International Journal of Clinical Practice最新文献

{"title":"Assessment of Attention in Emergency Physicians; Visuomotor Reaction Time Relationship","authors":"Damla Anbarli Metin,&nbsp;Bahri Oğulcan Tabak,&nbsp;Nurbanu Akdogan,&nbsp;Gizem Mermerkaya,&nbsp;Seref Emre Atis","doi":"10.1155/ijcp/7466778","DOIUrl":"https://doi.org/10.1155/ijcp/7466778","url":null,"abstract":"<p><b>Objective:</b> Emergency physicians require exceptionally high perceptual and cognitive performance during their shifts. Visuomotor reaction time (VMRT) serves as a key indicator of this performance. In the study, we examined the relationship between shift duration and VMRT in physicians working in the emergency department.</p><p><b>Materials and Methods:</b> The cross-sectional study was conducted among emergency physicians working 24-h shifts. Their VMRTs were measured using the FitLight Trainer at 0, 8, 12, 16, and 24 h into the shift.</p><p><b>Results:</b> The study included 29 physicians. 11 (37.9%) of the physicians included in the study were female, and the median age was 28.00 (25.50–31.00). A significant difference was found when the VMRTs of the measurements made at the 0^th hour, 8^th hour, 12^th hour, 16^th hour, and 24^th hour of the shift were compared (<i>p</i> = 0.035). When the post hoc analyses for the groups that created this difference were examined, the VMRT at 0 hour was 0.362 s [0.332–0.402], VMRT at 8 h was 0.358 s [0.328–382], VMRT at 12 hour was 0.353 s [0.319–0.391], VMRT at 16 hour was 0.349 s [0.319–0.383], and VMRT at 24 hour was 0.362 s [0.334–0.393]. While there was a significant difference between VMRT at 0, 8, 12, and 16 h (<i>p</i> = 0.005, <i>p</i> = 0.003, and <i>p</i> = 0.009, respectively), there was no significant difference between VMRT at 24 hour (<i>p</i> = 0.252, <i>p</i> = 0.776, and <i>p</i> = 0.764, respectively). There was no significant difference between shifts at 8, 12, and 16 h (<i>p</i> = 0.776 and <i>p</i> = 0.764, respectively).</p><p><b>Conclusion:</b> The VMRT decreased 16 h of physicians’ shift, after which physicians showed improved attention. Notably, there were no differences between the VMRT at 0 and 24 h.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/7466778","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Knowledge and Beliefs of Women With and Without HPV Diagnosis About the Virus and Vaccine","authors":"Özden Tandoğan,&nbsp;Eda Yakıt Ak,&nbsp;Mehmet Ali Şen,&nbsp;Arzu Akdemir,&nbsp;Gülin Gülen Sabancilar,&nbsp;Ezgi Yaraşır","doi":"10.1155/ijcp/5520955","DOIUrl":"https://doi.org/10.1155/ijcp/5520955","url":null,"abstract":"<p><b>Purpose:</b> This study aimed to compare the knowledge and health beliefs of women with and without an HPV diagnosis regarding the virus and its vaccine.</p><p><b>Methods:</b> Designed as a cross-sectional case–control study, the research was conducted with 478 women attending a gynecology outpatient clinic in Istanbul. Data were collected using a sociodemographic questionnaire, the Human Papillomavirus Knowledge Scale (HPV-KS), and the Health Belief Model Scale for HPV Infection and Vaccination (HPV-HBMS).</p><p><b>Results:</b> The findings indicated that women diagnosed with HPV had significantly higher knowledge scores and a greater perceived seriousness of the infection compared to those without an HPV diagnosis (<i>p</i> &lt; 0.05), although overall knowledge levels remained low in both groups. A significant difference was also found between the two groups in terms of HPV vaccine awareness, Pap smear testing, and vaccination status. Logistic regression analysis revealed that higher education level, older age, a family history of cervical cancer, previous HPV vaccination, and having undergone Pap smear testing were associated with a reduced risk of HPV infection (<i>p</i> &lt; 0.05).</p><p><b>Conclusion:</b> These findings underline the importance of targeted education and outreach efforts to improve HPV awareness and vaccine uptake among women.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/5520955","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of Phase Angle Changes for Functional Recovery and Nutritional Status in Patients With Intestinal Failure","authors":"Lulu Gu,&nbsp;Ni Yan,&nbsp;Jiajia Hu,&nbsp;Kangzhen Zhang,&nbsp;Cuili Wu,&nbsp;Xianghong Ye","doi":"10.1155/ijcp/9424189","DOIUrl":"https://doi.org/10.1155/ijcp/9424189","url":null,"abstract":"<p><b>Objective:</b> To investigate the relationship between phase angle (PhA) changes and daily activity ability, skeletal muscle mass, and grip strength in patients with intestinal failure.</p><p><b>Methods:</b> We enrolled 170 patients with intestinal failure, divided into a PhA increase group (<i>n</i> = 85) and a PhA decrease group (<i>n</i> = 85). General information was compared between the two groups. Bioelectrical impedance analysis was used to measure PhA, skeletal muscle mass index (SMI), and grip strength. The Functional Independence Measure (FIM) score was recorded at admission and discharge, and the changes of each indicator were calculated. <i>T</i>-test, chi-square test, Pearson correlation analysis, and multivariate linear regression analysis were performed to explore the relationship between PhA changes and prognosis.</p><p><b>Results:</b> Compared with the PhA decrease group, patients in the PhA increase group had larger changes in FIM (20 (18, 23) vs. 13 (12, 15)), SMI (0.21 (−0.49, 0.89) kg/m² vs. −0.28 (−1.51, 0.60) kg/m²), and grip strength (3.10 (1.95, 4.30) kg vs. 0.90 (0.50, 1.20) kg) (<i>p</i> &lt; 0.05). Multivariate regression analysis showed that PhA change was an independent influencing factor for FIM change (<i>β</i> = 0.816, <i>p</i> = 0.002) and SMI change (<i>β</i> = 0.270, <i>p</i> = 0.046). Admission PhA was negatively correlated with PhA change (<i>r</i> = −0.803, <i>p</i> &lt; 0.001).</p><p><b>Conclusion:</b> PhA change is closely related to the daily activity ability and skeletal muscle mass of patients with intestinal failure and can be used as an objective indicator for assessing nutritional status and prognosis. Clinically, attention should be paid to the dynamic changes of patients’ PhA, and targeted nutritional support and rehabilitation measures should be adopted to improve prognosis.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/9424189","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Acupuncture for Pain Control After Cesarean Delivery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","authors":"He Chen,&nbsp;Ying Zhan,&nbsp;Min Yang,&nbsp;Xinkun Liu,&nbsp;Jiamin Yi,&nbsp;Hangyu Shi,&nbsp;Yixing Xu,&nbsp;Zhishun Liu","doi":"10.1155/ijcp/6025759","DOIUrl":"https://doi.org/10.1155/ijcp/6025759","url":null,"abstract":"<p><b>Background:</b> Postcesarean pain significantly compromises maternal well-being and mother–newborn interaction. Given the side effects associated with conventional analgesics, alternative therapies such as acupuncture warrant consideration. However, evidence regarding the effects of acupuncture remains inconclusive. This systematic review and meta-analysis aims to evaluate the effects of acupuncture for postcesarean pain relief.</p><p><b>Methods:</b> A comprehensive literature search was conducted for relevant randomized controlled trials (RCTs) published until July 23, 2024. The primary outcome was pain intensity at 24 h after cesarean delivery, assessed via Numerical Rating Scale (NRS) or Visual Analog Scale (VAS). Secondary outcomes included pain intensity at other time points, analgesic consumption, and safety profiles.</p><p><b>Results:</b> Six RCTs involving 614 participants were included. Analysis of the primary outcome indicated that acupuncture combined with analgesics significantly reduced pain scores at 24 h postcesarean compared to analgesics alone (mean difference [MD] −0.59; 95% confidence interval [CI] −1.04 to −0.13; low certainty). Pooled data from three trials showed superior pain relief at 24 h postcesarean with acupuncture plus analgesics versus sham acupuncture (SA) plus analgesics (MD −1.79; 95% CI −2.70 to −0.88; <i>I</i>² = 80%; low certainty). However, one trial reported that SA plus analgesics was superior in pain reduction. Another trial found acupuncture comparable to lateral quadratus lumborum block (L-QLB) in pain alleviation. Results on analgesic consumption were inconsistent. No serious acupuncture-related adverse events were reported.</p><p><b>Conclusion:</b> Acupuncture may serve as a promising complementary therapy for postcesarean pain with a good safety profile. However, the evidence quality is limited and heterogeneous. Further high-quality studies are needed to inform clinical practice.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/6025759","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Percutaneous Transluminal Septal Myocardial Ablation Treating Hypertrophic Cardiomyopathy: Systematic Review and Meta-Analysis","authors":"Sun Qinyu,&nbsp;Deng Yifan,&nbsp;Yu Jiling,&nbsp;Zhang Zhaoyuan,&nbsp;Cao Gan,&nbsp;Yang Tianxiao,&nbsp;Fang Zhen,&nbsp;Ji Jun,&nbsp;He Shenghu,&nbsp;Zhang Jing","doi":"10.1155/ijcp/8869127","DOIUrl":"https://doi.org/10.1155/ijcp/8869127","url":null,"abstract":"<p><b>Background:</b> Percutaneous transluminal septal myocardial ablation (PTSMA) is one of the invasive therapeutic measures for the treatment of patients with obstructive hypertrophic cardiomyopathy (HCM).</p><p><b>Objective:</b> To systematically evaluate the efficacy and safety of PTSMA in patients with HCM.</p><p><b>Methods:</b> A systematic searching of Pubmed, Web of Science, Embase, and Cochrane Library databases was conducted for screening of studies conducted from library building to October 20, 2024 involving the treatment of PTSMA in patients with HCM. Two investigators independently screened the literature, extracted the data, and evaluated the risk of bias in the included study; meta-analysis was performed using Stata14.0 software.</p><p><b>Results:</b> A total of 10 literature articles were included. The mean LVOT PG reduction of 1910 patients with HCM after PTSMA treatment was 47.74 mmHg (95% CI: 39.75–55.72, <i>p</i> &lt; 0.01). The mean reduction in the maximum septal thickness was 4.76 mm (95% CI: 3.67–5.85, <i>p</i> &lt; 0.01). The incidence of the central package effusion in surgical complications was 2% (95% CI: 0%–3%, <i>p</i> &lt; 0.01). The incidence of the left bundle branch block was 19% (95% CI: 5%–39%, <i>p</i> &lt; 0.01).The incidence of right bundle branch block was 9% (95% CI: 4%–17%, <i>p</i> &lt; 0.01). The incidence of the all-cause death from follow-up events was 2% (95% CI: 0%–5%, <i>p</i> = 0.01). The incidence of pacemaker implantation was 6% (95% CI: 4%–10%, <i>p</i> &lt; 0.01).</p><p><b>Conclusion:</b> PTSMA is effective and safe in treating patients with HCM.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/8869127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145110840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of Electronic Apex Locators During Retreatment With Organic Gutta-Percha Solvents","authors":"Ahter Şanal Çıkman,&nbsp;Özge Başar,&nbsp;Feyza Çetinkaya","doi":"10.1155/ijcp/7891762","DOIUrl":"https://doi.org/10.1155/ijcp/7891762","url":null,"abstract":"<p><b>Background:</b> This study aimed to compare the accuracy of electronic apex locators (EALs) during the retreatment procedure using organic gutta-percha solvents.</p><p><b>Methods:</b> The actual working length (AWL) was determined with a stereomicroscope on 72 single-rooted teeth selected for the study. After the obturation, the teeth were embedded in an alginate mold and divided into 3 groups (<i>n</i> = 24) based on the gutta-percha solvent used: eucalyptol, turpentine, and orange oil. Once the solvents were applied, the WL was measured using the Root ZX Mini and Woodpex III. Two-way ANOVA and Fisher’s exact test were performed using SPSS with a 5% significance threshold.</p><p><b>Results:</b> There was no significant difference in the accuracy of the EALs among the solvent groups (<i>p</i> &gt; 0.05). Root ZX Mini showed accuracies of 40%, 41.7%, and 80% within ±0.5 mm for eucalyptol, turpentine, and orange oil, respectively, while the corresponding values for Woodpex III were 30%, 41.7%, and 70%. No overestimation (deviation from AWL &gt; 0.5 mm) was observed with either device when orange oil was used.</p><p><b>Conclusion:</b> Different types of EALs demonstrated acceptable determination of WL when using different gutta-percha solvents. The absence of overestimation in the orange oil group may affect clinical preferences.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/7891762","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effectiveness of Negative Pressure Physical Therapy in the Management of Nonorganic Erectile Dysfunction: A Multicenter Randomized Controlled Trial","authors":"Long Zhong,&nbsp;Qunlong Liu,&nbsp;Junhua Luo,&nbsp;Lingzhi Tao,&nbsp;Lusha Huang,&nbsp;Zhengping Zhao,&nbsp;Lanxuan Zheng,&nbsp;Kebing Wang,&nbsp;Yu Yang,&nbsp;Benlin Wei","doi":"10.1155/ijcp/8363471","DOIUrl":"https://doi.org/10.1155/ijcp/8363471","url":null,"abstract":"<p><b>Background:</b> Erectile dysfunction (ED) is a common male sexual dysfunction characterized by the inability to achieve and maintain an erection sufficient for satisfactory sexual performance. Current therapeutic approaches for this condition have certain limitations.</p><p><b>Objectives:</b> This study aims to investigate the efficacy of negative pressure physical therapy (NPPT) in the rehabilitation and treatment of nonorganic ED.</p><p><b>Methods:</b> This protocol divides subjects into two groups based on different intervention conditions. The experimental group received tadalafil every night before sleep along with the use of a male sexual function therapeutic device, whereas the control group received only tadalafil every night before sleep. A total of 124 patients were enrolled. The recovery and treatment efficacy for sexual dysfunction were evaluated by assessing improvements in erectile difficulty, penile circumference, and penile length.</p><p><b>Results:</b> In the full analysis set (FAS), the estimated mean change in IIEF-5 scores was 4.92 points in the experimental group and 3.13 points in the control group, resulting in a between-group difference of 1.79 points. In the per-protocol set (PPS), the estimated mean change was 4.96 points in the experimental group versus 3.01 points in the control group, with a between-group difference of 1.95 points. In the analysis of changes in penile girth, the experimental group exhibited a mean increase of 0.32 cm (standard deviation [SD] ± 0.44), which was significantly greater than the control group’s increase of 0.14 cm. In the subsequent follow-up 2, the mean girth change in the experimental group further increased to 0.49 cm (SD ± 0.71), whereas the control group showed only a 0.02 cm change; the PPS analysis yielded results consistent with the FAS. Regarding penile length, at follow-up 1, the experimental group demonstrated a mean increase of 0.51 cm (SD ± 0.81), significantly higher than the control group’s 0.19 cm (SD ± 0.32). At follow-up 2, the experimental group’s mean length change rose to 0.39 cm (SD ± 0.45), while the control group exhibited virtually no change (0.00 cm, SD ± 0.05), with the between-group difference being extremely significant (<i>p</i> &lt; 0.0001).</p><p><b>Discussion and Conclusion:</b> NPPT combined with tadalafil exhibited significantly superior efficacy in treating nonorganic ED, providing a safe and effective nonpharmacological option for clinical use.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/8363471","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145101852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transthoracic Echocardiography Combined With the Clinical History Can Predict Left Atrial Thrombus in Patients With Nonvalvular Atrial Fibrillation","authors":"Jing Wang,&nbsp;Hong-Ning Yin,&nbsp;Hong Zhou,&nbsp;Ya-Jing Miao,&nbsp;Xiao-Xu Wang,&nbsp;Wei Cui","doi":"10.1155/ijcp/7731198","DOIUrl":"https://doi.org/10.1155/ijcp/7731198","url":null,"abstract":"<p><b>Objectives:</b> This study has two main objectives: First, using transesophageal echocardiography (TEE) results, it evaluates the predictive accuracy of CHADS2 and CHA2DS2-VASc scores for left atrial (LA) thrombus (LAT) detected by TEE in patients with nonvalvular atrial fibrillation (NVAF) undergoing radiofrequency ablation or electrical cardioversion. Second, it assesses the predictive value of transthoracic echocardiography (TTE) combined with clinical risk factors for high-risk LAT to develop a simple yet effective predictive model for clinical decision-making.</p><p><b>Methods:</b> In our retrospective study, 923 patients with NVAF underwent TEE before radiofrequency ablation or conversion. TEE reports were examined for thrombus in the LA, including the LA appendage (LAA). CHADS2 and CHA2DS2-VASc scores were calculated from medical records, and their predictive abilities for high risk of LAT were analyzed using the receiver operating characteristic (ROC) curve.</p><p><b>Results:</b> Among the 923 patients with NVAF, the prevalence of spontaneous echo contrast (SEC) and sludge signs was 4.0% (37/923) and 0.4% (4/923), respectively. LAT was detected in 34 out of 923 patients (3.7%). The AUC of CHADS2 and CHA2DS2-VASc scores in predicting LAT in patients with NVAF were 0.664 and 0.614, respectively. There was no significant difference between areas under the ROC curve (AUC ROCs) of the CHADS2 score and the CHA2DS2-VASc score (<i>p</i> = 0.077). Multivariate logistic regression analysis revealed associations between LAT and diabetes, heart failure, left ventricular ejection fraction (LVEF), and LA diameter (LAD). Diabetes, heart failure, LAD, and LVEF were chosen as the new scoring indices, leading to the establishment of a novel scoring model (new model). The AUC value of the new model reached 0.827 (95% CI: 0.801–0.851). This recently developed algorithm for predicting LAT in patients with NVAF exhibited significantly higher accuracy than the CHADS2 and CHA2DS2-VASc scoring systems (<i>p</i> &lt; 0.01).</p><p><b>Conclusions:</b> The findings suggest that integrating and analyzing the clinical history information of heart failure and diabetes with the key parameter indicators obtained by TTE, such as LVEF and LAD, can more accurately predict the level of high atrial embolism risk in patients with NVAF. Its predictive efficacy is significantly better than that of traditional scoring systems such as CHADS2 or CHA2DS2-VASc.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/7731198","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145101528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioequivalence of a Metformin/Linagliptin Fixed-Dose Combination Tablet Compared With Coadministered Single Extended-Release Agents in Healthy Adult Subjects","authors":"Woo-Young Shin","doi":"10.1155/ijcp/7111508","DOIUrl":"https://doi.org/10.1155/ijcp/7111508","url":null,"abstract":"<p><b>Aim:</b> We aimed to demonstrate the bioequivalence of a fixed-dose combination (FDC) tablet of metformin 1000 mg and linagliptin 5 mg compared with the coadministration of their respective extended-release (XR) single tablets in healthy Korean adults under fasting conditions.</p><p><b>Methods:</b> This randomized, open-label, 2-sequence, 2-period crossover study included 64 healthy Korean adults. The participants received a single dose of the FDC tablet or the individual XR tablets of metformin and linagliptin, with a 49 days washout period between treatments. Blood samples were collected over a 72-h period to measure the pharmacokinetic parameters, including area under the curve (AUC) and maximum concentration (<i>C</i>_max). The safety and tolerability were also assessed.</p><p><b>Results:</b> Our pharmacokinetic analysis showed that the AUC and <i>C</i>_max for both metformin and linagliptin in the FDC tablet were within the bioequivalence range of 80%–125% compared with those of the individual XR tablets. Specifically, the geometric mean ratios (FDC to coadministration) for metformin were 101.1% (95% confidence interval (CI): 97.8–104.5) for AUC and 97.6% (95% CI: 94.5–100.9) for <i>C</i>_max and those for linagliptin were 98.4% (95% CI: 95.7–101.2) for AUC and 96.7% (95% CI: 93.9–99.5) for <i>C</i>_max. No serious adverse events (AEs) were reported, and both treatments were well tolerated.</p><p><b>Conclusion:</b> The metformin/linagliptin 1000 mg/5 mg FDC tablet is bioequivalent to coadministration of individual XR tablets in healthy Korean adults under fasting conditions. The FDC tablet was well tolerated, indicating that it is a safe and effective option that could improve medication adherence and treatment outcomes in patients with type 2 diabetes.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/7111508","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145038247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness and Attitudes Toward Medication-Related Osteonecrosis of the Jaw Among Physicians: A Cross-Sectional Study","authors":"Kadriye Ayça Dere,&nbsp;Ayşe Güllü","doi":"10.1155/ijcp/1684494","DOIUrl":"https://doi.org/10.1155/ijcp/1684494","url":null,"abstract":"<p><b>Background:</b> The aim of this study was to evaluate the knowledge and attitudes of medical physicians who prescribe antiresorptive and antiangiogenic drugs toward medication-related osteonecrosis of the jaw (MRONJ), a devastating complication.</p><p><b>Methods:</b> This cross-sectional study included physicians in the fields of internal medicine, orthopedics and traumatology, rheumatology, physical medicine and rehabilitation, oncology, hematology, and urology working in university hospitals, training and research hospitals, and private health institutions. Participating physicians were asked to answer a survey consisting of 25 questions to determine their knowledge, attitudes, and awareness about MRONJ.</p><p><b>Results:</b> Of the physicians participating in the study, 45% were academicians, 30.9% were specialists, and 24.2% were assistant physicians. 30.3% of the participate had never heard of the concept of MRONJ. The specialties most aware of the concept of MRONJ were internal medicine (21.74%), physical medicine and rehabilitation (18.26%), and orthopedics and traumatology (17.39%), respectively. In our study, it was determined that 38.78% of the participants did not receive information on this subject through lectures/presentations/seminars, etc., and 10.8% reported that they were not informed about the side effects of drugs that can cause MRONJ. 37% of the physicians never consulted their patients with a dentist before starting treatment with drugs that can cause MRONJ.</p><p><b>Conclusions:</b> The study results showed that physicians who prescribe drugs that can cause MRONJ have low awareness of preventing MRONJ and that their knowledge and sensitivity on this issue should be increased.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/1684494","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144934808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}