International Journal of Applied and Basic Medical Research最新文献

{"title":"Mechanism of Action of Natural Dipeptidyl Peptidase-IV Inhibitors (Berberine and Mangiferin) in Experimentally Induced Diabetes with Metabolic Syndrome","authors":"Rajesh Kumar Suman, Manjusha K Borde, Ipseeta Ray Mohanty, Hemant Kumar Singh","doi":"10.4103/ijabmr.ijabmr_115_23","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_115_23","url":null,"abstract":"Background: Berberine (BER) and mangiferin are known natural dipeptidyl peptidase (DPP-IV) inhibitors. Hence, the study was designed to elucidate the mechanism of action of natural DPP-IV inhibitors (BER and MNG) in experimentally induced diabetes with metabolic syndrome. Aim: The aim of this study was to observe mechanism through which natural DPP-IV inhibitor works in diabetes with metabolic syndrome rat model. Materials and Methods: Wistar rats were fed high-fat diet for 10 weeks and challenged with streptozotocin (STZ) (40 mg/kg) at the 3 rd week (high-fat diabetic control [HF-DC] group). After the confirmation of metabolic syndrome in the setting of diabetes, monotherapy (metformin [MET], vildagliptin [VIL], BER, and MNG) and combination (MET + VIL, MET + BER, and MET + MNG) therapy was orally fed to these rats from the 4 th to 10 th weeks. Results: Insulin resistance (IR) was seen in the HF-DC group as indicated by raised homeostasis model assessment of IR (HOMA-IR) in HF-DC group as compared with normal control (NC) groups. The treatment groups reduced IR as shown by a decrease in HOMA-IR as compared with HF-DC group rats. The marked reduction ( P < 0.001) of beta-cell function was observed in the HF-DC group as a reduced level of HOMA for beta-cell function (HOMA-β) was found as compared with the NC group. Increases in HOMA-β as compared to the HFDC group were observed in the therapy groups. The treatment group significantly reduced cholesterol and atherogenic index. The treatment group showed significant preservation of beta-cell mass as per immunohistochemistry and significant anti-apoptotic activity as per Terminal Deoxyribonucleotidyl Transferase-Mediated dUTP Nick End Labeling assay report. The treated rats significantly ( P < 0.05) reduced high-sensitivity C-reactive protein. Lipid peroxidation (thiobarbituric acid reactive substances) marker ( P < 0.001) was significantly reduced in the treatment group. Conclusion: The natural DPP-IV inhibitors BER and MNG treatment showed beneficial effects on various components of metabolic syndrome.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135843802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability of Grayscale Value for Bone Density Determination in Oral Rehabilitation using Dental Implants","authors":"Shalu Rai, Deepankar Misra, Akansha Misra, Himanshi Tomar, Ayush Dhawan, Rohit Gupta","doi":"10.4103/ijabmr.ijabmr_3_23","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_3_23","url":null,"abstract":"Introduction: Quality and quantity of jaw bones have been previously classified in literature using different methods. Imaging modalities such as computed tomography (CT), successfully determine bone density of jaws. This study aims to establish the role of cone-beam CT (CBCT) in determining the density of cortical and cancellous bones at different jaw sites. Materials and Methods: Eighty-three possible implant sites in healthy patients were evaluated using NewTomGiano CBCT machine. Cross-sections were obtained and cortical and cancellous bone densities on different aspects of the virtual implant in terms of Hounsfield unit (HU) were determined using New Net Technologies software version 6.1 and were classified according to software from D1 to D4. Data were entered into SPSS software (version 19.0) and were statistically analyzed. Results: The mean HU showed the highest value for cortical and cancellous in the anterior mandible (mean HU 1874.01 and 1131.73, respectively) followed by the posterior mandible (mean HU 1789.20 and 872.95, respectively) and least in posterior maxilla (mean HU 1068.26 and 830.04, respectively). Maximum D1 bone type was found in cortical bone and D2 bone type was noted in cancellous bone area. Males showed very highly significant cortical bone thickness ( P < 0.001) whereas females showed more cancellous bone thickness but the results were nonsignificant. Conclusion: A high degree of concordance between different regions of jaw bones with a strong correlation between the four bone types was obtained. Bone density plays a pivotal role in determining the prognosis of the implant. CBCT has proven to be beneficial in bone density analysis.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"167 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135844151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benign Mesenteric Lesion Presenting with Features of a Malignant Mass","authors":"Josefina Principe, Anna Mary Jose, Santiago Niño Basto, Isabela Castañeda, Abdul Rafay Pasha","doi":"10.4103/ijabmr.ijabmr_77_23","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_77_23","url":null,"abstract":"Encapsulated fat necrosis (EFN), most commonly, is an asymptomatic entity and is often found incidentally in images. However, in the abdomen, it may present as an acute abdomen. Mesenteric fat necrosis is part of a larger disease spectrum called collectively mesenteric sclerosis. It results in forming of a mass that can be confused with other pathologies such as liposarcoma, carcinoma of the cecum, and other more benign conditions such as appendagitis of the epiplon. We present the case of an 82-year-old male who presented with an asymptomatic right lower quadrant mass with concerning computed tomography findings with no previous abdominal surgery or trauma history. Diagnosing EFN is crucial as it can mimic bowel cancer and immune-related mesenteric pathology such as sclerosing mesenteritis, the management of which is far more extreme and aggressive than EFN.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135844468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One More Chance to See the World: A Rare Case Report on Sphenoid Mucocele Causing Vision Loss","authors":"Sharulatha Raguraman, Akshat Kushwaha, P. Lokesh Kumar, Sunil Kumar Saxena","doi":"10.4103/ijabmr.ijabmr_98_23","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_98_23","url":null,"abstract":"Mucocele of the sphenoid sinus is one of the rare diseases which an ENT surgeon can encounter in a clinical setup. It can often present as a chronic headache. It can remain undiagnosed unless a symptom due to the compression effect of the mucocele, such as diminution of vision, ophthalmoplegia, or any intracranial complication, occurs. Early diagnosis and emergency surgical intervention are imperative to prevent complications. Although late presentation can have a risk of permanent vision loss, improvement in vision postsurgery does not necessarily depend on the duration of symptoms. Here, we present a rare case scenario where, even after the delayed presentation, the patient had a significant vision improvement postsurgery.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135844452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thesis Writing: The T, H, E, S, I, S Approach – Review of the Book","authors":"V. Chauhan","doi":"10.4103/ijabmr.ijabmr_248_22","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_248_22","url":null,"abstract":"After going through the book, it inspired me to write a review. The title of the book is so catchy “THESIS WRITING ‒ the T, H, E, S, I, S. Approach.” It compelled me to peep into the book and explore the acronym ‒ T: Tickling, H: Hologram, E: Expansion, S: Scenarios, I: Improvisation, and S: Summary. I found that every chapter is crafted using this philosophy. The second reason which stimulated me to go through this book is that it has been authored by well‐known medical educationists who could appreciate the real need of the PGs of this country.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"12 1","pages":"220 - 222"},"PeriodicalIF":1.1,"publicationDate":"2022-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43572548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prescription-Event Monitoring Study on Safety and Efficacy of Levonadifloxacin (Oral and I.V.) in Management of Bacterial Infections: Findings of Real-World Observational Study","authors":"Y. Mehta, Anand Sutar, K. Zirpe, J. Kothari, Chakravarthi Alapati, Manu Pathak, V. Nagvekar, Kapil D. Mehta, Khokan Debnath","doi":"10.4103/ijabmr.ijabmr_602_21","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_602_21","url":null,"abstract":"Background: Levonadifloxacin is a novel broad-spectrum antibiotic belonging to the benzoquinolizine subclass of quinolones. It is available in intravenous as well as oral formulation for the treatment of infections caused by common Gram-positive bacterial pathogens including methicillin-resistant Staphylococcus aureus (MRSA). Patients and Methods: This study retrospectively assessed the real-world safety and efficacy of levonadifloxacin (oral and/or IV) in the treatment of 1229 patients across various clinical conditions. Study outcomes were clinical and microbiological success at the end of therapy. Results: The mean duration of levonadifloxacin therapy was 7.2 days, with a time to clinical improvement averaging at 4 days. Three hundred and three patients received oral therapy, 875 received IV, and 51 received a combination of IV followed by oral therapy. Patients were prescribed levonadifloxacin for skin and soft-tissue infections, diabetic foot infections, septicemia, catheter-related bloodstream infections, bone and joint infections, febrile neutropenia, and respiratory infections including COVID-19 pneumonia. High clinical success rates of 98.3%, 93.7%, and 96.1% with oral, IV, and IV followed by oral levonadifloxacin, respectively, were obtained. Only 11 mild adverse events were reported in 9 patients which included constipation, diarrhea, hyperglycemia, nausea, fatigue, and vomiting. Overall, 96.3% and 97.3% of investigators rated the efficacy and safety of levonadifloxacin as “good to excellent.” Conclusions: An excellent safety and efficacy profile of levonadifloxacin was observed in this study making it a suitable treatment option for management of various bacterial infections, including those caused by resistant Gram-positive pathogens such as MRSA and quinolone-resistant S. aureus.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"12 1","pages":"30 - 36"},"PeriodicalIF":1.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48664158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the Radio-contrast Media-Induced Self-Reported Adverse Drug Reactions in a Tertiary Care Hospital of North India: A Prospective Study","authors":"Pushpinder Singh, M. Gill, Mandeep Kaur, R. Mahajan, M. Kaur","doi":"10.4103/ijabmr.ijabmr_381_21","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_381_21","url":null,"abstract":"Background: Radio-contrast media are the agents which are used on daily basis in the radiological practice for either diagnostic or therapeutic purpose. Currently used agents are considered to be safe but not devoid of side effects. Objectives: Objectives of the study were to assess the incidence of adverse drug reactions (ADRs) in the patients who receive radiographic contrast media for computed tomography (CT) and intravenous pyelography (IVP), to stratify the ADRs into different types based on their time of appearance and as per their severity. Materials and Methods: A prospective and observational study of 1-year duration was done on all the patients who received radio-contrast media (Iohexol) intravenously for CT and IVP in the radiodiagnosis department. Patients who experienced ADRs were recorded for the basic demographic characteristics and types of ADRs. Stratification of ADRs as per their severity was done using common terminology criteria for adverse events scale and Modified Hartwig and Siegel ADR Severity Assessment Scale, and casualty assessment was done using Naranjo's Algorithm. Results: Out of the total 3522 patients who were included in the study, eight patients got 12 suspected ADRs with some of the patients having more than one type of ADR. The most frequent ADR was nausea and vomiting (25%), followed by fever, chills, or sweating. Incidence of ADRs was 0.23%. All the ADRs were acute and occurred within 30 min of contrast administration. As per the severity scales used, all the ADRs were mild (75%) to moderate (25%) in nature with none of the reactions to be severe. Causality assessment showed 87.5% of the reactions to be “probable” in nature. Conclusion: Low osmolar nonionic radio contrast media are associated with very low incidence of ADRs in the North Indian population.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"12 1","pages":"14 - 17"},"PeriodicalIF":1.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46141234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conceptualizing Problem-Based Learning: An Overview","authors":"A. Virk, R. Mahajan, T. Singh","doi":"10.4103/ijabmr.ijabmr_827_21","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_827_21","url":null,"abstract":"© 2022 International Journal of Applied and Basic Medical Research | Published by Wolters Kluwer ‐ Medknow In an attempt to restructure the medical undergraduate curricula so as to equip medical graduates with essential competencies expected of an Indian Medical Graduate (IMG) and to keep pace with the changing dynamics of health in India, the National Medical Commission has introduced competency-based medical education in Graduate Medical Education Regulations-2019.[1] Competency in medical graduates can be developed through the acquisition of knowledge integrated with clinical and attitudinal skills necessary to provide high-quality, effective patient care. Competency development is also influenced by the way medical educators facilitate the growth of an integrated knowledge structure in place of rote memorization of facts or procedural practice.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"12 1","pages":"1 - 3"},"PeriodicalIF":1.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44837169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trauma to Thrombus: A Case Report of Internal Jugular Vein Thrombosis","authors":"R. Lavadi, Challapalli Aditya, N. T. Tejaswi Karri, Tanuja Nambakam, S. Lokare","doi":"10.4103/ijabmr.ijabmr_372_21","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_372_21","url":null,"abstract":"Internal jugular vein (IJV) thrombosis is associated with several etiologies. Trauma is a rarely recorded causative factor. This case presents one such example of how trauma causes IJV thrombosis. A middle-aged woman presented to the general medicine outpatient department with complaints of pain in the base of the left side of the neck and swelling of the left arm and neck for six days. The symptoms had occurred following a trivial trauma to the left side of the neck due to pressure from a 25 L water can. Before the patient came to our hospital, she went to a local clinic, where magnetic resonance imaging was done and showed findings suspicious of thrombosis in her left IJV with extension into adjacent veins. A venous Doppler confirmed the findings. The patient was then treated conservatively with low-molecular-weight heparin, muscle relaxants, and antibiotics. Although uncommon, vascular injuries should also be thought of following minor trauma and not just musculoskeletal events. This case report proposes that IJV thrombosis can also occur without the classical etiological factors.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"12 1","pages":"61 - 63"},"PeriodicalIF":1.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46539765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Free Vascularized Supraclavicular Autologous Heterotopic Lymph Node Transfers Without Skin Paddle for Lymphedema Lower Limb","authors":"M. Mir, AJ Praveen, R. Maurya","doi":"10.4103/ijabmr.ijabmr_207_21","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_207_21","url":null,"abstract":"Free vascularized lymph node transfer (VLNT) is one of the new and highly efficacious procedures in the cases of lymphedema. In this case, we present a case of lower-limb lymphedema which was managed by this procedure where a supraclavicular LN was harvested and transferred to the lower leg. VLNT from the supraclavicular region is a very effective treatment for physiological restoration of the lymphatic flow in established cases of lower-limb lymphedema because of well-hidden favorable scar and minimal chances of secondary iatrogenic lymphedema in the donor region unlike other sites such as groin and axilla. The VLNT should be preferred over manual lymphatic drainage because it is very effective treatment for physiological restoration of the lymphatic flow, however, the further analytical studies are required to confirm statistically the effectiveness of the same over other modalities.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"12 1","pages":"57 - 60"},"PeriodicalIF":1.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49150042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}