International Journal of Applied and Basic Medical Research最新文献

{"title":"Salivary 1,5-Anhydroglucitol and its Correlation with Postprandial Hyperglycemia: Development and Validation of a Novel Assay.","authors":"Priyadarshini Subramaniam Kedarnath,&nbsp;S Sathasiva Subramanian,&nbsp;Emmanuel Bhaskar,&nbsp;Mohan Kasi,&nbsp;Vinod Pillai,&nbsp;Saravanan Subramanian,&nbsp;Venkat Manohar","doi":"10.4103/ijabmr.ijabmr_378_22","DOIUrl":"10.4103/ijabmr.ijabmr_378_22","url":null,"abstract":"<p><strong>Background: </strong>Saliva has the potential to be used as a noninvasive sample for testing hyperglycemia in diabetes mellitus. Serum 1,5-anhydroglucitol (1,5-AG) decreases with an increase in blood sugar >180 mg/dl. We hypothesized that salivary 1,5-AG can be used to identify blood sugar higher than 180 mg/dl using a novel biochemical method.</p><p><strong>Aim: </strong>This study aimed to develop a novel biochemical method for serum and salivary assessment of 1,5-AG and assess its correlation with postprandial blood sugar (PPBS) >180 mg/dl.</p><p><strong>Methodology: </strong>The study comprised 45 controls (healthy individuals) and 45 cases (type 2 diabetic patients with PPBS >180 mg/dl). Blood and salivary samples were collected according to the study protocol. A new method was developed for the quantification of 1,5-AG in serum and saliva using liquid chromatography-mass spectrometry.</p><p><strong>Results: </strong>The value of serum (mean -22.19 μg/ml and median -22.12 μg/ml) and salivary (mean -0.124 μg/ml and median -0.088 μg/ml) 1,5-AG was higher in healthy individuals compared to corresponding serum (mean -3.89 μg/ml and median -2.52 μg/ml) and salivary (mean -0.025 μg/ml and median - 0.025 μg/ml) levels in diabetics with PPBS >180 mg/dl. In diabetics, a significant negative correlation was noticed with PPBS levels and 1,5-AG levels in serum and saliva. Salivary 1,5-AG level <0.054 μg/ml had an 86.4% sensitivity and 87.2% specificity in predicting a blood sugar value >180 mg/dl.</p><p><strong>Conclusion: </strong>The results of our study suggest that the short-term glycemic marker 1,5-AG can be detected in saliva and can be useful as an adjunct marker in monitoring of glycemic status in diabetic patients.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5a/09/IJABMR-13-23.PMC10230528.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9572412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rifampicin Allergy Leading to Acute Renal Shutdown.","authors":"Ranjith Jeyasekharan,&nbsp;Ninoo George","doi":"10.4103/ijabmr.ijabmr_198_22","DOIUrl":"10.4103/ijabmr.ijabmr_198_22","url":null,"abstract":"<p><p>Rifampicin is a widely used drug to treat tuberculosis and leprosy. Its toxicity is predominantly hepatic and immunoallergic in character. While hepatic toxicity is dose-related, the immunoallergic effects are unpredictable and usually associated with intermittent therapy. These immunoallergic effects may be minor (a cutaneous, gastrointestinal, or influenza-like syndrome) or major (hemolytic anemia, shock, or acute renal failure). Herein, we report a case of rifampicin allergy in a patient who was on intermittent once monthly rifampicin therapy for neuritic leprosy and was on his 4^th month of treatment. Rifampicin exposure led to sudden shock and acute renal failure, which eventually required hemodialysis support. The patient made a complete recovery over the subsequent days and his renal function returned to normal over the next 3 weeks. He continues his multidrug therapy of leprosy without rifampicin.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b9/02/IJABMR-13-47.PMC10230526.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9572417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Parental Preparedness Package among Couples Conceived with Artificial Reproductive Techniques.","authors":"Nidhi Arora,&nbsp;Triza Jiwan,&nbsp;Sunil Kumar Juneja,&nbsp;Pooja Tandon","doi":"10.4103/ijabmr.ijabmr_447_22","DOIUrl":"10.4103/ijabmr.ijabmr_447_22","url":null,"abstract":"<p><strong>Introduction: </strong>The problem of infertility is experienced as a crisis or major life stressor with potentially serious negative effects on the couple's relationship and preparation toward the parenthood. According to Sharlip <i>et al</i>., it has been estimated that about 15% of couple would have trouble in conception, and at present, 48.5 million couples experience infertility globally. To decrease the stress among parents to be and to promote healthy parenting for bringing out healthy parent-child relationships, an intervention of Parent Education Program was planned and executed. A study was conducted with the aim to assess the effectiveness of parental preparedness package (PPP) on physical health among couple conceived with artificial reproductive techniques (ART).</p><p><strong>Materials and methods: </strong>The study was conducted to evaluate the effectiveness of PPP in fifty couples conceived with ART at Dayanand Medical College and Hospital, Ludhiana. Quantitative approach was used to collect the data of couples by doing pre- and postinterventional assessment of physical health of couple using the Structured Physical Health Assessment Scale. Analysis was done with the help of descriptive and inferential statistics.</p><p><strong>Results: </strong>The study revealed that mean score of physical health of couple (both husband and wife) increased significantly after the intervention which infers the effectiveness of PPP (<i>P</i> = 0.001).</p><p><strong>Conclusion: </strong>Our study concludes that PPP should be incorporated in the antenatal care protocol in all couples who conceive using ART.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4d/87/IJABMR-13-40.PMC10230524.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9572416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Book Review: Toolbox for Assessment of Clinical Competence","authors":"K. Ramnarayan","doi":"10.4103/ijabmr.ijabmr_400_23","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_400_23","url":null,"abstract":"Editors: Tejinder Singh and Rajiv Mahajan Publisher: Unistar Books Pvt Ltd., Chandigarh Year of publication: 2023 Price: Rs. 250 Number of pages: 124 Tagging objectives to assessment has become the hallmark of a robust curriculum; yet, it has been a daunting task to accomplish this pragmatically. In 1996, van der Vleuten so trenchantly said “assessment drives learning in at least four ways: its content, format, timing, and any subsequent feedback given to the examinee.” Over a quarter century later we, in medical education, are grappling with the knotty task of meaningfully aligning the assessment to the objectives. Scriven’s definition of assessment in 1991 envisaged a systematic, objective determination of merit, worth, or value to distinguish between the worthy and the unworthy. However, this definition had ignored formative assessment altogether. Moreover, the emphasis of today’s assessment has shifted toward integration to assess the ability of a student to integrate knowledge, skills, attitudes, and values into a clinical situation. It is in the background of this scenario that the manual “Toolbox for Assessment of Clinical Competence” edited by Tejinder Singh and Rajiv Mahajan becomes contextually relevant and timely. The authors have, in this repertoire, not only captured formative and summative assessments with all its nuances but have also linked the assessment tools to the various levels of Miller’s pyramid. The thoroughness with which the editors have organized the content is testimony to their expertise and ingenuity. Classifying assessment tools under the categories of “knows and knows how,” “shows,” and “does” is a refreshing approach to understanding and implementing the various assessment strategies. This manual is a primer in the assessment of clinical competence while serving as a ready reckoner with the choicest compendium of invaluable references for more in-depth exploration. A medical educator who is serious and sincere about using the power of assessment to decide the learning of competencies will derive a wealth of ideas from this treasury of assessment. Every medical education unit in a medical college as well as every practitioner of health professions education will be enriched and empowered by this sourcebook, which could serve as a guidepost to conceive and practice various approaches to measurement of competence while conceding that not everything that matters can or need to be measured! “Students can, with difficulty, escape from the effects of poor teaching, but they cannot (if they want to graduate) escape the effects of poor assessment” said David Boud. Therefore, it is incumbent on all of us, as educators, to strive to make assessment in health sciences meet its laudable goals, which this book has so masterfully accomplished.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135844143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a High Penetration Safe Irrigant from Withania somnifera","authors":"Manreet Parhar, Parveen Bansal","doi":"10.4103/ijabmr.ijabmr_89_23","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_89_23","url":null,"abstract":"Background: Herbal medicine is regaining a strong position in health care by virtue of better safety and minimal toxicity as compared to conventional chemotherapies. It is making a place in dental care in the form of various toothpastes, lotions, and mouthwashes. It has been analyzed that very few discrete herbal irrigants have an action comparable to that of sodium hypochlorite. No data about any study on penetration depth and penetration area for herbal-based irrigants used in root canal treatment are available. Aim: The aim of this study was to assess the efficacy of Withania somnifera extracts by assessing its penetration depth and area inside dentinal tubules using a confocal laser scanning microscope. Materials and Methods: Freshly extracted 25 maxillary central incisors were divided into three groups: Group 1: W. somnifera ; Group 2: sodium hypochlorite; and Group 3: distilled water. Results: W. somnifera showed better results with respect to penetration depth and area inside the dentinal tubules thansodium hypochlorite. Conclusion: From the study, it can be concluded that W. somnifera extract-based irrigant may be used as an alternative to sodium hypochlorite-based irrigant. It also shows that more herbal drugs need such types of screening and incorporation in dental practice to reduce the potential side effects of the conventional drugs used in daily practice.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135844765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID and Kidney: The Struggle So Far.","authors":"Simran Kaur,&nbsp;Sudhir Mehta","doi":"10.4103/ijabmr.ijabmr_571_22","DOIUrl":"10.4103/ijabmr.ijabmr_571_22","url":null,"abstract":"Severe acute respiratory syndrome coronavirus disease‐2 pandemic (SARS‐COVID‐19) posed a global health challenge, including many special concerns for patients with kidney diseases. As the pandemic began, the nephrology fraternity worldwide geared up for rapid reconfiguration of services to address the unprecedented increased demand for acute renal replacement therapy (RRT) in COVID critical care units. Strategies were devised to address the safety concerns of patients of incenter maintenance hemodialysis due to their inability to adhere to lockdown, social distancing, and home isolation norms given the compulsion to attend treatment. Concerns also existed about feasibility and rationale of kidney transplantation in pandemic scenario, as it might increase the risk of postoperative death in new recipients. Despite the rapid development of vaccines and identification of effective treatments for severe disease, many of these challenges persisted with the continuing emergence of novel SARS‐CoV‐2 variants. Numerous studies were published over the course of time addressing the above concerns. However, the ability to draw meaningful conclusions from these studies had been another challenge owing to various limitations such as different methodologies and lack of standardization in treatment. Now with COVID in hiatus, it is time to assimilate the lessons learned from the published literature in the past 2 years.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/44/6d/IJABMR-13-1.PMC10230525.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9572414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Team Triage Method on Emergency Department Performance Indexes: A quasi-interventional study","authors":"Zhila Yousefi, Hossein Feizollahzadeh, Kavous Shahsavarinia, Esmail Khodadadi","doi":"10.4103/ijabmr.ijabmr_614_22","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_614_22","url":null,"abstract":"Introduction: One of the effective methods of patient triage in the emergency department (ED) is the use of team triage, including physicians and nurses. Considering that there is no conclusive evidence about the effectiveness of team triage, this study aimed to investigate the effect of the team triage method on ED performance indexes. Methods: The present study is a quasi-interventional study in which 200 patients were referred to the ED in the hospitals of Tabriz in 2020. Participants were randomly assigned to two groups (team triage and conventional triage) and were evaluated. Data were collected by a three-part questionnaire including the participants’ demographic characteristics, the five-level triage form, and Press-Ganey satisfaction questionnaire were used. Data were analyzed by SPSS.22 statistical software. Results: The results showed that the mean score of waiting time for the first physician visit in team triage was statistically significantly lower than the conventional triage ( P = 0.001). Furthermore, the mean score of waiting time for receiving the first treatment in team triage was statistically significantly lower than the conventional triage ( P = 0.001). Finally, the mean score of patients’ satisfaction in team and conventional triage was statistically significantly higher in team triage ( P = 0.001). Conclusion: The study findings revealed that the team triage method, in comparison to conventional triage, decrease the waiting time for receiving the first service and length of stay, but leads to more patient’s satisfaction. Therefore, to improve the performance indicators of the ED, it is recommended that hospital managers use the team triage method.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135843801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ectopic Tooth with Odontogenic Keratocyst in Myasthenia Gravis: A Rare Coexistence","authors":"A. Christy Winnifred, T. Jones Raja Devathambi, R. Thanigainathan, Preethi Rajkumar","doi":"10.4103/ijabmr.ijabmr_4_23","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_4_23","url":null,"abstract":"Ectopic tooth in nondentate areas is uncommon. Odontogenic keratocyst arising from impacted tooth in the inferior border of orbit is very rare. This article reports the case of a 22-year-old female with odontogenic keratocyst arising from an impacted left maxillary third molar in the inferior border of the orbit causing symptoms of chronic sinusitis. The patient also had myasthenia gravis which confounded the diagnosis. The cyst was surgically enucleated along with the tooth which relieved the symptoms of the patient.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135843803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posterior Gastric Perforation with an Opening in Transverse Mesocolon: A Rare Case Report","authors":"Anand Singla, Sandeep Singh, Gagandeep Kaur, Deepak Jindal, Navjot Singh, Sakini Langstang","doi":"10.4103/ijabmr.ijabmr_92_23","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_92_23","url":null,"abstract":"Posterior gastric perforation is a very rare finding, difficult to diagnose due to the insidious onset of upper abdominal symptoms, and no air under the diaphragm on X-ray. Posterior gastric perforation which opens into transverse mesocolon is even rarer. This is a case report done to entail such a rare case, with only two cases reported in the past. We present the case of a 21-year-old female with pain in the epigastric region spreading to involve the whole abdomen, fever, vomiting, and anorexia. In our case, radiological findings revealed pneumoperitoneum. Intraoperatively, a tract was identified between the posterior wall of the stomach and transverse mesocolon. Tract was excised and primary repair was done using the Graham patch method.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135844138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lithium Toxicity - A Chameleon to Gastrointestinal Vasculitis as an Initial Presenter of Systemic Lupus Erythematosus.","authors":"Satyabrata Guru,&nbsp;Anupama Behera,&nbsp;Sadananda Barik,&nbsp;Ajitesh Sahu","doi":"10.4103/ijabmr.ijabmr_516_22","DOIUrl":"10.4103/ijabmr.ijabmr_516_22","url":null,"abstract":"<p><p>Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease. Gastrointestinal manifesting as nausea, vomiting, and pain abdomen are not so uncommon in SLE flare. However, gastrointestinal intestinal vasculitis as an initial presenter of SLE is very rare. This case report narrated gastrointestinal vasculitis as an initial presentation of systemic lupus erythematous, which mimicked lithium toxicity in a patient of preexisting bipolar disorder who was on long-term lithium therapy. A 26-year-old female presented with abdominal pain and persistent vomiting for 2 months. On further workup, she was antinuclear, anti-Smith, and anti-ds-DNA antibody positive. The serum lithium level was found to be normal computed tomography angiogram of the abdomen suggestive of vasculitis. A final diagnosis of SLE with gastrointestinal vasculitis as an initial presenter was made. She was treated with high-dose corticosteroid, cyclophosphamide, and other supportive care. She improved dramatically and was discharged with an oral corticosteroid, hydroxychloroquine, and ramipril.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a0/06/IJABMR-13-53.PMC10230520.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9572410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}