International Journal of Applied and Basic Medical Research最新文献_第9页

Practical Manual of Pharmacology for Medical Students: Book Review 医学生药理学实用手册：书评

IF 1.1

International Journal of Applied and Basic Medical Research Pub Date : 2021-10-01 DOI: 10.4103/ijabmr.ijabmr_628_21

R. Mahajan

引用次数: 0

Principles of Medical Education: A Review of Book's Fifth Edition 医学教育的原则:书评书的第五版

IF 1.1

International Journal of Applied and Basic Medical Research Pub Date : 2021-04-01 DOI: 10.4103/ijabmr.ijabmr_172_21

M. Joshi

引用次数: 0

Humanities in Medical Education 医学教育中的人文学科

IF 1.1

International Journal of Applied and Basic Medical Research Pub Date : 2020-10-01 DOI: 10.4103/ijabmr.IJABMR_604_20

A. Supe

引用次数: 1

Erratum 勘误表

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International Journal of Applied and Basic Medical Research Pub Date : 2020-01-14 DOI: 10.1159/000505248

引用次数: 0

Study of Association of C-Reactive Protein with Maternal Chorioamnionitis and Early-Onset Neonatal Sepsis in Premature Rupture of Membranes Deliveries: A Diagnostic Dilemma C反应蛋白与胎膜早破产妇绒毛膜羊膜炎和早期新生儿败血症的相关性研究：诊断难题

IF 1.1

International Journal of Applied and Basic Medical Research Pub Date : 2019-10-01 DOI: 10.4103/ijabmr.IJABMR_119_19

Aabha Suryavanshi, Ruchi Kalra

{"title":"Study of Association of C-Reactive Protein with Maternal Chorioamnionitis and Early-Onset Neonatal Sepsis in Premature Rupture of Membranes Deliveries: A Diagnostic Dilemma","authors":"Aabha Suryavanshi, Ruchi Kalra","doi":"10.4103/ijabmr.IJABMR_119_19","DOIUrl":"https://doi.org/10.4103/ijabmr.IJABMR_119_19","url":null,"abstract":"Introduction: Term prelabor rupture of membranes and preterm premature rupture of membranes (PROM), both pose significant risk to the mother and the fetus. Early identification of sepsis is essential as the mother has risk of chorioamnionitis and neonate is at the risk of early-onset sepsis. Aim: To evaluate the diagnostic value of positive maternal C-reactive protein (CRP) in association with maternal clinical chorioamnionitis and early-onset neonatal sepsis (EONS) in PROM deliveries after 28 weeks of gestation. Methodology: The study was conducted at People's College of Medical Science and Research Centre, Bhopal, from June 1, 2017, to May 31, 2018. Maternal serum CRP test was correlated to the signs of maternal chorioamnionitis and signs of EONS within 72 h of life. Results: The maternal CRP test was compared to clinical signs of chorioamnionitis. Sensitivity of CRP for diagnosing maternal chorioamnionitis was 48% (95% confidence interval [CI] −35.99–61.12), specificity was 81 (95% CI 71.55%–88.98%), and odds ratio of maternal chorioamnionitis was 4.1176 (95% CI 1.99–8.51) with P < 0.0001. Sensitivity of positive maternal CRP in diagnosing EONS was 56.67% (95% CI 43.24%–69.41%), specificity was 84.78% (95% CI 75.79%–91.42%), and odds ratio of neonatal sepsis in maternal CRP positive was 7.28 (95%CI 3.39–15.64) with P < 0.0001. Conclusion: Our study suggests that in PROM deliveries, if maternal CRP test is positive, then it indicates early delivery and neonate screening for EONS.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"9 1","pages":"236 - 240"},"PeriodicalIF":1.1,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43416804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Human Papillomavirus Detection in Oropharyngeal Squamous Cell Carcinoma Using p16 Immunohistochemistry 人乳头瘤病毒在口咽鳞状细胞癌中的p16免疫组化检测

IF 1.1

International Journal of Applied and Basic Medical Research Pub Date : 2019-10-01 DOI: 10.4103/ijabmr.IJABMR_221_18

D. Uppala, A. Sabu, NV Ratna Mouli, N. Tejaswini, V. Rohit, G. Nishitha

{"title":"Human Papillomavirus Detection in Oropharyngeal Squamous Cell Carcinoma Using p16 Immunohistochemistry","authors":"D. Uppala, A. Sabu, NV Ratna Mouli, N. Tejaswini, V. Rohit, G. Nishitha","doi":"10.4103/ijabmr.IJABMR_221_18","DOIUrl":"https://doi.org/10.4103/ijabmr.IJABMR_221_18","url":null,"abstract":"Introduction: Oral cancer ranks third among all cancers in the Indian population with approximately 45% of call cancer cases in India being diagnosed as oral cancer, among which 20%–50% of the cases are observed to be associated with human papillomavirus (HPV) infection. Aim: This study aims to detect and evaluate the presence of p16 in oropharyngeal squamous cell carcinoma (OPSCC) patients using immunohistochemistry (IHC). Materials and Methods: This study was based on samples collected from 21 patients with primary OPSCC who were diagnosed and treated during the period of December 2017–March 2018. Inclusion criteria were complete clinicopathologic data, adequate clinical follow-up, and availability of sufficient paraffin-embedded tumor material. HPV immunoreactivity was further investigated by means of IHC using p16 as a marker. Results: IHC results revealed p16 positivity in six OPSCC cases. There was no statistically significant association of the p16 positivity of HPV with the age, gender, or site. Conclusion: Our results suggest that IHC-based detection of p16 provides a suboptimal prognostic information if not combined with detection of HPV DNA. Although p16 expression and HPV DNA infection are correlated with HPV-associated OPSCCs, neither of the tests alone is the optimal method for HPV status detection.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"9 1","pages":"212 - 216"},"PeriodicalIF":1.1,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44488111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Validation and Clinical Application of Interferon-Gamma Release Assay for Diagnosis of Latent Tuberculosis Infection in Children. γ-干扰素释放试验诊断儿童潜伏性肺结核感染的验证和临床应用。

IF 1.1

International Journal of Applied and Basic Medical Research Pub Date : 2019-10-01 Epub Date: 2019-10-11 DOI: 10.4103/ijabmr.IJABMR_86_19

Kirtilaxmi K Benachinmardi, S Sangeetha, Mohan Rao, R Prema

{"title":"Validation and Clinical Application of Interferon-Gamma Release Assay for Diagnosis of Latent Tuberculosis Infection in Children.","authors":"Kirtilaxmi K Benachinmardi, S Sangeetha, Mohan Rao, R Prema","doi":"10.4103/ijabmr.IJABMR_86_19","DOIUrl":"https://doi.org/10.4103/ijabmr.IJABMR_86_19","url":null,"abstract":"Background: India has the highest tuberculosis (TB) burden, accounting for one-fifth of the global incidence and two-third of the cases in Southeast Asia with an estimated 1.9 million new cases every year. Identifying and treating latent TB infection (LTBI) can reduce the risk of development of active disease by up to 90%, thereby decreasing a major burden to the prevalence of the disease, and thus reducing potential sources in future.Aim: Early diagnosis of LTBI by tuberculin skin test (TST) and a newer interferon-gamma release assay (IGRA).Materials and methods: Seventy-seven clinically asymptomatic household contacts (≤18 years) of confirmed pulmonary TB patients were enrolled to compare the performance of TST and IGRA to diagnose LTBI. At baseline, all participants underwent testing for IGRA and TST.Results: TST showed positivity of 22%, while IGRA demonstrated positivity of 40% in the diagnosis of latent TB. Kappa value at 95% confidence interval was 0.4753, indicates a moderate agreement between the two tests. This indicates that IGRA is a better predictor of latent TB. Maximum positive percentage was in the age group of 16-18 years in both the tests followed by 1-5 years.Aim: Early diagnosis of LTBI by tuberculin skin test (TST) and a newer interferon-gamma release assay (IGRA).","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"9 4","pages":"241-245"},"PeriodicalIF":1.1,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/02/05/IJABMR-9-241.PMC6822318.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41199879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Vaginal Carcinoma with Third-Degree Uterine Prolapse 阴道癌伴三度子宫脱垂

IF 1.1

International Journal of Applied and Basic Medical Research Pub Date : 2019-10-01 DOI: 10.4103/ijabmr.IJABMR_211_18

Neha K Sheikh, S. Date, Yogita Darekar

引用次数: 1

Use of Machine Learning Algorithms for Prediction of Fetal Risk using Cardiotocographic Data 使用机器学习算法利用心脏病学数据预测胎儿风险

IF 1.1

International Journal of Applied and Basic Medical Research Pub Date : 2019-10-01 DOI: 10.4103/ijabmr.IJABMR_370_18

Z. Hoodbhoy, Mohammad Noman, Ayesha Shafique, A. Nasim, D. Chowdhury, B. Hasan

{"title":"Use of Machine Learning Algorithms for Prediction of Fetal Risk using Cardiotocographic Data","authors":"Z. Hoodbhoy, Mohammad Noman, Ayesha Shafique, A. Nasim, D. Chowdhury, B. Hasan","doi":"10.4103/ijabmr.IJABMR_370_18","DOIUrl":"https://doi.org/10.4103/ijabmr.IJABMR_370_18","url":null,"abstract":"Background: A major contributor to under-five mortality is the death of children in the 1st month of life. Intrapartum complications are one of the major causes of perinatal mortality. Fetal cardiotocograph (CTGs) can be used as a monitoring tool to identify high-risk women during labor. Aim: The objective of this study was to study the precision of machine learning algorithm techniques on CTG data in identifying high-risk fetuses. Methods: CTG data of 2126 pregnant women were obtained from the University of California Irvine Machine Learning Repository. Ten different machine learning classification models were trained using CTG data. Sensitivity, precision, and F1 score for each class and overall accuracy of each model were obtained to predict normal, suspect, and pathological fetal states. Model with best performance on specified metrics was then identified. Results: Determined by obstetricians' interpretation of CTGs as gold standard, 70% of them were normal, 20% were suspect, and 10% had a pathological fetal state. On training data, the classification models generated by XGBoost, decision tree, and random forest had high precision (>96%) to predict the suspect and pathological state of the fetus based on the CTG tracings. However, on testing data, XGBoost model had the highest precision to predict a pathological fetal state (>92%). Conclusion: The classification model developed using XGBoost technique had the highest prediction accuracy for an adverse fetal outcome. Lay health-care workers in low- and middle-income countries can use this model to triage pregnant women in remote areas for early referral and further management.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"9 1","pages":"226 - 230"},"PeriodicalIF":1.1,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48246055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42

Effect of Iodinated Contrast Media on Serum Electrolyte Concentrations in Patients Undergoing Routine Contrast Computed Tomography Scan Procedure 碘化造影剂对常规计算机断层扫描患者血清电解质浓度的影响

IF 1.1

International Journal of Applied and Basic Medical Research Pub Date : 2019-10-01 DOI: 10.4103/ijabmr.IJABMR_69_19

Sindhu Sankaran, G. Saharia, S. Naik, M. Mangaraj

{"title":"Effect of Iodinated Contrast Media on Serum Electrolyte Concentrations in Patients Undergoing Routine Contrast Computed Tomography Scan Procedure","authors":"Sindhu Sankaran, G. Saharia, S. Naik, M. Mangaraj","doi":"10.4103/ijabmr.IJABMR_69_19","DOIUrl":"https://doi.org/10.4103/ijabmr.IJABMR_69_19","url":null,"abstract":"Background and Objectives: Being hypertonic solutions, iodinated contrast media such as iohexol can cause a shift of fluids and electrolytes between different compartments of the body, but there is an ongoing discrepancy in data and current studies as to the effect of iodinated contrast media on serum electrolytes. Hence, this hospital-based prospective clinical observational study was carried out with objectives of evaluating the changes in serum electrolyte concentrations with intravenous iodinated contrast media administration in adult population and to correlate the changes in electrolyte concentrations, if any, with the demographic profile of the patients. Materials and Methods: We analyzed 103 numbers of adult patient samples over a period of 2 months by collecting blood both before administration of contrast and after 24 h of the contrast-enhanced computed tomography scan procedure. Serum concentrations of sodium, potassium, chloride, and ionized calcium were measured using Eschweiler Combiline analyzer based on ion-selective electrode principle. Results: The mean age of the study population in our study was 40.11 ± 20.51 years. We found that changes in serum sodium and chloride concentration after administration of contrast media are significant (sodium: 136.29 ± 3.53 vs. 132.49 ± 6.36 mmol/L and chloride: 100.03 ± 0.70 vs. 97.53 ± 0.70 mmol/L). Sodium concentration shows more decrease in females compared to males after administration of iodine contrast. The most probable reason for this decrease in serum electrolytes was secondary changes to hemodilution due to high osmolality of the contrast. Conclusions: Attending physicians must be alert for such possibilities of changes in electrolytes after contrast administration and be prepared to treat any adversity if one occurs.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"20 1","pages":"217 - 220"},"PeriodicalIF":1.1,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41301822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5