Distinct Clinical and Laboratory Markers Associated with Disease Duration and Viral Clearance in Foshan's 2025 Chikungunya Outbreak.

IF 4.3 2区医学 Q1 INFECTIOUS DISEASES

International Journal of Infectious Diseases Pub Date : 2025-09-24 DOI:10.1016/j.ijid.2025.108080

Zenghai Wang, Qun Lin, Caijie Liao, Yiqian Wang

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引用次数: 0

Abstract

Background: Chikungunya fever (CHIKV) is a re-emerging arboviral disease with significant public health impact. Data on clinical and laboratory predictors of disease course in China are limited. This study aimed to assess the associations between clinical and laboratory parameters with both time from symptom onset and viral clearance in patients with confirmed CHIKV infection.

Methods: We conducted a retrospective observational study of 372 patients with RT-PCR-confirmed CHIKV infection admitted to Lecong Hospital, Foshan, China, between July and August 2025. Demographic, clinical, and laboratory data were extracted from medical records. Pearson correlation was used to evaluate associations between clinical variables and (i) days from symptom onset, and (ii) time to viral clearance.

Results: Days from symptom onset were positively correlated with AST (r = 0.2088, P < 0.0001), ALT (r = 0.1533, P = 0.0043), and fever duration (r = 0.3401, P < 0.0001), while NEU showed a weak negative correlation (r = -0.1182, P = 0.0342). CK was negatively correlated with days from symptom onset (r = -0.1528, P = 0.0121). Time to viral clearance was positively correlated with age (r = 0.1896, P = 0.0069), joint pain duration (r = 0.2248, P = 0.0013), rash duration (r = 0.06763, P = 0.0339), and initial symptom duration (r = 0.1410, P = 0.0443).

Conclusion: Elevated liver enzymes and reduced neutrophil counts were associated with longer symptom duration, while older age and prolonged joint pain, rash, and initial symptoms predicted delayed viral clearance. These findings may assist clinicians in identifying patients at risk of prolonged illness and inform targeted management strategies during CHIKV outbreaks in China and similar settings. Our study represents one of the first systematic analyses of clinical and laboratory markers associated with disease course and viral clearance in CHIKV-infected patients in China.

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2025年佛山基孔肯雅热暴发中与病程和病毒清除相关的独特临床和实验室标志物

背景：基孔肯雅热（CHIKV）是一种重新出现的虫媒病毒性疾病，具有重大的公共卫生影响。在中国，有关疾病病程的临床和实验室预测指标的数据有限。本研究旨在评估临床和实验室参数与确诊的CHIKV感染患者出现症状和病毒清除时间之间的关系。方法：我们对2025年7月至8月在中国佛山市乐从医院住院的372例经rt - pcr确诊的CHIKV感染患者进行回顾性观察研究。从医疗记录中提取人口统计、临床和实验室数据。Pearson相关性用于评估临床变量与(i)症状出现天数和（ii）病毒清除时间之间的相关性。结果:天出现症状与AST呈正相关(r = 0.2088,P < 0.0001), ALT (r = 0.1533,P = 0.0043),和发热持续时间(r = 0.3401,P < 0.0001),而神经膜呈弱负相关(r = -0.1182,P = 0.0342)。CK与发病天数呈负相关（r = -0.1528,P = 0.0121）。病毒清除与年龄呈正相关(r = 0.1896,P = 0.0069),关节疼痛持续时间(r = 0.2248,P = 0.0013),皮疹持续时间(r = 0.06763,P = 0.0339),和初始症状持续时间(r = 0.1410,P = 0.0443)。结论：肝酶升高和中性粒细胞计数减少与症状持续时间延长有关，而年龄越大、关节疼痛、皮疹和初始症状延长预示着病毒清除延迟。这些发现可能有助于临床医生识别有长期患病风险的患者，并在中国和类似环境中为有针对性的管理策略提供信息。我们的研究首次系统分析了中国chikv感染患者与病程和病毒清除相关的临床和实验室标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Infectious Diseases 医学-传染病学

CiteScore

18.90

自引率

2.40%

发文量

1020

审稿时长

30 days

期刊介绍： International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.