International Journal of Clinical Practice最新文献

{"title":"The Potential Psychological Advantages of the Focusing-Oriented Therapy: A Pilot Quasiexperimental Study of “Proficiency as Focusing Partner” Training Workshop on Self-Compassion","authors":"Ming Yu Claudia Wong","doi":"10.1155/ijcp/8466900","DOIUrl":"https://doi.org/10.1155/ijcp/8466900","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Focusing therapy, formulated by Eugene Gendlin (1969), is a body-centered technique that targets bodily sensations and aims at promoting self-care, self-awareness, and self-soothing. Focusing therapy helps people to be more aware of their inner feelings, achieve peace with a purpose without being overwhelmed by anxiety or depression, and enhance mindfulness and self-compassion. Focusing is therefore seen as a tool for developing self-compassion, thereby focusing on our inner feelings and needs and embracing and acknowledging our inner senses. However, there is a dearth of research on practical focusing therapy training workshops for general adults. Therefore, this study aims to be the first research study to investigate the effect of a complete four-level focusing-oriented workshop on self-compassion.</p>\u0000 <p><b>Method:</b> Participants in this study were recruited using convenience sampling, specifically targeting those who had applied for the “Proficiency in Focusing Partnership” training workshop. 16 participants applied and actively engaged in all four levels of the workshop. Participants were asked to complete the questionnaire after finishing the second, third, and fourth levels of the workshop to analyze the influence of different levels of the workshop. The one-way repeated-measure analysis of variance (ANOVA) was used to examine the continuous changes in self-compassion across the three time points within the group.</p>\u0000 <p><b>Results and Conclusion:</b> This pilot study addresses the lack of research on focusing therapy training workshops for the general population. The findings suggest that the “Proficiency in Focusing Partnership” training workshop can significantly improve self-compassion, mainly by reducing negative self-compassion. However, further development of evidence-based focusing-oriented interventions is needed.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/8466900","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143908917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Into the Differences and Clinical Diagnostic Importance of Different Ct Values in COVID-19 Patients of Different Age, Albumin, Lactate Dehydrogenase, and Lymphocyte Percentages","authors":"Han Su,&nbsp;Li Xu,&nbsp;Fulu Chu,&nbsp;Guolin Bao,&nbsp;Shiyu Zhao,&nbsp;Shan Ding,&nbsp;Yiqing Liu","doi":"10.1155/ijcp/8818243","DOIUrl":"https://doi.org/10.1155/ijcp/8818243","url":null,"abstract":"<div>\u0000 <p><b>Introduction:</b> This study aims to investigate the differences and clinical diagnostic importance of different Ct (cycle threshold) values in COVID-19 patients of different age, albumin, lactate dehydrogenase (LDH), and lymphocyte percentage (LYM%).</p>\u0000 <p><b>Methods:</b> A total of 2836 patients confirmed with COVID-19 in our Hospital between January 1 and May 30, 2023 were divided into the high Ct value (34.21–40.00), the medium Ct value (26.51–34.21), and the low Ct value groups (0.00–26.51) using the interquartile method against the negative (control group).</p>\u0000 <p><b>Results:</b> Significant differences were observed in clinical indicators between the middle Ct group and the control group; however, no significant differences were noted between the middle and high Ct groups. In the high Ct group, notable disparities in albumin and LDH were found compared to the control. The low Ct group exhibited significant differences from the high Ct group regarding age and LYM%. Furthermore, age was significantly different within the low Ct group when compared to the middle one. Nonetheless, no significant variations in LDH were detected between the low Ct group and the control.</p>\u0000 <p><b>Conclusion:</b> People over 59 years old are at an elevated risk for higher viral loads and increased susceptibility to COVID-19 infection. Albumin and LYM% serve as protective factors against this disease. Age, albumin, and LYM% demonstrate favorable predictive values for distinguishing individuals within the low Ct category from other groups.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/8818243","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Dexmedetomidine on Posttraumatic Stress Disorder in Traumatic Brain Injury Patients Undergoing Emergency Craniotomy Surgery: A Retrospective Study","authors":"Yun-Qi Wang,&nbsp;Xian-Jie Zhang,&nbsp;Dan Zhou,&nbsp;Qing Li,&nbsp;Xin Liu","doi":"10.1155/ijcp/8880629","DOIUrl":"https://doi.org/10.1155/ijcp/8880629","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> The purpose of this study was to investigate the effect of dexmedetomidine (DEX) on the incidence of postoperative posttraumatic stress disorder (PTSD) in traumatic brain injury (TBI) patients undergoing emergency craniotomy.</p>\u0000 <p><b>Methods:</b> The TBI patients who underwent emergency craniotomy at our hospital from January 2017 to June 2023 were included in our study. The patients were divided into the DEX group and the control group. We analyzed the intraoperative data (bradycardia, hypotension, hypoxemia, duration of anesthesia, and duration of surgery) and the postoperative data (PTSD, the total length of hospital stay, and Glasgow Coma Scale [GCS] scores at discharge).</p>\u0000 <p><b>Results:</b> A total of 126 TBI patients were included in our study. Of these patients, 55 were treated with DEX (the mean rate of administration was 0.58 ± 0.22 μg/kg/h.) and 71 did not receive DEX. The incidence of bradycardia was significantly higher in the DEX group than in the control group (<i>p</i> &lt; 0.05). However, the incidence of PTSD was significantly higher in the control group than in the DEX group (<i>p</i> &lt; 0.05).</p>\u0000 <p><b>Conclusion:</b> The use of DEX during anesthesia was effective in reducing the incidence of postoperative PTSD in TBI patients undergoing craniotomy.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/8880629","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143901006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative Mendelian Randomization and Transcriptome Analysis Unveil Dual Pathways in Prostate Cancer Etiology","authors":"Dongdong Wang,&nbsp;Mingwei Zhan,&nbsp;Pengfei Liu,&nbsp;Yi Yu,&nbsp;Rijian Guan","doi":"10.1155/ijcp/9943789","DOIUrl":"https://doi.org/10.1155/ijcp/9943789","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Prostate cancer remains a significant global health challenge, influenced by both genetic and environmental factors. Despite extensive research, the specific metabolic pathways contributing to its pathogenesis are not fully understood.</p>\u0000 <p><b>Methods:</b> We obtained significant single nucleotide polymorphisms (SNPs) associated with 1400 metabolites and 731 immune cells from the GEWAS database and published literature. Using an integrative approach that combines single-cell and bulk transcriptome analysis with Mendelian randomization (MR) and machine learning, we identified significant SNPs related to metabolic and immune profiles, with a specific focus on glutathione metabolism and its downstream metabolite cysteinylglycine disulfide. Advanced statistical techniques, including inverse variance weighted MR, were employed to explore causal relationships between these metabolic markers and prostate cancer risk. Additionally, we investigated the role of ATP6V1G1 in prostate cancer cell lines through RNA interference and various functional assays.</p>\u0000 <p><b>Results:</b> Our MR analysis indicated that elevated cysteinylglycine disulfide levels are protective against prostate cancer. Conversely, higher monocyte counts were associated with increased cancer risk, suggesting a dual pathway influence on disease etiology through immune modulation and metabolic dysregulation. Machine learning algorithms further validated these associations and identified potential biomarkers for prostate cancer susceptibility. In vitro experiments demonstrated that silencing ATP6V1G1 significantly reduced the proliferation and migration of prostate cancer cells, highlighting its oncogenic potential.</p>\u0000 <p><b>Conclusion:</b> The study highlighted a significant association between prostate cancer occurrence, glutathione metabolism, and monocyte activity. The critical interplay between glutathione metabolism and immune cell dynamics in prostate cancer is underscored, proposing novel biomarkers for early diagnosis and potential therapeutic targets. Notably, ATP6V1G1 emerged as a key gene with significant diagnostic and prognostic value, offering new prospects for therapeutic intervention in prostate cancer.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/9943789","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Prognostic Markers for Patients With COVID-19 in a Low-Resource Setting: A Cross-Sectional Study","authors":"Md. Asaduzzaman,&nbsp;Mohammad Romel Bhuia,&nbsp;Mohammad Zabed Jillul Bari,&nbsp;Z. H. M. Nazmul Alam,&nbsp;Ranjon Kumer Roy,&nbsp;Soumitra Roy,&nbsp;Goutam Talukder,&nbsp;M. M. Jahangir Alam,&nbsp;Md. Shafiqul Bari","doi":"10.1155/ijcp/5595869","DOIUrl":"https://doi.org/10.1155/ijcp/5595869","url":null,"abstract":"<div>\u0000 <p><b>Aim:</b> Triaging patients based on prognostic biomarkers may contribute to better management of at-risk patients in resource-constrained settings. This study aimed to explore readily available and cost-effective predictors of mortality among COVID-19 patients.</p>\u0000 <p><b>Methods:</b> This cross-sectional study, conducted across multiple centers, involved patients with COVID-19 admitted to four hospitals in Bangladesh. The analysis encompassed demographic information, clinical features, laboratory findings, and in-hospital outcomes. Logistic regression was utilized to identify factors contributing to mortality risk.</p>\u0000 <p><b>Results:</b> Among 442 patients, 55 (12.44%) experienced mortality. The patients’ mean was 60 ± 14 years. DM (76% vs. 62%), IHD (42% vs. 19%), CKD (35% vs. 15%), and COPD (24% vs. 11%) were the most prevalent comorbidities in nonsurvivors. Compared to the survivor group, median NLR (7 vs. 4.1; <i>p</i> = 0.005), ferritin (507 vs. 328; <i>p</i> = 0.21), and D-dimer (900 vs. 567; <i>p</i> = 0.12) were higher in the nonsurvivor group. Higher age (OR = 1.05; 95% CI = 1.02–1.08), coexisting CKD (OR = 2.59; 95% CI = 1.27–5.29), leukocytosis (OR = 2.52; 95% CI = 1.21–5.28), thrombocytopenia (OR = 0.27; 95% CI = 0.12–0.61), lower SpO2 upon admission (OR = 0.92; 95% CI = 0.89–0.95), and more extensive lung involvement on CT (OR = 1.01; 95% CI = 1.001–1.03) were significant risk factors of in-hospital death.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/5595869","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Connection Between Oral Behaviors and Pain Intensity in Temporomandibular Disorder Patients Undergoing Orthodontic Treatment: A Cross-Sectional Study","authors":"Zihan Zhang,&nbsp;Li Zhang,&nbsp;Yanyu Sun,&nbsp;Rongrong Huo,&nbsp;Yanyue Tan,&nbsp;Fan He,&nbsp;Jun Wang,&nbsp;Shufang Du,&nbsp;Xin Xiong","doi":"10.1155/ijcp/9092053","DOIUrl":"https://doi.org/10.1155/ijcp/9092053","url":null,"abstract":"<div>\u0000 <p>Proper management of painful temporomandibular disorders (PTMDs) is important for guaranteeing optimal orthodontic outcomes. Although correlations between oral behaviors and PTMDs have been confirmed in the general population, there is limited corresponding research within the orthodontic patients. The purpose of this cross-sectional study was to examine how pain intensity correlates with the frequency of various oral behaviors in orthodontic patients. Participants completed a questionnaire survey containing demographic details, an eight-item oral behaviors checklist, the five major temporomandibular disorders symptoms (5Ts) checklist, and a visual analog scale (VAS) to gauge pain intensity. Participants were divided into two groups: PTMD and without PTMD (NPT). The correlation between specific oral behaviors and pain intensity was assessed using both univariate and multivariate linear regression analyses, with adjustment for demographic variables such as age, gender, systemic diseases, and level of education. The study gathered 267 valid questionnaires, showing a prevalence of 59.93% for PTMD. In comparison to the NPT group, the PTMD group exhibited a higher frequency of oral behaviors. Significant correlations were identified between various oral behaviors and pain intensity. Univariate and multivariate linear regression analyses demonstrated positive relationships between pain and oral behaviors. After adjusting for demographic variables, these connections remained statistically significant in the multivariate analysis for sleep bruxism (<i>β</i> = 0.17; 95% CI 0.03, 0.31; <i>p</i> = 0.0175), sleep position pressuring jaw (<i>β</i> = 0.15; 95% CI 0.03, 0.26; <i>p</i> = 0.0118), awake bruxism (<i>β</i> = 0.57; 95% CI 0.26, 0.88; <i>p</i> = 0.0004), and holding, tightening, or tensing muscle without clenching (<i>β</i> = 0.18; 95% CI 0.01, 0.36; <i>p</i> = 0.0415). A significant association was identified between the frequency of oral behaviors and pain intensity in orthodontic patients. Screening and management of oral behaviors might be crucial for controlling TMDs during orthodontic treatment.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/9092053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143875615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Pathogenic Bacteria and Associated Risk Factors of Bloodstream Infections in ICU Patients Undergoing ECMO Support Using mNGS Technology","authors":"Jie Kang,&nbsp;Yi Hang,&nbsp;Zheng Liu,&nbsp;Man Yuan,&nbsp;Xiaosong Qiu,&nbsp;Ying Ye,&nbsp;Yuzhu Zang,&nbsp;Xiaobo Huang,&nbsp;Siyuan Song,&nbsp;Yi Wang","doi":"10.1155/ijcp/4985868","DOIUrl":"https://doi.org/10.1155/ijcp/4985868","url":null,"abstract":"<div>\u0000 <p><b>Objective:</b> To analyze the characteristics of pathogens and related risk factors of bloodstream infections (BSI) in patients undergoing ECMO support using mNGS technology.</p>\u0000 <p><b>Methods:</b> A retrospective analysis was conducted on 59 patients who received ECMO support in the Emergency Intensive Care Unit (EICU) of the Affiliated Hospital of Xuzhou Medical University from January 2021 to March 2024. The patients were divided into two groups based on the presence of BSI: the infection group (BSI group) and the noninfection group (N-BSI group). The clinical data of the two groups were compared, and the characteristics of pathogens were analyzed using mNGS technology. Logistic regression was used to analyze the related risk factors for BSI associated with ECMO.</p>\u0000 <p><b>Results:</b> (1) The incidence of BSI in patients undergoing ECMO support was 20.34%. Compared to the N-BSI group, the BSI group had significantly higher levels of procalcitonin (14.9 ± 7.2 vs. 9.4 ± 4.7), C-reactive protein (140.58 ± 24.64 vs. 87.26 ± 11.06), blood lactate (8.55 ± 1.40 vs. 5.07 ± 0.55), and ECMO catheter indwelling time (12.00 ± 1.71 vs. 7.96 ± 0.76) (<i>p</i> &lt; 0.05). (2) mNGS detection indicated that the BSI group mainly identified viruses and Gram-negative bacilli (G-), with <i>Acinetobacter baumannii</i> being the most prevalent pathogen. The resistance genes were predominantly blaTEM, which confers resistance to penicillins and cephalosporins. (3) Logistic regression analysis revealed that diabetes, ECMO indwelling time, blood lactate levels, and G-bacilli infection were risk factors for BSI during ECMO.</p>\u0000 <p><b>Conclusion:</b> Gram-negative bacteria are the primary pathogens in BSI among patients undergoing ECMO support. Diabetes, ECMO catheter indwelling time, and elevated blood lactate are independent risk factors for these infections. Rational selection of antibiotics and strengthened management of related factors can effectively control the occurrence of BSI during ECMO support.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/4985868","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of a Three-Month Aquatic Training Program on Physical Functioning in Elderly Men: A Randomized Controlled Trial","authors":"Yaser Alikhajeh,&nbsp;Roghayyeh Afroundeh,&nbsp;Mohamad Motevalli,&nbsp;Gholam Rasul Mohammad Rahimi,&nbsp;Ozkan Isik","doi":"10.1155/ijcp/9157147","DOIUrl":"https://doi.org/10.1155/ijcp/9157147","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Aquatic training is emerging as a multifaceted therapy for enhancing health parameters, particularly among elderly populations. This study aimed to investigate the effects of a three-month aquatic training on physical functioning, including balance, muscular strength, and flexibility, among healthy older men.</p>\u0000 <p><b>Methods:</b> From an initial sample of 80 elderly men, 45 healthy participants (mean age: 75.5 years) were randomly assigned to either the intervention (<i>n</i> = 23) or control group (<i>n</i> = 22). The intervention group participated in three 60-min sessions per week for 12 weeks. Functional fitness variables, encompassing upper and lower body flexibility and muscular strength, along with dynamic and static balance, were assessed using multiple tests at both baseline and postintervention. The training load increased gradually over the 12-week program, ranging between 50% and 70% of heart rate reserve (HRR). Exercise intensity was controlled using the rate of perceived exertion (RPE) scale, aiming for a targeted range of 12–15 on the Borg scale. The control group maintained their usual daily activities throughout the study period, providing a basis for comparison with the exercise intervention group.</p>\u0000 <p><b>Results:</b> No significant baseline differences in demographic characteristics were observed between the study groups (<i>p</i> &gt; 0.05). Compared to the control group, the intervention group demonstrated significant improvements across all outcome measures, including static balance, dynamic balance, upper and lower body flexibility, and upper and lower body muscular strength (<i>p</i> &lt; 0.001).</p>\u0000 <p><b>Conclusion:</b> The study findings highlight the efficacy of aquatic training in enhancing various aspects of physical functioning among older men, supporting the growing recognition of aquatic training as an effective therapeutic approach for promoting vitality and independence in elderly populations.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/9157147","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Attitudes, and Practices Toward Orthostatic Intolerance Among Surgical Medical Staff in Chongqing, China: A Web-Based Cross-Sectional Study","authors":"Hongjie Yi,&nbsp;Wenfeng Tang","doi":"10.1155/ijcp/6622089","DOIUrl":"https://doi.org/10.1155/ijcp/6622089","url":null,"abstract":"<div>\u0000 <p><b>Objective:</b> To explore the knowledge, attitudes, and practices (KAPs) toward orthostatic intolerance (OI) among surgical medical staff in Chongqing, China.</p>\u0000 <p><b>Methods:</b> Surgical medical staff of the First Affiliated Hospital of Chongqing Medical University were recruited in this cross-sectional study between March and April 2023. The data were collected using a self-administered questionnaire. Statistical analyses, including tests of relationships such as Spearman correlation analysis and structural equation modeling (SEM), were performed using SPSS 22 and AMOS software.</p>\u0000 <p><b>Results:</b> A total of 392 valid questionnaires were analyzed, including 24 (6.12%) filled out by doctors and 368 (93.88%) filled out by nurses. Among the participants, there were 345 females (88.01%) and 47 males (11.99%), mostly aged between 20 and 40 years (86.7%). The average KAPs scores were 10.02 ± 2.08, 40.48 ± 6.87, and 43.27 ± 8.67, respectively. Positive correlations were found between knowledge and attitudes (<i>r</i> = 0.0289, <i>p</i> &lt; 0.001), knowledge and practices (<i>r</i> = 0.028, <i>p</i> &lt; 0.001), and attitudes and practices (<i>r</i> = 0.594, <i>p</i> &lt; 0.001). SEM revealed direct effects of knowledge on attitudes (Estimate = 0.625, <i>p</i> &lt; 0.001) and attitudes on practices (Estimate = 0.700, <i>p</i> &lt; 0.001), suggesting an indirect effect of knowledge on practices, with knowledge also directly influencing practices (Estimate = 0.375, <i>p</i> = 0.033).</p>\u0000 <p><b>Conclusion:</b> Surgical medical staff in Chongqing demonstrated moderate knowledge, positive attitudes, and moderate practices regarding OI. Targeted interventions to enhance knowledge and attitudes may improve practices and optimize patient outcomes.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/6622089","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics and Drug Susceptibility Profiling of Multidrug-Resistant Pseudomonas aeruginosa Infections","authors":"Mingxia Cai,&nbsp;Zhibin Zhou,&nbsp;Jiaming Huang,&nbsp;Yuxia Du","doi":"10.1155/ijcp/2755014","DOIUrl":"https://doi.org/10.1155/ijcp/2755014","url":null,"abstract":"<div>\u0000 <p><b>Objective:</b> To investigate the epidemiology of <i>Pseudomonas aeruginosa</i> (PA) in hospitalized patients with PA respiratory infections and to analyze the clinical characteristics and antibiotic resistance profiles of drug-resistant PA, providing valuable insights to inform clinical management strategies.</p>\u0000 <p><b>Methods:</b> A retrospective analysis of clinical data from hospitalized patients with PA respiratory infections was collected and analyzed to investigate the clinical features and their correlation with PA drug resistance.</p>\u0000 <p><b>Results:</b> In the study cohort, 34.1% (<i>n</i> = 93) of patients were classified as having multidrug-resistant <i>Pseudomonas aeruginosa</i> (MDR-PA), while 65.9% (<i>n</i> = 180) were non-MDR-PA. Logistic regression identified that male gender, ICU admission, hemiplegia, and mechanical ventilation were independent risk factors for MDR-PA infection (all <i>p</i> &lt; 0.05). Multivariate analysis showed male gender (OR 2.44, 95% CI 1.15–5.17) and hemiplegia (OR 2.99, 95% CI 1.02–8.82) as significant factors for MDR-PA infection. Both analyses also confirmed mechanical ventilation as an independent risk factor for difficult-to-treat <i>Pseudomonas aeruginosa</i> (DTR-PA) infections. MDR-PA exhibited low susceptibility to meropenem (32.3%) and imipenem (18.3%), whereas aminoglycosides showed higher effectiveness, with over 80% susceptibility against MDR-PA and more than 50% susceptibility against DTR-PA.</p>\u0000 <p><b>Conclusion:</b> Male patients with hemiplegia should be closely monitored for MDR-PA infections when PA is detected. Mechanical ventilation necessitates vigilance against DTR-PA. Aminoglycoside-based combination therapy offers an effective empirical option for resistant PA infections. These findings indicate the need for antimicrobial stewardship or infection control measures to address MDR-PA and DTR-PA infections.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/2755014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}