International Journal of Clinical Practice最新文献

{"title":"The Impact of Silymarin on Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","authors":"Mahdi Vajdi,&nbsp;Shaghayegh Adeli,&nbsp;Arash Karimi,&nbsp;Vahid Asghariazar,&nbsp;Arezoo Moini Jazani,&nbsp;Ramin Nasimidoost Azgomi","doi":"10.1155/ijcp/3985207","DOIUrl":"https://doi.org/10.1155/ijcp/3985207","url":null,"abstract":"<div>\u0000 <p>Numerous studies have investigated into the antioxidant and anti-inflammatory properties of silymarin, as well as its ability to reduce reactive oxygen species and inflammation biomarkers. The effect of silymarin on inflammation and oxidative stress was investigated using the keywords “milk thistle” OR “Silybum marianum” OR “Silybum” OR “silymarin” OR “Silibinin” AND “MDA” OR “Malondialdehyde” OR “TAC” OR “total antioxidant capacity” OR “IL-10” OR “Interleukin-10” OR “IL-6” OR “Interleukin-6” OR “TNF-α” OR “tumor necrosis factor alpha” on the Web of Science, Scopus, Embase, PubMed, and Cochrane Library, up until March 2023. Data were combined using a random-effects model, and the weighted/standardized mean differences (WMDs/SMDs) with a 95% confidence interval (CI) were used as the overall effect size. Our meta-analysis indicated that silymarin supplementation resulted in a significant decrease in levels of C-reactive protein (CRP) (WMD: −3.39 mg/L, 95% CI: −5.99, −0.79, <i>p</i> = 0.01) and malondialdehyde (MDA) (SMD: −1.69, 95% CI: −2.62, −0.76, <i>p</i> &lt; 0.001). Furthermore, silymarin significantly increases IL-10 (WMD: 2.03 pg/mL; 95% CI: 1.04, 3.01, <i>p</i> &lt; 0.001), superoxide dismutase (SOD) (SMD: 3.39, 95% CI: 1.42, 5.37, <i>p</i> = 0.001), and glutathione peroxidase (GPx) (SMD: 1.94; 95% CI, 0.89 to 2.99; <i>p</i> &lt; 0.001) level. However, silymarin supplementation did not have significant effects on TAC (SMD: 2.91; 95% CI: −0.30, 6.11, <i>p</i> = 0.076) and IL-6 (WMD: −0.70 pg/mL; 95% CI: −1.42, 0.02, <i>p</i> &lt; 0.056) level. Silymarin supplementation may significantly improve oxidative stress and inflammation in adults by decreasing CRP and MDA and increasing IL-10, SOD, and GPx. However, additional studies with longer study periods are required to ascertain the long-term effects of silymarin on oxidative stress and chronic inflammation.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/3985207","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143118189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Subtypes and Prognostic Outcomes of Rhabdomyolysis in ICU Patients","authors":"Shan Xu,&nbsp;Kaixiu Qin,&nbsp;Dan Zhang","doi":"10.1155/ijcp/3392487","DOIUrl":"https://doi.org/10.1155/ijcp/3392487","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Rhabdomyolysis (RM) is a severe clinical syndrome with substantial heterogeneity that involves the rapid dissolution of skeletal muscles. The condition has a high prevalence and poor prognosis, particularly in critically ill patients. Subtypes of RM in critically ill patients have not been investigated.</p>\u0000 <p><b>Objective:</b> The study aimed to link the clinical RM heterogeneity with distinct prognoses and associated characteristics among different subtypes using an unsupervised analysis.</p>\u0000 <p><b>Methods:</b> Patients diagnosed with RM in the intensive care unit (ICU) from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database and the eICU Collaborative Research Database (eICU) were retrospectively enrolled. K-means clustering, guided by correlation coefficients and expert opinions in intensive care medicine, was applied to identify distinct RM clinical subtypes using routinely available parameters from the first 24 h after patient ICU admission. The primary endpoint was 28-day mortality. We assessed associations between subtypes and 28-day mortality, as well as between treatments and 28-day mortality in the derived subtypes, using multivariate Cox proportional hazards regression. The eICU database patients served as an external validation set. The SHapley Additive exPlanations (SHAPs) were used to visualize features of each clinical subtype.</p>\u0000 <p><b>Results:</b> A total of 2269 eligible subjects were extracted from the MIMIC-IV. Two distinct subtypes were identified (A and B) using 17 readily available clinical and biological variables. Patients assigned to Subtype A (<i>n</i> = 511) had a higher 28-day mortality. The proportion of organ support, comorbidity index, SAPS II, and SOFA scores were all significantly higher in the Subtype A group than in the Subtype B group (<i>n</i> = 1836). After adjusting for relevant covariates, Subtype A patients were independently associated with increased 28-day mortality (HR [95% CI] = 1.70 [1.36–2.11], <i>p</i> &lt; 0.001). These findings were further validated using an external cohort from the eICU dataset. Notably, Subtype A patients showed a higher mortality risk associated with sodium bicarbonate use (HR [95% CI] 1.62 [1.20–2.19], <i>p</i> = 0.002).</p>\u0000 <p><b>Conclusions:</b> We identified two subtypes with distinct clinical features and outcomes. Subtype A is independently associated with poor outcomes and shows increased mortality risk with sodium bicarbonate use. These findings may help clinicians better distinguish prognoses and treatment responses among RM patients.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/3392487","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143117424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Community Pharmacists’ Knowledge, Attitudes, and Practices Regarding Biosimilar Drugs: A Cross-Sectional Survey","authors":"Anan S. Jarab,&nbsp;Walid Al-Qerem,&nbsp;Karem H. Alzoubi,&nbsp;Shrouq R. Abu Heshmeh,&nbsp;Yazid N. Al Hamarneh,&nbsp;Eman Alefishat,&nbsp;Salahdein Aburuz","doi":"10.1155/ijcp/2248512","DOIUrl":"https://doi.org/10.1155/ijcp/2248512","url":null,"abstract":"&lt;div&gt;\u0000 &lt;p&gt;&lt;b&gt;Background:&lt;/b&gt; Understanding pharmacists’ knowledge, attitudes, and practices towards biosimilar therapy and exploring the potential barriers are a preliminary step in the road to the adoption of biosimilar therapy in community pharmacy and clinical practice.&lt;/p&gt;\u0000 &lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; The aim of current study was to evaluate pharmacists’ understanding, investigate the factors that shape their attitudes and practices regarding biosimilar therapy, and identify the barriers to utilizing biosimilars in community pharmacies.&lt;/p&gt;\u0000 &lt;p&gt;&lt;b&gt;Methods:&lt;/b&gt; A validated self-administered survey was disseminated in person to community pharmacists in different geographical regions of the UAE. Eligible participants were individuals who graduated from universities recognized by the UAE Ministry of Higher Education and were registered as community pharmacists in the UAE. The questionnaire included five sections that evaluated sociodemographic characteristics, knowledge and attitudes with respect to biosimilar therapy, the extent of its utilization, and the potential barriers that may limit the use of this therapy in community pharmacy settings. A quantile regression analysis was performed to explore the variables associated with pharmacists’ attitudes and practices regarding biosimilar therapy.&lt;/p&gt;\u0000 &lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; The study included 504 pharmacists. The [median (IQR)] scores revealed a window for knowledge improvement [3 (1–5)] out of a maximum possible score of 8, unfavourable attitude [25 (22–30)] out of a maximum possible score of 40 and inadequate practice [27 (24–30) out of a maximum possible score of 45] concerning biosimilar utilization in clinical practice. The most commonly reported barriers to considering biosimilar therapy were lack of experience (40.67%), insufficient knowledge (40.47%) and lack of confidence (36.70%). Female pharmacists and those who had a B Pharm degree or used Lexicomp as an information source reported higher attitude scores. Moreover, pharmacists in charge or employee pharmacists, and those who had more than 10 years of experience and higher knowledge levels, reported improved attitude scores. However, pharmacists who dispensed less than 10 prescriptions per day, and those who reported lower knowledge and/or attitude scores exhibited lower practice levels.&lt;/p&gt;\u0000 &lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; The current study revealed a lack of knowledge, unfavourable attitudes and insufficient practices related to biosimilar therapy among community pharmacists, along with several identified barriers. Future efforts should focus on comprehensive educational programs that deliver up-to-date clinical information and emphasize the benefits of biosimilar drugs, specifically targeting male pharmacists, those with postgraduate degrees, pharmacy owners, pharmacists with less work experience, and those who dispense fewer prescriptions per day. These interventions are essential for enhancing pha","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/2248512","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143115509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality Assessment of Clinical Practice Guidelines for the Management and Surgical Treatment of Female Stress Urinary Incontinence","authors":"Mario Vásquez-Peralta,&nbsp;Alison Simancas-Racines,&nbsp;Juan Marcos Parise-Vasco,&nbsp;Camila Montesinos-Guevara,&nbsp;Daniel Simancas-Racines","doi":"10.1155/ijcp/3803266","DOIUrl":"https://doi.org/10.1155/ijcp/3803266","url":null,"abstract":"<div>\u0000 <p>Clinical practice guidelines (CPGs) are tools developed to support evidence-based decision making in healthcare. However, despite the availability of CPGs for the surgical management of female stress urinary incontinence (FSUI), their methodological quality has not been evaluated. The aim of this study was to assess the methodological quality of published guidelines for the surgical management of FSUI using the AGREE II tool. A systematic search of CPGs published between 2017 and 2023 was performed in databases including MEDLINE/PubMed, LILACS, Scopus, and Trip Medical Database. Data extraction and guideline selection were performed independently by two reviewers, as was the assessment using the AGREE II instrument. Of 1459 initial records, six guidelines met the eligibility criteria. The scores for each domain evaluated were as follows: scope and purpose (45.83%; SD: 22.69), stakeholder participation (30.56%; SD: 29.03), development (48.56%; SD: 30.42), presentation clarity (58.80%; SD: 22.25), applicability (24.04%; SD: 26.36), and editorial independence (44.87%; SD: 32.88). One of the six included CPGs was rated as high quality and recommended for clinical practice. Three CPGs with modifications were recommended because there were still areas that needed improvement to enhance their quality, and two CPGs were not recommended for clinical practice because the six domains evaluated scored below 60%. According to these findings, it is essential that new CPGs developed for the surgical management of FSUI adhere to greater methodological rigor to ensure that recommendations are based on the best available evidence. Furthermore, guidelines should take into account patient values and clinical expertise to improve and facilitate effective healthcare decision making.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/3803266","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143113643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Patient Understanding of Glomerular Disease Terms With ChatGPT","authors":"Yasir H. Abdelgadir,&nbsp;Charat Thongprayoon,&nbsp;Iasmina M. Craici,&nbsp;Wisit Cheungpasitporn,&nbsp;Jing Miao","doi":"10.1155/ijcp/9977290","DOIUrl":"https://doi.org/10.1155/ijcp/9977290","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Glomerular disease is complex and difficult for patients to understand, as it involves various pathophysiology, immunology, and pharmacology areas.</p>\u0000 <p><b>Objective:</b> This study explored whether ChatGPT can maintain accuracy while simplifying glomerular disease terms to enhance patient comprehension.</p>\u0000 <p><b>Methods:</b> 67 terms related to glomerular disease were analyzed using GPT-4 through two distinct queries. One aimed at a general explanation and another tailored for patients with an education level of 8th grade or lower. GPT-4’s accuracy was scored from 1 (incorrect) to 5 (correct and comprehensive). Its readability was assessed using the Consensus Reading Grade (CRG) Level, which incorporates seven readability indices including the Flesch–Kincaid Grade (FKG) and SMOG indices. Flesch Reading Ease (FRE) score, ranging from 0 to 100 with higher scores indicating easier-to-read text, was also used to evaluate the readability. A paired <i>t</i>-test was conducted to assess differences in accuracy and readability levels between different queries.</p>\u0000 <p><b>Results:</b> GPT-4’s general explanations of glomerular disease terms averaged at a college readability level, indicated by the CRG score of 14.1 and FKG score of 13.9. SMOG index also indicated the topic’s complexity, with a score of 11.8. When tailored for patients at or below an 8^th-grade reading level, readability improved, averaging 9.7 by the CRG score, 8.7 by FKG score, and 7.3 by SMOG score. The FRE score also indicated a further improvement of readability from 31.6 for general explanations to 63.5 for tailored explanations. However, the accuracy in GPT-4’s tailored explanations was significantly lower than that in general explanations (4.2 ± 0.4 versus 4.7 ± 0.3, <i>p</i> &lt; 0.0001).</p>\u0000 <p><b>Conclusion:</b> While GPT-4 effectively simplified information about glomerular diseases, it compromised its accuracy in the process. To implement these findings, we suggest pilot studies in clinical settings to assess patient understanding, using feedback from diverse groups to customize content, expanding research to enhance AI accuracy and reduce biases, setting strict ethical guidelines for AI in healthcare, and integrating with health informatics systems to provide tailored educational content to patients. This approach will promote effective and ethical use of AI tools like ChatGPT in patient education, empowering patients to make informed health decisions.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/9977290","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143114098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monkeypox Virus Outbreak 2022: Assessment of Knowledge Among Healthcare Workers in Two Countries—India and Saudi Arabia","authors":"Sachin Naik,&nbsp;Sajith Vellappally,&nbsp;Abdulaziz Abdullah Al Kheraif,&nbsp;Majed M. Alsarani,&nbsp;Santhosh Basavarajappa,&nbsp;Raghad Khalid Alhassoun,&nbsp;Mohamed Hashem,&nbsp;Hassan Fouad,&nbsp;Murtaza Saleem,&nbsp;Faisal Ali M Asiri,&nbsp;Meshal Saeed Mohammed Awaiyer","doi":"10.1155/ijcp/6921394","DOIUrl":"https://doi.org/10.1155/ijcp/6921394","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Healthcare workers play a crucial role in limiting the spread of the monkeypox virus. Studies show that healthcare worker’s (HCWs) understanding and communication about preventing infectious diseases can inspire various groups of individuals.</p>\u0000 <p><b>Objective:</b> This study aimed to compare the knowledge of HCWs in India and Saudi Arabia regarding monkeypox virus infection.</p>\u0000 <p><b>Methods:</b> A cross-sectional survey was conducted among HCWs in India and Saudi Arabia. The questionnaire was developed using information from the World Health Organization and Centers for Disease Control and Prevention websites. The validation of the questionnaire (Cronbach’s alpha = 0.87) was conducted for data collection. The mean scores between different demographic groups were compared using Student’s <i>t</i>-test and one-way ANOVA.</p>\u0000 <p><b>Results:</b> A total of 848 participants responded to the questionnaire (India = 424 and Saudi Arabia = 424). The average knowledge score in India was 12.59 ± 2.49, and in Saudi Arabia, it was 13.25 ± 2.99 out of 20. The percentage of participants with good knowledge about monkeypox was 22.2% in India and 36.1% in Saudi Arabia. Participants with poor knowledge about monkeypox constituted 11% in India and 12% in Saudi Arabia.</p>\u0000 <p><b>Conclusion:</b> HCWs in both countries had moderate to poor knowledge about the monkeypox outbreak. This might be because monkeypox is not prevalent in these countries. More education is needed to improve HCWs knowledge about monkeypox infection.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/6921394","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143113400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Clinical Characteristics and Nomogram for Predicting Mortality in Patients with Postoperative Bloodstream Infection in Surgical Intensive Care Unit”","authors":"Zengli Xiao,&nbsp;Yao Sun,&nbsp;Huiying Zhao,&nbsp;Youzhong An","doi":"10.1155/ijcp/9869207","DOIUrl":"https://doi.org/10.1155/ijcp/9869207","url":null,"abstract":"<p>In the article titled “Clinical Characteristics and Nomogram for Predicting Mortality in Patients with Postoperative Bloodstream Infection in Surgical Intensive Care Unit” [<span>1</span>], there was an incorrect grant number in the Acknowledgments section. The corrected section appears below:</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/9869207","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143113145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Analysis of FBXO43 Expression and Its Prognostic and Therapeutic Implications in Osteosarcoma","authors":"Jiang Jin,&nbsp;Kang Yao,&nbsp;Zhao Tingxiao,&nbsp;Yao Longtao,&nbsp;Li Yanlei,&nbsp;Tian Jinlong,&nbsp;Zhu Xiaojun,&nbsp;Han Liang","doi":"10.1155/ijcp/9026711","DOIUrl":"https://doi.org/10.1155/ijcp/9026711","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Osteosarcoma (OS) is the most common malignant bone tumor in children and adolescents. FBXO43, a member of the F-box protein family, has been identified as a crucial prognostic factor in several cancers. However, its role in osteosarcoma remains largely unexplored.</p>\u0000 <p><b>Methods:</b> This study investigated the expression and potential role of FBXO43 across the TCGA pan-cancer cohort, with a particular focus on sarcoma (SARC). We analyzed the relationship between FBXO43 expression and various cancer-related pathways, immune infiltration, and genomic features, including TP53 mutations. We also conducted immunotherapy predictive analyses using TIDE and Submap algorithms. To validate our findings, we performed a series of in vitro experiments, including cell invasion and wound healing assays.</p>\u0000 <p><b>Results:</b> FBXO43 was found to be significantly overexpressed in various cancers and was particularly associated with pathways such as E2F_TARGETS and G2M_CHECKPOINT in SARC samples. Differential FBXO43 expression was linked to distinct immune infiltration patterns and pathway enrichments. Notably, high FBXO43 expression in osteosarcoma was associated with a higher TP53 mutation rate. Predictive analyses indicated that patients with low FBXO43 expression had better immunotherapy responses, suggesting its potential as a diagnostic and prognostic biomarker. These findings were corroborated by our in vitro functional assays.</p>\u0000 <p><b>Conclusion:</b> Our comprehensive analysis reveals that FBXO43 plays a critical role in the progression of osteosarcoma, impacting both immune infiltration and genomic stability. FBXO43 expression levels may serve as valuable biomarkers for predicting immunotherapy responses in osteosarcoma patients. Future studies should aim to elucidate the molecular mechanisms driving FBXO43’s role and validating these findings in clinical settings to develop targeted therapeutic strategies.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/9026711","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143112480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge of Kidney Disease Among Allied Health Sciences Undergraduates: A Cross-Sectional Study in the University of Cape Coast","authors":"Victor Obiri Opoku,&nbsp;Theophilus Junior Yankey,&nbsp;Mainprice Akuoko Essuman,&nbsp;George Nkrumah Osei,&nbsp;Tetteh Attoh,&nbsp;Richard K. D. Ephraim","doi":"10.1155/ijcp/8671438","DOIUrl":"https://doi.org/10.1155/ijcp/8671438","url":null,"abstract":"<div>\u0000 <p><b>Introduction:</b> Knowledge of kidney disease (KD) is an essential element that is needed in the scope of every healthcare professional. This study assessed the level of awareness and understanding of allied health sciences undergraduates of University of Cape Coast regarding KDs and their risk factors.</p>\u0000 <p><b>Methodology:</b> Among the regular allied health sciences undergraduates of the University of Cape Coast, a cross-sectional study was conducted from March 2022 to June 2022. A well-structured questionnaire on knowledge of KDs and their risk factors was administered to consented participants. Data were analyzed accordingly using <i>R</i> Studio statistical software version 2022.02.3.</p>\u0000 <p><b>Results:</b> The study involved 383 participants (the majority being males (52.7%)) with an average age of 22.23 ± 3.03 years. Age (<i>p</i> &lt; 0.001), year of study (<i>p</i> &lt; 0.001), program of study (<i>p</i> &lt; 0.001), frequency of 30 min of exercise per week (<i>p</i> = 0.002), and body mass index (<i>p</i> = 0.023) showed statistically significant differences between males and females. The mean knowledge score of KD was 20.86 ± 3.88 (out of a maximum score of 27) with the majority of study participants having a high knowledge of KD (61.9% (237/383)). High knowledge level was observed for types and stages, diagnosis, and risk factors for KD (76.8% (3.84/5), 75.3% (5.27/7), and 81.6% (8.98/11), respectively) while moderate knowledge level was observed for signs and symptoms (69.3% (2.77/4)). Multivariate analysis showed that participants were found to be more knowledgeable about KDs if they indicated taking alcohol (OR = 5.96; 95% CI = 2.01–22.35; <i>p</i> = 0.003), being in second (OR = 3.27; 95% CI = 1.22–9.02; <i>p</i> = 0.020) or fourth (OR = 4.72; 95% CI = 1.63–14.37; <i>p</i> = 0.005) year of study, or classified themselves as being underweight (OR = 3.93; 95% CI = 1.22–15.85; <i>p</i> = 0.033). Students reporting alcohol use had almost six times higher odds of high KD awareness compared to those who did not report alcohol intake (OR = 5.96, 95% C = 2.01–22.35, <i>p</i> = 0.003).</p>\u0000 <p><b>Conclusion:</b> This study revealed an adequate knowledge level of KDs and their risk factors among allied health sciences undergraduates. However, an inadequate knowledge of its signs and symptoms was observed indicating a need for improved training.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/8671438","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143111152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Systematic, Scoping, Umbrella, and Narrative Reviews in Clinical Research: Critical Considerations and Future Directions","authors":"Mohamad Motevalli","doi":"10.1155/ijcp/9929300","DOIUrl":"https://doi.org/10.1155/ijcp/9929300","url":null,"abstract":"<div>\u0000 <p>Review studies play a key role in the development of clinical practice by synthesizing data and drawing conclusions from multiple scientific sources. In recent decades, there has been a significant increase in the number of review studies conducted and published by researchers. In clinical research, different types of review studies (systematic, scoping, umbrella, and narrative reviews) are conducted with different objectives and methodologies. Despite the abundance of guidelines for conducting review studies, researchers often face challenges in selecting the most appropriate review method, mainly due to their overlapping characteristics, including the complexity of matching review types to specific research questions. The aim of this article is to compare the main features of systematic, scoping, umbrella, and narrative reviews in clinical research and to address key considerations for selecting the most appropriate review approach. It also discusses future opportunities for updating their strategies based on emerging trends in clinical research. Understanding the differences between review approaches will help researchers, practitioners, journalists, and policymakers to effectively navigate the complex and evolving field of scientific research, leading to informed decisions that ultimately enhance the overall quality of healthcare practices.</p>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/9929300","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143111150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}