International Journal of Clinical Practice最新文献

{"title":"A Meta-Analysis on the Effect of Vitamin D Supplementation on Endothelial Function in Adults","authors":"Vali Musazadeh,&nbsp;Mahsa Mahmoudinezhad,&nbsp;Pedram Pam,&nbsp;Negar Karimi Javan,&nbsp;Ahmad Saedisomeolia,&nbsp;Farzad Shidfar","doi":"10.1155/ijcp/3788298","DOIUrl":"https://doi.org/10.1155/ijcp/3788298","url":null,"abstract":"<p>Vitamin D is recognized as a key regulator of endothelial function, and its deficiency has been implicated in the development of endothelial dysfunction, a critical contributor to cardiovascular diseases. Many randomized controlled trials (RCTs) have revealed the benefits of vitamin D on endothelial function, but the results are inconclusive. This meta-analysis of RCTs aimed to assess the effects of vitamin D on endothelial function. A systematic review of PubMed, Embase, Scopus, Web of Science, and Cochrane Library was conducted and covered all records from database inception through May 2025. Data were pooled using a random-effects model to calculate standardized mean differences (SMDs) and 95% confidence intervals (CIs). Thirty-one RCTs comprising 35 intervention arms with 3252 patients were included. Findings indicated no significant changes in terms of endothelial function following vitamin D administration including measures such as flow-mediated dilation (FMD) (SMD = 0.36; 95% CI: −0.11, 0.83, <i>p</i> = 0.131), augmentation index (AIx) level (SMD = −0.12; 95% CI: −0.33, 0.10, <i>p</i> = 0.293), pulse wave velocity (PWV) (SMD = −0.09; 95% CI: −0.25, 0.07, <i>p</i> = 0.258), and intercellular adhesion molecule-1 (ICAM-1) (SMD = −0.78; 95% CI: −1.79, 0.22, <i>p</i> = 0.125). However, subgroup analysis revealed that patients with chronic kidney disease showed a significant improvement in PWV following vitamin D supplementation. The present meta-analysis demonstrated no significant impact of vitamin D treatment on endothelial function. However, heterogeneity in study populations, baseline vitamin D status, dosage, and intervention duration may have influenced the outcomes. Further well-designed trials are warranted to illustrate its effects on vascular health in large scale.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/3788298","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144934866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Resistance Training With or Without Blood Flow Restriction on Bone Metabolism in Osteopenic Women: A Randomized Controlled Trial","authors":"Clodoaldo Antônio De Sá,&nbsp;Wan Cley Rabuske,&nbsp;Aline Mânica,&nbsp;Felipe Corbellini,&nbsp;Fátima Kremer Ferretti,&nbsp;Sedinei Lopes Copatti,&nbsp;Vanessa da Silva Corralo","doi":"10.1155/ijcp/3594381","DOIUrl":"https://doi.org/10.1155/ijcp/3594381","url":null,"abstract":"<p><b>Background and Aims:</b> Osteopenia in postmenopausal women increases the risk of fractures and functional decline. Exercise is a key nonpharmacological strategy to improve bone health. However, high-intensity resistance training (HI) may not be feasible for all individuals. This study aimed to analyze the effects of low-intensity resistance exercise with blood flow restriction (LI + BFR) compared to HI on bone metabolism in women with osteopenia.</p><p><b>Methods:</b> Physically inactive women (65.95 ± 8.42 years) were randomized into two groups and completed 8 weeks of intervention twice a week using a single LI + BFR or HI. Muscle strength and plasma concentrations of C-terminal crosslinking telopeptide of type I collagen (CTX-1), bone alkaline phosphatase (BAP), and osteocalcin (OC) were evaluated in the pre- and posttest.</p><p><b>Results:</b> Both groups showed significant gains in maximal strength (HI: ES = 2.18; LI + BFR: ES = 1.70; <i>p</i> &lt; 0.05), with no between-group differences. CTX-1 concentrations increased significantly in both groups (HI: ES = 0.59; LI + BFR: ES = 1.13; <i>p</i> &lt; 0.05), with no significant intergroup difference. No significant changes were observed in BAP or OC concentrations (<i>p</i> &gt; 0.05).</p><p><b>Conclusions:</b> LI + BFR and HI effectively increased maximal dynamic strength in postmenopausal women with osteopenia over an eight-week intervention period. Both HI and LI + BFR increased CTX-I concentrations after 8 weeks of intervention.</p><p><b>Trial Registration:</b> Brazilian Registry of Clinical Trials—ReBEC: RBR-4W8V93</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/3594381","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144923509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Admission Serum Glucose–Phosphate Ratio and In-Hospital Mortality in Critically Ill Patients With Intracranial Hemorrhage: A Retrospective Cohort Study","authors":"Hong-Bo Xu,&nbsp;Yuhong Xu,&nbsp;Ying He,&nbsp;Xiaohua Lin,&nbsp;Zhijun Suo,&nbsp;Haigang Zhang","doi":"10.1155/ijcp/6519461","DOIUrl":"https://doi.org/10.1155/ijcp/6519461","url":null,"abstract":"<p><b>Objective:</b> Early identification of spontaneous intracranial hemorrhage (ICH) patients at high risk of mortality is of great importance. This study aimed to investigate the association between admission serum glucose–phosphate ratio (GPR) and in-hospital mortality in critically ill ICH patients.</p><p><b>Methods:</b> Data were obtained from the Medical Information Mart for Intensive Care (MIMIC) IV database. Patients were grouped by tertiles of GPR. The primary outcome was in-hospital mortality. Multivariable Cox regression analysis, restricted cubic spline curves, subgroup analysis, and sensitivity analysis were conducted to assess the GPR-mortality association.</p><p><b>Results:</b> A total of 1711 patients were included in this study. The overall in-hospital mortality rate was 19.2% (328/1711). A linear relationship was observed between GPR and in-hospital mortality. After adjusting for potential confounders, each unit increase in GPR was independently associated with a 1% increase in mortality risk (adjusted HR 1.01, 95% CI 1.00–1.02; <i>p</i> = 0.003). This elevated risk exhibited logarithmic decay over time (interaction term HR = 1.00, 95% CI: 0.99–1.00, <i>p</i> = 0.049). Compared to the lower GPR tertile, patients in the middle and upper tertiles showed 53% (adjusted HR 1.53, 95% CI 1.13–2.09) and 60% (adjusted HR 1.60, 95% CI 1.18–2.18) increased mortality risks, respectively. Subgroup and sensitivity analyses confirmed the stability of the results.</p><p><b>Conclusion:</b> In critically ill patients with ICH, elevated admission GPR demonstrated a significant association with increased in-hospital mortality, suggesting its potential utility as a prognostic biomarker for early risk stratification in this population.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/6519461","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144910309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Lacosamide on Patients With Chronic Migraine: A Randomized, Double-Blind, Clinical Trial","authors":"Mobina Mirhosseini,&nbsp;Hamed Cheraghmakani,&nbsp;Monireh Ghazaeian,&nbsp;Abolfazl Hosseinnataj","doi":"10.1155/ijcp/2431261","DOIUrl":"https://doi.org/10.1155/ijcp/2431261","url":null,"abstract":"<p><b>Purpose:</b> Calcitonin gene-related peptide (CGRP) is a key peptide released during trigeminal system-initiated migraine attacks. Evidence suggests that lacosamide can inhibit CGRP release. This study aimed to assess the effectiveness of lacosamide in patients with chronic migraine.</p><p><b>Methods:</b> This double-blind, randomized clinical study involved 83 chronic migraine patients, who were assigned to either a lacosamide group or a placebo group. The intervention group received 50 mg of lacosamide twice daily, with a weekly increase to a maximum tolerated dose of 200 mg twice daily, along with topiramate 25 mg twice daily. The placebo group received a placebo along with topiramate for 12 weeks. Headache frequency and severity were assessed using the NRS and VAS. Disability was evaluated with the MIDAS questionnaire at baseline and after 3 months.</p><p><b>Results:</b> Of the 83 patients enrolled in the study, 66 completed it and were analyzed. The intervention group exhibited a significant reduction in headache severity, as measured by VAS and headache frequency (<i>p</i>: 0.001). Outdoor and indoor activity performance and headache-free and analgesic-free days significantly improved in the intervention group compared to the control group during the study period (<i>p</i>: &lt; 0.01). Most patients in the intervention group exhibited lower MIDAS disability scores, although the difference was not statistically significant between two groups (<i>p</i>: 0.291).</p><p><b>Conclusion:</b> In conclusion, our findings suggest that lacosamide could be effective in reducing the frequency and severity of headaches in people with chronic migraines. Additionally, the tolerability of this treatment regimen for migraine prevention was satisfactory, with no significant side effects.</p><p><b>Trial Registration:</b> Iranian Registry of Clinical Trials: IRCT20190804044429N9</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/2431261","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144905489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Patient Data–Based Quality Control in the Laboratory Serum Potassium and Magnesium Tests","authors":"Chaoqiong Zhou,&nbsp;Dahai He,&nbsp;Yanqun Liu,&nbsp;Shirong Dai,&nbsp;Wenli Xu,&nbsp;Huali Wang,&nbsp;Feng Wu,&nbsp;Yan Zhang,&nbsp;Lirui Kong","doi":"10.1155/ijcp/6345030","DOIUrl":"https://doi.org/10.1155/ijcp/6345030","url":null,"abstract":"<p><b>Objective:</b> The study aims to retrospectively analyze the results of serum potassium (K) and serum magnesium (Mg) tests conducted in the laboratory and evaluate the application of the patient data–based quality control (PDB-QC) in the laboratory.</p><p><b>Methods:</b> All serum K and serum Mg testing data and quality control (QC) results from February 2022 to January 2023 were collected. After patient outliers were excluded and the data were sorted by test time, the data of the first half-year period (from February 2022 to July 2022) constituted the training group, and the data of the second half-year period (from August 2022 to January 2023) constituted the testing group. Average values and standard deviations (SDs) were calculated, and <i>Z</i>-score charts were plotted for PDB-QC and internal quality control (IQC). The Sigma metrics (SMs) of K and Mg were calculated by using the Westgard online frequency calculator, and QC rules were determined according to the SM and the number of patient samples. The PDB-QC and IQC were compared according to the determined QC rules.</p><p><b>Results:</b> The laboratory used the 2_2S and 1_3S rules to judge the systematic and random errors, respectively. PDB-QC detected systematic errors 5 times and random errors 0 times for K, along with systematic errors 19 times and random errors 17 times for Mg. In comparison, IQC detected systematic errors 4 times and random errors 2 times for K, and systematic errors 1 time and random errors 2 times for Mg. Besides, PDB-QC was faster than IQC in systematic and random error identification.</p><p><b>Conclusion:</b> Compared with IQC, PDB-QC was capable of identifying more errors (except for random errors in K) with faster identification of both systematic and random errors for K and Mg. So, PDB-QC is an effective means of monitoring the measurement status and improving laboratory quality management and can serve as an effective supplement to IQC.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/6345030","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Impact of Albumin/Globulin and Lactate/Globulin Ratios Combined With sPESI and BOVA Scores in Pulmonary Embolism Mortality","authors":"Abdullah Şen,&nbsp;Cahfer Güloğlu","doi":"10.1155/ijcp/5339240","DOIUrl":"https://doi.org/10.1155/ijcp/5339240","url":null,"abstract":"<p><b>Objective:</b> Pulmonary embolism (PE) is a severe form of venous thromboembolism that poses a significant risk of morbidity and mortality by leading to acute respiratory and circulatory failure. Clinical scoring systems such as the simplified pulmonary embolism severity index (sPESI) and BOVA are widely used for prognostic prediction; however, their limitations highlight the need for novel biochemical markers. This study aims to evaluate the prognostic value of albumin/globulin (A/G) and lactate/globulin (L/G) ratios in predicting in-hospital mortality and to investigate their relationship with existing scoring systems.</p><p><b>Methods:</b> In this retrospective study, 151 patients diagnosed with PE between January 2018 and December 2023 was analyzed. Data on demographics, comorbidities, vital signs, laboratory values, and outcomes were collected. Prognostic performance of A/G and L/G ratios was assessed through logistic regression and receiver operating characteristic (ROC) curve analysis.</p><p><b>Results:</b> The mean age was 60.5 ± 20.0 years, with 53.6% female patients. Deceased patients showed significantly higher age, hemodynamic instability, and altered mental status (<i>p</i> &lt; 0.05). Among scoring systems, the PESI score exhibited the highest prognostic accuracy (AUC = 0.910), followed by sPESI (AUC = 0.856) and BOVA (AUC = 0.845). Lower A/G ratios and higher L/G ratios were significantly associated with mortality (<i>p</i> &lt; 0.05).</p><p><b>Conclusions:</b> This study demonstrated that A/G and L/G ratios, along with sPESI and BOVA scores, are effective in predicting in-hospital mortality in patients with pulmonary thromboembolism (PTE). A lower A/G ratio and a higher L/G ratio were associated with poor prognosis. Furthermore, the critical role of sPESI and BOVA scores in risk stratification was confirmed.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/5339240","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network Pharmacology-Based Experimental Validation on the Mechanism of Cang’erzi Powder in Treating Asthma","authors":"Linhui Huang,&nbsp;Jiwei Li,&nbsp;Guobiao Peng,&nbsp;Shaojing Xian,&nbsp;Bingli Zhang,&nbsp;Anyan Zhou,&nbsp;Yike Zhu,&nbsp;Chaochao Wei,&nbsp;Huagui Han,&nbsp;Yipeng Ding,&nbsp;Xingjun Cai,&nbsp;Xiuxiu Ding","doi":"10.1155/ijcp/6511743","DOIUrl":"https://doi.org/10.1155/ijcp/6511743","url":null,"abstract":"<p><b>Background:</b> Cang’erzi powder, a medicinal formula, has had an extensive application in the treatment of asthma in China. Network pharmacological methods and experimental validation were used to investigate the underlying mechanism of Cang’erzi powder in asthma treatment.</p><p><b>Methods:</b> The active components and corresponding targets of Cang’erzi powder and asthma-related targets were obtained from TCMSP or NCBI-Gene, OMIM, and GeneCards. The “herb–compounds–targets–asthma” and target PPI networks were visualized with Cytoscape 3.7.1. Molecular docking was performed utilizing MOE software for the binding capacity between compounds and targets. Cell viability and apoptosis assay were tested by CCK8 kit and Muse analyzer for antiasthmatic effects of beta-sitosterol, and the expression levels of six core targets were assessed by RT-qPCR.</p><p><b>Results:</b> Ninety-five ingredients and 62 intersected targets were identified. Molecular docking showed that the component beta-sitosterol could stably bind to the predicted target. Moreover, beta-sitosterol might accelerate cell viability and inhibit apoptosis in TNFα-induced 16HBE cells. Moreover, beta-sitosterol treatment led to decreases in the expression of PTGS2, JUN, MAPK14, and NOS2, while an increase in PTGS1 expression was observed.</p><p><b>Conclusion:</b> The antiasthmatic mechanism of the main active compound beta-sitosterol in Cang’erzi powder might be associated with inhibiting proliferation and accelerating apoptosis through multiple targets.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/6511743","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144894476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beer Potomania: A Systematic Review of Characteristics, Diagnosis and Treatment","authors":"Keila S. Micoanski,&nbsp;Mónica Gozalbo,&nbsp;José M. Soriano","doi":"10.1155/ijcp/3667721","DOIUrl":"https://doi.org/10.1155/ijcp/3667721","url":null,"abstract":"<p>Beer potomania is a rare but potentially severe cause of hyponatremia due to excessive intake of low-solute alcoholic fluids, particularly beer. In this systematic review, we aimed to synthesize the current literature on this condition, focusing on pathophysiology, clinical presentation, diagnostic criteria, and management approaches. Following PRISMA 2020 guidelines, we searched PubMed, Embase, Scopus, and Web of Science for studies published up to December 2024. Five observational studies involving a total of 443 patients met the inclusion criteria, primarily involving alcohol-dependent individuals or those with psychiatric disorders. Common clinical features included altered mental status, seizures, and weakness; treatments typically comprised isotonic saline infusion, fluid restriction, and—less frequently—desmopressin or loop diuretics. The methodological quality of included studies was moderate with heterogeneous diagnostic thresholds. Our findings highlight that beer potomania remains under-recognized in clinical practice; prompt identification and tailored treatment—including cautious sodium (Na) correction and monitoring to prevent osmotic demyelination syndrome—is crucial. Further research is needed to establish standardized diagnostic criteria, evaluate the role of dietary sodium strategies, and develop evidence-based management protocols.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/3667721","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144894379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Efficacy of Shensong Yangxin Capsule Combined With Conventional Drugs for Atrial Fibrillation: A Meta-Analysis","authors":"Youming Jie,&nbsp;Dongmei Wu,&nbsp;Zhiyi Xie,&nbsp;Hang Weng,&nbsp;Xiaohong Huang","doi":"10.1155/ijcp/5272962","DOIUrl":"https://doi.org/10.1155/ijcp/5272962","url":null,"abstract":"<p><b>Objective:</b> The objective of this study was to assess the impact of SYX on the treatment of atrial fibrillation (AF).</p><p><b>Methods:</b> 8 databases were examined to identify RCTs published from the beginning until April 2024. They included PubMed, Embase, Cochrane Library, and other databases. Outcome measures included cardiac parameters (LVEF, LVEDD, LVESD, LAD, NT-proBNP, and 6WMT), inflammatory parameters (interleukin-6, tumor necrosis factor α, and high-sensitivity C-reactive protein), and cardiac electrophysiologic data (Pd and Pmax). The RevMan 5.4 software was utilized to perform the meta-analysis.</p><p><b>Results:</b> The inclusion criteria were met by a total of 29 trials, involving 2847 patients with AF. The findings of our study suggest that the combination of Shensong Yangxin Capsule (SYC) and conventional medicines for AF led to a significant improvement in LVEF (MD = 4.55, 95% CI = 3.50 to 5.59, <i>p</i> &lt; 0.00001) and 6MWT (MD = 56.14, 95% CI = 45.64 to 66.64, <i>p</i> &lt; 0.00001), meanwhile decreased levels of NT-proBNP (MD = −151.39, 95% CI = −224.32 to −78.47, <i>p</i> &lt; 0.0001), Pd (MD = −9.58, 95% CI = −12.80 to −6.36, <i>p</i> &lt; 0.00001), LVEDD (MD = −5.09, 95% CI = −6.98 to −3.20, <i>p</i> &lt; 0.00001), LVESD (MD = −3.83, 95% CI = −6.70 to −0.95, <i>p</i> = 0.009), and Pmax (MD = −11.20, 95% CI = −16.25 to −6.16, <i>p</i> &lt; 0.00001) observed no significant adverse reactions.</p><p><b>Conclusion:</b> The combination of SYC and conventional medicines has been shown to enhance cardiac function and reduce inflammatory parameters, as evidenced by improvements in cardiac electrophysiology data.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/5272962","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144888150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of Physical Activity and Sedentary Behavior on the Preventive Effect of Serum 25(OH)D Levels on NAFLD","authors":"Jia Wang,&nbsp;Yuxiao Yang,&nbsp;Chen Yang,&nbsp;Ying Shi,&nbsp;Bin Cao","doi":"10.1155/ijcp/2802391","DOIUrl":"https://doi.org/10.1155/ijcp/2802391","url":null,"abstract":"<p><b>Background:</b> Uncertainty exists regarding the effects of physical activity (PA) and sedentary behavior on the connection between serum 25-hydroxyvitamin D (25(OH)D) levels and nonalcoholic fatty liver disease (NAFLD). This study aims to evaluate these variables’ potential consequences and offers fresh perspectives and prevention strategies for NAFLD.</p><p><b>Methods:</b> A total of 3765 participants were included in the NHANES database (2017-2018). The Global Physical Activity Questionnaire assessed PA and sedentary time as sedentary behavior. The risk of NAFLD was considered by utilizing vibration-controlled transient elastography measurements. Logistic regression and nonlinearity analyses were utilized to investigate the influence of PA and sedentary behavior on the connection between serum 25(OH)D levels and NAFLD.</p><p><b>Results:</b> Multivariate-adjusted OR (95% CI) of the highest quartile (Q4) participants of serum 25(OH)D levels was 0.40 (0.28–0.58) for NAFLD compared to the lowest quartile (Q1) participants of serum 25(OH)D levels. Compared to the Q1 of serum 25(OH)D levels and non-PA group (&lt; 600 MET-minutes/week) participants, the Q4 of serum 25(OH)D levels and low-intensity PA group (600–7999 MET-minutes/week) participants had a lower risk of NAFLD (OR = 0.38, 95% CI: 0.22–0.67), and the Q4 of serum 25(OH)D levels and high-intensity PA group (≥ 8000 MET-minutes/week) participants had the lowest risk of NAFLD (OR = 0.24, 95% CI: 0.13–0.43). Sedentary behavior (≥ 6 h/day) attenuated the enhancing effect of PA on the negative correlation between serum 25(OH)D and NAFLD.</p><p><b>Conclusions:</b> Increased PA and reduced sedentary time may further protect against NAFLD by acting on serum 25(OH)D in US adults.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/2802391","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}