The first reported case of monkeypox virus clade Ⅰb infection in china—clinical presentation and epidemiologic implications

IF 4.8 2区医学 Q1 INFECTIOUS DISEASES

International Journal of Infectious Diseases Pub Date : 2025-03-18 DOI:10.1016/j.ijid.2025.107881

Weizhe Pan , Rui Ge , Guoying Zhu , Yangyang Tian , Yong Yan , Xiaofei Fu , Wei Jiang , Dongfang Zhong , Zhongwen Chen

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引用次数: 0

Abstract

Recently, Monkeypox Virus (MPXV) clade Ib has caused serious health hazards in several countries. Herein, we report the first case of a clade Ib MPXV infection in China. MPXV was detected in a 28-year-old female on January 2, 2025. Whole-genome sequencing analysis revealed the strain to be clade Ib. The case presented with headache and disseminated rashes, with symptoms resolving symptomatic treatment and scabs shedding prior to discharge. Epidemiological studies and laboratory tests suggested transmission through close contact with a man who recently came from the Democratic Republic of Congo. Significantly, although some environmental samples tested positive, all contacts reminded negative, indicating that absence of secondary transmission. Furthermore, the clinical presentation of this case showed different manifestations from clade IIb MPXV infections. Epidemiological patterns also suggested sexual transmission served as the predominant route for clade Ib MPXV spread. These findings provide critical insights to enhance early detection strategies and inform targeted intervention measures aimed at curbing disease progression while mitigating risks of wider community spread.

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中国首例猴痘病毒分支Ⅰb感染病例的临床表现和流行病学意义。

最近，猴痘病毒（MPXV）分支Ib在一些国家造成了严重的健康危害。在此，我们报告了中国首例b支MPXV感染病例。2025年1月2日在一名28岁女性身上检测到MPXV。全基因组测序分析显示该菌株为进化支Ib。病例表现为头痛和弥散性皮疹，症状缓解，经症状治疗，出院前结痂脱落。流行病学研究和实验室检测表明，通过与最近来自刚果民主共和国的一名男子密切接触传播。值得注意的是，虽然一些环境样本检测呈阳性，但所有接触者提示呈阴性，表明没有二次传播。此外，该病例的临床表现与IIb支MPXV感染表现不同。流行病学模式还表明，性传播是Ib支MPXV传播的主要途径。这些发现为加强早期发现策略和提供有针对性的干预措施提供了重要见解，旨在遏制疾病进展，同时减轻更广泛社区传播的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Infectious Diseases 医学-传染病学

CiteScore

18.90

自引率

2.40%

发文量

1020

审稿时长

30 days

期刊介绍： International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.