International Journal of Clinical Practice最新文献

{"title":"Correction to “Efficacy and Safety of Acupuncture for Idiopathic Tinnitus: A Randomized Controlled Clinical Trial”","authors":"","doi":"10.1155/ijcp/9825823","DOIUrl":"https://doi.org/10.1155/ijcp/9825823","url":null,"abstract":"<p>L. L. Huang, J. Q. Man, Y. J. Gu, et al.,“Efficacy and Safety of Acupuncture for Idiopathic Tinnitus: A Randomized Controlled Clinical Trial,” <i>International Journal of Clinical Practice</i> (2026) 2026: 5489240, https://doi.org/10.1155/ijcp/5489240.</p><p>In the Funding section of the published article, the following funding acknowledgement was inadvertently omitted: “This study was supported by the Shanghai University of Traditional Chinese Medicine ‘Visiting Masters’ Program (No. 20230627).” The Funding section should have included this funding acknowledgement.</p><p>We apologize for this error.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/9825823","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149205687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comorbidity Burden and Early In-Hospital Outcomes After Intravenous Thrombolysis for Acute Ischemic Stroke","authors":"Sharbanu Battakova,&nbsp;Marina Grigolashvili,&nbsp;Dmitry Kasatkin,&nbsp;Irina Kadyrova,&nbsp;Yelena Shayakhmetova,&nbsp;Mira Beisembayeva,&nbsp;Shynar Muratbekova,&nbsp;Ivan Turkevich,&nbsp;Alina Koshelyuk","doi":"10.1155/ijcp/5517923","DOIUrl":"https://doi.org/10.1155/ijcp/5517923","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The prognostic relevance of comorbidity burden in patients with acute ischemic stroke (AIS) treated with intravenous thrombolysis (IVT) remains uncertain. This study examined the association between four comorbidity indices and early in-hospital outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This single-center retrospective study included 106 patients with AIS treated with IVT between January and December 2024. Comorbidity burden was assessed using the Charlson Comorbidity Index (CCI; 1987 and 2011 versions) and the Elixhauser Comorbidity Index (ECI; 2009 and 2017 versions). The primary outcome was unfavorable functional status at discharge, defined as a modified Rankin scale (mRS) score of 3–6. Multivariable logistic regression was used to identify factors associated with the primary outcome, and receiver operating characteristic (ROC) analyses assessed the discriminatory performance of the indices. Mortality comparisons were exploratory because only 10 in-hospital deaths occurred.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The median age was 68 years, and 60 patients (56.6%) were men. Unfavorable functional outcome (mRS 3–6) occurred in 73 patients (68.9%). Higher admission National Institutes of Health Stroke Scale (NIHSS) scores and glucose levels were independently associated with unfavorable functional status at discharge, whereas none of the four comorbidity indices remained significant after multivariable adjustment. The comorbidity indices showed limited to modest discriminatory performance, with an AUC of 0.645 (95% CI 0.531–0.760) for CCI 1987. Hemorrhagic transformation (HT) occurred exclusively in patients with an unfavorable outcome and was more frequent among nonsurvivors. Exploratory comparisons also showed higher prestroke mRS, admission NIHSS, CCI 1987, and CCI 2011 scores among nonsurvivors; no multivariable mortality analysis was performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>None of the evaluated comorbidity indices was independently associated with functional status at hospital discharge. Their discriminatory performance was modest, whereas admission stroke severity and glucose level showed stronger associations with short-term outcome. Given the retrospective single-center design, modest sample size, and limited number of deaths, the findings should be considered exploratory and hypothesis-generating and require confirmation in larger prospective studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/5517923","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149205688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Dysfunction Score and Transcriptomic Model for Distinguishing Tuberculosis States","authors":"Jun Zi,&nbsp;Lianbao Jiang,&nbsp;Yu Jiang,&nbsp;Xialing Huang","doi":"10.1155/ijcp/2761636","DOIUrl":"https://doi.org/10.1155/ijcp/2761636","url":null,"abstract":"<p>This study successfully classified patients into two subtypes (C1 and C2) with significant immune differences based on the immune characteristics related to the Rv2623 antigen by integrating the transcriptome dataset of tuberculosis (TB). Among them, the C2 subtype exhibited higher immune suppression and inflammatory response characteristics. By intersecting disease-state- and immune-subtype-associated differentially expressed genes, we identified eight genes that defined the two component gene sets used to calculate the immune dysfunction score (IMDS), which was found to be significantly elevated in TB samples and positively correlated with Type_II_IFN_Response and TNF_Family_Members. We further developed a GMM-LR classifier to distinguish active TB from latent TB infection (LTBI) and evaluated its discriminatory performance across multiple transcriptomic cohorts. Subsequent single-cell analysis identified 14 cell types and revealed a broader predicted intercellular communication network involving CD8+ T cells in TB samples. Among the 17 immune signatures, the activated CD8+ T-cell signature showed the greatest variation across cell types. Further analysis of CD8+ T-cell heterogeneity and inferred differentiation trajectories identified distinct effector subsets, including GZMK + CD8+ T cells. These findings provide an integrated transcriptomic framework for distinguishing TB states and characterizing the associated immune heterogeneity.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/2761636","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149205870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal MRI Radiomics for Predicting Neoadjuvant Therapy Response in Breast Cancer: A Data-Driven Tool Toward Precision Oncology Clinical Practice","authors":"Shuai Dong,&nbsp;Yueying Guo,&nbsp;Diaohan Xiong,&nbsp;Juntao Zhang,&nbsp;Yong Huang,&nbsp;Junping Wang","doi":"10.1155/ijcp/5680102","DOIUrl":"https://doi.org/10.1155/ijcp/5680102","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the value of radiomic features derived from multimodal MRI for predicting neoadjuvant therapy (NAT) response across different molecular subtypes of breast cancer and to develop a data-driven noninvasive tool to support individualized precision clinical practice for breast cancer treatment decision-making.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively analyzed 410 patients (July 2014–December 2025) who received NAT followed by surgery. Pretreatment breast MRI and clinical data were collected. Pathological response classified patients into pathologic complete response (pCR) and non-pCR groups. Tumor lesions were manually segmented slice-by-slice, and radiomic features were extracted. The entire cohort was randomly divided into training and test cohorts at a ratio of 7:3. Radiomics models with different sequence combinations, a clinical model, and a combined nomogram integrating optimal radiomics score and selected clinical factors were constructed and compared.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Subtypes included Luminal B (HER2-negative, <i>n</i> = 126, pCR = 19.0%), Luminal B (HER2-positive, <i>n</i> = 98, pCR = 52.0%), HER2-positive (<i>n</i> = 98, pCR = 73.5%), and triple-negative breast cancer (TNBC, <i>n</i> = 88, pCR = 52.3%). In the test cohort, the multimodal model achieved the highest area under the curve (AUC) for Luminal B (HER2-negative) (0.81), HER2-positive (0.84), and TNBC (0.80), while the DCE-MRI model achieved the highest AUC for Luminal B (HER2-positive) (0.80). Ki67 and T stage were identified as independent pCR predictors in relevant subtypes, while Ki67 and treatment plan also showed predictive value and were included in the combined model. The combined model outperformed the clinical model in most subtypes, with test AUCs of 0.83, 0.76, 0.84, and 0.80, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Pretreatment multimodal MRI-based radiomics effectively predicts NAT response across breast cancer subtypes. The combined model integrating imaging and clinical factors serves as a reliable noninvasive and translatable tool for individualized early response assessment, facilitating data-driven precision clinical practice of neoadjuvant therapy stratification in breast cancer.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/5680102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149205660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Turkish Version of the Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) in Men Using Inflatable Penile Prostheses and Their Partners: A Methodological Study","authors":"Bugra Cetin,&nbsp;Mine Kaya,&nbsp;Cem Tugrul Gezmis,&nbsp;Duygu Kirkik","doi":"10.1155/ijcp/6467649","DOIUrl":"https://doi.org/10.1155/ijcp/6467649","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Erectile dysfunction (ED) is a prevalent condition that affects quality of life and intimate relationships. Treatment satisfaction represents a broader patient-centered outcome than erectile function alone. The Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) assesses satisfaction from patient and partner perspectives. This study aimed to translate, culturally adapt, and evaluate the psychometric properties of the Turkish EDITS patient and partner forms in men using three-piece inflatable penile prostheses and their partners.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This methodological study included 200 men with ED who had used a three-piece inflatable penile prosthesis for at least six months. Of these, 122 had partners who completed the partner questionnaire, yielding 122 complete patient–partner dyads. The patient and partner forms were translated using a forward–backward translation procedure. Internal consistency was evaluated using Cronbach’s alpha and ordinal alpha. Construct validity was examined using single-factor confirmatory factor analysis (CFA) with a robust weighted least squares mean- and variance-adjusted estimator. Patient–partner association was evaluated using Spearman’s rho in the 122 matched dyads.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Complete item-level data were available for all 200 patient questionnaires and 122 partner questionnaires. Cronbach’s alpha was 0.97 for the patient form and 0.65 for the partner form; ordinal alpha was 0.98 and 0.70, respectively. No floor or ceiling effect was observed. CFA supported the proposed one-factor structure at the global-fit level, although the boundary fit indices were interpreted cautiously. Standardized factor loadings ranged from 0.83 to 0.90 for the patient form and from 0.40 to 0.80 for the partner form. The partner form demonstrated comparatively weaker convergent validity (CR = 0.73; AVE = 0.41). Patient and partner total scores demonstrated a statistically significant moderate-to-strong positive association among the 122 matched dyads (Spearman’s &lt;i&gt;ρ&lt;/i&gt; = 0.64, &lt;i&gt;p&lt;/i&gt; &lt; 0.001), which was interpreted as an association rather than agreement.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The Turkish EDITS patient form demonstrated strong internal consistency and factorial validity in men using three-piece inflatable penile prostheses. The partner form showed preliminary and comparatively weaker psychometric performance, with marginal internal consistency and lower convergent-validity indicators. Further studies ","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/6467649","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149205800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Burden of Liver Cancer Attributable to Drug Use and High Body Mass Index: A Machine Learning Prediction Study for Global Trend Assessment, Genetic Exploration, and Future Projection”","authors":"","doi":"10.1155/ijcp/9808509","DOIUrl":"https://doi.org/10.1155/ijcp/9808509","url":null,"abstract":"<p>G. Jiang, J. Chen, Y. Tang, X. Liu, K. Pang, and L. Zhou, “Burden of Liver Cancer Attributable to Drug Use and High Body Mass Index: A Machine Learning Prediction Study for Global Trend Assessment, Genetic Exploration, and Future Projection,” <i>International Journal of Clinical Practice</i> 2026 (2026): 9215080, https://doi.org/10.1155/ijcp/9215080.</p><p>In page 1, the text “Correspondence: Jia Chen (<span>[email protected]</span>)” was incorrect. The correct corresponding author of this study should be Lei Zhou (<span>[email protected]</span>).</p><p>We apologize for this error.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/9808509","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149205340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Cancer History on Clinical Outcomes Among Patients Without Standard Modifiable Cardiovascular Risk Factors Who Received PCI","authors":"Min Wang,&nbsp;Qizhi Chen,&nbsp;Huasu Zeng,&nbsp;Lin Gao,&nbsp;Mingxing Wu,&nbsp;Junfeng Zhang,&nbsp;Zhengde Tang,&nbsp;Jun Gu,&nbsp;Changqian Wang","doi":"10.1155/ijcp/3095145","DOIUrl":"https://doi.org/10.1155/ijcp/3095145","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Coronary artery disease (CAD) has traditionally been attributed to a cluster of standard modifiable cardiovascular risk factors (SMuRFs), including hypertension, diabetes, dyslipidemia, and smoking. Among SMuRF-less patients (those with none of the four SMuRFs), cancer emerges as an increasingly recognized nontraditional risk factor.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The purpose of this study was to evaluate the influence of coexisting cancer on the clinical outcomes among SMuRF-less patients who underwent percutaneous coronary intervention (PCI).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This single-center prospective cohort study enrolled 1416 SMuRF-less CAD patients from August 2016 to December 2024; 493 who received PCI with stents were included, and 468 were analyzed after exclusions (67 with cancer, 401 without). The primary outcome was the incidence of major adverse cardiovascular events (MACEs), including cardiovascular death, nonfatal myocardial infarction (MI), heart failure hospitalization, and nonfatal stroke. The secondary outcome was all-cause mortality.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;After a median follow-up of 46 months, the cancer group showed poorer prognosis than the noncancer group in terms of MACEs (25.37 vs. 10.97%; HR, 2.828; 95% CI, 1.614–4.957; &lt;i&gt;p&lt;/i&gt; &lt; 0.001) and all-cause mortality (13.43 vs. 3.49%; HR, 4.078; 95% CI, 1.764–9.427; &lt;i&gt;p&lt;/i&gt; &lt; 0.001). Moreover, proportional hazards analyses identified cancer history as an independent predictor for MACEs (HR 3.40, 95% CI 1.73–6.68, &lt;i&gt;p&lt;/i&gt; &lt; 0.001) and all-cause mortality (HR 5.44, 95% CI 2.14–13.84, &lt;i&gt;p&lt;/i&gt; &lt; 0.001) following coronary stent implantation. In addition, serum C-reactive protein (CRP) levels were significantly higher in the cancer group than in the noncancer group, and we determined the optimal cutoff value of CRP as 1.25 mg/L. Kaplan–Meier analysis showed that the high CRP group had lower MACE-free survival than that of the low CRP group (&lt;i&gt;p&lt;/i&gt; = 0.030) in cancer subgroup analyses. Among the cancer group, patients who were presented as having current cancer had more MACE events than those who were presented as having past cancer at the time of PCI (HR 3.60, 95% CI 1.28–10.13, &lt;i&gt;p&lt;/i&gt; = 0.015).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Cancer history was a potent, independent predictor of poorer prognosis in SMuRF-less CAD patients following PCI. Routine measurement of CRP ma","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/3095145","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149205406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xuesaitong Injection Combination Therapy in Patients With Acute Ischemic Stroke: Preliminary Findings From a Propensity Score–Matched Study","authors":"Chifei Zhang,&nbsp;Yanbin Chen,&nbsp;Pan Liang,&nbsp;Jing Li","doi":"10.1155/ijcp/4995992","DOIUrl":"https://doi.org/10.1155/ijcp/4995992","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Xuesaitong injection is widely used as an adjunctive therapy for acute ischemic stroke (AIS), but real-world evidence on its effectiveness remains limited. This study evaluated the association between Xuesaitong injection combination therapy and short-term clinical outcomes in patients with AIS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a retrospective observational study of hospitalized AIS patients treated with either Xuesaitong injection combination therapy or standard treatment alone. Propensity score matching (PSM) was performed at a 1:1 ratio to balance baseline characteristics between groups. Clinical outcomes after matching included favorable functional outcome at discharge (modified Rankin Scale [mRS] 0–2), discharge mRS score distribution, NIHSS improvement at discharge, NIHSS improvement ≥ 4 points, and length of hospital stay. Pair-aware crude and adjusted regression models were applied in the matched cohort, with additional adjustment for hypertension and onset-to-admission time.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Before matching, 213 patients received Xuesaitong combination therapy and 498 served as controls; after PSM, 203 matched pairs were included. In the matched cohort, the Xuesaitong group showed better short-term neurological recovery than the control group, with greater NIHSS improvement at discharge (4.5 ± 1.9 vs. 3.7 ± 1.9, <i>p</i> &lt; 0.001) and a higher proportion achieving NIHSS improvement ≥ 4 points (69.0% vs. 54.7%, <i>p</i> = 0.002). In pair-aware regression analyses, Xuesaitong combination therapy was associated with higher odds of NIHSS improvement ≥ 4 points (adjusted OR 1.82, 95% CI 1.24–2.69; <i>p</i> = 0.002) and a shorter length of stay (adjusted ratio of means 0.94, 95% CI 0.90–0.99; <i>p</i> = 0.016). The association with favorable functional outcome at discharge did not reach statistical significance (adjusted OR 1.53, 95% CI 0.98–2.38; <i>p</i> = 0.059).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Xuesaitong injection combination therapy was associated with improved early neurological recovery and shorter hospitalization in patients with AIS. The association with favorable functional outcome at discharge warrants further confirmation in prospective studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/4995992","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149205298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Performance of Platelet-to-Mean Platelet Volume Ratio (PVR) in Periprosthetic Joint Infection: A Systematic Review and Meta-Analysis","authors":"Amin Moradi,&nbsp;Jafar Ganjpour Sales,&nbsp;Alireza Sadeghpour Teymourlou,&nbsp;Mohammad Ali Jafari Zare,&nbsp;Hooman Yahyazadeh,&nbsp;Hossein Akbari Aghdam,&nbsp;Asghar Elmi,&nbsp;Mohammad Reza Aslani","doi":"10.1155/ijcp/8601173","DOIUrl":"https://doi.org/10.1155/ijcp/8601173","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Studies have explored the role of biomarkers, including the platelet–mean platelet volume ratio (PVR), in detecting periprosthetic joint infection (PJI) following total hip arthroplasty (THA) and total knee arthroplasty (TKA). The objective of this research was to perform an update systematic review and meta-analysis to evaluate the diagnostic effectiveness of PVR in detecting PJI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>To identify studies concerning the use of the PVR in diagnosing PJI, a review of databases such as Scopus, PubMed, and Web of Science was conducted. The evaluations covered sensitivity and specificity as well as positive/negative likelihood ratios, area under the curve (AUC), and diagnostic odds ratios.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A comprehensive review included 9223 patients across 17 different studies dedicated to TKA and THA. An estimated 30.11% of the participants, which equals 2777 individuals, mentioned having experienced PJI. For the combination of the PVR, sensitivity was recorded as 0.63 and specificity as 0.76. The analysis of subgroups indicated that increased sensitivity was observed with a patient population under 200, a PVR cutoff value of below 28, samples specifically from THA or TKA, and when applying the MSIS/EBJIS criteria.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The findings showed that PVR had poor diagnostic accuracy in relation to the incidence of PJI, but further research is needed to fine-tune the threshold criteria.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/8601173","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149205297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inverse Association of the Prognostic Nutritional Index With Gallstone Prevalence Among U.S. Adults","authors":"Kaizhi Xu,&nbsp;Zufa Zhang,&nbsp;Huqiang Dong,&nbsp;Afang Zuo","doi":"10.1155/ijcp/2529736","DOIUrl":"https://doi.org/10.1155/ijcp/2529736","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Gallstones are common and have been associated with nutritional and immune status. The Prognostic Nutritional Index (PNI) reflects both nutritional and immune-related conditions, but its association with gallstones remains unclear. This study examined this association in U.S. adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study analyzed data from 5060 individuals in the National Health and Nutrition Examination Survey (NHANES), with a mHean age of 48.62 years. Multivariable logistic regression was used to assess the association between PNI and gallstones. Restricted cubic spline (RCS) analysis was used to assess potential nonlinearity. Robustness was evaluated using subgroup analyses, interaction tests, and a sensitivity model with additional adjustment for fatty liver.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The prevalence of gallstones was 11.36%. In the fully adjusted model, each 1-unit increase in PNI was associated with 2% lower odds of gallstones (odds ratio [OR] = 0.98, 95% confidence interval [CI] 0.96–0.99, <i>p</i> = 0.0185). Compared with the lowest quartile, participants in the highest quartile had lower odds of gallstones (OR = 0.72, 95% CI 0.55–0.95, <i>p</i> = 0.0194). RCS analysis showed an overall association between PNI and gallstone prevalence (<i>p</i> for overall = 0.019), with no evidence of nonlinearity (<i>p</i> for nonlinearity = 0.165). After Bonferroni correction (<i>α</i>′ ≈ 0.0015), no subgroup association remained statistically significant, and no significant interactions were detected.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>An inverse association between PNI and gallstone prevalence remained after multivariable adjustment. PNI may serve as a potential complementary immunonutritional marker associated with gallstone prevalence.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/2529736","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149146352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}