International Journal of Clinical Practice最新文献

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The Severity of Preoperative Cervical Disc Degeneration Is an Important Risk Factor for Cervical Fusion Failure After Anterior Cervical Discectomy and Fusion 术前颈椎间盘退变的严重程度是前路颈椎间盘切除术融合后颈椎融合失败的重要危险因素
IF 2.4 4区 医学
International Journal of Clinical Practice Pub Date : 2025-08-18 DOI: 10.1155/ijcp/5439792
Bing Zhou, Youfeng Guo, Beiduo Shen, Haihong Zhao, Ziqi Zhu, Bin Yu, Tao Hu, Desheng Wu
{"title":"The Severity of Preoperative Cervical Disc Degeneration Is an Important Risk Factor for Cervical Fusion Failure After Anterior Cervical Discectomy and Fusion","authors":"Bing Zhou,&nbsp;Youfeng Guo,&nbsp;Beiduo Shen,&nbsp;Haihong Zhao,&nbsp;Ziqi Zhu,&nbsp;Bin Yu,&nbsp;Tao Hu,&nbsp;Desheng Wu","doi":"10.1155/ijcp/5439792","DOIUrl":"https://doi.org/10.1155/ijcp/5439792","url":null,"abstract":"<p><b>Background:</b> The relation between preoperative cervical disc degeneration and cervical fusion after anterior cervical discectomy and fusion (ACDF) remains unclear.</p><p><b>Methods:</b> We reviewed patients who received ACDF from 2019 to 2021. The Pfirrmann grading system was applied to six cervical discs (C2–T1) based on preoperative magnetic resonance imaging. The total degeneration score of six cervical discs was calculated as D Score. A mean degeneration score of operative cervical discs (Mean Surgery D Score) was calculated by dividing the total degeneration score of operative cervical discs by the number of operative segments. Postoperative computed tomography (CT) scans were conducted to determine the result of cervical fusion. Univariate and multivariate logistic regressions were used to explore the risk factors for cervical fusion failure. The receiver operating characteristic (ROC) curves were drawn according to multivariate results.</p><p><b>Results:</b> There were 159 patients in the nonfusion group and 135 patients in the fusion group. Univariate logistic regression showed that age, smoking, hypertension, coronary heart disease (CHD), D Score, and Mean Surgery D Score were associated with fusion failure. Hemoglobin, total protein, and albumin were associated with higher fusion rates. D Score (odds ratio [OR]: 1.887, 95%CI: 1.448–2.458, <i>p</i> = 0.001) and Mean Surgery D Score (OR: 8.827, 95%CI: 1.989–39.163, <i>p</i> = 0.004) were independent risk factors of fusion failure. The areas under the ROC curve of D Score and Mean Surgery D Score were 0.904 and 0.875, respectively.</p><p><b>Conclusions:</b> Patients with a higher preoperative D Score (&gt; 23.5) and Mean Surgery D Score (&gt; 4.125) have a higher risk of fusion failure after ACDF.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/5439792","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144861757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Syndrome Differentiation and Treatment Patterns of Hypertension in Traditional Chinese Medicine: A Quantitative Literature Analysis 中医高血压辨证论治模式:定量文献分析
IF 2.4 4区 医学
International Journal of Clinical Practice Pub Date : 2025-08-18 DOI: 10.1155/ijcp/6206443
Xu Xiaotai, Fang Qixiaoxiao
{"title":"Syndrome Differentiation and Treatment Patterns of Hypertension in Traditional Chinese Medicine: A Quantitative Literature Analysis","authors":"Xu Xiaotai,&nbsp;Fang Qixiaoxiao","doi":"10.1155/ijcp/6206443","DOIUrl":"https://doi.org/10.1155/ijcp/6206443","url":null,"abstract":"<p><b>Objective:</b> To analyze clinical studies on the use of traditional Chinese medicine (TCM) in the treatment of primary hypertension through mathematical analysis, aiming to explore the pathogenesis, treatment approaches, and formula patterns in TCM.</p><p><b>Methods:</b> A comprehensive search of both domestic and international databases was conducted to gather randomized controlled trials on TCM for primary hypertension. Data were extracted and analyzed to assess the pathogenesis, treatment strategies, and the frequency of prescription usage in TCM.</p><p><b>Results:</b> A total of nine TCM pathogenesis patterns related to primary hypertension were identified. The three most frequent patterns were hyperactivity of liver yang (54.73%), internal accumulation of phlegm-damp (28.40%), and blood stasis (12.35%). Statistical analysis revealed a significant difference between hyperactivity of liver yang and other pathogenesis patterns (<i>p</i> &lt; 0.05). Eleven treatment strategies related to TCM for this disease were identified. The three most frequent methods were calming the liver and subduing yang (54.73%), resolving phlegm and dampness (28.81%), and tonifying the spleen (20.99%). The method of calming the liver and subduing yang was found to be significantly more effective (<i>p</i> &lt; 0.05). Seventy-five relevant TCM treatment formulas were collected, with the three most commonly used being Tianma Gouteng decoction (20.58%), Banxia Baizhu Tianma decoction (11.93%), and Zhengan Xifeng decoction (4.53%). A significant difference was observed between Tianma Gouteng decoction and other formulas (<i>p</i> &lt; 0.05). The three most frequently used TCMs were Gastrodia elata (81.40%), Ostreae Testa (41.74%), and Mother of Pearl (40.50%). A significant difference was found between Gastrodia elata and other Chinese medicines (<i>p</i> &lt; 0.05).</p><p><b>Conclusion:</b> The primary pathogenesis of primary hypertension is associated with hyperactivity of liver yang and internal accumulation of phlegm-damp. The main treatment strategies are calming the liver and subduing yang, as well as resolving phlegm and dampness. Tianma Gouteng decoction, Banxia Baizhu Tianma decoction, and Zhengan Xifeng decoction are the most frequently used formulas in the treatment of primary hypertension. Gastrodia elata, Ostreae Testa, and Mother of Pearl are the most commonly used TCMs.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/6206443","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144861755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does Obesity Affect the Clinical Course and Accompanying Metabolic Disorders in Primary Hyperparathyroidism? 肥胖是否影响原发性甲状旁腺功能亢进的临床病程和伴随的代谢紊乱?
IF 2.4 4区 医学
International Journal of Clinical Practice Pub Date : 2025-08-18 DOI: 10.1155/ijcp/3021166
Işılay Kalan Sarı, Mehmet Aksoy
{"title":"Does Obesity Affect the Clinical Course and Accompanying Metabolic Disorders in Primary Hyperparathyroidism?","authors":"Işılay Kalan Sarı,&nbsp;Mehmet Aksoy","doi":"10.1155/ijcp/3021166","DOIUrl":"https://doi.org/10.1155/ijcp/3021166","url":null,"abstract":"<p>Several studies suggest an increased prevalence of obesity among patients with primary hyperparathyroidism (PHPT). Proposed mechanisms include parathyroid hormone (PTH) resistance, resistance to adipokines, and reduced lipolysis. Obesity may influence the clinical severity and presentation of PHPT. In addition to obesity, metabolic disorders such as diabetes mellitus and hypertension are also frequently observed in PHPT; however, the specific contribution of obesity to these comorbidities remains unclear. This study aimed to determine the prevalence of obesity in PHPT and to investigate its association with clinical presentation, laboratory parameters, and comorbid conditions. We retrospectively analyzed data from 152 patients with surgically confirmed PHPT. Patient records were reviewed for body mass index (BMI), laboratory values, coexisting metabolic conditions, and PHPT-related complications such as nephrolithiasis, osteoporosis, and fracture history. Among the patients, 20.4% had prediabetes, 13.8% had diabetes, and 34.9% had hypertension. Obesity (BMI ≥ 30 kg/m<sup>2</sup>) was present in 27%, and 36.8% were overweight. Thyroid nodules were found in 50.7%, and anti–thyroid peroxidase (anti-TPO) positivity was detected in 16.4%. Serum calcium and PTH levels were significantly higher in obese patients compared to those with normal BMI (<i>p</i> ≤ 0.001 and <i>p</i> = 0.017, respectively). There was no significant difference in the incidence of fractures, osteoporosis, or nephrolithiasis between the obese and nonobese groups. While diabetes was more prevalent in the nonobese group overall, subgroup analysis revealed a higher frequency of diabetes in overweight and obese patients compared to those with normal BMI. The prevalence of obesity in PHPT was higher than that in the general population. Although obesity was not associated with an increased frequency of osteoporosis, nephrolithiasis, or fractures, elevated serum calcium and PTH levels in obese patients may suggest a relationship with disease severity.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/3021166","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144861927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Student Educational Enhancement Programme (SEEP) on Study Skills of Nursing Students Needing Additional Curricular and Psychological Support at Selected Colleges 学生教育提升计划(SEEP)对有额外课程及心理支援需求的专科护生学习技巧的影响
IF 2.4 4区 医学
International Journal of Clinical Practice Pub Date : 2025-08-18 DOI: 10.1155/ijcp/2584205
Jayanthi Kuppunagulu, Renuka Kandaswamy, Chandrakala Sankarapandian, Noura Almadani, Majed Alamri
{"title":"Effect of Student Educational Enhancement Programme (SEEP) on Study Skills of Nursing Students Needing Additional Curricular and Psychological Support at Selected Colleges","authors":"Jayanthi Kuppunagulu,&nbsp;Renuka Kandaswamy,&nbsp;Chandrakala Sankarapandian,&nbsp;Noura Almadani,&nbsp;Majed Alamri","doi":"10.1155/ijcp/2584205","DOIUrl":"https://doi.org/10.1155/ijcp/2584205","url":null,"abstract":"<p><b>Background:</b> Transition from secondary school to higher education often presents challenges, particularly for nursing students who may face additional difficulties impacting their learning and study skills. Recognising and addressing these challenges are crucial for facilitating effective learning and improving study skills among students needing additional curricular and psychological support. The purpose of this study is to assess the efficacy of the Student Educational Enhancement Programme (SEEP) on study skills among nursing students needing additional curricular and psychological support. The study also correlated their effectiveness and associated study skills, with selected demographic variables.</p><p><b>Methods:</b> A true experimental design was employed to assess the effectiveness of the SEEP on the study skills of first-year B.Sc. (Nursing) students in Puducherry. The SEEP comprised structured group counselling, facial reflexology and INFINITI mind mapping learning. Pretest and post-test data were collected from study and control groups using standardised instruments. Statistical analyses, correlation and association tests were conducted to evaluate intervention’s impact and to explore relationships with demographic variables.</p><p><b>Results:</b> The study group demonstrated significant improvements in study skills (13.49% increase), compared to marginal improvements in the control group. Positive correlations were observed between the intervention and study outcomes in the study group, emphasising its efficacy.</p><p><b>Conclusion:</b> Therefore, the SEEP is considered as important in nursing education for enhancing study skills among nursing students needing additional curricular and psychological support.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/2584205","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Store-and-Forward Tele-Dermatology Pilot Study in Belgium: Patients and Physicians Satisfaction Study With Process Evaluation 储存和转发远程皮肤病学试点研究在比利时:患者和医生满意度研究与过程评价
IF 2.4 4区 医学
International Journal of Clinical Practice Pub Date : 2025-08-18 DOI: 10.1155/ijcp/2314602
Annemie Heselmans, Bert Aertgeerts, Koen Roegies, Hilde Beele, Evelien Verhaeghe, An De Sutter, Nicolas Delvaux
{"title":"Store-and-Forward Tele-Dermatology Pilot Study in Belgium: Patients and Physicians Satisfaction Study With Process Evaluation","authors":"Annemie Heselmans,&nbsp;Bert Aertgeerts,&nbsp;Koen Roegies,&nbsp;Hilde Beele,&nbsp;Evelien Verhaeghe,&nbsp;An De Sutter,&nbsp;Nicolas Delvaux","doi":"10.1155/ijcp/2314602","DOIUrl":"https://doi.org/10.1155/ijcp/2314602","url":null,"abstract":"<p><b>Background.</b> The use of telemedicine in dermatology is becoming more popular in Belgium and other countries as a result of increasing waiting lists. The objective of this study was to analyze if tele-dermatology is a valuable alternative for in-person consultations with the dermatologist and to get insight into the content of the remote consultations, the use, the barriers, and the satisfaction with this system.</p><p><b>Methods.</b> This study was a 1-year prospective pilot study in Belgium. The study implemented and evaluated a store-and-forward tele-dermatology system in the routine practice of Belgian family physicians and dermatologists.</p><p><b>Results.</b> A total of 320 family physicians and 43 dermatologists participated in the study. Analysis of remote consultations revealed a median response time of 24 h; 21% of patients needed an additional in-person consultation after the remote consultation. The majority of dermatologists (67.9%), family physicians (86.6%), and patients (81.4%) were generally satisfied with the service. A majority of the dermatologists agreed that there was sufficient clinical information in the electronic form (60.7%) and that the quality of the pictures was sufficient to allow correct decision making (57.1%). The family physicians had significantly higher percentages respectively, 84.5% and 71.8%. Dermatologists reported technical (73.9%) and organizational (43.5%) problems, whereas these percentages were statistically lower, respectively, 35.2% and 28.2% for the family physicians.</p><p><b>Conclusions.</b> The store-and-forward tele-dermatology system had the potential to allow a smooth transfer of high-quality dermatologic advice. Although there were differences between the dermatologists, the family physicians and the patients, general satisfaction with the system was high. There is a need for an extramural order management system in which the dermatologist could answer from his own electronic medical records.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/2314602","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144861756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic Performance of Uric Acid-to-Albumin Ratio for Detecting the Presence and Severity of Isolated Coronary Artery Ectasia 尿酸-白蛋白比值对孤立性冠状动脉扩张存在及严重程度的诊断价值
IF 2.4 4区 医学
International Journal of Clinical Practice Pub Date : 2025-08-13 DOI: 10.1155/ijcp/4936529
Mesut Karataş, Kenan Toprak
{"title":"Diagnostic Performance of Uric Acid-to-Albumin Ratio for Detecting the Presence and Severity of Isolated Coronary Artery Ectasia","authors":"Mesut Karataş,&nbsp;Kenan Toprak","doi":"10.1155/ijcp/4936529","DOIUrl":"https://doi.org/10.1155/ijcp/4936529","url":null,"abstract":"<p><b>Purpose:</b> In this study, we aimed to investigate the potential utility of the uric acid-to-albumin ratio (UAR) in identifying isolated coronary artery ectasia (iCAE) and to compare its performance with that of conventional inflammatory markers.</p><p><b>Objective:</b> In this study, we aimed to demonstrate the power of UAR to predict iCAE.</p><p><b>Methods:</b> A total of 440 patients were consecutively included in this retrospective study. Of the subjects, 110 were in the iCAE group, 110 were in the obstructive coronary artery disease (CAD) group accompanied by CAE, 110 were in the pure obstructive CAD group, and the remaining 110 were in the group with normal coronary artery on angiography. The groups were compared with each other in terms of UAR and traditional inflammatory markers. The normality of continuous variables was assessed using the Kolmogorov–Smirnov test. Continuous variables were compared using the independent Student’s t-test, Mann–Whitney U test, and Kruskal–Wallis test, where appropriate. Bonferroni and Brown–Forsythe post hoc tests were applied for multiple group comparisons. Categorical variables were analyzed with the <i>χ</i><sup>2</sup> test.</p><p><b>Results:</b> UAR levels were significantly higher in the iCAE group compared with the other groups (<i>p</i> &lt; 0.05, for all). UAR levels were significantly higher in Markis I classification, which is the group with the highest severity of iCAE, compared with Markis II-III-IV. In Spearman’s correlation analysis, a moderate but significant positive correlation was found between UAR and CRP (<i>r</i> = 0.186, <i>p</i> &lt; 0.001). UAR was identified as an independent risk factor for iCAE in the regression analysis (OR: 7.166; CI: 6.996–13.892; &lt; 0.001).</p><p><b>Conclusion:</b> UAR was found to be superior to traditional biomarkers. UAR may be an important biomarker in the etiopathogenesis of iCAE and a useful biomarker in clinical practice that can lead to the identification of high-risk individuals for iCAE and to take intensive preventive measures.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/4936529","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Integrative Gene Expression Profiling Analysis Indicates Bisphenol A Promotes Osteosarcoma Progression by Interacting With Seven Prognosis-Related Genes 一项综合基因表达谱分析表明双酚A通过与七个预后相关基因相互作用促进骨肉瘤的进展
IF 2.4 4区 医学
International Journal of Clinical Practice Pub Date : 2025-08-10 DOI: 10.1155/ijcp/7309718
Jin Liu, Peng Zhang, Meng Xu, Fan Chen, Wenjing Yu, Ting Xia
{"title":"An Integrative Gene Expression Profiling Analysis Indicates Bisphenol A Promotes Osteosarcoma Progression by Interacting With Seven Prognosis-Related Genes","authors":"Jin Liu,&nbsp;Peng Zhang,&nbsp;Meng Xu,&nbsp;Fan Chen,&nbsp;Wenjing Yu,&nbsp;Ting Xia","doi":"10.1155/ijcp/7309718","DOIUrl":"https://doi.org/10.1155/ijcp/7309718","url":null,"abstract":"<p>With more and more application of the endocrine disruptors (EDCs) in the daily use, there is evidence that EDCs can cause cancer, and they can cause a variety of deleterious effects. It has been known for many years that bisphenol A (BPA), a xenoestrogen found in many consumer products, dysregulates a wide array of signaling pathways in the body. In this study, we employed a novel integrative approach to assess the impact of BPA on human osteosarcoma (OS), leveraging genome-wide gene expression profiling to uncover the molecular interactions and pathways influenced by BPA in this context. In our study, we analyzed genes identified from the Comparative Toxicogenomics Database (CTD) as being associated with BPA. These genes were further examined through protein–protein interaction network analysis to explore their potential interconnectivity and functional roles in the context of human OS. In addition, the KEGG enrichment analysis demonstrated that many cancers, including OS, are closely associated with the BPA. The single sample gene set enrichment analysis algorithm was further used to explore the genes that may play a key role in the OS. An in silico analysis was performed based on gene expression data extracted from TARGET database. On the basis of the BPA-based prognostic prediction model in OS cohort, we discovered that seven BPA-related genes (IHH, ELFN1-AS1, AL161909.1, IGHV4-39, CSAG1, ACTA2, and SSX1) are closely associated with the prognosis of the OS patients. The enrichment pathways analysis reveals that these seven genes are closely associated with the many tumor-related pathways, such as TNFA signaling via NFKB, interferon alpha response, inflammatory response, IL6 JAK STAT3 signaling, and IL2 STAT5 signaling pathways. Additionally, the exposure of 10 μM BPA was found to promote the proliferation ability of OS cells in vitro. Our findings suggest that BPA can promote the proliferation of OS cells. IHH, ELFN1-AS1, AL161909.1, IGHV4-39, CSAG1, ACTA2, and SSX1 are among the most critical targets for BPA to act as a carcinogen.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/7309718","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Triglyceride–Glucose Index as a Predictor of Chronic Kidney Injury in Primary Hypothyroidism: A Retrospective Cohort Study 甘油三酯-葡萄糖指数作为原发性甲状腺功能减退慢性肾损伤的预测指标:一项回顾性队列研究
IF 2.4 4区 医学
International Journal of Clinical Practice Pub Date : 2025-08-04 DOI: 10.1155/ijcp/9583252
Qianqian Cao, Shuangshan Bu, Yifang Xu, Yuemeng Wu, Le Kang
{"title":"Triglyceride–Glucose Index as a Predictor of Chronic Kidney Injury in Primary Hypothyroidism: A Retrospective Cohort Study","authors":"Qianqian Cao,&nbsp;Shuangshan Bu,&nbsp;Yifang Xu,&nbsp;Yuemeng Wu,&nbsp;Le Kang","doi":"10.1155/ijcp/9583252","DOIUrl":"https://doi.org/10.1155/ijcp/9583252","url":null,"abstract":"<div>\u0000 <p><b>Introduction:</b> Primary hypothyroidism is a common endocrine disorder, and recent studies have shown a complex relationship between it and chronic kidney disease (CKD). The triglyceride–glucose (TyG) index, a novel metabolic marker, may have significant value in predicting CKD risk in patients with hypothyroidism. This study aims to evaluate the association between the TyG index and CKD risk in this population.</p>\u0000 <p><b>Materials and Methods:</b> This retrospective cohort study included 2658 primary hypothyroidism patients from the Lejiu database of Dongyang Hospital. Basic demographic characteristics and clinical laboratory data were collected, and the TyG index was calculated. The association between the TyG index and CKD risk was explored using Cox proportional hazards regression models, Kaplan–Meier survival analysis, and mediation analysis.</p>\u0000 <p><b>Results:</b> Among the 2658 patients, the prevalence of CKD was 18.06%. Kaplan–Meier survival analysis revealed a significantly higher incidence of CKD in patients with the highest TyG quartile compared to the lowest (log-rank test, <i>p</i> = 0.014). Multivariable Cox regression analysis showed that, although the overall hazard ratio (HR) did not reach significance in Model 3, after adjusting for multiple covariates, patients in the TyG Q4 group had a significantly increased risk of CKD compared to the Q1 group (HR = 1.40, 95% CI: 1.06–1.85, <i>p</i> = 0.017). Restricted cubic spline analysis further confirmed a significant nonlinear association between the TyG index and CKD risk, particularly prominent in females (<i>p</i>-nonlinear = 0.01). Subgroup analysis indicated that the TyG index was more strongly associated with CKD risk in females, overweight individuals, and those with hyperlipidemia, anemia, or malnutrition. Mediation analysis revealed that diabetes mellitus had the largest indirect effect, accounting for 76.76% of the total effect, followed by hypertension (70.52%) and systolic blood pressure (64.42%), with all indirect effects reaching statistical significance (<i>p</i> &lt; 0.05).</p>\u0000 <p><b>Conclusion:</b> The TyG index is an effective clinical tool for predicting CKD risk in patients with primary hypothyroidism and holds important clinical application potential.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/9583252","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of Musculoskeletal Disorders in Male Construction Workers and Their Relationship With Quality of Life and Physical Activity Level: A Cross-Sectional Study 男性建筑工人肌肉骨骼疾病患病率及其与生活质量和体力活动水平的关系:一项横断面研究
IF 2.4 4区 医学
International Journal of Clinical Practice Pub Date : 2025-07-31 DOI: 10.1155/ijcp/7323728
Musa Çankaya, Muhammet Erçiçek
{"title":"Prevalence of Musculoskeletal Disorders in Male Construction Workers and Their Relationship With Quality of Life and Physical Activity Level: A Cross-Sectional Study","authors":"Musa Çankaya,&nbsp;Muhammet Erçiçek","doi":"10.1155/ijcp/7323728","DOIUrl":"https://doi.org/10.1155/ijcp/7323728","url":null,"abstract":"<div>\u0000 <p><b>Objectives:</b> The prevalence of work-related musculoskeletal disorders (WMSDs) is very high among construction workers worldwide. It was aimed to investigate the prevalence of musculoskeletal disorders in male construction workers and their relationship with quality of life and physical activity level.</p>\u0000 <p><b>Methods:</b> One hundred and seventy male construction workers had a mean age of 37.17 ± 14.23 years. The musculoskeletal symptoms in the last 12 months were assessed with The Extended Version of the Scandinavian Musculoskeletal Questionnaire (NMQ-E) and Cornell Musculoskeletal Discomfort Questionnaire (CMDQ). Physical activity level was assessed using the International Physical Activity Questionnaire short form (IPAQ-sf) and quality of life was assessed using the World Health Organization Quality of Life Questionnaire (WHOQOL-Bref).</p>\u0000 <p><b>Results:</b> NMQ-E last 12-month prevalence rate of WMSDs was 26.5% (<i>n</i> = 45) neck, 37.9% (<i>n</i> = 64) shoulder, and 35.9% (<i>n</i> = 61). Quality of life assessed by WHOQOL-Bref has a significant negative weak correlation with WMSDs neck, shoulder, and low back (<i>r</i> = −0.154, <i>p</i> = 0.022; <i>r</i> = −0.159, <i>p</i> = 0.019; and <i>r</i> = −0.161, <i>p</i> = 0.018, respectively). Physical activity level assessed by IPAQ-sf has a significant negative weak relationship with WMSDs (<i>r</i> = −0.268, <i>p</i> &lt; 0.001) neck, (<i>r</i> = −0.254, <i>p</i> &lt; 0.001) shoulder, (<i>r</i> = −1.196, <i>p</i> = 0.005) upper back, (<i>r</i> = −0.128, <i>p</i> = 0.048) elbow, (<i>r</i> = −0.129, <i>p</i> = 0.046) wrist, and (<i>r</i> = −0.128, <i>p</i> = 0.048) knee.</p>\u0000 <p><b>Conclusion:</b> Prevalence rates for different body regions were reported with the highest prevalence rates being WMSDs in the shoulder and low back region. Quality of life and physical activity level were negatively affected by WMSDs in construction workers. It was determined that there was a significant relationship between those with and without WMSDs in general according to body regions.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/7323728","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative Analysis of Transcutaneous Bilirubin Measurement Techniques and Their Agreement With Serum Bilirubin Levels in Neonatal Jaundice: A Prospective Study 新生儿黄疸经皮胆红素测量技术及其与血清胆红素水平一致性的比较分析:一项前瞻性研究
IF 2.4 4区 医学
International Journal of Clinical Practice Pub Date : 2025-07-31 DOI: 10.1155/ijcp/1688130
Merve Kucukoglu Keser, Evrim Alyamac Dizdar, Esra Beser, Esin Okman, Fatma Nur Sari
{"title":"Comparative Analysis of Transcutaneous Bilirubin Measurement Techniques and Their Agreement With Serum Bilirubin Levels in Neonatal Jaundice: A Prospective Study","authors":"Merve Kucukoglu Keser,&nbsp;Evrim Alyamac Dizdar,&nbsp;Esra Beser,&nbsp;Esin Okman,&nbsp;Fatma Nur Sari","doi":"10.1155/ijcp/1688130","DOIUrl":"https://doi.org/10.1155/ijcp/1688130","url":null,"abstract":"<div>\u0000 <p><b>Aim:</b> This prospective study aimed to assess the accuracy and agreement of two transcutaneous bilirubin (TcB) devices—BiliCare and MBJ20—compared with serum total bilirubin (STB) in neonates with jaundice.</p>\u0000 <p><b>Methods:</b> Eighty-eight infants born at ≥ 34 weeks of gestation were included. TcB was measured from the auricle using BiliCare and from the sternum using MBJ20, concurrently with STB testing.</p>\u0000 <p><b>Results:</b> The median gestational age was 38 weeks and mean birth weight was 3108 g; 39% were delivered by cesarean section and 49% were male. Mean bilirubin levels were 14.6 mg/dL (MBJ20), 12.9 mg/dL (BiliCare), and 14.4 mg/dL (STB). Both devices showed strong correlation with STB (MBJ20: <i>r</i> = 0.756, BiliCare: <i>r</i> = 0.772; <i>p</i> &lt; 0.001). Mean differences from STB were −0.12 mg/dL for MBJ20 and 1.54 mg/dL for BiliCare. BiliCare showed higher predictive accuracy (AUC = 0.814) than MBJ20 (AUC = 0.751). Optimal TcB cutoff values were 14.2 mg/dL (BiliCare) and 15.6 mg/dL (MBJ20). Regression analysis showed no significant bias for either device. Based on STB measurements, 15% of the infants required phototherapy (PT).</p>\u0000 <p><b>Conclusion:</b> Both devices provide reliable noninvasive screening though BiliCare has a better accuracy in predicting the need for PT.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/1688130","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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