Personalized aerosolized bacteriophage treatment of a pulmonary infection due to carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae in an infant.

Abstract

A 9-month-old ICU patient with persistent carbapenem-resistant Acinetobacter baumannii pneumonia developed a secondary infection of carbapenem-resistant Klebsiella pneumoniae. A customized, preoptimized phage cocktail was administered twice daily for 3 consecutive days, resulting in eradication of the pathogens and reduction in their abundance in the lung and gut microbiota.