International Journal of Clinical Practice最新文献

{"title":"Corrigendum to “Evaluation of Atrioventricular Valve Regurgitation in Detection of Atrioventricular Septal Defects at First Trimester Ultrasound”","authors":"","doi":"10.1155/ijcp/9893219","DOIUrl":"https://doi.org/10.1155/ijcp/9893219","url":null,"abstract":"<p>Z. Guo, Y. Yan, Y. Zhili, et al., “Evaluation of Atrioventricular Valve Regurgitation in Detection of Atrioventricular Septal Defects at First Trimester Ultrasound,” <i>International Journal of Clinical Practice</i> 2024, no. 1 (2024): 1–8, https://doi.org/10.1155/2024/5027009.</p><p>In the article titled “Evaluation of Atrioventricular Valve Regurgitation in Detection of Atrioventricular Septal Defects at First Trimester Ultrasound,” there was an error in affiliation numbers 1–3. In the corrected affiliation, the hospital name has been changed from “Jiangxi Provincial Maternal and Child Health Hospital” to “Jiangxi Maternal and Child Health Hospital.” The corrected affiliation appears below:</p><p>¹Department of Ultrasound, Jiangxi Maternal and Child Health Hospital, Nanchang, China</p><p>²Department of Prenatal Diagnosis, Jiangxi Maternal and Child Health Hospital, Nanchang, China</p><p>³Department of Reproduction Medicine Center, Jiangxi Maternal and Child Health Hospital, Nanchang, China</p><p>We apologize for this error.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/9893219","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144197234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Death Risk Score Model of Hospitalized COVID-19 Patients: A Cohort Study","authors":"Gustavo A. Cruz,&nbsp;Thais B. Boteon,&nbsp;Henrique Pott,&nbsp;Sigrid de Sousa dos Santos,&nbsp;Bruna Dias de Lima Fragelli,&nbsp;Cynthia Aparecida de Castro,&nbsp;Joice Margareth de Almeida Rodolpho,&nbsp;Davi Casale Aragon,&nbsp;Fernanda de F. Anibal,&nbsp;Meliza Goi Roscani","doi":"10.1155/ijcp/6356936","DOIUrl":"https://doi.org/10.1155/ijcp/6356936","url":null,"abstract":"<div>\u0000 <p><b>Introduction:</b> The aim of this study was to establish a predictive model of risk of mortality in hospitalized COVID-19 patients.</p>\u0000 <p><b>Methods:</b> Cohort study in hospitalized patients due to COVID-19 followed-up until death or discharge. They underwent clinical evaluation and laboratory tests on hospital admission and were investigated until death or hospital discharge. A death model risk was purposed based on clinical predictors on hospital admission.</p>\u0000 <p><b>Results:</b> A total of 215 patients were enrolled, with 39 deaths. The predictors of risk of mortality were age (relative risk (RR): 3,05 [1.65–5.63]), serum creatinine (RR: 7.39 [3.81–14.34]), peripheral blood lymphocyte counts (RR: 5.94 [3.78–9.31]), platelet counts (RR: 3.26 [1.81–5.9]), serum lactate dehydrogenase (LDH; RR: 5.85 [3.75–9.17), and C-reactive protein (CRP; RR: 3.36 [1.66–6.79]). The death risk considering the punctuation (points) above was age &gt; 64 years (1 point), platelet counts &lt; 197,000 cell/mm³ (1 point), LDH &gt; 823 UI/L (1 point), lymphocytes &lt; 373,000 cell/mm³ (1 point), creatinine &gt; 1.2 mg/dL (1 point), and CRP &gt; 7.68 mg/dL (1 point). The death risk considering the punctuation (points) above was 6: 95%, 5: 85%–92%, 4: 50%–88%, 3: 29%–74%, 2: 17%–39%, and 1: 14%–31%.</p>\u0000 <p><b>Conclusion:</b> The routine laboratory on hospital admission may be a good predictor of mortality during the hospitalization follow-up of COVID-19 patients. A score risk may be adjusted and calculated based on these markers.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/6356936","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Therapeutic Effectiveness of Segmental Lung Resection Versus Lobectomy in Patients With Isolated Lung Metastases From Colorectal Cancer: Evidence From a Retrospective Cohort Study","authors":"Changhao Que,&nbsp;Qi Wang,&nbsp;Zhibo Ye,&nbsp;Peiyuan Lu,&nbsp;Chengfang Li,&nbsp;Dacheng Jin,&nbsp;Yaping Wang,&nbsp;Yunjiu Gou","doi":"10.1155/ijcp/9035094","DOIUrl":"https://doi.org/10.1155/ijcp/9035094","url":null,"abstract":"<div>\u0000 <p><b>Introduction:</b> In patients with solitary pulmonary metastasis from colorectal cancer, surgical resection is considered a standard treatment protocol and is routinely performed in thoracic surgery. However, there is a paucity of studies that delve into the detailed discussion of the efficacy and safety of lobectomy and segmentectomy in the treatment of pulmonary metastatic cancer. Our study retrospectively analyzed the surgical outcomes of 62 patients from a single center and reported the findings.</p>\u0000 <p><b>Methods:</b> A retrospective analysis was meticulously conducted on a cohort of 62 patients who underwent either lung segmental resection (<i>n</i> = 31) or lobectomy (<i>n</i> = 31) for isolated lung metastases at the department of thoracic surgery of Gansu Provincial People’s Hospital, spanning a decade from September 2015 to September 2024. The surgical data were thoroughly examined, encompassing perioperative details and patient outcomes.</p>\u0000 <p><b>Results:</b> Both surgical approaches achieved successful resection of colorectal cancer lung metastases, without any perioperative mortality reported. In comparison to the group undergoing lung segmental resection, the cohort receiving lobectomy exhibited significantly larger tumor diameters (<i>p</i> &lt; 0.001), prolonged operative durations (<i>p</i> &lt; 0.001), increased intraoperative bleeding (<i>p</i> = 0.002), augmented drainage volume on the first postoperative day (<i>p</i> &lt; 0.001), greater total postoperative drainage (<i>p</i> &lt; 0.001), and elevated operative costs (<i>p</i> &lt; 0.001). However, there were no statistically significant differences between the two groups regarding postoperative pain scores (<i>p</i> = 0.755), time to postoperative extubation (<i>p</i> = 0.744), time to postoperative ambulation (<i>p</i> = 0.742), duration of postoperative hospital stay (<i>p</i> = 0.870), lymph node metastasis (<i>p</i> = 0.671), postoperative complications (<i>p</i> = 0.562), survival rate (<i>p</i> = 0.550), recurrence-free survival rate (<i>p</i> = 0.450), and cumulative incidence (<i>p</i> = 0.321).</p>\u0000 <p><b>Conclusions:</b> Pulmonary segmentectomy offers superior advantages in terms of operative time, intraoperative blood loss, drainage volume on the first postoperative day, total postoperative drainage volume, and surgical costs.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/9035094","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prediction of 28-Day Mortality in Crush Syndrome by Evaluating Lactate/Albumin Ratio in Patients Presented to the Emergency Department After an Earthquake","authors":"Bilgehan Demir,&nbsp;İbrahim Çaltekin","doi":"10.1155/ijcp/5391050","DOIUrl":"https://doi.org/10.1155/ijcp/5391050","url":null,"abstract":"<div>\u0000 <p><b>Introduction:</b> Crush syndrome (CS) is a primary cause of mortality among survivors following earthquakes. Determining discharge outcomes and mortality in cases of CS is critical for guiding management strategies. Biomarkers may be utilized to predict survival and mortality in CS cases early and accurately; however, those currently used are primarily intended for disease diagnosis.</p>\u0000 <p><b>Objectives:</b> Considering that cases associated with impaired vital signs and organ perfusion show alterations in lactate, albumin, and the lactate/albumin (L/A) ratio, it was hypothesized that the L/A ratio could serve as a prognostic and mortality predictor in CS cases.</p>\u0000 <p><b>Methods:</b> Following the February 2023 Kahramanmaraş earthquake, 1145 trauma patients presenting to the hospital emergency department were evaluated. Among these, 62 patients meeting the inclusion criteria were diagnosed with CS. Patient records were retrieved from archives and the hospital management information system. Anamnesis, physical examination findings, laboratory results, consultations, and discharge summaries were retrospectively analyzed.</p>\u0000 <p><b>Results:</b> A total of 62 CS cases meeting the inclusion criteria were included in the study. Upon evaluating the patients’ initial lactate, albumin, and L/A ratio levels, lactate and L/A ratio levels were significantly higher in the deceased group compared to the survivors, while albumin levels were significantly lower (<i>p</i> = 0.018, <i>p</i> = 0.003, and <i>p</i> = 0.007, respectively). To predict 28-day mortality, a cutoff value of 4.35 was determined for lactate with 73.3% sensitivity and 66% specificity (AUC: 0.735). For the L/A ratio, a cutoff value of 1.2 was identified with 86.7% sensitivity and 70.2% specificity (AUC: 0.811). For albumin, a cutoff value of 3.35 was established with 66% sensitivity and 60% specificity (AUC: 0.721). K, lactate, and albumin showed low correlation with mortality, whereas the L/A ratio demonstrated a moderate correlation with mortality.</p>\u0000 <p><b>Conclusion:</b> The serum L/A ratio can serve as a guide in diagnostic decision making for the prediction of CS in patients, and the blood L/A ratio has been found to be a biomarker that can be used to predict 28-day mortality in patients with CS.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/5391050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144125973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Diagnostic Biomarker Model for Chronic Fibrosis After Liver Transplantation","authors":"Meicheng Pan,&nbsp;Yawei Qian,&nbsp;Junjie Zhou,&nbsp;Yi Liu,&nbsp;Zhihan Xiao,&nbsp;Lian Gu","doi":"10.1155/ijcp/6433958","DOIUrl":"https://doi.org/10.1155/ijcp/6433958","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Liver transplantation is a critical treatment for chronic liver disease; however, rejection and chronic fibrosis of the transplanted liver remain significant challenges. Understanding the mechanisms and high-level factors contributing to these complications has garnered considerable interest.</p>\u0000 <p><b>Methods:</b> Gene expression matrices from homozygous liver samples in the Gene Expression Omnibus database were screened for inclusion. Differentially expressed genes (DEGs) between nonfibrotic and fibrotic liver groups were identified to construct a diagnostic biomarker model using logistic regression and functional enrichment analysis. Additionally, the relationships between immune cell infiltration, fibrosis, and differential gene expression were explored through immune infiltration analysis.</p>\u0000 <p><b>Results:</b> The gene expression matrix from frequent liver puncture biopsy samples in the GSE193135 dataset identified 11 DEGs (STMN2, JCHAIN, IGHA1, IGHG3, DCDC2, GSN, KRT7, HLA-DRB5, CRP, CXCL13, and SPINK1). These genes were utilized to construct a predictive model, achieving robust performance (area under the curve = 0.805, 95% confidence interval: 0.736–0.862). Enrichment and immune infiltration analyses further elucidated the differential gene pathways and immune cell infiltration patterns associated with liver fibrosis.</p>\u0000 <p><b>Conclusion:</b> We developed a predictive model for identifying the risk of fibrosis in transplanted livers and investigated the role of immune cell infiltration during fibrosis progression. This model provides valuable insights for understanding and managing fibrosis in liver transplantation.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/6433958","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative Stress-Related Targets POR and MAPK13 Elucidated for Sarcoidosis Therapy Through Multiomics Analysis","authors":"Xun Yang,&nbsp;Hao Jiang,&nbsp;Xiaoyun Li","doi":"10.1155/ijcp/3094370","DOIUrl":"https://doi.org/10.1155/ijcp/3094370","url":null,"abstract":"<div>\u0000 <p><b>Purpose:</b> We aimed to identify potential plasma protein targets genetically associated with oxidative stress genes in sarcoidosis.</p>\u0000 <p><b>Methods:</b> We performed summary data-based Mendelian randomization (SMR) analyses using summary statistics from the FinnGen cohorts and multiomics data on quantitative trait loci (QTLs) linked to oxidative stress genes at protein, RNA, and methylation levels. We validated the findings with two independent datasets from published studies. Bayesian colocalization analysis confirmed shared genetic bases and excluded pleiotropy. We also identified relevant plasma regulatory transcription factors (TFs) and constructed protein–protein interaction (PPI) networks. In addition, molecular docking was conducted for drug ligand-protein binding assays.</p>\u0000 <p><b>Results:</b> MAPK13 and POR were identified as significant in proteome-wide SMR, transcriptome-wide SMR, and methylation-wide SMR analyses. These findings were validated through Bayesian colocalization and confirmed in two additional sarcoidosis cohorts. In PSMR analysis, the A allele of rs10447396 near MAPK13 (p38<i>δ</i>) (<i>p</i> = 0.0068 and <i>β</i> = 0.6009) and the A allele of rs59882870 at POR (<i>p</i> = 0.0006 and <i>β</i> = 0.3924) were associated with increased sarcoidosis risk. NFATC3 and NFKB1 were identified as common TFs influencing MAPK13 and POR expression in plasma. Molecular docking identified two potential MAPK13-targeting drugs, ilorasertib and SNS-314, both showing strong affinities for MAPK13.</p>\u0000 <p><b>Conclusion:</b> This study is the first to identify MAPK13 and POR as potential drug targets for sarcoidosis. In addition, molecular docking preliminarily identified potential therapeutic compounds targeting these proteins, suggesting avenues for future experimental validation and the potential development of targeted therapies.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/3094370","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Quality in Surgical Intensive Care: The Critical Impact of Intensivist Presence and the Semiopen Unit Model","authors":"Serdar Efe,&nbsp;Şenay Yiğit Avcı,&nbsp;Ekrem Kaya,&nbsp;Emel Yılmaz","doi":"10.1155/ijcp/8731737","DOIUrl":"https://doi.org/10.1155/ijcp/8731737","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> It is well known that intensivist in the intensive care unit (ICU) is critical for optimal patient care. However, today the majority of surgical intensive care units (SICUs) provide service in an open model. Our aim was to assess the effects of appointing an intensivist to the SICU and transitioning to a semi-open working model on patient outcomes and various quality indicators.</p>\u0000 <p><b>Methods:</b> This retrospective study was conducted in a seven-bed SICU of a university hospital. Two groups were created from patients treated before (preintensivist period) and after (postintensivist period) the change of ICU management. Demographic data of the patients, disease severity scores, surgical interventions performed, and intensive care quality indicators were collected and statistically compared between the two periods. Reporting of this study complied with the “Revised Standards for Quality Improvement Reporting Excellence (SQUIRE 2.0)” standards.</p>\u0000 <p><b>Results:</b> With the introduction of an intensive care specialist during working hours and the adoption of a semiopen working model, the following improvements were observed: the average length of stay decreased from 11 days versus 5 days, the average duration of mechanical ventilation reduced from 5.6 days versus 1 day, and the rate of mechanical ventilation use decreased from 48% versus 21%. A significant reduction in the need for tracheostomy was also noted (<i>p</i> &lt; 0.001). Furthermore, the bed turnover rate increased from 20 versus 24, enhancing bed utilization efficiency. Additionally, the observed mortality rate of 15% was lower than the expected rate of 25%, resulting in a significant reduction in the standardized mortality ratio (from 1.05 vs. 0.6).</p>\u0000 <p><b>Conclusion:</b> This study proves that surgeon-intensivist collaboration and a semiopen model in ICUs play a critical role by reducing mortality, increasing resource utilization efficiency, and improving patient outcomes. Our findings emphasize the need to restructure SICU processes with a multidisciplinary approach.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/8731737","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144100466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Idiopathic Neck Pain or Neck Pain of Gastric Origin? A Systematic Review of Rat Experimental Studies on Gastric Harm Pathophysiology and Therapy","authors":"Ángel Oliva-Pascual-Vaca,&nbsp;Ignacio Navarro-Carmona,&nbsp;Jesús Oliva-Pascual-Vaca,&nbsp;Inmaculada Riquelme,&nbsp;Luis Gabriel Luque-Romero,&nbsp;José Manuel López-Millán","doi":"10.1155/ijcp/8835586","DOIUrl":"https://doi.org/10.1155/ijcp/8835586","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Most cases of neck pain are classified as nonspecific or idiopathic pain and show characteristics such as sensitization, hyperalgesia, limited range of motion, and muscle spasm. Visceral disorders can trigger all those features, and gastric disorders are related to neck pain. Furthermore, stress and anxiety are frequently somaticized as neck pain. However, its pathophysiological link has never been determined.</p>\u0000 <p><b>Objectives:</b> To identify the electromyographic and postural response to experimental gastric insult in rats.</p>\u0000 <p><b>Methods:</b> A systematic review was undertaken. Searches were conducted in the PubMed and Web of Science databases. The date of publication was not limited. References from included articles were assessed. The sample, experimental intervention, and the results were retrieved from each study.</p>\u0000 <p><b>Results:</b> Sixteen studies were included. Acromiotrapezius muscle showed the highest activity to gastric damage, being up to 8–10 times higher than abdominal muscles contraction. Also, a postural response compatible with neck muscles spasm was observed. The threshold for reaching cervical spasm was lowered by the addition of stress, gastritis, dyspepsia, ulcers, diabetes, or inflammation of the colon. Increased visceromotor response persisted even more than 60 days after gastric insult, despite no obvious injury was already visible in the stomach. Furthermore, prenatal or neonatal gastric injury also produced gastric hypersensitivity and increased trapezius spasm in adult rats. On the contrary, neck spasm was reduced by reversing diabetes or blocking the gastric receptors and its afferent pathways.</p>\u0000 <p><b>Conclusions:</b> Gastric harm triggers neck muscles spasm. Since many gastric conditions and hypersensitivity are common and tend to be chronic, this may contribute to explain the persistence of neck pain and sensitization in many patients. Prenatal and neonatal gastrointestinal suffering increases trapezius visceromotor response in adults. Furthermore, our findings might contribute to explain why stress is frequently somaticized as neck pain.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/8835586","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain Perception and Lumbar Biomechanics Are Modified After the Biering–Sorensen Maneuver in Patients With Low Back Pain","authors":"Rafael Escamilla-Ugarte,&nbsp;Pilar Alberola-Zorrilla,&nbsp;Victoria Juana Díaz-Benito,&nbsp;Daniel Sánchez-Zuriaga","doi":"10.1155/ijcp/6471144","DOIUrl":"https://doi.org/10.1155/ijcp/6471144","url":null,"abstract":"<div>\u0000 <p><b>Purpose:</b> Both isometric and aerobic physical exercise have shown to cause an increase in pain thresholds through the effect known as exercise-induced hypoalgesia. A sustained isometric contraction of the lumbopelvic extensor muscles such as the one elicited by the Biering–Sorensen maneuver has been observed to increase pain thresholds in pain-free subjects. Nevertheless, little is known about exercise-induced hypoalgesia induced by isometric exercise in low back pain (LBP), and its possible effects in lumbopelvic biomechanics. The present study tries to show the effect of exercise-induced hypoalgesia after an isometric Biering–Sorensen maneuver in nonspecific LBP patients and pain-free subjects.</p>\u0000 <p><b>Methods:</b> This cross-sectional observational study was conducted on 16 nonspecific LBP patients and 16 pain-free control participants. Before and after the intervention, pain-pressure thresholds (PPTs) were assessed with an electronic algometer in the lumbar region over the biceps femoris area and on the thenar eminence. Erector spinae (ES) activity and motion patterns of the lumbopelvic region were analyzed during a trunk flexion–extension exercise by surface electromyography (EMG) and electrogoniometry techniques, respectively. The intervention consisted of a 60-s isometric Biering–Sorensen maneuver.</p>\u0000 <p><b>Results:</b> After the isometric contraction, PPTs were significantly higher on all areas, both in healthy participants and LBP patients (<i>p</i> &lt; 0.01), especially over the muscles most activated by the maneuver. LBP patients perceived a lower level of pain after the isometric maneuver (<i>p</i> &lt; 0.01). From all the EMG and electrogoniometry variables recorded during trunk flexion extension, participants in both groups only showed significant differences in the time spent in maximum lumbar flexion, which was longer after the isometric maneuver (<i>p</i> &lt; 0.05).</p>\u0000 <p><b>Conclusions:</b> The Biering–Sorensen maneuver induces a hypoalgesic effect locally over the areas of the extensor lumbopelvic muscles, and remotely, on the thenar eminence, both in nonspecific LBP patients and healthy people. The maneuver also causes alterations in trunk motion patterns. This study shows that the Biering–Sorensen maneuver could be useful to alleviate LBP and improve trunk motion patterns. The effects of isometric exercise should be investigated further to confirm its possible role as a supplementary analgesic measure in the treatment of LBP patients.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/6471144","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Hypertension and Blood Pressure Control in Familial Mediterranean Fever Patients","authors":"Gozde Kavgaci,&nbsp;Haci Hasan Yeter,&nbsp;Muge Uzerk Kibar,&nbsp;Tolga Yildirim,&nbsp;Banu Balci Peynircioglu,&nbsp;Seref Rahmi Yilmaz,&nbsp;Yunus Erdem","doi":"10.1155/ijcp/9977641","DOIUrl":"https://doi.org/10.1155/ijcp/9977641","url":null,"abstract":"<div>\u0000 <p><b>Background and Objective:</b> Familial Mediterranean fever (FMF) is characterized by inflammatory febrile attacks with polyserositis and is associated with an increased risk of cardiovascular disease. We aimed to determine the prevalence of hypertension (HT) in FMF patients and compare the frequency with that of the general population.</p>\u0000 <p><b>Methods:</b> This was a retrospective cohort study. Patients diagnosed with FMF between 2000 and 2020 and participants in the PatenT 2 study were included. We used office blood pressure measurements taken with calibrated sphygmomanometers.</p>\u0000 <p><b>Results:</b> We enrolled 528 patients with FMF and 1234 age- and gender-matched controls. The mean age of the study population was 35.48 ± 13.54, and 314 (59.5%) of the total patients were female. The prevalence of HT was lower in FMF patients compared to the control group [68 (12.9%) vs. 215 (17.4%), <i>p</i> = 0.02]. Patients without amyloidosis had significantly lower mean systolic blood pressure (SBP) and higher mean diastolic blood pressure (DBP) compared to the control group (113.4 ± 15.5 vs. 120.9 ± 15.94, <i>p</i> &lt; 0.001, and 72.4 ± 11.03 vs. 71.07 ± 10.53, <i>p</i> = 0.05, respectively). Of the patients without amyloidosis, 294 (63.1%) had normal SBP and DBP, while 28 (45.2%) patients with amyloidosis and 616 (49.9%) control group participants had normal SBP and DBP. Regression analysis showed that GFR &lt; 60 mL/min/1.73 m² and increasing age were risk factors for the development of HT.</p>\u0000 <p><b>Conclusion:</b> The prevalence of HT, mean blood pressure, and achievement of target blood pressure are better in FMF patients than in the general population. However, blood pressure control decreases with increasing age, especially when eGFR falls below 60 mL/min/1.73 m².</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/9977641","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}