International Journal of Applied and Basic Medical Research最新文献

{"title":"Assessment of Cardiovascular Parameters on Submaximal Treadmill Exercise in Obese versus Nonobese Adults.","authors":"Aditya Gupta, Ravinder Garg, Sumit Pal Singh Chawla, Sarabjot Kaur, Shiwali Goyal","doi":"10.4103/ijabmr.ijabmr_290_23","DOIUrl":"10.4103/ijabmr.ijabmr_290_23","url":null,"abstract":"<p><strong>Background: </strong>Obesity and overweight, irrespective of metabolic status, confer an increased risk of adverse consequences including cardiovascular diseases (CVDs). The mechanisms underlying altered cardiovascular responses in obese individuals during and after submaximal treadmill exercise are the subjects of great interest to public health. After graded exercise, delayed heart rate recovery (HRR), exaggerated blood pressure (BP) response, and prolongation of QT interval are the powerful predictors of cardiovascular morbidity and mortality that may facilitate timely identification of individuals at risk of CVD and help to evaluate the effectiveness of treatment interventions.</p><p><strong>Aim: </strong>To compare the cardiovascular parameters on submaximal treadmill exercise in obese and nonobese adults.</p><p><strong>Materials and methods: </strong>This study was conducted on 80 subjects, 40 obese (cases) and 40 normal-weight individuals (controls), belonging to the age group of 18-60 years. Each participant was subjected to submaximal treadmill exercise according to the Bruce protocol. Heart rate (HR), systolic BP and diastolic BP (SBP and DBP), mean arterial pressure (MAP), QT and corrected QT (QTc) intervals, and rate pressure product (RPP) were measured preexercise, immediately after exercise, and during passive recovery at 1 min and 5 min after exercise. The Chi-square test and Mann-Whitney <i>U</i>-test, whichever is appropriate, were employed for the comparison of variables between the two study groups. <i>P</i> < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>Mean HR immediately after exercise, at 1 min and 5 min postexercise was significantly higher in obese when compared to nonobese participants (<i>P</i> = 0.006, <i>P</i> = 0.001, <i>P</i> = 0.001) despite similar resting HR in both the groups (<i>P</i> = 0.874). Mean SBP, DBP, MAP, and RPP were significantly higher in obese in comparison to nonobese subjects in all stages, i.e. before exercise, immediately after exercise, at 1 min and 5 min after exercise. QT and QTc intervals were also found to be significantly greater in obese than nonobese subjects in all stages (<i>P</i> = 0.001 each).</p><p><strong>Conclusion: </strong>Obese subjects had higher resting BP (SBP, DBP, and MAP), QT/QTc interval, RPP, and increased response to submaximal treadmill exercise activity. Delayed HRR after exercise was also noted in obese subjects which indicates that obese populations are at risk of developing CVDs due to alteration in autonomic functions with sympathetic hyperactivity.</p>","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"13 4","pages":"212-217"},"PeriodicalIF":1.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10789467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139477294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectrum of Hemophagocytosis in Bone Marrow Aspirates: Experience from a Tertiary Care Hospital in North India","authors":"Vandana Bhatti, Kanwardeep Singh Kwatra, Naveen Kakkar, M. Joseph John","doi":"10.4103/ijabmr.ijabmr_232_23","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_232_23","url":null,"abstract":"Background: Hemophagocytosis refers to the engulfment of hematopoietic cells by histiocytes. It can be seen in various conditions but is usually reported in the setting of hemophagocytic lymphohistiocytosis (HLH). Optimal interpretation of hemophagocytosis in the bone marrow in relation to the underlying disease significantly contributes to correct patient management. Aim: The present study was done to identify the spectrum of conditions associated with hemophagocytosis in the bone marrow aspirates and grade the degree of hemophagocytosis. Material and Methods: This retrospective observational study included all the bone marrow aspirates showing hemophagocytosis, identified over a period of 5 years (January 2015 to January 2020). Two pathologists independently reviewed bone marrow slides. Hemophagocytosis was graded as mild, moderate, or severe by observing the number of histiocytes showing hemophagocytosis per 500 nucleated cells. Results: Eighty-eight patients showing hemophagocytosis in the bone marrow aspirate smear were included in the study. The most common cause of hemophagocytosis was infection (18%). There were 4 (5%) cases of HLH. Grade 1 (mild) hemophagocytosis was seen in 25 (29%) cases followed by Grade 2 (moderate) in 53 (60%) cases and Grade 3 (severe) in 10 (11%) cases. Fever was the most common clinical symptom present in 45 (51%) cases. Conclusion: Hemophagocytosis in bone marrow aspirates is a common and under-reported finding. It is not only seen in cases of HLH but also in infections and other conditions. Documenting hemophagocytosis, even in the absence of fulfilled HLH criteria, is vital to explain cytopenias.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135844457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Book Review: Toolbox for Assessment of Clinical Competence","authors":"K. Ramnarayan","doi":"10.4103/ijabmr.ijabmr_400_23","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_400_23","url":null,"abstract":"Editors: Tejinder Singh and Rajiv Mahajan Publisher: Unistar Books Pvt Ltd., Chandigarh Year of publication: 2023 Price: Rs. 250 Number of pages: 124 Tagging objectives to assessment has become the hallmark of a robust curriculum; yet, it has been a daunting task to accomplish this pragmatically. In 1996, van der Vleuten so trenchantly said “assessment drives learning in at least four ways: its content, format, timing, and any subsequent feedback given to the examinee.” Over a quarter century later we, in medical education, are grappling with the knotty task of meaningfully aligning the assessment to the objectives. Scriven’s definition of assessment in 1991 envisaged a systematic, objective determination of merit, worth, or value to distinguish between the worthy and the unworthy. However, this definition had ignored formative assessment altogether. Moreover, the emphasis of today’s assessment has shifted toward integration to assess the ability of a student to integrate knowledge, skills, attitudes, and values into a clinical situation. It is in the background of this scenario that the manual “Toolbox for Assessment of Clinical Competence” edited by Tejinder Singh and Rajiv Mahajan becomes contextually relevant and timely. The authors have, in this repertoire, not only captured formative and summative assessments with all its nuances but have also linked the assessment tools to the various levels of Miller’s pyramid. The thoroughness with which the editors have organized the content is testimony to their expertise and ingenuity. Classifying assessment tools under the categories of “knows and knows how,” “shows,” and “does” is a refreshing approach to understanding and implementing the various assessment strategies. This manual is a primer in the assessment of clinical competence while serving as a ready reckoner with the choicest compendium of invaluable references for more in-depth exploration. A medical educator who is serious and sincere about using the power of assessment to decide the learning of competencies will derive a wealth of ideas from this treasury of assessment. Every medical education unit in a medical college as well as every practitioner of health professions education will be enriched and empowered by this sourcebook, which could serve as a guidepost to conceive and practice various approaches to measurement of competence while conceding that not everything that matters can or need to be measured! “Students can, with difficulty, escape from the effects of poor teaching, but they cannot (if they want to graduate) escape the effects of poor assessment” said David Boud. Therefore, it is incumbent on all of us, as educators, to strive to make assessment in health sciences meet its laudable goals, which this book has so masterfully accomplished.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135844143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a High Penetration Safe Irrigant from Withania somnifera","authors":"Manreet Parhar, Parveen Bansal","doi":"10.4103/ijabmr.ijabmr_89_23","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_89_23","url":null,"abstract":"Background: Herbal medicine is regaining a strong position in health care by virtue of better safety and minimal toxicity as compared to conventional chemotherapies. It is making a place in dental care in the form of various toothpastes, lotions, and mouthwashes. It has been analyzed that very few discrete herbal irrigants have an action comparable to that of sodium hypochlorite. No data about any study on penetration depth and penetration area for herbal-based irrigants used in root canal treatment are available. Aim: The aim of this study was to assess the efficacy of Withania somnifera extracts by assessing its penetration depth and area inside dentinal tubules using a confocal laser scanning microscope. Materials and Methods: Freshly extracted 25 maxillary central incisors were divided into three groups: Group 1: W. somnifera ; Group 2: sodium hypochlorite; and Group 3: distilled water. Results: W. somnifera showed better results with respect to penetration depth and area inside the dentinal tubules thansodium hypochlorite. Conclusion: From the study, it can be concluded that W. somnifera extract-based irrigant may be used as an alternative to sodium hypochlorite-based irrigant. It also shows that more herbal drugs need such types of screening and incorporation in dental practice to reduce the potential side effects of the conventional drugs used in daily practice.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135844765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Team Triage Method on Emergency Department Performance Indexes: A quasi-interventional study","authors":"Zhila Yousefi, Hossein Feizollahzadeh, Kavous Shahsavarinia, Esmail Khodadadi","doi":"10.4103/ijabmr.ijabmr_614_22","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_614_22","url":null,"abstract":"Introduction: One of the effective methods of patient triage in the emergency department (ED) is the use of team triage, including physicians and nurses. Considering that there is no conclusive evidence about the effectiveness of team triage, this study aimed to investigate the effect of the team triage method on ED performance indexes. Methods: The present study is a quasi-interventional study in which 200 patients were referred to the ED in the hospitals of Tabriz in 2020. Participants were randomly assigned to two groups (team triage and conventional triage) and were evaluated. Data were collected by a three-part questionnaire including the participants’ demographic characteristics, the five-level triage form, and Press-Ganey satisfaction questionnaire were used. Data were analyzed by SPSS.22 statistical software. Results: The results showed that the mean score of waiting time for the first physician visit in team triage was statistically significantly lower than the conventional triage ( P = 0.001). Furthermore, the mean score of waiting time for receiving the first treatment in team triage was statistically significantly lower than the conventional triage ( P = 0.001). Finally, the mean score of patients’ satisfaction in team and conventional triage was statistically significantly higher in team triage ( P = 0.001). Conclusion: The study findings revealed that the team triage method, in comparison to conventional triage, decrease the waiting time for receiving the first service and length of stay, but leads to more patient’s satisfaction. Therefore, to improve the performance indicators of the ED, it is recommended that hospital managers use the team triage method.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135843801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ectopic Tooth with Odontogenic Keratocyst in Myasthenia Gravis: A Rare Coexistence","authors":"A. Christy Winnifred, T. Jones Raja Devathambi, R. Thanigainathan, Preethi Rajkumar","doi":"10.4103/ijabmr.ijabmr_4_23","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_4_23","url":null,"abstract":"Ectopic tooth in nondentate areas is uncommon. Odontogenic keratocyst arising from impacted tooth in the inferior border of orbit is very rare. This article reports the case of a 22-year-old female with odontogenic keratocyst arising from an impacted left maxillary third molar in the inferior border of the orbit causing symptoms of chronic sinusitis. The patient also had myasthenia gravis which confounded the diagnosis. The cyst was surgically enucleated along with the tooth which relieved the symptoms of the patient.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135843803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posterior Gastric Perforation with an Opening in Transverse Mesocolon: A Rare Case Report","authors":"Anand Singla, Sandeep Singh, Gagandeep Kaur, Deepak Jindal, Navjot Singh, Sakini Langstang","doi":"10.4103/ijabmr.ijabmr_92_23","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_92_23","url":null,"abstract":"Posterior gastric perforation is a very rare finding, difficult to diagnose due to the insidious onset of upper abdominal symptoms, and no air under the diaphragm on X-ray. Posterior gastric perforation which opens into transverse mesocolon is even rarer. This is a case report done to entail such a rare case, with only two cases reported in the past. We present the case of a 21-year-old female with pain in the epigastric region spreading to involve the whole abdomen, fever, vomiting, and anorexia. In our case, radiological findings revealed pneumoperitoneum. Intraoperatively, a tract was identified between the posterior wall of the stomach and transverse mesocolon. Tract was excised and primary repair was done using the Graham patch method.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135844138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and Reliability of Students’ Assessment: Case for Recognition as a Unified Concept of Valid Reliability","authors":"Kapil Gupta","doi":"10.4103/ijabmr.ijabmr_382_23","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_382_23","url":null,"abstract":"Students’ assessment, the major component of learning cycle, and curriculum serve many functions.[1-4] Assessment suggests areas of improvement during the training; the selection of students based on performance helps in the evaluation of the program and also has predictive utility. The assessment can be of learning – summative assessment, for learning - formative assessment, and can be without any external supervision – internal assessment. The importance and necessity of assessment in the learning cycle of the students can be gauged from the wordings of various proverbs in use, such as – ”assessment derives learning,” “assessment leads to learning,” and “assessment are the tail that wags the curriculum dog.” The students do modify their learning as per assessment. To make a precise decision about student’s learning and competency, the assessment must have both measurable and nonmeasurable components.[5] Van der Vleuten and Schuwirth defined assessment “as any formal or purported action to obtain information about the competence and performance of a student.”[6] Further, the assessment can be either criterion-referenced-comparing the competence of students against some fixed criteria or norm-referenced-comparing the performance of students with each other. Besides an aid to learning by virtue of having a provision of feedback and thus improve learning, assessment has reverse side too-improperly designed assessment can disfigure the learning. Therefore, any assessment should possess certain qualities or attributes. Traditional Concept Two important attributes defining students’ assessment are – reliability and validity. Conventionally, reliability of an assessment tool has commonly been referred to as “reproducibility” or “getting the same scores/marks under same conditions” or “precision of the measurement” or “consistency with which a test measures what it is supposed to assess.”[7] Reliability is measurable. As per classical test theory, the alpha coefficient (AC) is a range from 0 (no reliability) to 1 (perfect reliability); so if the test has an AC of 0.8%, it means it has a reliability of 80%, while measurement error is 20%.[8] The major factor affecting reliability is content or domain specificity. How an assessment can be reliable if it is based on a limited sampling of content or large content has been included in a single sample or if it is based on a single test? Moreover, a score that is derived from solving one problem cannot be interpolated for the second one. For example, assessment scores that are based on a single long case or viva for a single patient sample cannot produce reliable scores for another problem. If at the end of any professional year, subject knowledge is assessed by single multiple-choice questions (MCQs) based test of 10 items, can it measure students’ knowledge for the whole subject? Such assessments can be held valid but not reliable. Therefore, for any assessment test to be reliable, it is important to have a ","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135844744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are Buffy-coat Pooled Platelet Concentrates an Effective Alternative to Apheresis Platelet Concentrates? An In vitro Analysis at a Tertiary Care Center in Northern India","authors":"Prashant Agarwal, Ashish Jain, Priti Elhence, Anupam Verma","doi":"10.4103/ijabmr.ijabmr_73_23","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_73_23","url":null,"abstract":"Background: There is a need for platelet products to have the best quality. Apheresis platelet concentrates (PCs) obtained from single-donors PCs (SD-PCs) are considered best but have issues such as feasibility and cost. Buffy-coat pooled PCs (BCP-PCs) are considered an alternative to SD-PCs. This study compares BCP-PCs and SD-PCs for in vitro quality parameters and their changes during storage. Materials and Methods: Fifteen units of BCP-PCs and 15 units of SD-PCs were prepared. In this study, a pool of five buffy coats was prepared. Fifteen units of BCP-PCs were analyzed on day 1 and day 5 of storage, while 15 SD-PCs were analyzed on day 1 while ten units on day 5. The parameters analyzed were volume, hematological parameters, pH, swirling, and sterility. Results: The mean platelets count of SD-PCs was found to be significantly higher as compared to BCP-PCs. White blood cells (WBCs) contamination was significantly lower in BCP-PCs as compared to SD-PCs. The mean pH and mean platelet volume of SD-PCs were significantly lower than BCP-PCs. During storage, the mean platelets count of BCP-PCs was decreased significantly while that of SD-PCs nonsignificantly. The mean WBCs count and pH decreased in both BCP-PCs and SD-PCs significantly. All units in both types of PCs were sterile. Conclusion: Platelet yield was significantly better in SD-PCs, while mean WBCs contamination was significantly lower in BCP-PCs. BCP-PCs may be preferred in place of SD-PCs in case of nonavailability of apheresis, difficulty in finding a willing donor, or when the cost is of consideration.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135844140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating 18-Glycosyl Hydrolase Protein Chitiotriosidase-1 is Associated with Renal Dysfunction and Systemic Inflammation in Diabetic Kidney Disease","authors":"Kuppuswami Jayashree, Gandhipuram Periyasamy Senthilkumar, Mehalingam Vadivelan, Sreejith Parameswaran","doi":"10.4103/ijabmr.ijabmr_42_23","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_42_23","url":null,"abstract":"Introduction: Chitotriosidase-1 (CHIT-1) is a marker of macrophage activation and recently attributed to type 2 diabetes mellitus (T2DM). However, its role in the development and progression of diabetic kidney disease (DKD) has been sparsely discussed in the recent literature. Materials and Methods: In this cross-sectional exploratory study, 81 participants with T2DM were classified into two groups based on the presence of DKD. Their anthropometric, biochemical, and pathological profiles were estimated. Circulatory CHIT-1 concentration was determined using the enzyme-linked immuno-sorbent assay (ELISA) in plasma. Results: CHIT-1 was significantly elevated in diabetic nephropathy, independent of age and gender. It is associated with severity of kidney disease, as assessed using urinary protein-creatinine ratio (uPCR) in a multiple linear regression model, independent of age, gender, diabetes duration, and insulin resistance. CHIT-1 positively predicted the likelihood of DKD in the study population (area under the curve = 0.724, P < 0.05). The duration of diabetes correlated positively with uPCR and negatively with estimated glomerular-filtration rate. Neutrophil-Lymphocyte ratio was elevated in participants with DKD. This well-established marker of systemic inflammation exhibited significant positive association with CHIT-1. Conclusion: Plasma CHIT-1 protein is elevated in DKD and associated with disease progression. It is capable of reflecting disease severity and is closely related to systemic inflammation possibly caused by pro-inflammatory circulatory immune cells.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135844441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}