The Association of Diet With High Phosphatemic Index With Odds of Nonalcoholic Fatty Liver Disease

IF 2.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of Clinical Practice Pub Date : 2025-02-07 DOI:10.1155/ijcp/4066662

Mitra Kazemi Jahromi, Mostafa Norouzzadeh, Farshad Teymoori, Niloufar Saber, Hamid Ahmadirad, Hossein Farhadnejad, Ammar Salehi-Sahlabadi, Parvin Mirmiran

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引用次数: 0

Abstract

Aim: A high intake of dietary phosphorus with an effect on the serum phosphorus level may affect the health status and predict the occurrence of some clinical disorders. Therefore, in the current study, we aimed to determine phosphatemic index (PI) according to serum levels of phosphorus after intake of different foods and assess its association with the odds of nonalcoholic fatty liver disease (NAFLD).

Methods: The current study was conducted with case-control design on 225 newly diagnosed NAFLD cases and 450 controls aged 20–60 years. Dietary intake data were collected by a validated food frequency questionnaire. The PI was calculated as the area under the curve (AUC) of serum phosphorus after eating test food divided by the AUC for the food supply containing an equal quantity of phosphorus. Multivariable logistic regression models were used to evaluate the NAFLD odds according to tertiles of the PI score.

Results: The median (IQR) of dietary PI in participants of case and control groups was 83.9 (55.8–114.2) and 82.1 (52.6–119.6), respectively. In the age and sex-adjusted model, there was no statistically significant association between PI and the odds of NAFLD (OR = 1.47; 95% CI: 0.98–2.19, P_trend = 0.065). However, in fully adjusted model, after controlling the effects of age, sex, waist-to-hip ratio, smoking, dietary intake of energy, dietary fiber, physical activity, and socioeconomic status, the odds of NAFLD increased across tertiles of PI (OR = 1.97; 95% CI: 1.08–3.58, P_trend = 0.028).

Conclusions: Our results suggested that a diet with a higher PI score may contribute to an increase in the odds of NAFLD independent of common confounders.

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高血磷指数饮食与非酒精性脂肪肝发病率的关系

目的：高磷饮食对血清磷水平的影响可能影响健康状况，并可预测某些临床疾病的发生。因此，在本研究中，我们的目的是根据摄入不同食物后的血清磷水平来确定血磷指数（PI），并评估其与非酒精性脂肪性肝病（NAFLD）发病率的关系。方法：采用病例-对照设计对225例新诊断的NAFLD患者和450例年龄在20-60岁的对照组进行研究。膳食摄入数据通过有效的食物频率问卷收集。PI的计算方法为食用试验食品后血清磷的曲线下面积（AUC）除以含磷量相等的食品的AUC。采用多变量logistic回归模型，根据PI评分的分位数评估NAFLD的几率。结果：病例组和对照组饮食PI的中位数（IQR）分别为83.9（55.8-114.2）和82.1（52.6-119.6）。在年龄和性别校正模型中，PI与NAFLD的发生率无统计学意义(OR = 1.47；95% CI: 0.98-2.19, Ptrend = 0.065)。然而，在完全调整模型中，在控制了年龄、性别、腰臀比、吸烟、膳食能量摄入、膳食纤维、身体活动和社会经济地位的影响后，NAFLD的几率在PI的各分位数上都有所增加(OR = 1.97；95% CI: 1.08-3.58, Ptrend = 0.028)。结论：我们的研究结果表明，PI评分较高的饮食可能会增加NAFLD的几率，而不受常见混杂因素的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Clinical Practice 医学-医学：内科

CiteScore

5.30

自引率

0.00%

发文量

274

审稿时长

3-8 weeks

期刊介绍： IJCP is a general medical journal. IJCP gives special priority to work that has international appeal. IJCP publishes: Editorials. IJCP Editorials are commissioned. [Peer reviewed at the editor''s discretion] Perspectives. Most IJCP Perspectives are commissioned. Example. [Peer reviewed at the editor''s discretion] Study design and interpretation. Example. [Always peer reviewed] Original data from clinical investigations. In particular: Primary research papers from RCTs, observational studies, epidemiological studies; pre-specified sub-analyses; pooled analyses. [Always peer reviewed] Meta-analyses. [Always peer reviewed] Systematic reviews. From October 2009, special priority will be given to systematic reviews. [Always peer reviewed] Non-systematic/narrative reviews. From October 2009, reviews that are not systematic will be considered only if they include a discrete Methods section that must explicitly describe the authors'' approach. Special priority will, however, be given to systematic reviews. [Always peer reviewed] ''How to…'' papers. Example. [Always peer reviewed] Consensus statements. [Always peer reviewed] Short reports. [Always peer reviewed] Letters. [Peer reviewed at the editor''s discretion] International scope IJCP publishes work from investigators globally. Around 30% of IJCP articles list an author from the UK. Around 30% of IJCP articles list an author from the USA or Canada. Around 45% of IJCP articles list an author from a European country that is not the UK. Around 15% of articles published in IJCP list an author from a country in the Asia-Pacific region.