Lymphocyte-to-Monocyte Ratio as a Prognostic Biomarker for Acute Myocardial Infarction: A Systematic Review and Meta-Analysis

IF 2.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of Clinical Practice Pub Date : 2025-03-12 DOI:10.1155/ijcp/5560827

Hanshuo Gu, Yian Lu, Jiaxin Luo, Zhaoshun Yuan

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Abstract

Background: The prognostic value of lymphocyte-to-monocyte ratio (LMR) for acute myocardial infarction (AMI) has been underscored by multiple studies. Therefore, we initiated this meta-analysis to examine the correlation between LMR and prognostic outcomes in patients with AMI.

Methods: A comprehensive literature search was conducted across multiple databases, including Embase, PubMed, Web of Science, and the Cochrane Library, covering the period from the inception of the databases to October 24, 2024, focusing on studies comparing mortality and/or incidence of major adverse cardiovascular events (MACEs) by the pooled odds ratios (ORs) and respective 95% confidence intervals (CIs) between different LMR levels in AMI patients.

Results: Our meta-analysis encompasses 11 studies and involves a total of 7719 patients. The results indicate that individuals in the lower LMR group exhibit notably elevated mortality rates (OR = 2.43, 95% CI: 1.46–4.04, and p = 0.0006) and increased incidence of MACE (OR = 1.57, 95% CI: 1.27–1.95, and p = 0.0001) compared with those with high LMR. Subgroup analysis further reveals that lower LMR correlated with higher mortality and MACE in the context of confounding factors such as the sample size and cutoff value.

Conclusion: Our meta-analysis confirms the prognostic value of LMR in AMI patients. Lower LMR levels correlate with elevated mortality and increased incidence of MACE. This implies the clinical potential of LMR as an effective prognostic biomarker aiding in better risk assessment, personalized treatment strategies, and improved clinical outcomes.

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淋巴细胞/单核细胞比率作为急性心肌梗死的预后生物标志物：系统回顾和荟萃分析

背景：多项研究强调了淋巴细胞与单核细胞比值（LMR）对急性心肌梗死（AMI）的预后价值。因此，我们启动了这项荟萃分析，以检查LMR与AMI患者预后结果之间的相关性。方法：对Embase、PubMed、Web of Science和Cochrane Library等多个数据库进行全面的文献检索，检索时间从数据库建立到2024年10月24日，重点研究通过不同LMR水平AMI患者的合并优势比（ORs）和各自的95%置信区间（CIs）比较AMI患者的死亡率和/或主要不良心血管事件（mace）发生率。结果：我们的荟萃分析包括11项研究，共涉及7719名患者。结果表明，与高LMR组相比，低LMR组的个体死亡率显著升高（OR = 2.43, 95% CI: 1.46-4.04, p = 0.0006）， MACE发生率显著升高（OR = 1.57, 95% CI: 1.27-1.95, p = 0.0001）。亚组分析进一步显示，在样本量和截止值等混杂因素的背景下，较低的LMR与较高的死亡率和MACE相关。结论：我们的荟萃分析证实了LMR在AMI患者中的预后价值。较低的LMR水平与死亡率升高和MACE发生率增加相关。这意味着LMR作为一种有效的预后生物标志物的临床潜力，有助于更好的风险评估、个性化治疗策略和改善临床结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Clinical Practice 医学-医学：内科

CiteScore

5.30

自引率

0.00%

发文量

274

审稿时长

3-8 weeks

期刊介绍： IJCP is a general medical journal. IJCP gives special priority to work that has international appeal. IJCP publishes: Editorials. IJCP Editorials are commissioned. [Peer reviewed at the editor''s discretion] Perspectives. Most IJCP Perspectives are commissioned. Example. [Peer reviewed at the editor''s discretion] Study design and interpretation. Example. [Always peer reviewed] Original data from clinical investigations. In particular: Primary research papers from RCTs, observational studies, epidemiological studies; pre-specified sub-analyses; pooled analyses. [Always peer reviewed] Meta-analyses. [Always peer reviewed] Systematic reviews. From October 2009, special priority will be given to systematic reviews. [Always peer reviewed] Non-systematic/narrative reviews. From October 2009, reviews that are not systematic will be considered only if they include a discrete Methods section that must explicitly describe the authors'' approach. Special priority will, however, be given to systematic reviews. [Always peer reviewed] ''How to…'' papers. Example. [Always peer reviewed] Consensus statements. [Always peer reviewed] Short reports. [Always peer reviewed] Letters. [Peer reviewed at the editor''s discretion] International scope IJCP publishes work from investigators globally. Around 30% of IJCP articles list an author from the UK. Around 30% of IJCP articles list an author from the USA or Canada. Around 45% of IJCP articles list an author from a European country that is not the UK. Around 15% of articles published in IJCP list an author from a country in the Asia-Pacific region.