International Journal of Clinical Practice最新文献

{"title":"Diagnostic Role of Plateletcrit in Pleural Effusion","authors":"Burcu Akkok,&nbsp;Fatos Kozanli","doi":"10.1155/ijcp/5553736","DOIUrl":"https://doi.org/10.1155/ijcp/5553736","url":null,"abstract":"<div>\u0000 <p><b>Objectives:</b> Pleural effusion arises from either increased fluid production or reduced absorption within the pleural space. In instances where thoracentesis is contraindicated or unfeasible, alternative, less invasive diagnostic approaches are necessary. Thoracentesis with simultaneous venous blood sampling is pivotal for differentiating transudative from exudative pleural fluid, guided by the Light criteria In instances where thoracentesis is contraindicated or unfeasible, alternative, less invasive diagnostic approaches are necessary. Parameters such as platelet (PLT) count, plateletcrit (PCT), PLT distribution width (PDW), and mean PLT volume (MPV) have been proposed as adjuncts to other acute phase reactants in identifying inflammation activation. This study aims to investigate the feasibility of Plt activation markers in diagnosing pleural effusion.</p>\u0000 <p><b>Methods:</b> This retrospective observational study involved patients diagnosed with pleural effusion who were admitted to hospital between 01 January 2021 and 31 May 2023. Cases where the effusion nature was determined through thoracentesis were included. Among the complete blood count parameters, neutrophil, lymphocyte, Plt count, PCT, PDW and MPV were calculated.</p>\u0000 <p><b>Results:</b> The study encompassed a cohort of 155 cases, comprising 43.2% females and 56.8% males.Thoracentesis revealed 66.5% exudative effusions and 33.5% transudative effusions. PDW and MPV were significantly lower in the exudate group than in the transudate group. PCT values demonstrated significant effectiveness (area under the curve, 0.740 [0.653–0.828]) in distinguishing patients with exudates from those with transudates. A cut-off value of 0.275 for PCT yielded significant effectiveness with a sensitivity of 83.5%, and a specificity of 61.5%. For a PDW cut-off value of 10.5, the sensitivity was 49.5%, and specificity was 75.0%.</p>\u0000 <p><b>Conclusions:</b> The sensitivity and specificity of Plt parameters in differentiating patients in transudate and exudate groups were found to be high.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/5553736","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Iron Accumulation on Bone Mineral Density in Patients Diagnosed With Transfusion-Dependent Thalassemia","authors":"Cem Selim,&nbsp;Rafiye Çiftçiler,&nbsp;Ayşe Hilal Eroğlu Küçükdiler,&nbsp;Fatma Keklik Karadağ,&nbsp;Nur Soyer","doi":"10.1155/ijcp/5411059","DOIUrl":"https://doi.org/10.1155/ijcp/5411059","url":null,"abstract":"<div>\u0000 <p><b>Introduction:</b> Transfusion-dependent thalassemia (TDT) is most commonly caused by defects in beta globin chain production. Iron overload, hypogonadism, vitamin D deficiency, adverse effects of desferrioxamine treatment, and delayed puberty due to loss of bone mass are the main complications of TDT. In the present study, we aimed to investigate bone complications and precursor markers in TDT patients.</p>\u0000 <p><b>Materials and Methods:</b> Our retrospective study included 93 patients, aged between 18 and 45, who were followed up in a tertiary care institution and did not have any disease other than TDT. The patients’ BMD values and biochemical parameters were compared.</p>\u0000 <p><b>Results:</b> Osteoporosis was observed in 33 of 93 patients, and the mean transferrin saturation of patients with osteoporosis was 60%, and the mean transferrin saturation of patients without osteoporosis was 42%. Patients with osteoporosis had transferrin saturation that was observed to be considerably higher than that of the group without osteoporosis (<i>p</i> = 0.006), with an average of 60%.</p>\u0000 <p><b>Conclusion:</b> Our investigation has demonstrated that in patients with TDT, elevated transferrin saturation may be a sign of osteoporosis.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/5411059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Myasthenic Crisis in Patients With Myasthenia Gravis: A Retrospective Study in Southwest China","authors":"Xue Lin,&nbsp;Hongxi Chen,&nbsp;Xiaofei Wang,&nbsp;Ziyan Shi,&nbsp;Rui Wang,&nbsp;Hongyu Zhou","doi":"10.1155/ijcp/9145129","DOIUrl":"https://doi.org/10.1155/ijcp/9145129","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Myasthenic crisis (MC) is a rare but potentially fatal complication that can significantly worsen the prognosis of patients with myasthenia gravis (MG). However, predicting the occurrence of MC remains challenging. Therefore, this study aimed to identify potential risk factors associated with MC.</p>\u0000 <p><b>Methods:</b> A retrospective study was conducted using the MG Cohort Database at the West China Hospital of Sichuan University from January 2004 to August 2023. The multivariate Cox regression analysis was performed to determine the risk factors for MC.</p>\u0000 <p><b>Results:</b> Among the 1150 patients with MG included in the final analysis, 128 (11.1%) experienced at least one episode of MC. Independent risk factors identified for MC included age (hazard ratio [HR]: 1.02, 95% confidence interval [CI]: 1.01–1.03, <i>p</i> &lt; 0.001), quantitative MG (QMG) score (HR: 1.04, 95% CI: 1.01–1.07, <i>p</i> = 0.003), MG Foundation of America (MGFA) class at diagnosis (HR: 3.19, 95% CI: 2.38–4.28, <i>p</i> &lt; 0.001), and the presence of thymoma (HR: 3.21, 95% CI: 2.13–4.85, <i>p</i> &lt; 0.001). In contrast, generalized MG (<i>p</i> = 0.891) and the presence of antimuscle-specific tyrosine kinase (MuSK) antibodies (<i>p</i> = 0.107) did not significantly increase the risk of developing MC.</p>\u0000 <p><b>Conclusion:</b> Age, disease severity as indicated by the QMG score and MGFA class at diagnosis, along with thymoma presence were identified as potential predictors for MC in patients diagnosed with MG.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/9145129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143431680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Hand Edema on Weaning From Mechanical Ventilation in ICU Patients: A Single Center Nested Case-Control Study","authors":"Dingye Wu,&nbsp;Junfeng Heng,&nbsp;Fengming Liang,&nbsp;Tao Zhou,&nbsp;Qiuhui Wang,&nbsp;Hongyang Xu","doi":"10.1155/ijcp/7382862","DOIUrl":"https://doi.org/10.1155/ijcp/7382862","url":null,"abstract":"<div>\u0000 <p><b>Objective:</b> To investigate the impact of hand edema on weaning from mechanical ventilation among ICU patients.</p>\u0000 <p><b>Methods:</b> A nested case-control study was conducted, collecting data from mechanically ventilated patients admitted to the ICU of Wuxi People’s Hospital from October 1, 2023, to January 31, 2024. Patients were monitored for the occurrence of hand edema within the first 7 days of ICU stay and their weaning outcomes were recorded to analyze the impact of hand edema on weaning success.</p>\u0000 <p><b>Results:</b> The study included 124 patients, 97 successfully weaned while 27 failed. The failed weaning group had higher ages (70.8 ± 10.5 years), SOFA scores (17.7 ± 3.1), and levels of hand edema (Grade 0 in 6 patients, Grade 1 in 9, Grade 2 in 6, Grade 3 in 3, and Grade 4 in 3) compared with the successful weaning group (ages 61.1 ± 9.8 years, SOFA scores 14.3 ± 3.1, hand edema levels: Grade 0 in 78, Grade 1 in 15, Grade 2 in 3, Grade 3 in 1, and Grade 4 in 0). Multivariable binary logistic regression analysis indicated that the level of hand edema is an independent risk factor for weaning failure within 1 week in ICU patients on mechanical ventilation (OR = 3.209, 95% CI: 1.641–6.274, and <i>p</i> &lt; 0.05).</p>\u0000 <p><b>Conclusion:</b> The occurrence of hand edema in ICU patients on mechanical ventilation increases the risk of weaning failure.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/7382862","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Stress Ball Utilization on Dyspnea Severity and Anxiety Level in Patients Receiving Nebulizer Therapy: Randomized Controlled Study","authors":"Yasemin Ceyhan,&nbsp;Sevil Güler,&nbsp;Seda Şahan","doi":"10.1155/ijcp/9770027","DOIUrl":"https://doi.org/10.1155/ijcp/9770027","url":null,"abstract":"<div>\u0000 <p><b>Aim:</b> The study primarily aimed at examining the effect of stress ball utilization on dyspnea and anxiety during nebulizer therapy. The secondary aim was to determine the effect of stress ball utilization on the duration of therapy and vital signs.</p>\u0000 <p><b>Methods:</b> The study has a randomized controlled experimental design. The study population consisted of inpatients receiving nebulizer therapy. A total of 80 patients, 40 in the intervention group and 40 in the control group, were included in the sample. The study was conducted between October 2023 and March 2024. Patients in the intervention group were asked to use a stress ball during nebulizer therapy. Data were collected using a Patient Information Form, the Visual Analog Scale, and the State-Trait Anxiety Inventory. Descriptive statistics, Chi-square, paired test, and one sample <i>t</i>-test were used in data analysis.</p>\u0000 <p><b>Results:</b> The mean age of the patients was 65 years and over and 78% of them had COPD. Stress ball utilization caused a significant effect on the severity of dyspnea (intervention: <i>t</i> = 2.862, <i>p</i> &lt;  0.001; control: <i>t</i> = 2.755, <i>p</i> &lt; 0.001) and anxiety levels (intervention: <i>t</i> = 4.647, <i>p</i> &lt; 0.001; control: <i>t</i> = 6.597, <i>p</i> &lt; 0.001) in intragroup comparisons. In intergroup comparisons, a significant difference (<i>t</i>^<i>ı</i> = 4.455, <i>p</i> &lt; 0.001) was obtained in anxiety level with a high effect (<i>d</i> = 0.70). In addition, the durations of nebulizer (minutes) administration were significantly (<i>p</i> &lt; 0.001) longer in the intervention group (19.10 ± 11.95) than in the control group (13.16 ± 3.02). Stress ball utilization did not affect vital signs and saturation values (<i>p</i> &gt; 0.05).</p>\u0000 <p><b>Conclusions:</b> Utilization of a stress ball during nebulizer therapy has a positive effect on reducing anxiety levels and prolonging the duration of nebulizer use.</p>\u0000 <p><b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT06297356</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/9770027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Diabetes Mellitus and Glycemic Parameters on the Prognosis of COVID-19 Disease","authors":"Işılay Kalan Sarı,&nbsp;Olgun Keskin,&nbsp;Ayşegül Seremet Keskin","doi":"10.1155/ijcp/5566405","DOIUrl":"https://doi.org/10.1155/ijcp/5566405","url":null,"abstract":"<div>\u0000 <p>Studies show that coronavirus disease 2019 (COVID-19) is more severe in people with diabetes. Although diabetes has been shown to be a risk factor for severe COVID-19 disease, the relationship between fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c) with mortality and prognosis in COVID-19 is still controversial. We designed this study to investigate the impact of diabetes on the prognosis of COVID-19 and to show the relationship between FBG and HbA1c and COVID-19 mortality. In this study, patients with COVID-19 who were hospitalized in the COVID-19 Ward of the Department of Chest Diseases and Intensive Care Unit of Antalya Research and Training Hospital between December 2019 and December 2021 were included. The patients’ demographic data, treatment and laboratory results, developing complications, and clinical outcomes were extracted from their electronic medical records. The mortality of patients with diabetes was significantly higher than that of patients without diabetes (<i>p</i> : 0.0001). The duration of hospitalization, the development of complications, and the need for oxygen, antibiotics, and steroids were higher in patients with diabetes than in patients without diabetes (<i>p</i> : 0.0001). C-reactive protein, erythrocyte sedimentation rate, and fibrinogen, which are associated with poor prognosis in studies, were higher in patients with diabetes (<i>p</i> : 0.0001). When comparing discharged and deceased patients with diabetes, HbA1c was higher in discharged patients and FBG was higher in deceased patients (<i>p</i> : 0.003 and <i>p</i> : 0.030, respectively). Our study confirms the finding that COVID-19 patients with diabetes have a poor prognosis and mortality. It also shows that FBG level is related to COVID-19 mortality. Contrary to some studies, the low detection of HbA1c in deceased patients may indicate that initial blood glucose rather than glycemic control prior to infection, is associated with COVID-19 mortality. The influence of HbA1c and FBG on COVID-19 prognosis could be investigated in larger studies.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/5566405","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the Extent of Exposure to Environmental Tobacco Smoke With Exhaled Nitric Oxide and Eosinophils: A Cross-Sectional Study Based on the NHANES 2007–2012 Database","authors":"Xingfang Hou,&nbsp;Shufen Hou,&nbsp;Chenggong Hou,&nbsp;Xuelian Chen,&nbsp;Yuling Tang","doi":"10.1155/ijcp/3384282","DOIUrl":"https://doi.org/10.1155/ijcp/3384282","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Previous studies have demonstrated that exposure to environmental tobacco smoke is associated with a reduction in fractional exhaled nitric oxide (FeNO) levels, elevation in eosinophil (EOS) counts and alterations in airway inflammation patterns, influencing the efficacy of glucocorticoid therapy for TH2 inflammation. No previous study has investigated the association of the extent of exposure to environmental tobacco smoke with FeNO levels. This study aimed to investigate the association of the extent of exposure to environmental tobacco smoke with FeNO level and EOS count.</p>\u0000 <p><b>Methods:</b> In this retrospective cohort study, we included 12,766 individuals from the National Health and Nutrition Examination Survey 2007–2012. The extent of exposure to environmental tobacco smoke was assessed by measuring serum cotinine levels. Participants were categorised into quintiles based on their cotinine levels. Logistic regression models were developed to evaluate the association of serum cotinine levels with FeNO levels and EOS count.</p>\u0000 <p><b>Findings:</b> In the unadjusted and adjusted models, the highest quintile of serum cotinine levels (&gt; 105 ng/mL) was significantly negatively associated with FeNO levels. However, low-to-moderate quintiles of serum cotinine levels were not significantly associated with FeNO levels. Based on sensitivity analyses, the negative associations between the highest quintile of serum cotinine levels and FeNO levels remained consistent among participants with asthma, chronic bronchitis and respiratory symptoms within 7 days. Increased serum cotinine levels were significantly associated with increased EOS counts, which in turn were significantly associated with increased FeNO levels. EOS significantly mediated 7.59% of cotinine-associated reductions in FeNO levels.</p>\u0000 <p><b>Conclusions:</b> Our findings indicated that high levels of tobacco smoke exposure are associated with a decrease in FeNO levels and an increase in EOS count. The smoking status should be considered when evaluating type 2 airway inflammation based on FeNO levels and EOS count.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/3384282","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143404581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Risk Factors for Postpartum Hemorrhage in Forceps-Assisted and Vacuum-Assisted Vaginal Deliveries","authors":"Hui Li,&nbsp;Yurong Jiang,&nbsp;Hua Pan","doi":"10.1155/ijcp/1538613","DOIUrl":"https://doi.org/10.1155/ijcp/1538613","url":null,"abstract":"<div>\u0000 <p><b>Objective:</b> This study aims to compare the clinical outcomes of forceps-assisted vaginal delivery (FAVD) and vacuum-assisted vaginal delivery (VAVD) in primiparous women and to identify risk factors contributing to moderate and severe postpartum hemorrhage (PPH) associated with these delivery methods.</p>\u0000 <p><b>Methods:</b> A retrospective analysis was conducted on clinical data from 1237 primiparous women who delivered at the Obstetrics Department of Hunan Maternal and Child Health Hospital between April 2018 and April 2022. Among these, 711 underwent FAVD and 526 underwent VAVD. Maternal and neonatal characteristics, including age, gestational age, prepregnancy body mass index (BMI), pregnancy weight gain, neonatal weight, and labor duration, were evaluated. The study assessed labor duration, neonatal weight, maternal complications, neonatal complications, and the incidence and severity of PPH. Binary logistic regression analysis was performed to identify risk factors for moderate (500–1000 mL blood loss) and severe (&gt; 1000 mL blood loss) PPH associated with the two delivery methods.</p>\u0000 <p><b>Results:</b> Compared with FAVD, VAVD was associated with a higher incidence of uterine atony (<i>p</i> &lt; 0.05) and increased risks of both moderate and severe PPH (<i>p</i> &lt; 0.05). Pregnant women with significant gestational weight gain more frequently underwent VAVD (<i>p</i> &lt; 0.05), which also correlated with prolonged second and total labor stages compared with FAVD (<i>p</i> &lt; 0.05). Logistic regression revealed that uterine atony was a significant risk factor for both moderate and severe PPH (<i>p</i> &lt; 0.05). Prolonged total labor independently increased the risk of severe PPH in VAVD cases (<i>p</i> &lt; 0.05 and OR 1.575), while gestational weight gain and prolonged labor were independent risk factors for moderate PPH in FAVD cases (<i>p</i> &lt; 0.05, OR 1.047 and OR 1.287, respectively).</p>\u0000 <p><b>Conclusions:</b> VAVD is associated with longer labor duration, a higher likelihood of PPH, and increased neonatal scalp hematoma incidence compared with FAVD. Prolonged total labor significantly contributes to moderate PPH risk in FAVD and severe PPH risk in VAVD. Uterine atony is an independent predictor of both moderate and severe PPH.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/1538613","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143396818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Predictive Association Between Inflammatory Cytokines and Vitiligo: A Bidirectional Mendelian Randomization Study","authors":"Tianbing Lei,&nbsp;Yao Ni","doi":"10.1155/ijcp/1093015","DOIUrl":"https://doi.org/10.1155/ijcp/1093015","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Previous studies have indicated a close association between vitiligo and inflammatory cytokines, yet the genetic predictive association remains unclear. The study aimed to predict the relationship between vitiligo and inflammatory cytokines in genetics.</p>\u0000 <p><b>Methods:</b> A bidirectional analysis was conducted by the two-sample MR. We selected independent genetic tools for significant levels associated with inflammatory cytokines and vitiligo from corresponding meta-analyses of genome-wide association study (GWAS). The summary data for inflammatory cytokines were derived from a GWAS meta-analysis conducted on three separate Finnish population cohorts, comprising a total of 8293 individuals (<i>N</i> = 8293). The vitiligo data, on the other hand, were extracted from a GWAS meta-analysis conducted on individuals of European ancestry, totaling 44,266 individuals (<i>N</i> = 44,266). As the primary analytical approach, we employed the inverse variance weighted (IVW) method, and to ensure the reliability of our main findings, we also performed sensitivity analysis to evaluate the robustness.</p>\u0000 <p><b>Results:</b> Compelling evidence indicated a causal association between genetically predicted IL-18 and IL-8 with vitiligo (odds ratio, OR: 1.162, 95% CI: 1.043–1.295, <i>p</i> = 0.006, and <i>p</i>_fdr = 0.020 and OR: 0.726, 95% CI: 0.602–0.876, <i>p</i> = 0.001, and <i>p</i>_fdr = 0.004). In addition, cytokines including stromal cell-derived factor-1 alpha (SDF1a) (Beta: 0.032, <i>p</i> = 0.016, and <i>p</i>_fdr = 0.039), IL-17 (Beta: 0.038, <i>p</i> = 0.005, and <i>p</i>_fdr = 0.027), basic fibroblast growth factor (FGFBasic) (Beta: 0.028, <i>p</i> = 0.034, and <i>p</i>_fdr = 0.170), monocyte chemoattractant protein-1(MCP1) (Beta: 0.026, <i>p</i> = 0.046, and <i>p</i>_fdr = 0.189), and platelet-derived growth factor BB (PDGFbb) (Beta: 0.026, <i>p</i> = 0.040, and <i>p</i>_fdr = 0.198) were suggested to be the consequences of vitiligo.</p>\u0000 <p><b>Conclusions:</b> According to this investigation, it has been proposed that the etiology of vitiligo is likely associated with IL-18 and IL-8, whereas the downstream progression of vitiligo can be attributed to several inflammatory cytokines such as IL-17, SDF1a, PDGFbb, MCP1, and FGFBasic.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/1093015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of 3D Printing Technology and Artificial Intelligence Assisted in Total Knee Arthroplasty","authors":"Jingbo Pan,&nbsp;Qi Zhang,&nbsp;Gang Kong,&nbsp;Dan Liu,&nbsp;Xiujiang Sun,&nbsp;Guodong Zhang,&nbsp;Yue Zou,&nbsp;Kegui Liu","doi":"10.1155/ijcp/8793065","DOIUrl":"https://doi.org/10.1155/ijcp/8793065","url":null,"abstract":"<div>\u0000 <p>This study aimed to evaluate the efficacy of personalized 3D printing osteotomy guides and artificial intelligence (AI)-assisted surgical planning in total knee arthroplasty (TKA). A cohort of 60 cases was randomly allocated into two groups: one receiving assistance from personalized 3D printing osteotomy guides and the other benefiting from AI-assisted surgical planning for the procedure. We compared surgical duration, intraoperative bleeding, postoperative incision drainage, length of hospital stay, surgical accuracy, and postoperative visual analog scale (VAS) and Hospital for Special Surgery (HSS) outcomes between the two groups. Continuous data conforming to a normal distribution were analyzed using independent-samples <i>t</i>-tests, while categorical data were assessed with chi-square tests. The findings of our study indicated that the 3D printing-assisted TKA (3D-TKA) group experienced significant lower levels (<i>p</i> &lt; 0.05) of bleeding and drainage (160.1 ± 24.3 mL, 199.5 ± 29.6 mL) compared to the AI-assisted TKA (AI-TKA) group (174.7 ± 25.7 mL, 223.8 ± 29.2 mL). Furthermore, the duration of surgery and hospital stay (81.4 ± 8.9 min, 7.7 ± 1.3 day) was significantly longer (<i>p</i> &lt; 0.05) in the 3D-TKA group than the AI-TKA group (72.9 ± 10.0 min, 6.8 ± 1.6 day). No significant differences (<i>p</i> &gt; 0.05) were observed in surgical accuracy between the two groups. On the first day postoperation, VAS scores were significantly lower (<i>p</i> = 0.001) in the 3D-TKA group. In summary, each surgical approach offers distinct benefits. 3D printing primarily enhances patient outcomes, whereas AI assistance tends to favor surgical efficiency.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/8793065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143379946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}