Assessment of the Correlation Between Renal Function Markers and Serum Ferritin Levels in Thalassemia Patients

IF 2.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of Clinical Practice Pub Date : 2025-02-10 DOI:10.1155/ijcp/6915906

Mohammad Tammadondar, Ali Vatankhah, Niloufar Khatibzade-Nasari

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引用次数: 0

Abstract

Background: This study aimed to analyze renal function markers and correlate the results with serum ferritin levels in patients with thalassemia in Bandar Abbas, Iran, in 2020.

Method: A cross-sectional study was conducted, and patients with a proven hemoglobinopathy diagnosis were included. Fasting blood was obtained to measure creatinine, sodium, potassium, calcium, phosphorus, magnesium, uric acid, and ferritin. In addition, a 24-h urine specimen was collected to determine the level of urine albumin, creatinine, sodium, potassium, calcium, phosphorus, magnesium, uric acid, and β2-microglobulin. Fractional excretion of sodium, potassium, calcium, phosphorus, magnesium, and uric acid was also calculated. Spearman’s coefficient of correlation was used to determine the correlations between serum ferritin level and other variables.

Results: Of the sixty-six patients studied, 3.0% had sickle cell thalassemia, 80.3% had major thalassemia, and 72.7% had intermediate thalassemia. In our study, serum ferritin, 24-h urine protein, and fractional excretion of sodium, calcium, and urine were higher than the normal range in thalassemia patients. There was a significant correlation between serum ferritin level and fractional excretion of magnesium, calcium, sodium, phosphorus, and uric acid with a negative correlation coefficient (p ≤ 0.05). We also found that the serum ferritin levels strongly correlated with microalbuminuria (p ≤ 0.05).

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来源期刊

International Journal of Clinical Practice 医学-医学：内科

CiteScore

5.30

自引率

0.00%

发文量

274

审稿时长

3-8 weeks

期刊介绍： IJCP is a general medical journal. IJCP gives special priority to work that has international appeal. IJCP publishes: Editorials. IJCP Editorials are commissioned. [Peer reviewed at the editor''s discretion] Perspectives. Most IJCP Perspectives are commissioned. Example. [Peer reviewed at the editor''s discretion] Study design and interpretation. Example. [Always peer reviewed] Original data from clinical investigations. In particular: Primary research papers from RCTs, observational studies, epidemiological studies; pre-specified sub-analyses; pooled analyses. [Always peer reviewed] Meta-analyses. [Always peer reviewed] Systematic reviews. From October 2009, special priority will be given to systematic reviews. [Always peer reviewed] Non-systematic/narrative reviews. From October 2009, reviews that are not systematic will be considered only if they include a discrete Methods section that must explicitly describe the authors'' approach. Special priority will, however, be given to systematic reviews. [Always peer reviewed] ''How to…'' papers. Example. [Always peer reviewed] Consensus statements. [Always peer reviewed] Short reports. [Always peer reviewed] Letters. [Peer reviewed at the editor''s discretion] International scope IJCP publishes work from investigators globally. Around 30% of IJCP articles list an author from the UK. Around 30% of IJCP articles list an author from the USA or Canada. Around 45% of IJCP articles list an author from a European country that is not the UK. Around 15% of articles published in IJCP list an author from a country in the Asia-Pacific region.