression models were used to identify demographic and behavioral factors associated with seropositivity.

Results

MPXV IgG seroprevalence was 4.6% (12/262). Seropositivity was significantly higher among males than females (5.2% vs 4.0%, P = 0.011). In multivariable analysis, male gender (OR = 3.23, 95% CI: 1.10-9.47, P = 0.032), blood transfusion history (OR = 4.40, 95% CI: 1.35-14.25, P = 0.013) and sharing sharp objects with others (OR = 4.55, 95% CI: 1.12-18.48, P = 0.034) were significantly associated with Mpox seropositivity.

Conclusion

Our findings reveal undetected MPXV circulation among Chiang Mai sex workers. The identified risk factors suggest overlapping parenteral and sexual vulnerabilities, emphasizing the need for integrated surveillance and targeted interventions.

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泰国清迈性工作者中m痘病毒感染血清阳性率评估

目标：2022年全球麻疹疫情揭示了重大的监测缺口，特别是在性工作者等边缘化人群中，他们在未被发现的MPXV传播中的作用仍然知之甚少。本研究旨在评估泰国清迈性工作者中MPXV IgG抗体的血清阳性率，并确定相关危险因素。方法：在这项横断面研究中，使用针对重组MPXV E8L抗原的内部间接ELISA检测了2022年3月至12月招募的262名性工作者是否有MPXV暴露史。使用逻辑回归模型确定与血清阳性相关的人口统计学和行为因素。结果：MPXV IgG血清阳性率为4.6%（12/262）。男性血清阳性率明显高于女性（5.2%比4.0%,p=0.011）。在多变量分析中，男性（OR=3.23, 95%CI: 1.10 ~ 9.47, p= 0.032）、输血史（OR=4.40, 95%CI: 1.35 ~ 14.25, p=0.013）、与他人共用尖锐物品（OR = 4.55,95%CI: 1.12 ~ 18.48, p=0.034）与m痘血清阳性显著相关。结论：我们的研究结果揭示了清迈性工作者中未被检测到的MPXV传播。已确定的风险因素表明肠外和性脆弱性重叠，强调需要进行综合监测和有针对性的干预。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Infectious Diseases 医学-传染病学

CiteScore

18.90

自引率

2.40%

发文量

1020

审稿时长

30 days

期刊介绍： International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.