Sero-epidemiology of measles immunoglobulin G antibodies among newborns from South-East Asia and sub-Saharan Africa: an observational, multicenter study

IF 4.8 2区医学 Q1 INFECTIOUS DISEASES

International Journal of Infectious Diseases Pub Date : 2025-03-11 DOI:10.1016/j.ijid.2025.107882

Carine Bokop , Nisha Dhar , Alane Izu , Musa Mohammed Ali , Godwin Akaba , Hellen C. Barsosio , James A Berkley , Manisha Madhai Beck , Tolossa E Chaka , Clare L. Cutland , Phurb Dorji , Adama Mamby Keita , Feleke Belachew Lema , Nubwa Medugu , Salim Mwarumba , Stella Mwakio , Stephen Obaro , Eyinade K Olateju , Rani Diana Sahni , Samir K Saha , Gaurav Kwatra

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引用次数: 0

Abstract

Objectives

To investigate the transplacental acquisition of measles immunoglobulin (Ig)G in newborns at delivery in Bangladesh, Bhutan, India, Ethiopia, Mozambique, Kenya, Nigeria, Mali, and South Africa.

Methods

Archived cord serum, from a multicenter study on Group B Streptococcus, were tested for measles IgG using a commercial enzyme link immunosorbent assay (ELISA). We tested 323 randomly selected samples from each of the sites. Models using various measles antibody decay rates in infancy were explored.

Results

Overall, 2,907 cord serum samples were analyzed. At birth, 49.9% of newborns were measles IgG seronegative. Measles seronegativity ranged from 21.7% in Nigeria to 73.4% in Bhutan. The adjusted odds of seronegativity in infants of mothers born after measles vaccination implementation was 1.78 times that for infants born to unvaccinated mothers (adjusted odds ratio 1.78; 95% confidence interval 1.43-2.21; P <0.001). Modeling measles-IgG kinetics predicted that 70.8%, 88.3%, and 100% of infants would be seronegative by 2, 4, and 6 months, respectively, without further exposure.

Conclusions

Our findings suggest low transplacental acquisition of measles IgG in newborns, which is likely to yield susceptibility to measles infection at a very young age. The currently recommended measles vaccine schedules in low- and middle-income countries (LMICs), with the first dose recommended from 9 months of age and onward, warrant reconsideration, including the need for earlier dosing schedules.

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来源期刊

International Journal of Infectious Diseases 医学-传染病学

CiteScore

18.90

自引率

2.40%

发文量

1020

审稿时长

30 days

期刊介绍： International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.