Focus on Visceral Fat Screening in Nonobese Patients With Type 2 Diabetes to Prevent Nonalcoholic Fatty Liver

IF 2.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of Clinical Practice Pub Date : 2025-03-17 DOI:10.1155/ijcp/4278518

Wei-hua Sun, Lu-lu Yang, Chen-chen Wu, Wen-di Zhao, Li Xue

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Abstract

Objective: To identify risk factors associated with nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes (T2DM) and provide a basis for improved prevention and treatment strategies for NAFLD.

Methods: A total of 156 hospitalized patients with T2DM were enrolled and divided into NAFLD and non-NAFLD groups (75 and 81 patients, respectively) based on the ultrasonic diagnosis results. Biochemical data were collected from all patients. A bioelectrical impedance analyzer (OMRON, HDS-2000 DUALSCANR) was used to analyze visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) in the abdomen. Statistical analyses were conducted using SPSS 22.0 software.

Results: Statistically significant differences were observed between the NAFLD and non-NAFLD groups in body weight, body mass index (BMI), waist and hip circumference (WC and HC), waist-to-hip ratio (WHR), fasting C-peptide (FCP), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), total triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), apolipoprotein B (apoB), superoxide dismutase (SOD), free fatty acids (FFA), VAT, and SAT (all p < 0.05). VAT was positively correlated with BMI (r = 0.703, p < 0.001), WC (r = 0.685, p < 0.001), HC (r = 0.547, p < 0.001), SAT (r = 0.774, p < 0.001), TG (r = 0.365, p < 0.001), FCP (r = 0.287, p < 0.001), ALT (r = 0.282, p < 0.001), and GGT (r = 0.273, p = 0.001) and negatively correlated with HDL-C (r = −0.201, p = 0.012). Multivariable logistic regression analysis indicated that VAT and FFA are independent influencing factors for NAFLD (p < 0.01). A receiver operating characteristic curve showed that the sensitivity and specificity of VAT for predicting NAFLD in T2DM were 88.0% and 57.8%, respectively.

Conclusions: VAT and FFA are independent risk factors for NAFLD in patients with T2DM, with VAT serving as a reliable predictor for NAFLD screening. Screening for NAFLD should not be limited to overweight or obese individuals; attention should also be given to nonobese and lean patients.

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关注 2 型糖尿病非肥胖患者的内脏脂肪筛查，预防非酒精性脂肪肝

目的：探讨2型糖尿病（T2DM）患者非酒精性脂肪性肝病（NAFLD）的相关危险因素，为改善NAFLD的防治策略提供依据。方法：选取住院T2DM患者156例，根据超声诊断结果分为NAFLD组75例，非NAFLD组81例。收集所有患者的生化数据。采用欧姆龙HDS-2000 DUALSCANR生物阻抗分析仪分析腹部内脏脂肪组织（VAT）和皮下脂肪组织（SAT）。采用SPSS 22.0软件进行统计学分析。结果：NAFLD组与非NAFLD组在体重、体质量指数（BMI）、腰臀围（WC和HC）、腰臀比（WHR）、空腹c肽（FCP）、丙氨酸转氨酶（ALT）、γ -谷氨酰转肽酶（GGT）、总甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、载脂蛋白B （apoB）、超氧化物歧化酶（SOD）、游离脂肪酸（FFA）、VAT、SAT (p <；0.05)。VAT与BMI呈正相关(r = 0.703, p <；0.001), WC (r = 0.685, p <；0.001), HC (r = 0.547, p <；0.001), SAT (r = 0.774, p <；0.001), TG (r = 0.365, p <；0.001), FCP (r = 0.287, p <；0.001), ALT (r = 0.282, p <；GGT （r = 0.273, p = 0.001）与HDL-C呈负相关（r = - 0.201, p = 0.012）。多变量logistic回归分析显示，VAT和FFA是NAFLD的独立影响因素(p <；0.01)。受试者工作特征曲线显示，VAT预测T2DM患者NAFLD的敏感性和特异性分别为88.0%和57.8%。结论：VAT和FFA是T2DM患者NAFLD的独立危险因素，VAT可作为筛查NAFLD的可靠预测因子。NAFLD筛查不应局限于超重或肥胖个体；非肥胖和瘦弱的患者也应予以注意。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Clinical Practice 医学-医学：内科

CiteScore

5.30

自引率

0.00%

发文量

274

审稿时长

3-8 weeks

期刊介绍： IJCP is a general medical journal. IJCP gives special priority to work that has international appeal. IJCP publishes: Editorials. IJCP Editorials are commissioned. [Peer reviewed at the editor''s discretion] Perspectives. Most IJCP Perspectives are commissioned. Example. [Peer reviewed at the editor''s discretion] Study design and interpretation. Example. [Always peer reviewed] Original data from clinical investigations. In particular: Primary research papers from RCTs, observational studies, epidemiological studies; pre-specified sub-analyses; pooled analyses. [Always peer reviewed] Meta-analyses. [Always peer reviewed] Systematic reviews. From October 2009, special priority will be given to systematic reviews. [Always peer reviewed] Non-systematic/narrative reviews. From October 2009, reviews that are not systematic will be considered only if they include a discrete Methods section that must explicitly describe the authors'' approach. Special priority will, however, be given to systematic reviews. [Always peer reviewed] ''How to…'' papers. Example. [Always peer reviewed] Consensus statements. [Always peer reviewed] Short reports. [Always peer reviewed] Letters. [Peer reviewed at the editor''s discretion] International scope IJCP publishes work from investigators globally. Around 30% of IJCP articles list an author from the UK. Around 30% of IJCP articles list an author from the USA or Canada. Around 45% of IJCP articles list an author from a European country that is not the UK. Around 15% of articles published in IJCP list an author from a country in the Asia-Pacific region.