International Journal of Clinical Practice最新文献

{"title":"Advancing Biomedical Engineering With Artificial Intelligence and Machine Learning: A Systematic Review","authors":"Abebe Belay Adege","doi":"10.1155/ijcp/9888902","DOIUrl":"https://doi.org/10.1155/ijcp/9888902","url":null,"abstract":"<div>\u0000 <p>The inclusion of artificial intelligence (AI) and machine learning (ML) in biomedical engineering opens new frontiers of innovation and better decision-making and allows the art to cross new thresholds in healthcare technologies. This review focuses on the primary contributions of AI and ML to the advancement of biomedical engineering, particularly in the areas of diagnostic tools, predictive analytics, and personalized medicine. This will further allow us to identify possible the state-of-the-art solutions by using new frameworks for applications including medical imaging, wearables, and biomanufacturing. Also, it reflects on how ethics in AI and ML for biomedical challenges address important issues such as bias, privacy, and accountability. It also underlines how different opportunities and challenges can be opened or addressed by the integration of AI-driven systems in biomedical workflows: engineering, clinicians, and data scientists have to cooperate. Emerging technologies, including but not limited to deep learning, natural language processing, and reinforcement learning, are discussed for their potential to alter biomedical research and clinical practice. The work concludes with a look at the future of biomedical engineering, where AI and ML have brought a domain of synergy into innovation, better patient outcomes, and impactful advancement. It thus also provides a prescription for the need for ethics in the adoption of AI, together with collaborative efforts toward maximum transformative technology.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/9888902","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excessive Daytime Sleepiness and Oral Behaviors: A Pilot Investigation Among Patients With Temporomandibular Disorders","authors":"Jie Xiang,&nbsp;Jiaqi Liu,&nbsp;Zihan Zhang,&nbsp;Zejin Liu,&nbsp;Yunhao Zheng,&nbsp;Yating Yi,&nbsp;Xueman Zhou,&nbsp;Jun Wang,&nbsp;Fan Yang,&nbsp;Xin Xiong","doi":"10.1155/ijcp/6688314","DOIUrl":"https://doi.org/10.1155/ijcp/6688314","url":null,"abstract":"<div>\u0000 <p><b>Objective:</b> To explore the relationship between excessive daytime sleepiness (EDS) and oral behaviors of patients with temporomandibular disorders (TMD).</p>\u0000 <p><b>Methods:</b> A total of 567 TMD patients were included in the pilot study. The Oral Behavior Checklist (OBC) was employed to evaluate the oral behaviors of participants, and the Epworth Sleepiness Scale was utilized to assess EDS. Besides, the seven-item generalized anxiety disorder (GAD-7) and nine-item Patient Health Questionnaire (PHQ-9) were applied to assess the severity of anxiety and depression. All assessment tools were used in validated Chinese versions. Statistical analyses were conducted appropriately to detect the possible differences and correlations.</p>\u0000 <p><b>Results:</b> Compared with non-EDS counterparts, TMD patients with EDS exhibited higher OBC scores and OBC level (<i>p</i> &lt; 0.05). Binary logistic analyses demonstrated a significant correlation between EDS and OBC level (odds ratio (OR) = 1.780, <i>p</i> = 0.031). Specifically, “Awake grinding” (OR = 6.854, <i>p</i> = 0.020), “Awake clenching” (OR = 2.190, <i>p</i> = 0.012), and “Press tongue forcibly against teeth” (OR = 3.477, <i>p</i> = 0.032) were identified to be positively correlated with EDS in TMD patients.</p>\u0000 <p><b>Conclusions:</b> Elevated OBC scores and oral behavior level were associated with the presence of EDS in TMD patients. Behaviors including awake grinding, awake clenching, and press tongue forcibly against teeth may serve as reliable predictors of EDS in individuals with TMD. Addressing these parafunctional oral behaviors could potentially yield therapeutic benefits in the comprehensive management of TMD patients. Longitudinal trials in the future are worthwhile for a further validation.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/6688314","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carpal Tunnel Syndrome Diagnostics Revisited: A Comprehensive Review","authors":"Stanisław Słyk,&nbsp;Nina Kamińska-Słyk,&nbsp;Izabela Domitrz","doi":"10.1155/ijcp/2893823","DOIUrl":"https://doi.org/10.1155/ijcp/2893823","url":null,"abstract":"<div>\u0000 <p>Carpal tunnel syndrome (CTS) remains the most common peripheral entrapment neuropathy worldwide. There are several challenges associated with CTS diagnostic process. The most widely accepted gold standard is clinical assessment. Its subjective nature and the experience required pose an insurmountable challenge when aiming to achieve satisfactory accuracy and consistency. Nerve conduction and imaging studies are not widely available to general practitioners and have to be performed by specialists, which prolongs the diagnostic process. Meanwhile, the syndrome may progress, leading to the exacerbation of symptoms. Furthermore, the therapeutic decisions have to be well-founded, as invasive surgeries are often considered as the treatment of choice in more severe CTS cases. A resurging alternative method, which shows a lot of promise, is quantitative sensory testing. For the purposes of this review, databases available in Medical University of Warsaw resources were screened and evaluated by two independent reviewers. 29 studies were identified for further assessment. There is a need to reconsider the commonplace trends and establish proper diagnostic guidelines. The available diagnostic methods should be viewed as complementary rather than standalone. Choosing the right combination can provide a more accurate and comprehensive evaluations of CTS, helping to confirm the diagnosis, assess severity, and guide treatment options.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/2893823","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Research Progress and Hotspots: A Bibliometric Analysis of Hip Dislocation","authors":"Jingyue Su,&nbsp;Chenhao Jia,&nbsp;Pengyu Xiang,&nbsp;Shanshan Gao,&nbsp;Xin Chen,&nbsp;Shengwu Yang,&nbsp;Zhenhan Deng,&nbsp;Chunwu Zhang","doi":"10.1155/ijcp/8897100","DOIUrl":"https://doi.org/10.1155/ijcp/8897100","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Hip dislocation is a common and complicated orthopedic problem for clinicians. However, there is a lack of literature that systematically analyzes the global research development in the past decade on hip dislocation.</p>\u0000 <p><b>Objective:</b> To provide a more comprehensive perspective on the development trends, research hotspots, and frontiers, this study utilizes the bibliometric methods to analyze published literature with regard to hip dislocation.</p>\u0000 <p><b>Methods:</b> Literature concerning hip dislocation published between January 1, 2015, and October 23, 2024, was retrieved from the Web of Science Core Collection database. The retrieved data were imported into CiteSpace, VOSviewer, and the Bibliometrix package of R software for bibliometric analysis.</p>\u0000 <p><b>Results:</b> The results showed that Domb B and Abdel MP were the two authors with the highest output. Journal of Arthroplasty was the journal with the most publications. Hospital for Special Surgery was the most relevant institution. The United States was the biggest contributor. “Dislocation,” “replacement,” and “total hip arthroplasty” were the most frequent keywords in the literature, while “spinal deformity,” “tumor,” “3d printing,” “health,” and “scoliosis” represent the current and future research hotspots.</p>\u0000 <p><b>Conclusion:</b> Driven by authors, institutions, and journals mainly in the United States, research on hip dislocation has been steadily advancing, accompanied by emerging trends focusing on new surgical methods, innovations in implants, and personalized risk mitigation strategies, etc.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/8897100","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Frailty-Adjusted Prognosis Tool for 30-Day Mortality in Older Emergency Department Patients","authors":"A. Z. Szczesna,&nbsp;S. K. Nissen,&nbsp;M. Brabrand,&nbsp;R. Bingisser,&nbsp;C. H. Nickel","doi":"10.1155/ijcp/2048711","DOIUrl":"https://doi.org/10.1155/ijcp/2048711","url":null,"abstract":"<div>\u0000 <p><b>Aim:</b> Accurate prognostication in the older population in the emergency department (ED) is a crucial but difficult skill. Both frailty and vital signs are independent predictors of mortality, but relying on vital signs alone underestimates risk. The Frailty-adjusted Prognosis tool (FaP-ED) was developed to predict 30-day mortality in older ED patients by combining vital signs with degree of frailty. We aim to validate FaP-ED in an independent ED population for 30-day mortality prediction.</p>\u0000 <p><b>Method:</b> This study is based on a single-centre, observational prospective cohort of undifferentiated consecutive ED patients ≥ 65 years. FaP-ED combines the National Early Warning Score (NEWS) and the Clinical Frailty Scale (CFS) in multivariable logistic regression. We assessed discrimination of FaP-ED with area under the receiver operating characteristic (AUROC) and calibration using slope and intercept.</p>\u0000 <p><b>Results:</b> Among 1166 analysed patients, median age was 78%, and 53.1% were female. In total, 2.7% died within 30 days of presentation to ED. The median NEWS was 1.0 and the median CFS was 3. FaP-ED showed good discrimination with an area under the curve (AUC) of 0.84 in comparison with NEWS (AUC 0.82) and CFS (AUC 0.79) as well as good calibration (slope 1.05; intercept −0.27) compared to NEWS (slope 1.13; intercept −0.24) and CFS (slope 0.95; intercept −0.57).</p>\u0000 <p><b>Conclusion:</b> FaP-ED showed robust prognostic performance in temporal validation, with less biased estimates than NEWS and CFS alone. It could be implemented as an integral adjunct in addition to holistic, pragmatic, patient-centred care of the older population.</p>\u0000 <p><b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT05400707</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/2048711","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eligibility for Magnetic Resonance-Guided High Intensity Focused Ultrasound in Patients Referred for Radiotherapy on Painful Nonspinal Bone Metastases","authors":"Renée Hovenier,&nbsp;Derk J. Slotman,&nbsp;Chiara Gasperini,&nbsp;Alice Zamagni,&nbsp;Mira Huhtala,&nbsp;Manon N. G. J. A. Braat,&nbsp;Wietse S. C. Eppinga,&nbsp;Nicolien Kasperts,&nbsp;Erik C. J. Phernambucq,&nbsp;Martijn F. Boomsma,&nbsp;Ingrid M. Nijholt,&nbsp;Roberto Blanco Sequeiros,&nbsp;Alberto Bazzocchi,&nbsp;Alessio G. Morganti,&nbsp;Chrit T. W. Moonen,&nbsp;Clemens Bos,&nbsp;Helena M. Verkooijen,&nbsp;the FURTHER Consortium","doi":"10.1155/ijcp/4962457","DOIUrl":"https://doi.org/10.1155/ijcp/4962457","url":null,"abstract":"<div>\u0000 <p><b>Purpose:</b> This prospective observational study aims to investigate which proportion of patients with bone metastases referred for External Beam Radiation Therapy (EBRT) would be able to undergo Magnetic Resonance-guided High Intensity Focused Ultrasound (MR-HIFU) as alternative to EBRT, and to examine reasons for ineligibility.</p>\u0000 <p><b>Materials and Methods:</b> Adult patients with nonspinal bone metastases referred to four radiotherapy departments were included. Local, multidisciplinary teams assessed which patients would be eligible for MR-HIFU. The main reason(s) for ineligibility were categorized as patient-related or lesion-related. A random subsample of 30 ineligible patients were analyzed in detail to identify all reasons of ineligibility.</p>\u0000 <p><b>Results:</b> Overall, 57 of 741 (8%) nonspinal bone lesions were eligible for MR-HIFU as alternative to EBRT. In total, 153 lesions (21%) in 130 patients were ineligible because of patient-related factors, including curative treatment intent for oligo-metastatic disease (10%), and poor performance status (8%). Of the remaining 588 bone metastases in 526 patients, 531 lesions (470 patients) were ineligible because of lesion-related factors, including ‘lesion too extensive/advanced’ (29%), ‘(impending) pathological fracture’ (15%), ‘no moderate/severe pain from target lesion’ (11%). Proportion of ineligibility varied between centers from 70% to 96%, which was mainly attributable to differences in patient-related factors. Within the random subsample of 30 ineligible patients, 27 patients had multiple reasons for ineligibility.</p>\u0000 <p><b>Conclusion:</b> A small proportion of patients, referred for EBRT of bone metastases, would be eligible to undergo MR-HIFU as alternative palliation option. Taken together, patients presenting with small, localized lesions in nonspinal regions, primarily seeking pain relief without additional treatment goals are the most promising candidates for this therapy. These factors could be used to triage patients eligible for MR-HIFU, thereby reducing unnecessary screening efforts, enhancing patient selection, and ultimately improve patient management strategies by optimizing the use of MR-HIFU as a treatment option.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/4962457","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144550903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Improvement of General Condition and Immunity Function of CKD After Treatment With Bailing Capsule: A Randomized Clinical Trial","authors":"Wanjia Chen,&nbsp;Rong Zheng,&nbsp;Xiaohong Cheng,&nbsp;Hongtao Yang,&nbsp;Yueyi Deng","doi":"10.1155/ijcp/7803666","DOIUrl":"https://doi.org/10.1155/ijcp/7803666","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> The management of chronic kidney disease (CKD) presents significant challenges, with people often exploring new treatment strategies and medications in an attempt to slow disease progression. This study seeks to evaluate the efficacy of Bailing capsules in the treatment of CKD.</p>\u0000 <p><b>Methods:</b> A total of 148 patients with CKD and renal and spleen qi insufficiency were included in this study. The experimental group (<i>n</i> = 87) received Bailing capsules in addition to the standard treatment, while the control group (<i>n</i> = 61) received only the standard treatment. The study used both subjective and objective endpoints, including traditional Chinese medicine (TCM) syndrome scores, routine blood tests, biochemical markers, and lymphocyte counts, to evaluate the efficacy of Bailing capsules.</p>\u0000 <p><b>Results:</b> After statistical analysis, we found that the experimental group showed a significant decrease in TCM syndrome scores and in various biochemical indices, including reduced levels of cystatin C, 24-h urine protein, bilirubin, gamma-glutamyl transferase, and urinary red blood cell count (<i>p</i> &lt; 0.05). Additionally, the experimental group demonstrated an increase in white blood cell counts and regulation of immune function markers, such as CD3, CD4, and CD19 (<i>p</i> &lt; 0.05).</p>\u0000 <p><b>Conclusion:</b> After treatment, the relevant indicators of CKD showed significant improvement, and the patients’ immune function was also partially regulated. Notably, no significant adverse reactions were observed that would necessitate the termination of the study. Further investigation is required to gain a deeper understanding of these findings, particularly regarding the effects of Bailing capsules on immune function regulation in CKD.</p>\u0000 <p><b>Trial Registration:</b> Chinese Registry of Clinical Trials: ChiCTR-IPR-17014157</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/7803666","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144524505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Biomarkers in Pleural Effusions: ACE1, ACE2, and KLK12 Levels","authors":"Serkan Sen,&nbsp;Ahmet Dumanli","doi":"10.1155/ijcp/4269986","DOIUrl":"https://doi.org/10.1155/ijcp/4269986","url":null,"abstract":"<div>\u0000 <p><b>Aim:</b> This study aims to investigate the potential roles of angiotensin converting enzyme (ACE) 1 and ACE2, along with kallikrein-related peptidase 12 (KLK12) levels in pleural fluids and serum, in distinguishing between transudative and exudative pleural effusions.</p>\u0000 <p><b>Methods:</b> Pleural fluid and serum samples were collected from a total of 46 patients. Levels of ACE1, ACE2, and KLK12 were measured using the ELISA method. Patients were classified as having transudative or exudative pleural effusions based on Light’s criteria. Data were analyzed using statistical methods.</p>\u0000 <p><b>Results:</b> According to the study findings, ACE1 levels in pleural fluid were significantly higher in the exudative group compared with the transudative group. There was no significant difference observed in ACE2 levels between the two groups. Interestingly, KLK12 levels were found to be higher in the transudative group compared with the exudative group. In serum, both ACE1 and ACE2 levels were significantly higher in the exudative group.</p>\u0000 <p><b>Discussion:</b> These results indicate that ACE1 and KLK12 may serve as important biomarkers in the diagnostic evaluation of pleural effusions. In particular, the pleural fluid to serum (PF/S) ratios of ACE1 and KLK12 showed statistically significant differences between transudative and exudative groups, highlighting their potential in differentiating pleural effusion etiologies. While pleural fluid ACE2 levels alone did not show a significant difference, serum ACE2 concentrations and PF/S ACE2 ratios differed significantly, suggesting possible systemic changes. These findings underscore the importance of evaluating serum parameters alongside pleural fluid analysis as such comparisons may enhance diagnostic accuracy. However, the relatively small sample size limits the generalizability of these results, and further studies with larger cohorts are warranted to confirm these findings.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/4269986","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144524506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrocardiographic Findings in Patients Hospitalized With COVID-19: Retrospective Study","authors":"Sima Sobhani Shahri,&nbsp;Fateme Mahdizadeh,&nbsp;Abdol Sattar Pagheh,&nbsp;Mohammad Reza Khazdair,&nbsp;Mohamad Karimi,&nbsp;Seyed Mohammad Riahi,&nbsp;Mohammad Yousof Qoddusi,&nbsp;Moloud Foogerdi,&nbsp;Anahita Arian,&nbsp;Shima Heidary,&nbsp;Toba Kazemi","doi":"10.1155/ijcp/3806729","DOIUrl":"https://doi.org/10.1155/ijcp/3806729","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> COVID-19 can involve the heart, which is associated with an increase in morbidity and mortality and can detected by electrocardiogram (ECG). So, in this study, we assess ECG changes in COVID-19-infected patients during hospitalization.</p>\u0000 <p><b>Methods:</b> In this study, we examined the ECGs of 474 patients with COVID-19 positive at Birjand Vali-Asr Hospital (east of Iran). All the ECGs were taken by a single device and interpreted by a cardiologist. Demographic information, past medical history, and severity of COVID disease (in terms of oxygen saturation, respiratory distress, and need for emergency care) were entered in the checklist. Data were entered into SPSS Version 22 and analyzed. A <i>p</i> value of ≤ 0.05 was considered as a significant level.</p>\u0000 <p><b>Results:</b> The patient’s mean age was 57.13 ± 18.7 years, and 55% of them were men; 428 (89.5%) patients survived and 49 (10.5%) died. About 78% of patients had abnormal ECG, which was higher in deceased patients significantly (91.8%, <i>p</i> = 0.03). Most frequent abnormalities include 40.3% of dysrhythmia (sinus tachycardia, atrial fibrillation, and sinus bradycardia), 30.1% of abnormal rate (tachycardia, bradycardia), and 30% of low-voltage ECG. Statistical analysis showed that after multivariable logistic regression, tachycardia (OR = 2.65 [1.2–5.8]; <i>p</i> = 0.015) and ST-segment elevation (OR = 2.9 [1.2–7.2]; <i>p</i> = 0.023) were directly related to the disease severity and mortality.</p>\u0000 <p><b>Conclusion:</b> ECG changes are very common in COVID-19 patients, especially rate and rhythm changes. Tachycardia and ST segment elevation were associated with mortality. ECG changes are very common in COVID-19 patients, especially changes in rate and rhythm. Tachycardia and ST segment elevation were associated with mortality. Since the ECG is a simple, cheap, and safe diagnostic method, it is necessary to take an initial ECG from the patient in acute upper respiratory infections such as COVID-19, at least for patients with severe disease. In our study, the significant point was the presence of low voltage in ECG in one-third of the patients with COVID-19, which requires further research in this field.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/3806729","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlations Between Thyroid Hormone Levels of Women With Twin Pregnancies in the Third Trimester and Pregnancy Complications and Pregnancy Outcomes","authors":"Lin Yang,&nbsp;Dan Lu,&nbsp;Zhi Liu,&nbsp;Anbang Wang,&nbsp;Aocheng Wang,&nbsp;Jianbo Xia","doi":"10.1155/ijcp/8447857","DOIUrl":"https://doi.org/10.1155/ijcp/8447857","url":null,"abstract":"&lt;div&gt;\u0000 &lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; To explore changes in thyroid hormone levels of women with twin pregnancies in the third trimester under different pregnancy complications and pregnancy outcomes and to analyze their associated correlations.&lt;/p&gt;\u0000 &lt;p&gt;&lt;b&gt;Methods:&lt;/b&gt; A total of 646 women with twin pregnancies who attended their first prenatal visit and received subsequent prenatal care in our hospital were enrolled in this study. Their thyroid hormone levels—free thyroxine (FT4), thyroid-stimulating hormone (TSH), and thyroid peroxidase antibody (TPO-Ab)—in the third trimester were collected for analysis of correlations with pregnancy complications and outcomes, using Spearman’s correlation and a logistic regression model.&lt;/p&gt;\u0000 &lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Adverse events, such as premature birth, premature rupture of membranes, placental abruption, fetal distress, fetal growth restriction, neonatal asphyxia, pregnancy-induced hypertension, gestational diabetes mellitus, and postpartum hemorrhage, occurred among the 646 women with twin pregnancies in the third trimester. The highest proportion of pregnancy outcomes was premature birth, accounting for 42.26%, and the top two pregnancy complications were gestational diabetes mellitus and pregnancy-induced hypertension, accounting for 31.42% and 20.28%, respectively. Assisted reproduction and twin type correlated with fetal distress during the third trimester of pregnancy and neonatal asphyxia. Maternal age correlated with gestational diabetes mellitus in the third trimester of pregnancy and postpartum hemorrhage. FT4 levels varied in pregnant women with placental abruption, TSH levels varied in pregnant women with pregnancy-induced hypertension, and TPO-Ab levels varied in pregnant women with premature birth, placental abruption, and postpartum hemorrhage.&lt;/p&gt;\u0000 &lt;p&gt;&lt;b&gt;Study Limitations:&lt;/b&gt; This study only analyzed thyroid hormone levels at a single timepoint (third trimester) during pregnancy. Dynamic changes in hormone levels across different gestational stages—such as TSH suppression patterns in the first trimester due to hCG elevation or FT4 adjustments in the second trimester—were not tracked. This limitation may hinder the understanding of how temporal hormonal variations contribute to complications like gestational diabetes mellitus or placental abruption. For instance, transient TSH fluctuations in early pregnancy or mid-trimester FT4 instability might differently influence outcomes. Future studies should incorporate longitudinal monitoring at multiple intervals (e.g., first, second, and third trimesters) to capture hormonal trajectories and their phase-specific associations with adverse outcomes. Additionally, the exclusion of women with preexisting thyroid conditions or medication use limits the generalizability of findings to high-risk populations who may benefit most from thyroid monitoring. The single-timepoint design also precludes causal inference—while correlat","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/8447857","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}