International Journal of Clinical Practice最新文献

{"title":"Comprehensive Analysis of FBXO43 Expression and Its Prognostic and Therapeutic Implications in Osteosarcoma","authors":"Jiang Jin,&nbsp;Kang Yao,&nbsp;Zhao Tingxiao,&nbsp;Yao Longtao,&nbsp;Li Yanlei,&nbsp;Tian Jinlong,&nbsp;Zhu Xiaojun,&nbsp;Han Liang","doi":"10.1155/ijcp/9026711","DOIUrl":"https://doi.org/10.1155/ijcp/9026711","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Osteosarcoma (OS) is the most common malignant bone tumor in children and adolescents. FBXO43, a member of the F-box protein family, has been identified as a crucial prognostic factor in several cancers. However, its role in osteosarcoma remains largely unexplored.</p>\u0000 <p><b>Methods:</b> This study investigated the expression and potential role of FBXO43 across the TCGA pan-cancer cohort, with a particular focus on sarcoma (SARC). We analyzed the relationship between FBXO43 expression and various cancer-related pathways, immune infiltration, and genomic features, including TP53 mutations. We also conducted immunotherapy predictive analyses using TIDE and Submap algorithms. To validate our findings, we performed a series of in vitro experiments, including cell invasion and wound healing assays.</p>\u0000 <p><b>Results:</b> FBXO43 was found to be significantly overexpressed in various cancers and was particularly associated with pathways such as E2F_TARGETS and G2M_CHECKPOINT in SARC samples. Differential FBXO43 expression was linked to distinct immune infiltration patterns and pathway enrichments. Notably, high FBXO43 expression in osteosarcoma was associated with a higher TP53 mutation rate. Predictive analyses indicated that patients with low FBXO43 expression had better immunotherapy responses, suggesting its potential as a diagnostic and prognostic biomarker. These findings were corroborated by our in vitro functional assays.</p>\u0000 <p><b>Conclusion:</b> Our comprehensive analysis reveals that FBXO43 plays a critical role in the progression of osteosarcoma, impacting both immune infiltration and genomic stability. FBXO43 expression levels may serve as valuable biomarkers for predicting immunotherapy responses in osteosarcoma patients. Future studies should aim to elucidate the molecular mechanisms driving FBXO43’s role and validating these findings in clinical settings to develop targeted therapeutic strategies.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/9026711","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143112480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge of Kidney Disease Among Allied Health Sciences Undergraduates: A Cross-Sectional Study in the University of Cape Coast","authors":"Victor Obiri Opoku,&nbsp;Theophilus Junior Yankey,&nbsp;Mainprice Akuoko Essuman,&nbsp;George Nkrumah Osei,&nbsp;Tetteh Attoh,&nbsp;Richard K. D. Ephraim","doi":"10.1155/ijcp/8671438","DOIUrl":"https://doi.org/10.1155/ijcp/8671438","url":null,"abstract":"<div>\u0000 <p><b>Introduction:</b> Knowledge of kidney disease (KD) is an essential element that is needed in the scope of every healthcare professional. This study assessed the level of awareness and understanding of allied health sciences undergraduates of University of Cape Coast regarding KDs and their risk factors.</p>\u0000 <p><b>Methodology:</b> Among the regular allied health sciences undergraduates of the University of Cape Coast, a cross-sectional study was conducted from March 2022 to June 2022. A well-structured questionnaire on knowledge of KDs and their risk factors was administered to consented participants. Data were analyzed accordingly using <i>R</i> Studio statistical software version 2022.02.3.</p>\u0000 <p><b>Results:</b> The study involved 383 participants (the majority being males (52.7%)) with an average age of 22.23 ± 3.03 years. Age (<i>p</i> &lt; 0.001), year of study (<i>p</i> &lt; 0.001), program of study (<i>p</i> &lt; 0.001), frequency of 30 min of exercise per week (<i>p</i> = 0.002), and body mass index (<i>p</i> = 0.023) showed statistically significant differences between males and females. The mean knowledge score of KD was 20.86 ± 3.88 (out of a maximum score of 27) with the majority of study participants having a high knowledge of KD (61.9% (237/383)). High knowledge level was observed for types and stages, diagnosis, and risk factors for KD (76.8% (3.84/5), 75.3% (5.27/7), and 81.6% (8.98/11), respectively) while moderate knowledge level was observed for signs and symptoms (69.3% (2.77/4)). Multivariate analysis showed that participants were found to be more knowledgeable about KDs if they indicated taking alcohol (OR = 5.96; 95% CI = 2.01–22.35; <i>p</i> = 0.003), being in second (OR = 3.27; 95% CI = 1.22–9.02; <i>p</i> = 0.020) or fourth (OR = 4.72; 95% CI = 1.63–14.37; <i>p</i> = 0.005) year of study, or classified themselves as being underweight (OR = 3.93; 95% CI = 1.22–15.85; <i>p</i> = 0.033). Students reporting alcohol use had almost six times higher odds of high KD awareness compared to those who did not report alcohol intake (OR = 5.96, 95% C = 2.01–22.35, <i>p</i> = 0.003).</p>\u0000 <p><b>Conclusion:</b> This study revealed an adequate knowledge level of KDs and their risk factors among allied health sciences undergraduates. However, an inadequate knowledge of its signs and symptoms was observed indicating a need for improved training.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/8671438","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143111152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Systematic, Scoping, Umbrella, and Narrative Reviews in Clinical Research: Critical Considerations and Future Directions","authors":"Mohamad Motevalli","doi":"10.1155/ijcp/9929300","DOIUrl":"https://doi.org/10.1155/ijcp/9929300","url":null,"abstract":"<div>\u0000 <p>Review studies play a key role in the development of clinical practice by synthesizing data and drawing conclusions from multiple scientific sources. In recent decades, there has been a significant increase in the number of review studies conducted and published by researchers. In clinical research, different types of review studies (systematic, scoping, umbrella, and narrative reviews) are conducted with different objectives and methodologies. Despite the abundance of guidelines for conducting review studies, researchers often face challenges in selecting the most appropriate review method, mainly due to their overlapping characteristics, including the complexity of matching review types to specific research questions. The aim of this article is to compare the main features of systematic, scoping, umbrella, and narrative reviews in clinical research and to address key considerations for selecting the most appropriate review approach. It also discusses future opportunities for updating their strategies based on emerging trends in clinical research. Understanding the differences between review approaches will help researchers, practitioners, journalists, and policymakers to effectively navigate the complex and evolving field of scientific research, leading to informed decisions that ultimately enhance the overall quality of healthcare practices.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/9929300","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143111150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Syndrome and Its Determinants in Patients Undergoing Obesity Screening Within the Scope of the Disease Management Platform","authors":"Esranur Yayın,&nbsp;Hasan Esad Yayın","doi":"10.1155/ijcp/3827904","DOIUrl":"https://doi.org/10.1155/ijcp/3827904","url":null,"abstract":"<div>\u0000 <p><b>Objective:</b> We aimed to detect rates of metabolic syndrome and overweight, patients screened for obesity within the scope of the Disease Management Platform (DMP).</p>\u0000 <p><b>Methods:</b> This cross-sectional study was completed with 387 patients who were examined for fasting plasma glucose, triglyceride, and high-density lipoprotein levels, waist circumference, blood pressure measurements, chronic diseases, body mass index, and medication use.</p>\u0000 <p><b>Results:</b> In total of whom 387 underwent blood tests as recommended by the DMP. The mean age and body mass index were 55.26 ± 14.50 years and 27.02 ± 3.69 kg/m², respectively. While 26.6% of the patients had normal weight, 56.1% had overweight. Metabolic syndrome was present in 52.2% of the patients.</p>\u0000 <p><b>Conclusion:</b> The significant increases in the rates of overweight and metabolic syndrome have drawn attention in the community. Therefore, family physicians necessitate additional platforms, such as the DMP, to effectively combat metabolic syndrome and overweight, a pivotal initial step in tackling obesity.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2024 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/3827904","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristic and Prognostic Value of Serum Bone Turnover Markers in Pregnant Women With Pre-Eclampsia: A Prospective Cohort Study","authors":"Fan Yu,&nbsp;Xiaocui Huang,&nbsp;Yuanting Tang,&nbsp;Yiduo Zhang,&nbsp;Qing Li,&nbsp;Yongmei Jiang","doi":"10.1155/ijcp/8816587","DOIUrl":"https://doi.org/10.1155/ijcp/8816587","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Pre-eclampsia is a severe pregnancy complication affecting about 4%–5% of pregnancies, but the causes and clinical management were full of controversial. Bone turnover markers (BTMs) were sensitive indicators for estimating bone metabolism and were found to be changed in many pregnancy-related diseases. However, the characteristic and prognostic value of serum BTMs with pre-eclampsia was uncovered.</p>\u0000 <p><b>Methods:</b> A multicenter prospective cohort study was performed in three different hospitals in West China. Pre-eclampsia patients and healthy pregnant women were recruited from January 2023 to January 2024. Clinical information of included participants was collected, and serum BTM levels were detected by electrochemiluminescence immunoassay. Clinical outcomes including disease aggravation (severe pre-eclampsia, eclampsia, and HELLP syndrome), low live birth weight (LBW), and premature delivery were followed up.</p>\u0000 <p><b>Results:</b> A total of 69 pre-eclampsia patients and 75 healthy pregnant women were recruited finally, and 48 pre-eclampsia patients and 48 healthy controls who matched for age and gestational weeks were selected among them. The pre-eclampsia patients had elevated BTM levels compared with healthy controls. ß-CTX was an independent risk factor for disease aggravation, LBW, and premature delivery among pre-eclampsia patients. ß-CTX was a valuable predictive factor for disease aggravation, LBW, and premature delivery among pre-eclampsia patients (AUC were 0.772, 0.768, and 0.930, respectively, and <i>p</i> values were 0.001, 0.002, and &lt; 0.001, respectively).</p>\u0000 <p><b>Conclusion:</b> Pre-eclampsia patients may have an activated bone metabolism status compared with healthy controls. Pre-eclampsia patients with elevated bone resorptive marker ß-CTX should pay more attention to the risk of disease aggravation and adverse pregnancy outcomes.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2024 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/8816587","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143120956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NT5E Mediates Cisplatin Resistance in NSCLC Through the PI3K-AKT Signaling Pathway","authors":"Liangfeng Zheng,&nbsp;Jian Liu,&nbsp;Feiyue Ji,&nbsp;Chunxiang Li,&nbsp;Ye Qian,&nbsp;Lili Shao,&nbsp;Xiaomin Lu","doi":"10.1155/ijcp/3920444","DOIUrl":"https://doi.org/10.1155/ijcp/3920444","url":null,"abstract":"<div>\u0000 <p><b>Objective:</b> The aim of this study was to investigate the role of NT5E and its mechanism in cisplatin (diamminedichloroplatinum, DDP) resistance in non-small cell lung cancer (NSCLC) and to explore the value of NT5E in the clinical prognosis of NSCLC patients.</p>\u0000 <p><b>Methods:</b> First, the genes related to drug resistance were identified by constructing an A549/DDP cell line with DDP resistance and performing transcriptome sequencing and bioinformatics analysis. Gene ontology (GO) as well as the Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathways were enriched for the related genes using the Metascape database. The STRING database was further applied to construct protein–protein interaction networks (PPIs), and heatmaps were used to visualize the coexpression relationships of genes in the modules, as well as to screen for key genes. Subsequently, immunohistochemistry and molecular biology experiments were conducted to confirm the expression levels of NT5E in DDP-resistant NSCLC tissues and cells. Additionally, its effects on cell proliferation, migration, and invasion were assessed through NT5E knockdown assays. Finally, RNA sequencing and signaling pathway analyses revealed that NT5E regulates DDP resistance in NSCLC cells through the PI3K-AKT signaling pathway and analyzed the correlation between the expression of NT5E and survival outcomes in NSCLC patients.</p>\u0000 <p><b>Results:</b> NT5E was found to be upregulated in drug-resistant cells and increased in DDP-resistant NSCLC tissues and cells. The drug-resistant genes were primarily involved in cell adhesion and the extracellular matrix. Functional experiments confirmed that the knockdown of NT5E inhibited cell proliferation, migration, and invasion. Signaling pathway analysis indicated that NT5E mediated the resistance of NSCLC cells to DDP through the PI3K/AKT signaling pathway. Moreover, high NT5E expression was found to be negatively correlated with the overall survival of NSCLC patients.</p>\u0000 <p><b>Conclusion:</b> NT5E may be a key gene for DDP resistance in NSCLC cells, while its high expression may indicate a poor prognosis for patients. This finding provides important insights for a deeper understanding of the mechanism of drug resistance in lung cancer and serves as a theoretical basis for the development of new therapeutic strategies and drugs.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2024 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/3920444","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143120195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Model of Tibial Nerve Depth for Needle-Based Interventions With Broader Applications: An Observational Study in a Spanish Cohort","authors":"Isabel Mínguez-Esteban,&nbsp;Carlos Romero-Morales,&nbsp;Jorge Hugo Villafañe,&nbsp;Juan Antonio Valera-Calero,&nbsp;Gustavo Plaza-Manzano,&nbsp;Ángel González-de-la-Flor","doi":"10.1155/ijcp/1451340","DOIUrl":"https://doi.org/10.1155/ijcp/1451340","url":null,"abstract":"<div>\u0000 <p><b>Objective:</b> To develop a predictive model for estimating the depth of the tibial nerve using anthropometric and demographic data to improve the safety and accuracy of needle-based interventions.</p>\u0000 <p><b>Design:</b> Cross-sectional observational study.</p>\u0000 <p><b>Setting:</b> European University of Madrid, Spain.</p>\u0000 <p><b>Methods:</b> Fifty volunteers aged 18–45 years, without any conditions affecting muscle tone, significant lower limb asymmetries, or history of lower limb surgeries. Demographic and anthropometric data, including sex, age, height, weight, BMI, and measurements of leg length and circumference at specific points, were collected. Ultrasound imaging was used to measure the depth of the tibial nerve at the popliteal fossa and mid-third of the leg.</p>\u0000 <p><b>Results:</b> The predictive model identified leg girth at the mid-third as a significant predictor of tibial nerve depth, explaining 22.3% of the variance (<i>R</i>² = 0.223, <i>p</i> &lt; 0.05). Gender and leg girth together explained up to 17.8% of the variance for proximal tibial nerve depth (<i>R</i>² = 0.178, <i>p</i> &lt; 0.05). Additionally, males exhibited greater leg length (mean = 95.9 cm) compared to females (mean = 90.8 cm, <i>p</i> = 0.01), with no significant difference in tibial nerve depth between genders (<i>p</i> &gt; 0.05). Strong correlations were observed between tibial nerve depth and BMI at both the proximal and mid-third levels (<i>r</i> = 0.4–0.5, <i>p</i> &lt; 0.001).</p>\u0000 <p><b>Conclusion:</b> This predictive model shows that leg girth and gender are significant predictors of tibial nerve depth in a healthy cohort. However, its clinical utility remains preliminary and requires external validation in larger, diverse, and pathology-specific populations to confirm broader applicability in clinical settings.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2024 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/1451340","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143119622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Protective Role of PGC-1α in Cystitis Glandularis: Mitigating Mitochondrial Injury and Inflammation","authors":"Min Chen,&nbsp;Yongbo Tang,&nbsp;Yue Fu,&nbsp;Haiwei Hu,&nbsp;Ende Cui,&nbsp;Zhouliang Wen,&nbsp;Wei Zhong,&nbsp;Jimin Su,&nbsp;Bo Ge","doi":"10.1155/ijcp/8164243","DOIUrl":"https://doi.org/10.1155/ijcp/8164243","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α), a regulator of mitochondrial function, plays a critical role in inflammation and may be involved in cystitis glandularis (CG) development.</p>\u0000 <p><b>Methods:</b> LPS was administered to establish a CG model in female Sprague–Dawley (SD) rats and to induce cellular injury in the human urothelial cell line SV-HUC-1. Subsequently, to elucidate the role of PGC-1α signaling in CG, both the animal and cellular models were treated with ZLN005, a specific activator of PGC-1α. Cell viability was assessed using the cell-counting kit-8 (CCK8) assay. Mitochondrial damage was quantified by measuring reactive oxygen species (ROS), assessing mitochondrial membrane potential, and examining mitochondrial ultrastructure via transmission electron microscopy (TEM). Enzyme-linked immunosorbent assays (ELISA) were utilized to determine the levels of inflammatory cytokines, namely, IL-1β, IL-6, and TNF-α. Furthermore, the protein expression of silent information regulation 1 (SIRT1), PGC-1α, mitochondrial transcription factor A (TFAM), nuclear respiratory factor 1 (NRF1), and nuclear respiratory factor 2 (NRF2) was evaluated using immunohistochemistry and/or Western blot analysis.</p>\u0000 <p><b>Results:</b> LPS-treated rat bladder exhibited histological characteristics of CG, including increased urothelial proliferation and inflammation. PGC-1α protein levels were downregulated in human CG tissues, LPS-treated rat bladders, and SV-HUC-1 cells. Mitochondrial damage was observed in both rat CG and LPS-irritated cells with elevated ROS and diminished mitochondrial membrane potential. TEM documented mitochondrial morphological injury of the urothelium in rat CG. ZLN005 attenuated LPS-induced epithelial hyperplasia and inflammatory cytokine secretion in the rat CG model. Furthermore, ZLN005 partially reversed LPS-induced mitochondrial damage, as indicated by reduced ROS levels, restored mitochondrial membrane potential, and mitigated mitochondrial morphological injury in both rat CG and LPS-stimulated cells. In addition, ZLN005 restored the expression of PGC-1α and its associated signaling proteins SIRT1, TFAM, NRF1, and NRF2.</p>\u0000 <p><b>Conclusions:</b> The downregulation of PGC-1α suggests its potential as a molecular marker for the progression of CG. Targeting the PGC-1α signaling pathway may offer an effective therapeutic intervention for the clinical management of CG.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2024 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/8164243","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143119199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Nanocurcumin Supplementation on Inflammatory and Biochemical Indicators in Hospitalized Patients With COVID-19: A Randomized Controlled Clinical Trial","authors":"Sedigheh Ahmadi,&nbsp;Mohsen Mohit,&nbsp;Zeinab Mehrabi,&nbsp;Mohammad Reza Heydari,&nbsp;Seyed Nooreddin Faraji,&nbsp;Shoeleh Yaghoubi,&nbsp;Morteza Zare,&nbsp;Seyed Jalil Masoumi","doi":"10.1155/ijcp/6675459","DOIUrl":"https://doi.org/10.1155/ijcp/6675459","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> The prior studies showed that nanocurcumin (NC) has potential anti-viral properties against a wide range of viral infections, making it a promising candidate for treating COVID-19. This study aimed to investigate the effect of NC supplementation on the acute phase proteins, including interleukin-6 (IL-6), C-reactive protein (CRP), albumin (ALB) and Erythrocyte Sedimentation Rate (ESR), and biochemical markers including lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine transaminase (ALT) and complete blood cells (CBC) in the hospitalized patients with Coronavirus disease 2019 (COVID-19).</p>\u0000 <p><b>Methods and Materials:</b> In a double-blind placebo-controlled clinical trial conducted at Ali-Asghar Hospital of Shiraz University of Medical Sciences, 76 COVID-19 patients with mild to moderate disease severity were randomly assigned to two groups. All patients received the national treatment guideline for COVID-19. The intervention group was administered 160 mg/day of NC for a period of 2 weeks. Blood samples were obtained at the start and the end of the research, and nutritional consumption was determined using a 24 h dietary recall.</p>\u0000 <p><b>Results:</b> The mean age of participants in the NC and placebo groups was 54.69 ± 13.44 and 53.94 ± 11.62 years, respectively. In the NC group, compared with placebo group, the levels of IL-6 (<i>p</i> = 0.017) and LDH (<i>p</i> = 0.004) was significantly reduced. There was no significant difference in the mean changes of AST (<i>p</i> = 0.197), ALT (<i>p</i> = 0.086), ALB (<i>p</i> = 0.560), CRP (<i>p</i> = 0.197), ESR (<i>p</i> = 0.298), hemoglobin (Hb) (<i>p</i> = 0.372), white blood cells (WBC) (<i>p</i> = 0.995), neutrophils (<i>p</i> = 0.264), and lymphocyte (<i>p</i> = 0.418) between two groups.</p>\u0000 <p><b>Conclusion:</b> According to the research results, it seems that adding NC supplementation to the treatment plan for COVID-19 patients who are hospitalized and have mild to moderate illness severity might possibly reduce inflammation.</p>\u0000 <p><b>Trial Registration:</b> ClinicalTrials.gov identifier: IRCT20211126053183N1.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2024 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/6675459","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143118489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Analysis of Nonmetastatic Nasopharyngeal Carcinoma in Older Patients Undergoing Intensity-Modulated Radiotherapy","authors":"Shuangyue Wang,&nbsp;Heqing Huang,&nbsp;Fengqiao Huang,&nbsp;Haiyan Wu,&nbsp;Zhiru Li,&nbsp;Ziyan Zhou,&nbsp;Min Kang","doi":"10.1155/ijcp/8833803","DOIUrl":"https://doi.org/10.1155/ijcp/8833803","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> We investigated a visual model for estimating prognosis in older patients with nonmetastatic nasopharyngeal carcinoma (NPC) and analyzed the survival rates in different patient groups during intensity-modulated radiotherapy (IMRT).</p>\u0000 <p><b>Methods:</b> Between January 2012 and March 2021, patients with NPC aged &gt; 65 years who received IMRT and were initially diagnosed with no distant metastases were enrolled. Propensity score analysis with 1:1 matching was used to balance baseline characteristics, including age, sex, tumor stage, and comorbidities. Kaplan–Meier analysis was used to calculate survival. Cox regression analysis was used to identify independent prognostic factors for overall survival (OS). A nomogram was constructed based on the determined prognostic factors, and prediction accuracy was evaluated using receiver operating characteristic (ROC) and calibration curves.</p>\u0000 <p><b>Results:</b> In total, 140 patients were included in the analysis (median age: 69 years; range: 66–81 years). The median follow-up was 84.9 (26.2–131.5) months. Compared with radiotherapy (RT) alone, chemotherapy during RT failed to improve OS (54.2% vs. 50.0%, respectively; <i>p</i> = 0.969), cancer-specific survival (CSS) (59.1% vs. 60.5%, respectively; <i>p</i> = 0.712), distant metastasis–free survival (DMFS) (66.7% vs. 70.5%, respectively; <i>p</i> = 0.824), or locoregional relapse–free survival (LRFS) (85.0% vs. 86.9%, respectively; <i>p</i> = 0.811). After the final regression analysis, age, age-adjusted Charlson comorbidity index (ACCI) score, N stage, and total stage were identified as independent factors affecting OS prognosis. The OS nomogram was applied to the data and, based on the value of the area under the ROC and calibration curves, demonstrated satisfactory predictive performance.</p>\u0000 <p><b>Conclusions:</b> Survival outcomes in older patients with NPC treated with RT alone were similar to those in patients treated with both chemotherapy and RT. Our nomogram had good performance in predicting OS in older patients with NPC and may benefit the clinical decision-making process.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2024 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/8833803","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143118570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}