International Journal of Clinical Practice最新文献

{"title":"The Effect of Diabetes Mellitus and Glycemic Parameters on the Prognosis of COVID-19 Disease","authors":"Işılay Kalan Sarı,&nbsp;Olgun Keskin,&nbsp;Ayşegül Seremet Keskin","doi":"10.1155/ijcp/5566405","DOIUrl":"https://doi.org/10.1155/ijcp/5566405","url":null,"abstract":"<div>\u0000 <p>Studies show that coronavirus disease 2019 (COVID-19) is more severe in people with diabetes. Although diabetes has been shown to be a risk factor for severe COVID-19 disease, the relationship between fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c) with mortality and prognosis in COVID-19 is still controversial. We designed this study to investigate the impact of diabetes on the prognosis of COVID-19 and to show the relationship between FBG and HbA1c and COVID-19 mortality. In this study, patients with COVID-19 who were hospitalized in the COVID-19 Ward of the Department of Chest Diseases and Intensive Care Unit of Antalya Research and Training Hospital between December 2019 and December 2021 were included. The patients’ demographic data, treatment and laboratory results, developing complications, and clinical outcomes were extracted from their electronic medical records. The mortality of patients with diabetes was significantly higher than that of patients without diabetes (<i>p</i> : 0.0001). The duration of hospitalization, the development of complications, and the need for oxygen, antibiotics, and steroids were higher in patients with diabetes than in patients without diabetes (<i>p</i> : 0.0001). C-reactive protein, erythrocyte sedimentation rate, and fibrinogen, which are associated with poor prognosis in studies, were higher in patients with diabetes (<i>p</i> : 0.0001). When comparing discharged and deceased patients with diabetes, HbA1c was higher in discharged patients and FBG was higher in deceased patients (<i>p</i> : 0.003 and <i>p</i> : 0.030, respectively). Our study confirms the finding that COVID-19 patients with diabetes have a poor prognosis and mortality. It also shows that FBG level is related to COVID-19 mortality. Contrary to some studies, the low detection of HbA1c in deceased patients may indicate that initial blood glucose rather than glycemic control prior to infection, is associated with COVID-19 mortality. The influence of HbA1c and FBG on COVID-19 prognosis could be investigated in larger studies.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/5566405","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143423862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the Extent of Exposure to Environmental Tobacco Smoke With Exhaled Nitric Oxide and Eosinophils: A Cross-Sectional Study Based on the NHANES 2007–2012 Database","authors":"Xingfang Hou,&nbsp;Shufen Hou,&nbsp;Chenggong Hou,&nbsp;Xuelian Chen,&nbsp;Yuling Tang","doi":"10.1155/ijcp/3384282","DOIUrl":"https://doi.org/10.1155/ijcp/3384282","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Previous studies have demonstrated that exposure to environmental tobacco smoke is associated with a reduction in fractional exhaled nitric oxide (FeNO) levels, elevation in eosinophil (EOS) counts and alterations in airway inflammation patterns, influencing the efficacy of glucocorticoid therapy for TH2 inflammation. No previous study has investigated the association of the extent of exposure to environmental tobacco smoke with FeNO levels. This study aimed to investigate the association of the extent of exposure to environmental tobacco smoke with FeNO level and EOS count.</p>\u0000 <p><b>Methods:</b> In this retrospective cohort study, we included 12,766 individuals from the National Health and Nutrition Examination Survey 2007–2012. The extent of exposure to environmental tobacco smoke was assessed by measuring serum cotinine levels. Participants were categorised into quintiles based on their cotinine levels. Logistic regression models were developed to evaluate the association of serum cotinine levels with FeNO levels and EOS count.</p>\u0000 <p><b>Findings:</b> In the unadjusted and adjusted models, the highest quintile of serum cotinine levels (&gt; 105 ng/mL) was significantly negatively associated with FeNO levels. However, low-to-moderate quintiles of serum cotinine levels were not significantly associated with FeNO levels. Based on sensitivity analyses, the negative associations between the highest quintile of serum cotinine levels and FeNO levels remained consistent among participants with asthma, chronic bronchitis and respiratory symptoms within 7 days. Increased serum cotinine levels were significantly associated with increased EOS counts, which in turn were significantly associated with increased FeNO levels. EOS significantly mediated 7.59% of cotinine-associated reductions in FeNO levels.</p>\u0000 <p><b>Conclusions:</b> Our findings indicated that high levels of tobacco smoke exposure are associated with a decrease in FeNO levels and an increase in EOS count. The smoking status should be considered when evaluating type 2 airway inflammation based on FeNO levels and EOS count.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/3384282","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143404581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Risk Factors for Postpartum Hemorrhage in Forceps-Assisted and Vacuum-Assisted Vaginal Deliveries","authors":"Hui Li,&nbsp;Yurong Jiang,&nbsp;Hua Pan","doi":"10.1155/ijcp/1538613","DOIUrl":"https://doi.org/10.1155/ijcp/1538613","url":null,"abstract":"<div>\u0000 <p><b>Objective:</b> This study aims to compare the clinical outcomes of forceps-assisted vaginal delivery (FAVD) and vacuum-assisted vaginal delivery (VAVD) in primiparous women and to identify risk factors contributing to moderate and severe postpartum hemorrhage (PPH) associated with these delivery methods.</p>\u0000 <p><b>Methods:</b> A retrospective analysis was conducted on clinical data from 1237 primiparous women who delivered at the Obstetrics Department of Hunan Maternal and Child Health Hospital between April 2018 and April 2022. Among these, 711 underwent FAVD and 526 underwent VAVD. Maternal and neonatal characteristics, including age, gestational age, prepregnancy body mass index (BMI), pregnancy weight gain, neonatal weight, and labor duration, were evaluated. The study assessed labor duration, neonatal weight, maternal complications, neonatal complications, and the incidence and severity of PPH. Binary logistic regression analysis was performed to identify risk factors for moderate (500–1000 mL blood loss) and severe (&gt; 1000 mL blood loss) PPH associated with the two delivery methods.</p>\u0000 <p><b>Results:</b> Compared with FAVD, VAVD was associated with a higher incidence of uterine atony (<i>p</i> &lt; 0.05) and increased risks of both moderate and severe PPH (<i>p</i> &lt; 0.05). Pregnant women with significant gestational weight gain more frequently underwent VAVD (<i>p</i> &lt; 0.05), which also correlated with prolonged second and total labor stages compared with FAVD (<i>p</i> &lt; 0.05). Logistic regression revealed that uterine atony was a significant risk factor for both moderate and severe PPH (<i>p</i> &lt; 0.05). Prolonged total labor independently increased the risk of severe PPH in VAVD cases (<i>p</i> &lt; 0.05 and OR 1.575), while gestational weight gain and prolonged labor were independent risk factors for moderate PPH in FAVD cases (<i>p</i> &lt; 0.05, OR 1.047 and OR 1.287, respectively).</p>\u0000 <p><b>Conclusions:</b> VAVD is associated with longer labor duration, a higher likelihood of PPH, and increased neonatal scalp hematoma incidence compared with FAVD. Prolonged total labor significantly contributes to moderate PPH risk in FAVD and severe PPH risk in VAVD. Uterine atony is an independent predictor of both moderate and severe PPH.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/1538613","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143396818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Predictive Association Between Inflammatory Cytokines and Vitiligo: A Bidirectional Mendelian Randomization Study","authors":"Tianbing Lei,&nbsp;Yao Ni","doi":"10.1155/ijcp/1093015","DOIUrl":"https://doi.org/10.1155/ijcp/1093015","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Previous studies have indicated a close association between vitiligo and inflammatory cytokines, yet the genetic predictive association remains unclear. The study aimed to predict the relationship between vitiligo and inflammatory cytokines in genetics.</p>\u0000 <p><b>Methods:</b> A bidirectional analysis was conducted by the two-sample MR. We selected independent genetic tools for significant levels associated with inflammatory cytokines and vitiligo from corresponding meta-analyses of genome-wide association study (GWAS). The summary data for inflammatory cytokines were derived from a GWAS meta-analysis conducted on three separate Finnish population cohorts, comprising a total of 8293 individuals (<i>N</i> = 8293). The vitiligo data, on the other hand, were extracted from a GWAS meta-analysis conducted on individuals of European ancestry, totaling 44,266 individuals (<i>N</i> = 44,266). As the primary analytical approach, we employed the inverse variance weighted (IVW) method, and to ensure the reliability of our main findings, we also performed sensitivity analysis to evaluate the robustness.</p>\u0000 <p><b>Results:</b> Compelling evidence indicated a causal association between genetically predicted IL-18 and IL-8 with vitiligo (odds ratio, OR: 1.162, 95% CI: 1.043–1.295, <i>p</i> = 0.006, and <i>p</i>_fdr = 0.020 and OR: 0.726, 95% CI: 0.602–0.876, <i>p</i> = 0.001, and <i>p</i>_fdr = 0.004). In addition, cytokines including stromal cell-derived factor-1 alpha (SDF1a) (Beta: 0.032, <i>p</i> = 0.016, and <i>p</i>_fdr = 0.039), IL-17 (Beta: 0.038, <i>p</i> = 0.005, and <i>p</i>_fdr = 0.027), basic fibroblast growth factor (FGFBasic) (Beta: 0.028, <i>p</i> = 0.034, and <i>p</i>_fdr = 0.170), monocyte chemoattractant protein-1(MCP1) (Beta: 0.026, <i>p</i> = 0.046, and <i>p</i>_fdr = 0.189), and platelet-derived growth factor BB (PDGFbb) (Beta: 0.026, <i>p</i> = 0.040, and <i>p</i>_fdr = 0.198) were suggested to be the consequences of vitiligo.</p>\u0000 <p><b>Conclusions:</b> According to this investigation, it has been proposed that the etiology of vitiligo is likely associated with IL-18 and IL-8, whereas the downstream progression of vitiligo can be attributed to several inflammatory cytokines such as IL-17, SDF1a, PDGFbb, MCP1, and FGFBasic.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/1093015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of 3D Printing Technology and Artificial Intelligence Assisted in Total Knee Arthroplasty","authors":"Jingbo Pan,&nbsp;Qi Zhang,&nbsp;Gang Kong,&nbsp;Dan Liu,&nbsp;Xiujiang Sun,&nbsp;Guodong Zhang,&nbsp;Yue Zou,&nbsp;Kegui Liu","doi":"10.1155/ijcp/8793065","DOIUrl":"https://doi.org/10.1155/ijcp/8793065","url":null,"abstract":"<div>\u0000 <p>This study aimed to evaluate the efficacy of personalized 3D printing osteotomy guides and artificial intelligence (AI)-assisted surgical planning in total knee arthroplasty (TKA). A cohort of 60 cases was randomly allocated into two groups: one receiving assistance from personalized 3D printing osteotomy guides and the other benefiting from AI-assisted surgical planning for the procedure. We compared surgical duration, intraoperative bleeding, postoperative incision drainage, length of hospital stay, surgical accuracy, and postoperative visual analog scale (VAS) and Hospital for Special Surgery (HSS) outcomes between the two groups. Continuous data conforming to a normal distribution were analyzed using independent-samples <i>t</i>-tests, while categorical data were assessed with chi-square tests. The findings of our study indicated that the 3D printing-assisted TKA (3D-TKA) group experienced significant lower levels (<i>p</i> &lt; 0.05) of bleeding and drainage (160.1 ± 24.3 mL, 199.5 ± 29.6 mL) compared to the AI-assisted TKA (AI-TKA) group (174.7 ± 25.7 mL, 223.8 ± 29.2 mL). Furthermore, the duration of surgery and hospital stay (81.4 ± 8.9 min, 7.7 ± 1.3 day) was significantly longer (<i>p</i> &lt; 0.05) in the 3D-TKA group than the AI-TKA group (72.9 ± 10.0 min, 6.8 ± 1.6 day). No significant differences (<i>p</i> &gt; 0.05) were observed in surgical accuracy between the two groups. On the first day postoperation, VAS scores were significantly lower (<i>p</i> = 0.001) in the 3D-TKA group. In summary, each surgical approach offers distinct benefits. 3D printing primarily enhances patient outcomes, whereas AI assistance tends to favor surgical efficiency.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/8793065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143379946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the Correlation Between Renal Function Markers and Serum Ferritin Levels in Thalassemia Patients","authors":"Mohammad Tammadondar,&nbsp;Ali Vatankhah,&nbsp;Niloufar Khatibzade-Nasari","doi":"10.1155/ijcp/6915906","DOIUrl":"https://doi.org/10.1155/ijcp/6915906","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> This study aimed to analyze renal function markers and correlate the results with serum ferritin levels in patients with thalassemia in Bandar Abbas, Iran, in 2020.</p>\u0000 <p><b>Method:</b> A cross-sectional study was conducted, and patients with a proven hemoglobinopathy diagnosis were included. Fasting blood was obtained to measure creatinine, sodium, potassium, calcium, phosphorus, magnesium, uric acid, and ferritin. In addition, a 24-h urine specimen was collected to determine the level of urine albumin, creatinine, sodium, potassium, calcium, phosphorus, magnesium, uric acid, and β2-microglobulin. Fractional excretion of sodium, potassium, calcium, phosphorus, magnesium, and uric acid was also calculated. Spearman’s coefficient of correlation was used to determine the correlations between serum ferritin level and other variables.</p>\u0000 <p><b>Results:</b> Of the sixty-six patients studied, 3.0% had sickle cell thalassemia, 80.3% had major thalassemia, and 72.7% had intermediate thalassemia. In our study, serum ferritin, 24-h urine protein, and fractional excretion of sodium, calcium, and urine were higher than the normal range in thalassemia patients. There was a significant correlation between serum ferritin level and fractional excretion of magnesium, calcium, sodium, phosphorus, and uric acid with a negative correlation coefficient (<i>p</i> ≤ 0.05). We also found that the serum ferritin levels strongly correlated with microalbuminuria (<i>p</i> ≤ 0.05).</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/6915906","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143379945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association of Diet With High Phosphatemic Index With Odds of Nonalcoholic Fatty Liver Disease","authors":"Mitra Kazemi Jahromi,&nbsp;Mostafa Norouzzadeh,&nbsp;Farshad Teymoori,&nbsp;Niloufar Saber,&nbsp;Hamid Ahmadirad,&nbsp;Hossein Farhadnejad,&nbsp;Ammar Salehi-Sahlabadi,&nbsp;Parvin Mirmiran","doi":"10.1155/ijcp/4066662","DOIUrl":"https://doi.org/10.1155/ijcp/4066662","url":null,"abstract":"<div>\u0000 <p><b>Aim:</b> A high intake of dietary phosphorus with an effect on the serum phosphorus level may affect the health status and predict the occurrence of some clinical disorders. Therefore, in the current study, we aimed to determine phosphatemic index (PI) according to serum levels of phosphorus after intake of different foods and assess its association with the odds of nonalcoholic fatty liver disease (NAFLD).</p>\u0000 <p><b>Methods:</b> The current study was conducted with case-control design on 225 newly diagnosed NAFLD cases and 450 controls aged 20–60 years. Dietary intake data were collected by a validated food frequency questionnaire. The PI was calculated as the area under the curve (AUC) of serum phosphorus after eating test food divided by the AUC for the food supply containing an equal quantity of phosphorus. Multivariable logistic regression models were used to evaluate the NAFLD odds according to tertiles of the PI score.</p>\u0000 <p><b>Results:</b> The median (IQR) of dietary PI in participants of case and control groups was 83.9 (55.8–114.2) and 82.1 (52.6–119.6), respectively. In the age and sex-adjusted model, there was no statistically significant association between PI and the odds of NAFLD (OR = 1.47; 95% CI: 0.98–2.19, <i>P</i>_trend = 0.065). However, in fully adjusted model, after controlling the effects of age, sex, waist-to-hip ratio, smoking, dietary intake of energy, dietary fiber, physical activity, and socioeconomic status, the odds of NAFLD increased across tertiles of PI (OR = 1.97; 95% CI: 1.08–3.58, <i>P</i>_trend = 0.028).</p>\u0000 <p><b>Conclusions:</b> Our results suggested that a diet with a higher PI score may contribute to an increase in the odds of NAFLD independent of common confounders.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/4066662","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Vaccine Hesitancy Levels Among Turkish Parents in 2024 After Pandemic; Key Influencing Factors: A Cross-Sectional Study","authors":"Zehra Kılınç,&nbsp;Songül Beycur Işık","doi":"10.1155/ijcp/5511192","DOIUrl":"https://doi.org/10.1155/ijcp/5511192","url":null,"abstract":"&lt;div&gt;\u0000 &lt;p&gt;&lt;b&gt;Objectives:&lt;/b&gt; This study aimed to evaluate the level of vaccine hesitancy and related factors regarding childhood vaccines among parents with children under 5 years of age receiving services from a health center in Turkey.&lt;/p&gt;\u0000 &lt;p&gt;&lt;b&gt;Materials and Methods:&lt;/b&gt; This cross-sectional study was conducted with parents with children under 5 years of age who applied to a primary care family health center in Diyarbakır province between 1 November and 1 December 2023. The number of children under 5 years of age registered at the family health center was approximately 800, and the minimum sample size was calculated as 219 using the Open Epi program with a 13% vaccine hesitancy frequency, 99% confidence interval, and 80% power. A total of 214 parents who had no communication problems and voluntarily agreed to participate were included in the study. Data were collected through face-to-face interviews using a data form including demographic information of parents and their children, vaccination knowledge, the impact of the COVID-19 pandemic on vaccination attitudes, and the Parents’ Attitudes Toward Childhood Vaccines Scale (PACV) Scale. Data were analyzed using SPSS (Version 24.0).&lt;/p&gt;\u0000 &lt;p&gt;&lt;b&gt;Findings:&lt;/b&gt; The mean age of the participants was 32.2 ± 5.9 years, 73.4% were mothers, 70.1% and 62.6% of their spouses had high school education or less, and 60.7% were not employed. A total of 65.9% of the parents were at the middle-income level and 76.6% stated that they had sufficient knowledge about child vaccines. They mostly received vaccine information from family health center nurses or physicians (84.1%). The vaccine hesitation rate was 16.8% and the PACV Scale’s mean score was 34.38 ± 15.60. No significant difference was found between the hesitation levels of the parents. While the rate of hesitation was 36.1% in parents with sufficient knowledge about vaccination, this rate was 63.9% in those with insufficient knowledge, and this difference was found to be statistically significant (&lt;i&gt;p&lt;/i&gt; = 0.01). In addition, vaccine hesitancy was found to be higher in parents who did not have a negative impact of the COVID-19 pandemic on the vaccination decision. Parents with university and higher education level had higher and statistically significant safety-effectiveness scale subdimension scores (&lt;i&gt;p&lt;/i&gt; &lt; 0.001).&lt;/p&gt;\u0000 &lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; In this study, vaccine hesitation was found in 16.8% of the parents and the level of hesitation was found to be associated with knowledge and education levels. The hesitation rate was found to be lower in parents who had sufficient knowledge about childhood vaccines. The higher hesitation levels of parents who reported that the pandemic did not negatively affect their vaccination decisions suggest the effect of social and psychological factors. The findings emphasize the importance of education and awareness-raising activities for parents to reduce vaccine hesitanc","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/5511192","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143110998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep-Breath–Related Characteristics in Males With Chronic Rhinosinusitis","authors":"Wenjun Xue,&nbsp;Qianqian Zhang,&nbsp;Xiaolin Wu,&nbsp;Huaming Zhu,&nbsp;Xinyi Li,&nbsp;Yunhai Feng,&nbsp;Haibo Ye","doi":"10.1155/ijcp/3662245","DOIUrl":"https://doi.org/10.1155/ijcp/3662245","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Patients with chronic rhinosinusitis (CRS) often exhibit sleep impairments that are closely associated with obstructive sleep apnea (OSA). However, objective evaluations of sleep quality in inpatients with CRS are lacking. This study explored the sleep-breath–related characteristics of CRS patients without nasal polyps (CRSsNP).</p>\u0000 <p><b>Methods:</b> In this cross-sectional single-center study, we recruited 147 adult male inpatients diagnosed with CRSsNP between March 2019 and April 2020. OSA was diagnosed using standard PSG. The patients were classified into two groups based on the apnea–hypopnea index: CRSsNP with OSA and CRSsNP without OSA groups. Demographic features and sleep parameters were evaluated and compared between the groups.</p>\u0000 <p><b>Results:</b> Inpatients with CRSsNP were at high risk of OSA (61.2%). Interestingly, the oxygen desaturation index (ODI), sleep efficiency (SE), and wake duration showed no differences between the CRSsNP with OSA and CRSsNP without OSA patients. The CRSsNP with OSA group exhibited a higher prevalence of obesity, slept for less time, was more easily aroused, and exhibited higher SE and larger CT90 scores during sleep (<i>p</i> &lt; 0.05) compared to the CRSsNP without OSA group. Linear regression analysis revealed that the average SpO₂ value (<i>β</i> = 1.182; <i>p</i> = 0.036) and ODI (<i>β</i> = 0.818; <i>p</i> &lt; 0.001) remained significantly associated with OSA in CRS patients even after adjusting for age and body mass index.</p>\u0000 <p><b>Conclusions:</b> Male inpatients with CRSsNP exhibited a high prevalence of OSA. CRSsNP patients evidenced severe hypoxia and exhibited more awakenings during sleep.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/3662245","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143110669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Silymarin on Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","authors":"Mahdi Vajdi,&nbsp;Shaghayegh Adeli,&nbsp;Arash Karimi,&nbsp;Vahid Asghariazar,&nbsp;Arezoo Moini Jazani,&nbsp;Ramin Nasimidoost Azgomi","doi":"10.1155/ijcp/3985207","DOIUrl":"https://doi.org/10.1155/ijcp/3985207","url":null,"abstract":"<div>\u0000 <p>Numerous studies have investigated into the antioxidant and anti-inflammatory properties of silymarin, as well as its ability to reduce reactive oxygen species and inflammation biomarkers. The effect of silymarin on inflammation and oxidative stress was investigated using the keywords “milk thistle” OR “Silybum marianum” OR “Silybum” OR “silymarin” OR “Silibinin” AND “MDA” OR “Malondialdehyde” OR “TAC” OR “total antioxidant capacity” OR “IL-10” OR “Interleukin-10” OR “IL-6” OR “Interleukin-6” OR “TNF-α” OR “tumor necrosis factor alpha” on the Web of Science, Scopus, Embase, PubMed, and Cochrane Library, up until March 2023. Data were combined using a random-effects model, and the weighted/standardized mean differences (WMDs/SMDs) with a 95% confidence interval (CI) were used as the overall effect size. Our meta-analysis indicated that silymarin supplementation resulted in a significant decrease in levels of C-reactive protein (CRP) (WMD: −3.39 mg/L, 95% CI: −5.99, −0.79, <i>p</i> = 0.01) and malondialdehyde (MDA) (SMD: −1.69, 95% CI: −2.62, −0.76, <i>p</i> &lt; 0.001). Furthermore, silymarin significantly increases IL-10 (WMD: 2.03 pg/mL; 95% CI: 1.04, 3.01, <i>p</i> &lt; 0.001), superoxide dismutase (SOD) (SMD: 3.39, 95% CI: 1.42, 5.37, <i>p</i> = 0.001), and glutathione peroxidase (GPx) (SMD: 1.94; 95% CI, 0.89 to 2.99; <i>p</i> &lt; 0.001) level. However, silymarin supplementation did not have significant effects on TAC (SMD: 2.91; 95% CI: −0.30, 6.11, <i>p</i> = 0.076) and IL-6 (WMD: −0.70 pg/mL; 95% CI: −1.42, 0.02, <i>p</i> &lt; 0.056) level. Silymarin supplementation may significantly improve oxidative stress and inflammation in adults by decreasing CRP and MDA and increasing IL-10, SOD, and GPx. However, additional studies with longer study periods are required to ascertain the long-term effects of silymarin on oxidative stress and chronic inflammation.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/3985207","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143118189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}