Clinical Impact of Influenza A Coinfection on Staphylococcus aureus Pneumonia during the 2024-2025 Influenza Season in New York City.

IF 4.3 2区医学 Q1 INFECTIOUS DISEASES

International Journal of Infectious Diseases Pub Date : 2025-09-17 DOI:10.1016/j.ijid.2025.108072

Kimberly Mae Soultan, Anjali Kewalramani, Alison Bradbury, Yongsheng Wang, Marie Abdallah, Briana Episcopia Rn, John Quale

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引用次数: 0

Abstract

Background: Prior studies have emphasized adverse outcomes of bacterial pneumonia, especially due to methicillin-resistant Staphylococcus aureus (MRSA), in patients co-infected with influenza.

Methods: Listings of patients, admitted from an 11-hospital system in New York City, with community-onset pneumonia due to SA were obtained during the winter 2024 and 2025 influenza seasons.

Results: Compared to winter 2024, in 2025 the number of patients admitted with SA pneumonia increased from 55 cases (2.2 patients per 1000 admissions) to 84 cases (3.2 patients per 1000 admissions, P=.03). This increase was driven by influenza-related cases: from 0.28 cases/1000 admissions in 2024 to 1.1 cases/1000 admissions (P=.0005) in 2025. Of the 28 influenza-related cases in 2025, 1) 27 had co-infection with influenza A, 2) 13 were bacteremic, and 3) 15 had methicillin-susceptible SA (MSSA). Patients with MSSA coinfection were more likely to require ICU admission. Only two of the 28 patients had received the seasonal influenza vaccination prior to admission.

Conclusion: During the 2025 influenza season in New York City, there was a significant rise, compared to the 2024 season, of admitted patients with SA pneumonia co-infected with influenza. Nearly half had concomitant bacteremia and patients with MSSA had a more virulent onset of illness.

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纽约市2024-2025年流感季节甲型流感合并感染金黄色葡萄球菌肺炎的临床影响

背景：先前的研究强调了细菌性肺炎的不良后果，特别是由于耐甲氧西林金黄色葡萄球菌（MRSA），合并感染流感的患者。方法：收集纽约市11家医院系统在2024年冬季和2025年冬季流感季节因SA引起的社区发作性肺炎的患者名单。结果：与2024年冬季相比，2025年收治的SA肺炎患者从55例（每1000例入院2.2例）增加到84例（每1000例入院3.2例，P= 0.03）。这一增长是由流感相关病例推动的：从2024年的0.28例/1000例增加到2025年的1.1例/1000例（P= 0.0005）。在2025年的28例流感相关病例中，1)合并甲型流感感染27例，2)菌血症13例，3)甲氧西林敏感SA (MSSA) 15例。合并msa感染的患者更有可能需要进入ICU。28名患者中只有2名在入院前接种了季节性流感疫苗。结论：纽约市在2025年流感季节期间，与2024年流感季节相比，入院的SA肺炎合并流感患者明显增加。近一半的患者伴有菌血症，并且MSSA患者的发病毒性更大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Infectious Diseases 医学-传染病学

CiteScore

18.90

自引率

2.40%

发文量

1020

审稿时长

30 days

期刊介绍： International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.