Diagnostic Role of Plateletcrit in Pleural Effusion

IF 2.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of Clinical Practice Pub Date : 2025-02-24 DOI:10.1155/ijcp/5553736

Burcu Akkok, Fatos Kozanli

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引用次数: 0

Abstract

Objectives: Pleural effusion arises from either increased fluid production or reduced absorption within the pleural space. In instances where thoracentesis is contraindicated or unfeasible, alternative, less invasive diagnostic approaches are necessary. Thoracentesis with simultaneous venous blood sampling is pivotal for differentiating transudative from exudative pleural fluid, guided by the Light criteria In instances where thoracentesis is contraindicated or unfeasible, alternative, less invasive diagnostic approaches are necessary. Parameters such as platelet (PLT) count, plateletcrit (PCT), PLT distribution width (PDW), and mean PLT volume (MPV) have been proposed as adjuncts to other acute phase reactants in identifying inflammation activation. This study aims to investigate the feasibility of Plt activation markers in diagnosing pleural effusion.

Methods: This retrospective observational study involved patients diagnosed with pleural effusion who were admitted to hospital between 01 January 2021 and 31 May 2023. Cases where the effusion nature was determined through thoracentesis were included. Among the complete blood count parameters, neutrophil, lymphocyte, Plt count, PCT, PDW and MPV were calculated.

Results: The study encompassed a cohort of 155 cases, comprising 43.2% females and 56.8% males.Thoracentesis revealed 66.5% exudative effusions and 33.5% transudative effusions. PDW and MPV were significantly lower in the exudate group than in the transudate group. PCT values demonstrated significant effectiveness (area under the curve, 0.740 [0.653–0.828]) in distinguishing patients with exudates from those with transudates. A cut-off value of 0.275 for PCT yielded significant effectiveness with a sensitivity of 83.5%, and a specificity of 61.5%. For a PDW cut-off value of 10.5, the sensitivity was 49.5%, and specificity was 75.0%.

Conclusions: The sensitivity and specificity of Plt parameters in differentiating patients in transudate and exudate groups were found to be high.

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血小板电图在胸腔积液中的诊断作用

目的：胸腔积液是由胸膜腔内液体产生增加或吸收减少引起的。在胸穿刺禁忌或不可行的情况下，有必要采用其他侵入性较小的诊断方法。在Light标准的指导下，胸穿刺同时采集静脉血是区分渗出性胸腔液和渗出性胸腔液的关键。在胸穿刺禁忌或不可行的情况下，有必要采用其他侵入性较小的诊断方法。血小板（PLT）计数、血小板电积（PCT）、血小板分布宽度（PDW）和平均血小板体积（MPV）等参数已被提出作为识别炎症激活的其他急性期反应物的辅助物。本研究旨在探讨Plt激活标志物诊断胸腔积液的可行性。方法：本回顾性观察研究纳入了2021年1月1日至2023年5月31日住院的诊断为胸腔积液的患者。通过胸腔穿刺确定积液性质的病例也包括在内。全血细胞计数参数中，计算中性粒细胞、淋巴细胞、Plt计数、PCT、PDW、MPV。结果：本研究纳入155例病例，其中女性43.2%，男性56.8%。胸腔穿刺66.5%为渗出性积液，33.5%为渗出性积液。渗出液组的PDW和MPV明显低于渗出液组。PCT值（曲线下面积，0.740[0.653-0.828]）在区分渗出物患者和渗出物患者方面显示出显著的有效性。PCT的临界值为0.275，敏感性为83.5%，特异性为61.5%。当PDW临界值为10.5时，敏感性为49.5%，特异性为75.0%。结论：Plt参数在鉴别渗出液组和渗出液组患者中的敏感性和特异性较高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Clinical Practice 医学-医学：内科

CiteScore

5.30

自引率

0.00%

发文量

274

审稿时长

3-8 weeks

期刊介绍： IJCP is a general medical journal. IJCP gives special priority to work that has international appeal. IJCP publishes: Editorials. IJCP Editorials are commissioned. [Peer reviewed at the editor''s discretion] Perspectives. Most IJCP Perspectives are commissioned. Example. [Peer reviewed at the editor''s discretion] Study design and interpretation. Example. [Always peer reviewed] Original data from clinical investigations. In particular: Primary research papers from RCTs, observational studies, epidemiological studies; pre-specified sub-analyses; pooled analyses. [Always peer reviewed] Meta-analyses. [Always peer reviewed] Systematic reviews. From October 2009, special priority will be given to systematic reviews. [Always peer reviewed] Non-systematic/narrative reviews. From October 2009, reviews that are not systematic will be considered only if they include a discrete Methods section that must explicitly describe the authors'' approach. Special priority will, however, be given to systematic reviews. [Always peer reviewed] ''How to…'' papers. Example. [Always peer reviewed] Consensus statements. [Always peer reviewed] Short reports. [Always peer reviewed] Letters. [Peer reviewed at the editor''s discretion] International scope IJCP publishes work from investigators globally. Around 30% of IJCP articles list an author from the UK. Around 30% of IJCP articles list an author from the USA or Canada. Around 45% of IJCP articles list an author from a European country that is not the UK. Around 15% of articles published in IJCP list an author from a country in the Asia-Pacific region.