{"title":"评估<s:1>基ye带状疱疹（带状疱疹）感染的临床特征、危险因素和预后：VARICOMP-Adult-2研究","authors":"Ozge Ozgen-Top, Zehra Karacaer, Ece Firuze Ozkan, Hasan Selcuk Ozger, Nese Saltoglu, Nefise Oztoprak-Cuvalci, Ayse Seza Inal, Birsen Mutlu, Damla Boztas, Rehile Zengin, Alpay Azap, Sema Alp-Cavus, Ali Acar, Didem Tuba Akcalı, Irem Akdemir, Dilek Bayramgurler, Hande Berk-Cam, Ahmet Çagkan Inkaya, Dilek Dasgın, Secil Deniz, Gamze Erfan, Ozlem Guler, Nilsel Ilter, Behice Kurtaran, Zekayi Kutlubay, Selda Sayin-Kutlu, Ayse Sesin Kocagoz, Ener Cagri Dinleyici, Esin Senol","doi":"10.1016/j.ijid.2025.108105","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The study aimed to determine the estimated prevalence of herpes zoster (HZ) infection in the adult population in Türkiye and the rates of HZ-associated complications and risk factors.</p><p><strong>Methods: </strong>This retrospective, multicenter (n=11), cross-sectional study was conducted between January 2016 and January 2022 and included all patients aged ≥18 years diagnosed with shingles following screening based on ICD-10 codes. The prevalence of HZ infection was calculated; rates of HZ-related complications (recurrence, hospitalization, postherpetic neuralgia [PHN]) and associated risk factors were determined.</p><p><strong>Results: </strong>A total of 6114 HZ patients were included; the estimated 5-year HZ prevalence in Turkiye was 908.7 per 100,000 population. Of the patients, 851 (14.2%) were immunocompromised, 366 (6%) were hospitalized due to HZ, 284 (8.9%) experienced PHN, 97 (3.2%) experienced recurrence of the patients. Risk factors for PHN were older age (≥50 years [OR=3.19; p<0.001)], and trigeminal dermatome involvement (OR=2.45; p=0.006). Antiviral use was associated with reduced PHN risk (OR=0.16; p<0.001).</p><p><strong>Conclusions: </strong>Our multicenter cross-sectional study revealed the high burden of HZ in Türkiye and highlighted the potential for increasing prevalence due to risk factors including aging and comorbidities.</p>","PeriodicalId":14006,"journal":{"name":"International Journal of Infectious Diseases","volume":" ","pages":"108105"},"PeriodicalIF":4.3000,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of Clinical Characteristics, Risk Factors and Prognosis of Herpes Zoster (Shingles) Infection in Türkiye: VARICOMP-Adult-2 Study.\",\"authors\":\"Ozge Ozgen-Top, Zehra Karacaer, Ece Firuze Ozkan, Hasan Selcuk Ozger, Nese Saltoglu, Nefise Oztoprak-Cuvalci, Ayse Seza Inal, Birsen Mutlu, Damla Boztas, Rehile Zengin, Alpay Azap, Sema Alp-Cavus, Ali Acar, Didem Tuba Akcalı, Irem Akdemir, Dilek Bayramgurler, Hande Berk-Cam, Ahmet Çagkan Inkaya, Dilek Dasgın, Secil Deniz, Gamze Erfan, Ozlem Guler, Nilsel Ilter, Behice Kurtaran, Zekayi Kutlubay, Selda Sayin-Kutlu, Ayse Sesin Kocagoz, Ener Cagri Dinleyici, Esin Senol\",\"doi\":\"10.1016/j.ijid.2025.108105\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The study aimed to determine the estimated prevalence of herpes zoster (HZ) infection in the adult population in Türkiye and the rates of HZ-associated complications and risk factors.</p><p><strong>Methods: </strong>This retrospective, multicenter (n=11), cross-sectional study was conducted between January 2016 and January 2022 and included all patients aged ≥18 years diagnosed with shingles following screening based on ICD-10 codes. The prevalence of HZ infection was calculated; rates of HZ-related complications (recurrence, hospitalization, postherpetic neuralgia [PHN]) and associated risk factors were determined.</p><p><strong>Results: </strong>A total of 6114 HZ patients were included; the estimated 5-year HZ prevalence in Turkiye was 908.7 per 100,000 population. Of the patients, 851 (14.2%) were immunocompromised, 366 (6%) were hospitalized due to HZ, 284 (8.9%) experienced PHN, 97 (3.2%) experienced recurrence of the patients. Risk factors for PHN were older age (≥50 years [OR=3.19; p<0.001)], and trigeminal dermatome involvement (OR=2.45; p=0.006). Antiviral use was associated with reduced PHN risk (OR=0.16; p<0.001).</p><p><strong>Conclusions: </strong>Our multicenter cross-sectional study revealed the high burden of HZ in Türkiye and highlighted the potential for increasing prevalence due to risk factors including aging and comorbidities.</p>\",\"PeriodicalId\":14006,\"journal\":{\"name\":\"International Journal of Infectious Diseases\",\"volume\":\" \",\"pages\":\"108105\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2025-10-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Infectious Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.ijid.2025.108105\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Infectious Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ijid.2025.108105","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Evaluation of Clinical Characteristics, Risk Factors and Prognosis of Herpes Zoster (Shingles) Infection in Türkiye: VARICOMP-Adult-2 Study.
Objective: The study aimed to determine the estimated prevalence of herpes zoster (HZ) infection in the adult population in Türkiye and the rates of HZ-associated complications and risk factors.
Methods: This retrospective, multicenter (n=11), cross-sectional study was conducted between January 2016 and January 2022 and included all patients aged ≥18 years diagnosed with shingles following screening based on ICD-10 codes. The prevalence of HZ infection was calculated; rates of HZ-related complications (recurrence, hospitalization, postherpetic neuralgia [PHN]) and associated risk factors were determined.
Results: A total of 6114 HZ patients were included; the estimated 5-year HZ prevalence in Turkiye was 908.7 per 100,000 population. Of the patients, 851 (14.2%) were immunocompromised, 366 (6%) were hospitalized due to HZ, 284 (8.9%) experienced PHN, 97 (3.2%) experienced recurrence of the patients. Risk factors for PHN were older age (≥50 years [OR=3.19; p<0.001)], and trigeminal dermatome involvement (OR=2.45; p=0.006). Antiviral use was associated with reduced PHN risk (OR=0.16; p<0.001).
Conclusions: Our multicenter cross-sectional study revealed the high burden of HZ in Türkiye and highlighted the potential for increasing prevalence due to risk factors including aging and comorbidities.
期刊介绍：
International Journal of Infectious Diseases (IJID)
Publisher: International Society for Infectious Diseases
Publication Frequency: Monthly
Type: Peer-reviewed, Open Access
Scope:
Publishes original clinical and laboratory-based research.
Reports clinical trials, reviews, and some case reports.
Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases.
Emphasizes diseases common in under-resourced countries.
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